WO2002050300A3 - Human hyperpolarization-activated cyclic nucleotide-gated cation channel hcn3 - Google Patents

Human hyperpolarization-activated cyclic nucleotide-gated cation channel hcn3 Download PDF

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Publication number
WO2002050300A3
WO2002050300A3 PCT/US2001/047903 US0147903W WO0250300A3 WO 2002050300 A3 WO2002050300 A3 WO 2002050300A3 US 0147903 W US0147903 W US 0147903W WO 0250300 A3 WO0250300 A3 WO 0250300A3
Authority
WO
WIPO (PCT)
Prior art keywords
hcn3
cyclic nucleotide
cation channel
human
gated cation
Prior art date
Application number
PCT/US2001/047903
Other languages
French (fr)
Other versions
WO2002050300A2 (en
Inventor
Kimberly L Folander
Yuan Liu
Edward Mckenna
Richard J Swanson
Original Assignee
Merck & Co Inc
Kimberly L Folander
Yuan Liu
Edward Mckenna
Richard J Swanson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Kimberly L Folander, Yuan Liu, Edward Mckenna, Richard J Swanson filed Critical Merck & Co Inc
Priority to CA002432274A priority Critical patent/CA2432274A1/en
Priority to EP01991006A priority patent/EP1358196A4/en
Priority to US10/451,127 priority patent/US20040115668A1/en
Publication of WO2002050300A2 publication Critical patent/WO2002050300A2/en
Publication of WO2002050300A3 publication Critical patent/WO2002050300A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention is directed to novel human DNA sequences encoding human HCN3 proteins, the protein encoded by the DNA sequences, vectors comprising the DNA sequences, host cells containing the vectors, and methods of identifying inhibitors and activators of cation channels containing the human HCN3 proteins.
PCT/US2001/047903 2000-12-20 2001-12-14 Human hyperpolarization-activated cyclic nucleotide-gated cation channel hcn3 WO2002050300A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002432274A CA2432274A1 (en) 2000-12-20 2001-12-14 Human hyperpolarization-activated cyclic nucleotide-gated cation channel hcn3
EP01991006A EP1358196A4 (en) 2000-12-20 2001-12-14 Human hyperpolarization-activated cyclic nucleotide-gated cation channel hcn3
US10/451,127 US20040115668A1 (en) 2001-12-14 2001-12-14 Human hyperpolarization-activated cyclic nucleotide-gated cation channel hcn3

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25680000P 2000-12-20 2000-12-20
US60/256,800 2000-12-20

Publications (2)

Publication Number Publication Date
WO2002050300A2 WO2002050300A2 (en) 2002-06-27
WO2002050300A3 true WO2002050300A3 (en) 2003-09-04

Family

ID=22973626

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/047903 WO2002050300A2 (en) 2000-12-20 2001-12-14 Human hyperpolarization-activated cyclic nucleotide-gated cation channel hcn3

Country Status (3)

Country Link
EP (1) EP1358196A4 (en)
CA (1) CA2432274A1 (en)
WO (1) WO2002050300A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8859273B2 (en) * 2003-12-24 2014-10-14 Medtronic, Inc. Methods of using HCN genes to treat cardiac arrhythmias
WO2013183985A1 (en) * 2012-06-05 2013-12-12 Erasmus University Medical Center Rotterdam Method of treating cognitive impairment and compounds for use therein

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000063349A1 (en) * 1999-04-15 2000-10-26 Icagen, Inc. Human hac3

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004513618A (en) * 2000-07-07 2004-05-13 インサイト・ゲノミックス・インコーポレイテッド Transporters and ion channels
CA2449934A1 (en) * 2001-06-08 2002-12-19 Ortho-Mcneil Pharmaceutical, Inc. Treating pain by targeting hyperpolarization-activated, cyclic nucleotide-gated channels

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000063349A1 (en) * 1999-04-15 2000-10-26 Icagen, Inc. Human hac3

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1358196A4 *

Also Published As

Publication number Publication date
EP1358196A4 (en) 2004-11-03
WO2002050300A2 (en) 2002-06-27
CA2432274A1 (en) 2002-06-27
EP1358196A2 (en) 2003-11-05

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