WO2002044412A8 - Method and apparatus using a surface-selective nonlinear optical technique for detection of probe-target interactions - Google Patents

Method and apparatus using a surface-selective nonlinear optical technique for detection of probe-target interactions

Info

Publication number
WO2002044412A8
WO2002044412A8 PCT/US2001/022411 US0122411W WO0244412A8 WO 2002044412 A8 WO2002044412 A8 WO 2002044412A8 US 0122411 W US0122411 W US 0122411W WO 0244412 A8 WO0244412 A8 WO 0244412A8
Authority
WO
WIPO (PCT)
Prior art keywords
optical technique
nonlinear optical
detection
probe
selective
Prior art date
Application number
PCT/US2001/022411
Other languages
French (fr)
Other versions
WO2002044412A1 (en
Inventor
Joshua S Salafsky
Original Assignee
Joshua S Salafsky
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Joshua S Salafsky filed Critical Joshua S Salafsky
Priority to IL15611401A priority Critical patent/IL156114A0/en
Priority to EP01957166A priority patent/EP1346064A4/en
Priority to JP2002546760A priority patent/JP2004521323A/en
Priority to AU2001278937A priority patent/AU2001278937A1/en
Priority to CA002430430A priority patent/CA2430430A1/en
Publication of WO2002044412A1 publication Critical patent/WO2002044412A1/en
Publication of WO2002044412A8 publication Critical patent/WO2002044412A8/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Nanotechnology (AREA)
  • Materials Engineering (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Composite Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Length Measuring Devices By Optical Means (AREA)

Abstract

A surface-selective nonlinear optical technique, such as second harmonic or sum frequency generation, is used to detect reactions between surface-attached probes and labeled targets or used to perform imaging of a surface. The surface-selective optical technique allows detection of only those target components near the interface while ignoring those present in the sample bulk. In addition, the direction of the nonlinear light is scattered from the surface in a well-defined direction and because of this, its incidence at a detector some distance from the surface may be easily mapped to a specific and known location on the surface.
PCT/US2001/022411 2000-11-29 2001-07-17 Method and apparatus using a surface-selective nonlinear optical technique for detection of probe-target interactions WO2002044412A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IL15611401A IL156114A0 (en) 2000-11-29 2001-07-17 Method and apparatus using a surface-selective nonlinear optical technique for detection of probe-target interactions
EP01957166A EP1346064A4 (en) 2000-11-29 2001-07-17 Method and apparatus using a surface-selective nonlinear optical technique for detection of probe-target interactions
JP2002546760A JP2004521323A (en) 2001-03-27 2001-07-17 Method and apparatus for detecting probe-target interactions using surface selective nonlinear optical techniques
AU2001278937A AU2001278937A1 (en) 2000-11-29 2001-07-17 Method and apparatus using a surface-selective nonlinear optical technique for detection of probe-target interactions
CA002430430A CA2430430A1 (en) 2000-11-29 2001-07-17 Method and apparatus using a surface-selective nonlinear optical technique for detection of probe-target interactions

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US25386200P 2000-11-29 2000-11-29
US60/253,862 2000-11-29
US26024901P 2001-01-08 2001-01-08
US60/260,249 2001-01-08
US26577501P 2001-02-01 2001-02-01
US60/265,775 2001-02-01
US27864101P 2001-03-27 2001-03-27
US60/278,641 2001-03-27

Publications (2)

Publication Number Publication Date
WO2002044412A1 WO2002044412A1 (en) 2002-06-06
WO2002044412A8 true WO2002044412A8 (en) 2003-12-11

Family

ID=27500490

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/022411 WO2002044412A1 (en) 2000-11-29 2001-07-17 Method and apparatus using a surface-selective nonlinear optical technique for detection of probe-target interactions

Country Status (5)

