WO2002047665A3 - Methods and compositions for encapsulating active agents - Google Patents

Methods and compositions for encapsulating active agents Download PDF

Info

Publication number
WO2002047665A3
WO2002047665A3 PCT/US2001/046181 US0146181W WO0247665A3 WO 2002047665 A3 WO2002047665 A3 WO 2002047665A3 US 0146181 W US0146181 W US 0146181W WO 0247665 A3 WO0247665 A3 WO 0247665A3
Authority
WO
WIPO (PCT)
Prior art keywords
particles
colloidosomes
methods
solvent
biocompatible
Prior art date
Application number
PCT/US2001/046181
Other languages
French (fr)
Other versions
WO2002047665A2 (en
Inventor
Andreas Bausch
Anthony Dinsmore
Ming Hsu
Michael Nikolaides
David Weitz
Original Assignee
Harvard College
Andreas Bausch
Anthony Dinsmore
Ming Hsu
Michael Nikolaides
David Weitz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Andreas Bausch, Anthony Dinsmore, Ming Hsu, Michael Nikolaides, David Weitz filed Critical Harvard College
Priority to AU2002243277A priority Critical patent/AU2002243277A1/en
Priority to EP01989162A priority patent/EP1385488A2/en
Priority to US10/433,753 priority patent/US20040096515A1/en
Publication of WO2002047665A2 publication Critical patent/WO2002047665A2/en
Publication of WO2002047665A3 publication Critical patent/WO2002047665A3/en
Priority to US12/712,620 priority patent/US20100213628A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)

Abstract

Methods for making self-assembled, selectively permeable elastic microscopie structures, referred to herein as colloidosomes, that have controlled pore-size, porosity and advantageous mechanical properties are described. In one form of the invention, a method of forming colloidosomes includes providing particles formed from a biocompatible material in a first solvent and forming an emulsion by adding a first fluid to the first solvent wherein the emulsion is defined by droplets of the first fluid surrounded by the first solvent. The method includes coating the surface of droplet with the particles and the stabilizing the particles on the surface of droplet. The colloidosomes produced typically have a yield strength of at least about 20 Pascals. In certain forms of the invention, the particles are spherical and are formed of a biocompatible polymer. Colloidosomes formed according to the methods described herein are also provided. In one form, a colloidosome includes a shell formed of biocompatible, substantially spherical particles wherein each of the particles are linked to neighboring particles. The shell defines an inner chamber sized for housing a desired active agent and has a plurality of pores extending therethrough. The colloidosomes are structurally stable, typically having a yield strength of at least about 20 Pascals. Colloidal suspension and methods of encapsulating a desired active agent are also described.
PCT/US2001/046181 2000-12-07 2001-12-07 Methods and compositions for encapsulating active agents WO2002047665A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2002243277A AU2002243277A1 (en) 2000-12-07 2001-12-07 Methods and compositions for encapsulating active agents
EP01989162A EP1385488A2 (en) 2000-12-07 2001-12-07 Methods and compositions for encapsulating active agents
US10/433,753 US20040096515A1 (en) 2001-12-07 2001-12-07 Methods and compositions for encapsulating active agents
US12/712,620 US20100213628A1 (en) 2000-12-07 2010-02-25 Methods and compositions for encapsulating active agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25421000P 2000-12-07 2000-12-07
US60/254,210 2000-12-07

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/712,620 Continuation US20100213628A1 (en) 2000-12-07 2010-02-25 Methods and compositions for encapsulating active agents

Publications (2)

Publication Number Publication Date
WO2002047665A2 WO2002047665A2 (en) 2002-06-20
WO2002047665A3 true WO2002047665A3 (en) 2003-07-24

Family

ID=22963357

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/046181 WO2002047665A2 (en) 2000-12-07 2001-12-07 Methods and compositions for encapsulating active agents

Country Status (3)

