WO2002051306A3 - Vorrichtung zur bestimmung der konzentration von stickstoffmonoxid - Google Patents

Vorrichtung zur bestimmung der konzentration von stickstoffmonoxid Download PDF

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Publication number
WO2002051306A3
WO2002051306A3 PCT/DE2001/004744 DE0104744W WO02051306A3 WO 2002051306 A3 WO2002051306 A3 WO 2002051306A3 DE 0104744 W DE0104744 W DE 0104744W WO 02051306 A3 WO02051306 A3 WO 02051306A3
Authority
WO
WIPO (PCT)
Prior art keywords
concentration
probe
sensor
signal
nitrogen monoxide
Prior art date
Application number
PCT/DE2001/004744
Other languages
English (en)
French (fr)
Other versions
WO2002051306A2 (de
Inventor
Rudolf Gambert
Mats Carlsson
Original Assignee
It Dr Gambert Gmbh
Rudolf Gambert
Mats Carlsson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by It Dr Gambert Gmbh, Rudolf Gambert, Mats Carlsson filed Critical It Dr Gambert Gmbh
Priority to DE10195592T priority Critical patent/DE10195592D2/de
Priority to AU2002219011A priority patent/AU2002219011A1/en
Publication of WO2002051306A2 publication Critical patent/WO2002051306A2/de
Publication of WO2002051306A3 publication Critical patent/WO2002051306A3/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
    • A61B5/4222—Evaluating particular parts, e.g. particular organs
    • A61B5/4255—Intestines, colon or appendix
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/0004—Gaseous mixtures, e.g. polluted air
    • G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
    • G01N33/0027—General constructional details of gas analysers, e.g. portable test equipment concerning the detector
    • G01N33/0036—General constructional details of gas analysers, e.g. portable test equipment concerning the detector specially adapted to detect a particular component
    • G01N33/0037—NOx
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/20—Air quality improvement or preservation, e.g. vehicle emission control or emission reduction by using catalytic converters

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physiology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

Die Erfindung bezieht sich auf eine neuartige Vorrichtung zur in situ Messung des Partialdrucks oder der Konzentration intestinalen Stickstoffmonoxids beim Mensch oder Tier. Erfindungsgemäss erzeugt ein elektrochemischer Sensor, der sich in einem Tubus befindet und in den Intestinaltrakt eingeführt werden kann, ein elektrisches Signal, das der Konzentration an NO im Intestinaltrakt proportional ist. Der Sensor wird dabei von einer für NO durchlässigen Membran oder Folie bedeckt. Innerhalb oder ausserhalb des Tubus befindet sich ein elektronischer Potentiostat, der zwischen Referenz- und Messelektrode des elektrochemischen Sensors ein definiertes elektrisches Potential aufbaut und zumindest über die Messdauer hält. Der Tubus ist mit einem Kabel versehen über das das Sensorsignal an eine elektronische Auswerteeinheit weitergeleitet wird, die das Signal registriert und zur Anzeige bringt. Alternativ kann der Tubus einen Sender enthalten, der eine telemetrische Datenübertragung zu einer elektronischen Auswerteeinheit ermöglicht, die sich ausserhalb des menschlichen oder tierischen Körpers befindet.
PCT/DE2001/004744 2000-12-23 2001-12-15 Vorrichtung zur bestimmung der konzentration von stickstoffmonoxid WO2002051306A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE10195592T DE10195592D2 (de) 2000-12-23 2001-12-15 Vorrichtung zur Bestimmung der Konzentration von Stickstoffmonoxid
AU2002219011A AU2002219011A1 (en) 2000-12-23 2001-12-15 Device for the determination of the concentration of nitrogen monoxide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10065081.3 2000-12-23
DE10065081A DE10065081A1 (de) 2000-12-23 2000-12-23 Vorrichtung zur Bestimmung der Konzentration von Stickstoffmonoxid im Intestinaltrakt von Mensch oder Tier

Publications (2)

Publication Number Publication Date
WO2002051306A2 WO2002051306A2 (de) 2002-07-04
WO2002051306A3 true WO2002051306A3 (de) 2007-11-15

Family

ID=7669035

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2001/004744 WO2002051306A2 (de) 2000-12-23 2001-12-15 Vorrichtung zur bestimmung der konzentration von stickstoffmonoxid

Country Status (3)

Country Link
AU (1) AU2002219011A1 (de)
DE (2) DE10065081A1 (de)
WO (1) WO2002051306A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020229654A1 (en) * 2019-05-16 2020-11-19 Dropnostix Gmbh Device and method for detecting a pressure in a rumen of a ruminant

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0608872A1 (de) * 1993-01-29 1994-08-03 Kyoto Daiichi Kagaku Co., Ltd. Stromdetektierende trocken operierende ionenselektive Elektrode
WO2000059370A1 (en) * 1999-04-06 2000-10-12 Cambridge University Technical Services Limited Implantable sensor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3933612A (en) * 1971-06-30 1976-01-20 Corning Glass Works Glass electrode structure for radio capsule
GB2111215A (en) * 1981-10-31 1983-06-29 Alastair Sibbald Electrochemical sensor assembly
SE503876C2 (sv) * 1994-11-30 1996-09-23 Kjell Alving Detektion av inflammatoriska tillstånd i tarmkanalen genom att mäta kväveoxidhalten i ett prov taget ur tarmlumen

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0608872A1 (de) * 1993-01-29 1994-08-03 Kyoto Daiichi Kagaku Co., Ltd. Stromdetektierende trocken operierende ionenselektive Elektrode
WO2000059370A1 (en) * 1999-04-06 2000-10-12 Cambridge University Technical Services Limited Implantable sensor

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
IWASHITA E: "Greatly increased mucosal nitric oxide in ulcerative colitis determined in situ by a novel nitric oxide-selective microelectrode.", JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. AUSTRALIA APR 1998, vol. 13, no. 4, April 1998 (1998-04-01), pages 391 - 395, XP002200427, ISSN: 0815-9319 *
LIU X ET AL: "Microelectrode electrochemical detection of nitric oxide in gut inflammation affords real time measurements and enhanced sensitivity.", GASTROENTEROLOGY, vol. 110, no. 4 SUPPL., 1996, 96th Annual Meeting of the American Gastroenterological Association and the Digestive Disease Week;San Francisco, California, USA; May 19-22, 1996, pages A343, XP002200426, ISSN: 0016-5085 *
MOROZ L L ET AL: "The use of NO-sensitive microelectrodes for direct detection of nitric oxide (NO) production in molluscs.", ACTA BIOLOGICA HUNGARICA, vol. 46, no. 2-4, 1995, pages 155 - 167, XP002200430, ISSN: 0236-5383 *
SMITS GEERT J M ET AL: "Evaluation of an electrochemical microprobe for direct NO measurement in the rat gastric fundus.", JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, vol. 37, no. 2, 1997, pages 97 - 103, XP002200428, ISSN: 1056-8719 *
WADA KOUICHIROU ET AL: "Direct measurement of nitric oxide release in gastric mucosa during ischemia-reperfusion in rats.", AMERICAN JOURNAL OF PHYSIOLOGY, vol. 274, no. 3 PART 1, March 1998 (1998-03-01), pages G465 - G471, XP002200429, ISSN: 0002-9513 *

Also Published As

Publication number Publication date
AU2002219011A8 (en) 2008-01-10
AU2002219011A1 (en) 2002-07-08
WO2002051306A2 (de) 2002-07-04
DE10195592D2 (de) 2003-12-24
DE10065081A1 (de) 2002-07-11

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