WO2002056013A3 - Oxazolidinone photoaffinity probes, uses and compounds - Google Patents

Oxazolidinone photoaffinity probes, uses and compounds Download PDF

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Publication number
WO2002056013A3
WO2002056013A3 PCT/US2001/048455 US0148455W WO02056013A3 WO 2002056013 A3 WO2002056013 A3 WO 2002056013A3 US 0148455 W US0148455 W US 0148455W WO 02056013 A3 WO02056013 A3 WO 02056013A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
photoaffinity probes
oxazolidinone
probes
oxazolidinone photoaffinity
Prior art date
Application number
PCT/US2001/048455
Other languages
French (fr)
Other versions
WO2002056013A2 (en
Inventor
Gerard R. Colca
William G. Mcdonald
Dean L. Shinabarger
Original Assignee
Pharmacia & Upjohn Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Company filed Critical Pharmacia & Upjohn Company
Priority to JP2002556217A priority Critical patent/JP2004537265A/en
Priority to AU2002245127A priority patent/AU2002245127A1/en
Priority to CA002432162A priority patent/CA2432162A1/en
Priority to EP01993282A priority patent/EP1386153A2/en
Publication of WO2002056013A2 publication Critical patent/WO2002056013A2/en
Publication of WO2002056013A3 publication Critical patent/WO2002056013A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9446—Antibacterials

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Disclosed are novel methods of identifying biological targets of oxazolidinone type compounds that have antimicrobial activity by use of photoaffinity probes.
PCT/US2001/048455 2000-12-15 2001-12-14 Oxazolidinone photoaffinity probes, uses and compounds WO2002056013A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2002556217A JP2004537265A (en) 2000-12-15 2001-12-14 Oxazolidinone photoaffinity probes, their uses and compounds
AU2002245127A AU2002245127A1 (en) 2000-12-15 2001-12-14 Oxazolidinone photoaffinity probes, uses and compounds
CA002432162A CA2432162A1 (en) 2000-12-15 2001-12-14 Oxazolidinone photoaffinity probes, uses and compounds
EP01993282A EP1386153A2 (en) 2000-12-15 2001-12-14 Oxazolidinone photoaffinity probes, uses and compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25605300P 2000-12-15 2000-12-15
US60/256,053 2000-12-15

Publications (2)

Publication Number Publication Date
WO2002056013A2 WO2002056013A2 (en) 2002-07-18
WO2002056013A3 true WO2002056013A3 (en) 2003-11-06

Family

ID=22970924

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/048455 WO2002056013A2 (en) 2000-12-15 2001-12-14 Oxazolidinone photoaffinity probes, uses and compounds

Country Status (5)

Country Link
EP (1) EP1386153A2 (en)
JP (1) JP2004537265A (en)
AU (1) AU2002245127A1 (en)
CA (1) CA2432162A1 (en)
WO (1) WO2002056013A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003035073A1 (en) 2001-10-25 2003-05-01 Astrazeneca Ab Isoxazoline derivatives useful as antimicrobials
EP1892530A1 (en) * 2006-08-25 2008-02-27 Boehringer Ingelheim Pharma GmbH & Co. KG Method for determining transport activity of a transport protein
WO2008046584A2 (en) * 2006-10-16 2008-04-24 Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften Lepa as a target for antibacterial agents
WO2023215514A2 (en) * 2022-05-04 2023-11-09 Promega Corporation Bioluminescence-triggered photocatalytic labeling

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6861433B2 (en) * 2000-12-15 2005-03-01 Pharmacia & Upjohn Company Oxazolidinone photoaffinity probes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LIN ET AL.: "The oxazolidinone eperezolid binds to the 50S ribosomal subunit and competes with binding of chloramphenicol and lincomycin.", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 41, no. 10, 1997, pages 2127 - 2131, XP002240237 *
MATASSOVA N B ET AL: "RIBOSOMAL RNA IS THE TARGET FOR OXAZOLIDINONES, A NOVEL CLASS OF TRANSLATIONAL INHIBITORS", RNA, CAMBRIDGE UNIVERSITY PRESS, CAMBRIDGE, GB, vol. 5, no. 7, 1999, pages 939 - 946, XP001079539, ISSN: 1355-8382 *
See also references of EP1386153A2 *

Also Published As

Publication number Publication date
CA2432162A1 (en) 2002-07-18
JP2004537265A (en) 2004-12-16
EP1386153A2 (en) 2004-02-04
WO2002056013A2 (en) 2002-07-18
AU2002245127A1 (en) 2002-07-24

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