Country Link
EP (1) EP1385488A2 (en)
AU (1) AU2002243277A1 (en)
WO (1) WO2002047665A2 (en)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102008925B (en) * 2010-12-17 2012-11-28 天津大学 Method for preparing inorganic/organic composite microspheres
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
US8871444B2 (en) 2004-10-08 2014-10-28 Medical Research Council In vitro evolution in microfluidic systems
US9012390B2 (en) 2006-08-07 2015-04-21 Raindance Technologies, Inc. Fluorocarbon emulsion stabilizing surfactants
US9150852B2 (en) 2011-02-18 2015-10-06 Raindance Technologies, Inc. Compositions and methods for molecular labeling
US9228229B2 (en) 2010-02-12 2016-01-05 Raindance Technologies, Inc. Digital analyte analysis
US9273308B2 (en) 2006-05-11 2016-03-01 Raindance Technologies, Inc. Selection of compartmentalized screening method
US9328344B2 (en) 2006-01-11 2016-05-03 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
US9364803B2 (en) 2011-02-11 2016-06-14 Raindance Technologies, Inc. Methods for forming mixed droplets
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US9440232B2 (en) 2007-02-06 2016-09-13 Raindance Technologies, Inc. Manipulation of fluids and reactions in microfluidic systems
US9448172B2 (en) 2003-03-31 2016-09-20 Medical Research Council Selection by compartmentalised screening
US9498759B2 (en) 2004-10-12 2016-11-22 President And Fellows Of Harvard College Compartmentalized screening by microfluidic control
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US9562897B2 (en) 2010-09-30 2017-02-07 Raindance Technologies, Inc. Sandwich assays in droplets
US12038438B2 (en) 2021-10-25 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006507921A (en) 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ Method and apparatus for fluid dispersion
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
EP3616781A1 (en) 2003-04-10 2020-03-04 President and Fellows of Harvard College Formation and control of fluidic species
CN1842368B (en) 2003-08-27 2014-05-28 哈佛大学 Electronic control of fluidic species
US9477233B2 (en) 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
JP2008535644A (en) 2005-03-04 2008-09-04 プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ Method and apparatus for the formation of multiple emulsions
CA2608226C (en) * 2005-06-07 2015-02-24 University Of South Australia Dried formulations of nanoparticle-coated capsules
AU2006255477B2 (en) * 2005-06-07 2012-07-05 Reformpharm Pty Ltd Dried formulations of nanoparticle-coated capsules
US20090181076A1 (en) * 2006-05-04 2009-07-16 University Of South Australia Drug Release From Nanoparticle-Coated Capsules
US7776927B2 (en) 2007-03-28 2010-08-17 President And Fellows Of Harvard College Emulsions and techniques for formation
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
US8093038B2 (en) 2007-09-17 2012-01-10 Illinois Institute Of Technology Apparatus and method for encapsulating pancreatic cells
GB0718300D0 (en) * 2007-09-20 2007-10-31 Univ Leeds Microcapsules and methods
US8778400B2 (en) 2008-04-21 2014-07-15 University Of South Australia Nanoparticle-stabilized capsule formulation for treatment of inflammation
EP2128180A1 (en) 2008-05-29 2009-12-02 Unilever N.V. Amphiphilic branched polymers and their use as emulsifiers
WO2009148598A1 (en) * 2008-06-05 2009-12-10 President And Fellows Of Harvard College Polymersomes, colloidosomes, liposomes, and other species associated with fluidic droplets
EP2315629B1 (en) 2008-07-18 2021-12-15 Bio-Rad Laboratories, Inc. Droplet libraries
WO2010033200A2 (en) 2008-09-19 2010-03-25 President And Fellows Of Harvard College Creation of libraries of droplets and related species
WO2010111231A1 (en) 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation of microfluidic droplets
CN102574078B (en) 2009-09-02 2016-05-18 哈佛学院院长等 Use and spray the multiple emulsion producing with other technology
US10520500B2 (en) 2009-10-09 2019-12-31 Abdeslam El Harrak Labelled silica-based nanomaterial with enhanced properties and uses thereof
EP2517025B1 (en) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Methods for reducing the exchange of molecules between droplets
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
NL2004533C2 (en) 2010-04-09 2011-10-11 Friesland Brands Bv Particle preparation by centrifugal dispersing.
CN101857700B (en) * 2010-06-21 2011-08-17 郑州大学 Method for self assembling non-spherical polystyrene grains to form into multihole and ordered structure
WO2012162296A2 (en) 2011-05-23 2012-11-29 President And Fellows Of Harvard College Control of emulsions, including multiple emulsions
EP2714970B1 (en) 2011-06-02 2017-04-19 Raindance Technologies, Inc. Enzyme quantification
GB2491387A (en) * 2011-06-02 2012-12-05 Magnequench Ltd Rare earth material capsule used in making a magnet
WO2013006661A2 (en) 2011-07-06 2013-01-10 President And Fellows Of Harvard College Multiple emulsions and techniques for the formation of multiple emulsions
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US20160279068A1 (en) 2013-11-08 2016-09-29 President And Fellows Of Harvard College Microparticles, methods for their preparation and use
GB201319923D0 (en) * 2013-11-12 2013-12-25 Cambridge Entpr Ltd Novel composition
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US11193176B2 (en) 2013-12-31 2021-12-07 Bio-Rad Laboratories, Inc. Method for detecting and quantifying latent retroviral RNA species
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
JP2018537414A (en) 2015-10-13 2018-12-20 プレジデント アンド フェローズ オブ ハーバード カレッジ System and method for making and using gel microspheres

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0478326A1 (en) * 1990-09-27 1992-04-01 Quest International B.V. Encapsulating method and products containing encapsulated material
WO2001085138A2 (en) * 2000-05-10 2001-11-15 Aveka, Inc. Particulate encapsulation of liquid beads

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0478326A1 (en) * 1990-09-27 1992-04-01 Quest International B.V. Encapsulating method and products containing encapsulated material
US5500223A (en) * 1990-09-27 1996-03-19 Unilever Patent Holdings B.V. Encapsulating method and products containing encapsulated material
WO2001085138A2 (en) * 2000-05-10 2001-11-15 Aveka, Inc. Particulate encapsulation of liquid beads