Country Link
EP (1) EP1346064A4 (en)
AU (1) AU2001278937A1 (en)
CA (1) CA2430430A1 (en)
IL (1) IL156114A0 (en)
WO (1) WO2002044412A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6953694B2 (en) * 2000-12-06 2005-10-11 The Trustees Of Columbia University In The City Of New York Attachment of second harmonic-active moiety to molecules for detection of molecules at interfaces
US20030148391A1 (en) * 2002-01-24 2003-08-07 Salafsky Joshua S. Method using a nonlinear optical technique for detection of interactions involving a conformational change
US8088628B2 (en) 2002-09-30 2012-01-03 Intel Corporation Stimulated and coherent anti-stokes raman spectroscopic methods for the detection of molecules
US20040142484A1 (en) 2002-09-30 2004-07-22 Intel Corporation Spectroscopic analysis system and method
AU2002334118B2 (en) * 2002-10-07 2007-05-17 The Secretary Of State For Defence A waveguide structure
JP4173746B2 (en) * 2003-02-12 2008-10-29 富士フイルム株式会社 measuring device
JP2004279040A (en) * 2003-03-12 2004-10-07 Toyobo Co Ltd Flow cell for measuring surface plasmon resonance
JP4374447B2 (en) 2003-12-25 2009-12-02 独立行政法人産業技術総合研究所 Method for analyzing the interaction between protein and sugar chain
JP3918040B2 (en) * 2004-03-03 2007-05-23 アイダエンジニアリング株式会社 Method of bonding microchip and PDMS substrate to facing substrate
EP2453239B1 (en) 2005-05-23 2017-04-26 Harald F. Hess Optical microscopy with transformable optical labels
US9182406B2 (en) 2008-08-04 2015-11-10 Biodesy, Inc. Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
US8699032B2 (en) 2009-01-27 2014-04-15 Panasonic Corporation Surface plasmon resonance sensor, localized plasmon resonance sensor, and method for manufacturing same
WO2012129347A1 (en) 2011-03-21 2012-09-27 Biodesy, Llc Classification of kinase inhibitors using nonlinear optical techniques
US9989534B2 (en) * 2014-06-30 2018-06-05 Biodesy, Inc. Systems and methods for high throughput analysis of conformation in biological entities
WO2016106286A1 (en) 2014-12-23 2016-06-30 Biodesy, Inc. Attachment of proteins to interfaces for use in nonlinear optical detection
EP3455628A4 (en) 2016-05-09 2019-12-04 Biodesy, Inc. Methods and devices for detection of peripheral membrane protein interactions using nonlinear optical techniques
WO2018222800A2 (en) * 2017-05-31 2018-12-06 Centrillion Technologies, Inc. Oligonucleotide probe array with electronic detection system
CN110487686B (en) * 2019-09-03 2022-09-02 中国工程物理研究院流体物理研究所 Air aerosol single particle multi-mode spectrum diagnosis device and diagnosis method

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9508559D0 (en) * 1995-04-27 1995-06-14 Polytech Transfer Ltd Surface second harmonic and sum-frequency generation immuno and enzyme assays
US5633724A (en) * 1995-08-29 1997-05-27 Hewlett-Packard Company Evanescent scanning of biochemical array
US5821060A (en) * 1996-08-02 1998-10-13 Atom Sciences, Inc. DNA sequencing, mapping, and diagnostic processes using hybridization chips and unlabeled DNA
JPH11119270A (en) * 1997-10-17 1999-04-30 Naoya Ogata Organic nonlinear optical material and its production
US6953694B2 (en) * 2000-12-06 2005-10-11 The Trustees Of Columbia University In The City Of New York Attachment of second harmonic-active moiety to molecules for detection of molecules at interfaces

Also Published As

Publication number Publication date
EP1346064A1 (en) 2003-09-24
AU2001278937A1 (en) 2002-06-11
EP1346064A4 (en) 2005-01-19
IL156114A0 (en) 2003-12-23
CA2430430A1 (en) 2002-06-06
WO2002044412A1 (en) 2002-06-06

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