WO2002042439A3 - Aggrecanase adamts9 - Google Patents

Aggrecanase adamts9 Download PDF

Info

Publication number
WO2002042439A3
WO2002042439A3 PCT/US2001/049814 US0149814W WO0242439A3 WO 2002042439 A3 WO2002042439 A3 WO 2002042439A3 US 0149814 W US0149814 W US 0149814W WO 0242439 A3 WO0242439 A3 WO 0242439A3
Authority
WO
WIPO (PCT)
Prior art keywords
aggrecanase
adamts9
disclosed
enzymes
aggrecan
Prior art date
Application number
PCT/US2001/049814
Other languages
French (fr)
Other versions
WO2002042439A2 (en
Inventor
Lisa Anne Racie
Natalie Constance Twine
Michael John Agostino
Neil Michael Wolfman
Elisabeth Ann Morris
Original Assignee
Inst Genetics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Genetics Llc filed Critical Inst Genetics Llc
Priority to AU2002239680A priority Critical patent/AU2002239680A1/en
Publication of WO2002042439A2 publication Critical patent/WO2002042439A2/en
Publication of WO2002042439A3 publication Critical patent/WO2002042439A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Aggrecanase proteins and the nucleotides sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
PCT/US2001/049814 2000-10-27 2001-10-25 Aggrecanase adamts9 WO2002042439A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002239680A AU2002239680A1 (en) 2000-10-27 2001-10-25 Aggrecanase adamts9

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24391600P 2000-10-27 2000-10-27
US60/243,916 2000-10-27

Publications (2)

Publication Number Publication Date
WO2002042439A2 WO2002042439A2 (en) 2002-05-30
WO2002042439A3 true WO2002042439A3 (en) 2004-03-25

Family

ID=22920645

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/049814 WO2002042439A2 (en) 2000-10-27 2001-10-25 Aggrecanase adamts9

Country Status (2)

Country Link
AU (1) AU2002239680A1 (en)
WO (1) WO2002042439A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1022371C2 (en) * 2003-01-13 2003-11-18 Hoffmann La Roche Novel metalloprotease containing a thrombospondin domain (MPTS protein) is useful to treat aggrecan associated disease including rheumatoid arthritis and osteoarthritis
WO2004073657A2 (en) * 2003-02-19 2004-09-02 Protein Design Labs, Inc. Methods of diagnosis of cancer and other diseases, composition and methods of screening for modulators of cancer and other diseases
MX2019014400A (en) 2017-06-02 2020-02-10 Merck Patent Gmbh Adamts binding immunoglobulins.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1004674A1 (en) * 1997-06-03 2000-05-31 Kureha Chemical Industry Co., Ltd. Human adamts-1 protein, gene coding for the same, pharmaceutical composition, and method for immunologically assaying human adamts-1 protein
WO2001011074A2 (en) * 1999-08-06 2001-02-15 The Cleveland Clinic Foundation Nucleic acids encoding zinc metalloproteases

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1004674A1 (en) * 1997-06-03 2000-05-31 Kureha Chemical Industry Co., Ltd. Human adamts-1 protein, gene coding for the same, pharmaceutical composition, and method for immunologically assaying human adamts-1 protein
WO2001011074A2 (en) * 1999-08-06 2001-02-15 The Cleveland Clinic Foundation Nucleic acids encoding zinc metalloproteases

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CLARK MELODY E ET AL: "ADAMTS9, a novel member of the ADAM-TS/metallospondin gene family.", GENOMICS, vol. 67, no. 3, 1 August 2000 (2000-08-01), pages 343 - 350, XP002228337, ISSN: 0888-7543 *
DATABASE EMBL [online] 14 March 2000 (2000-03-14), XP002228338, retrieved from EMBL Database accession no. AB037733 *
FLANNERY C R ET AL: "EXPRESSION OF ADAMTS HOMOLOGUES IN ARTICULAR CARTILAGE", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 260, no. 2, 1999, pages 318 - 322, XP002937896, ISSN: 0006-291X *
TORTORELLA M D ET AL: "PURIFICATION AND CLONING OF AGGRECANASE-1: MEMBER OF THE ADAMTS FAMILY OF PROTEINS", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 284, June 1999 (1999-06-01), pages 1664 - 1666, XP002937898, ISSN: 0036-8075 *

Also Published As

Publication number Publication date
AU2002239680A1 (en) 2002-06-03
WO2002042439A2 (en) 2002-05-30

Similar Documents

Publication Publication Date Title
MX2010001481A (en) Acid fungal proteases.
AU1478802A (en) Dipeptidyl peptidases
ATE340857T1 (en) METHOD FOR PRODUCING L-AMINO ACIDS BY INCREASING CELLULAR NADPH
WO2002031134A3 (en) Novel serine protease genes related to dppiv
WO2002000860A3 (en) Novel proteases
DE10345772A1 (en) Process for the preparation of 3-methylamino-1- (thien-2-yl) -propan-1-ol
ATE346938T1 (en) POLYKETIDE SYNTHASE ENZYMES AND RECOMBINANT DNA CONSTRUCTS FOR PRODUCING COMPOUNDS RELATED TO FK-506 AND FK-520
WO2003064622A3 (en) Aggrecanase molecules
MX2007007387A (en) Thienopyrimidine derivatives as phosphodiesterase 10 inhibitors.
DE60142226D1 (en) MUSHROOM TRANSCRIPTION ACTIVATOR FOR USE IN PROCESSES FOR THE PREPARATION OF POLYPEPTIDES
DE602004024686D1 (en) CEPHALOSPORIN C-ACYLASE MUTANT AND METHOD FOR THE PRODUCTION OF 7-ACA THEREWITH
WO2003097810A3 (en) Nitrilases, nucleic acids encoding them and methods for making and using them
DE60119110D1 (en) PROCEDURE FOR SOURCING
WO2002033093A3 (en) Aggrecanase molecules
WO2002042439A3 (en) Aggrecanase adamts9
WO2003064597A3 (en) Aggrecanase molecules
WO2003004607A3 (en) Aggrecanase molecules
HUP0500383A2 (en) Microorganisms and processes for enhanced production of pantothenate
WO2002034895A3 (en) Novel aggrecanase molecules
WO2003012038A3 (en) Aggrecanase molecules
WO2003057842A3 (en) Aggrecanase molecules
WO2003066822A3 (en) Truncated aggrecanase molecules
EA200700287A1 (en) IMPROVED ENZYMES
WO2000047723A3 (en) Human diacylglycerol kinase beta (hdagk beta) proteins and nucleotide sequences encoding the same
AU2002336564A1 (en) Method of enzyme production by microorganisms

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2001987472

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 2001987472

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

NENP Non-entry into the national phase

Ref country code: JP