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DINSMORE A.D. ET AL: "Colloidosomes: Selectively permeable capsules composed of colloidal particles.", SCIENCE, vol. 298, 1 November 2002 (2002-11-01), pages 1006 - 1009, XP002229136 *
VELEV O.D. ET AL: "Assembly of latex particles by using emulsion droplets as templates. 1. Microstructured hollow spheres.", LANGMUIR, vol. 12, 1996, pages 2374 - 2384, XP002229133 *
VELEV O.D. ET AL: "Assembly of latex particles by using emulsion droplets as templates. 2. Ball-like and composite aggregates.", LANGMUIR, vol. 12, 1996, pages 2385 - 2391, XP002229134 *
VELEV O.D. ET AL: "Assembly of latex particles by using emulsion droplets. 3. Reverse (water in oil) system.", LANGMUIR, vol. 13, 1996, pages 1856 - 1859, XP002229135 *

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9448172B2 (en) 2003-03-31 2016-09-20 Medical Research Council Selection by compartmentalised screening
US9186643B2 (en) 2004-10-08 2015-11-17 Medical Research Council In vitro evolution in microfluidic systems
US8871444B2 (en) 2004-10-08 2014-10-28 Medical Research Council In vitro evolution in microfluidic systems
US9498759B2 (en) 2004-10-12 2016-11-22 President And Fellows Of Harvard College Compartmentalized screening by microfluidic control
US9410151B2 (en) 2006-01-11 2016-08-09 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
US9534216B2 (en) 2006-01-11 2017-01-03 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
US9328344B2 (en) 2006-01-11 2016-05-03 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
US9273308B2 (en) 2006-05-11 2016-03-01 Raindance Technologies, Inc. Selection of compartmentalized screening method
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US9012390B2 (en) 2006-08-07 2015-04-21 Raindance Technologies, Inc. Fluorocarbon emulsion stabilizing surfactants
US9498761B2 (en) 2006-08-07 2016-11-22 Raindance Technologies, Inc. Fluorocarbon emulsion stabilizing surfactants
US9440232B2 (en) 2007-02-06 2016-09-13 Raindance Technologies, Inc. Manipulation of fluids and reactions in microfluidic systems
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US9228229B2 (en) 2010-02-12 2016-01-05 Raindance Technologies, Inc. Digital analyte analysis
US9562897B2 (en) 2010-09-30 2017-02-07 Raindance Technologies, Inc. Sandwich assays in droplets
CN102008925B (en) * 2010-12-17 2012-11-28 天津大学 Method for preparing inorganic/organic composite microspheres
US9364803B2 (en) 2011-02-11 2016-06-14 Raindance Technologies, Inc. Methods for forming mixed droplets
US9150852B2 (en) 2011-02-18 2015-10-06 Raindance Technologies, Inc. Compositions and methods for molecular labeling
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
US12038438B2 (en) 2021-10-25 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification

Also Published As

Publication number Publication date
AU2002243277A1 (en) 2002-06-24
WO2002047665A2 (en) 2002-06-20
EP1385488A2 (en) 2004-02-04

Similar Documents

Publication Publication Date Title
WO2002047665A3 (en) Methods and compositions for encapsulating active agents
JP5418934B2 (en) Method for producing porous hollow particles
CA2344945A1 (en) Modified photocatalyst sol
WO2001064164A3 (en) Nanocapsule encapsulation system and method
EP2263788A3 (en) Microcapsules loaded with active ingredients and a method for their preparation
GB0115681D0 (en) Process for making polymeric particles
DE69414735T2 (en) Process for the production of microcapsules
CA2533952A1 (en) Microcapsules
KR20210033943A (en) Thermally expandable microspheres and their uses
CA2391401A1 (en) Method for the production of particles
EP0923955A3 (en) Manufacturing method of artificial organ, hollow fiber membrane, and dialyzer of hollow fiber membrane type
KR102145536B1 (en) Method for prreparing organic-inorganic hybrid microcapsule
ATE286430T1 (en) NANOCAPSULES
WO2006015358A3 (en) Aqueous suspension of nanoscale drug particles from supercritical fluid processing
CA2349712A1 (en) Method of fabricating porous membrane with unique pore structure for aerosolized delivery of drugs
KR20200004153A (en) METHOD FOR PRREPARING Organic-inorganic hybrid micro-capsule
EP1498174B1 (en) Process and apparatus for producing inorganic spheres
CA2452409A1 (en) Preparation of polymer particles
WO2002068454A3 (en) Proteins in a porous support
JPH04122434A (en) Porous body containing functional substance and its preparation
NZ284825A (en) Microspheres containing a gelified polar core around which are superimposed lipid or lipid containing layers
EP0906931A3 (en) Solvent removal from suspended polymer solution droplets
KR970015543A (en) Pesticide-containing granular fertilizer composition and preparation method thereof
KR20090110059A (en) Methods of preparing Fibroin Microsphere, Emulsion including the same and Dispersion Liquid including the same
JPH04318029A (en) Homogeneous uniform spherical fine particle of polysaccharides derived from seaweed and its production

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWE Wipo information: entry into national phase

Ref document number: 2001989162

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 10433753

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 2001989162

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP