WO2002044128A3 - Analogues de salicylate utilises en tant qu'antagonistes d'interleukine-4 - Google Patents

Analogues de salicylate utilises en tant qu'antagonistes d'interleukine-4 Download PDF

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Publication number
WO2002044128A3
WO2002044128A3 PCT/US2001/044643 US0144643W WO0244128A3 WO 2002044128 A3 WO2002044128 A3 WO 2002044128A3 US 0144643 W US0144643 W US 0144643W WO 0244128 A3 WO0244128 A3 WO 0244128A3
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WO
WIPO (PCT)
Prior art keywords
interleukin
antagonists
analogs
salicylate
salicylate analogs
Prior art date
Application number
PCT/US2001/044643
Other languages
English (en)
Other versions
WO2002044128A2 (fr
Inventor
Kenneth J Barr
Brian C Cunningham
William Michael Flanagan
Wanli Lu
Brian C Raimundo
Nathan D Waal
Jennifer Wilkinson
Jiang Zhu
Wenjin Yang
Original Assignee
Sunesis Pharmaceuticals Inc
Kenneth J Barr
Brian C Cunningham
William Michael Flanagan
Wanli Lu
Brian C Raimundo
Nathan D Waal
Jennifer Wilkinson
Jiang Zhu
Wenjin Yang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sunesis Pharmaceuticals Inc, Kenneth J Barr, Brian C Cunningham, William Michael Flanagan, Wanli Lu, Brian C Raimundo, Nathan D Waal, Jennifer Wilkinson, Jiang Zhu, Wenjin Yang filed Critical Sunesis Pharmaceuticals Inc
Priority to AU2002219920A priority Critical patent/AU2002219920A1/en
Publication of WO2002044128A2 publication Critical patent/WO2002044128A2/fr
Publication of WO2002044128A3 publication Critical patent/WO2002044128A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/48—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/105—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/19—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups having unsaturation outside the aromatic ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention porte sur des analogues de salicylate représentés par la formule I, sur des méthodes de fabrication, sur des compostions pharmaceutiques les contenant et sur des méthodes d'utilisation. Ces composés sont des antagonistes d'interleukine-4 et conviennent au traitement de l'asthme et des allergies.
PCT/US2001/044643 2000-11-28 2001-11-27 Analogues de salicylate utilises en tant qu'antagonistes d'interleukine-4 WO2002044128A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002219920A AU2002219920A1 (en) 2000-11-28 2001-11-27 Salicylate analogs as interleukin-4 antagonists

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72478200A 2000-11-28 2000-11-28
US09/724,782 2000-11-28

Publications (2)

Publication Number Publication Date
WO2002044128A2 WO2002044128A2 (fr) 2002-06-06
WO2002044128A3 true WO2002044128A3 (fr) 2003-03-13

Family

ID=24911884

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/044643 WO2002044128A2 (fr) 2000-11-28 2001-11-27 Analogues de salicylate utilises en tant qu'antagonistes d'interleukine-4

Country Status (2)

Country Link
AU (1) AU2002219920A1 (fr)
WO (1) WO2002044128A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004010136A1 (fr) 2002-07-24 2004-01-29 Keddem Bio-Science Ltd. Procede de decouverte d'un medicament
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
UA98772C2 (ru) 2006-06-23 2012-06-25 Эбботт Леборетриз Производные циклопропиламина как модуляторы н3-гистаминового рецептора
US9186353B2 (en) 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
WO2012037258A1 (fr) 2010-09-16 2012-03-22 Abbott Laboratories Procédés de préparation de dérivés cyclopropyliques substitués en 1,2

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1266058A (fr) * 1969-07-08 1972-03-08
WO1997043241A1 (fr) * 1996-05-13 1997-11-20 Nippon Shinyaku Co., Ltd. Composes d'ethylene substitue et medicaments
WO1999001127A1 (fr) * 1997-07-03 1999-01-14 Smithkline Beecham Corporation Composes et procedes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1266058A (fr) * 1969-07-08 1972-03-08
WO1997043241A1 (fr) * 1996-05-13 1997-11-20 Nippon Shinyaku Co., Ltd. Composes d'ethylene substitue et medicaments
WO1999001127A1 (fr) * 1997-07-03 1999-01-14 Smithkline Beecham Corporation Composes et procedes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
OMU, ALEXANDER E. ET AL: "Effect of antihypertensive therapy in preeclampsia on levels of serum interleukin -4", GYNECOLOGIC AND OBSTETRIC INVESTIGATION (1996), 42(4), 230-236, 1996, XP008008293 *
TCHERDAKOFF P.: "Side-effects with long-term labetalol: an open study of 251 patients in a single centre", PHARMATHERAPEUTICA., vol. 3, no. 5, 1983, CLAYTON-WRAY PUBLICATIONS, LONDON., GB, pages 342 - 348, XP008008752, ISSN: 0308-051X *

Also Published As

Publication number Publication date
WO2002044128A2 (fr) 2002-06-06
AU2002219920A1 (en) 2002-06-11

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