WO2002038185A3 - Injectable sustained release delivery system with loperamide - Google Patents

Injectable sustained release delivery system with loperamide Download PDF

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Publication number
WO2002038185A3
WO2002038185A3 PCT/US2001/047116 US0147116W WO0238185A3 WO 2002038185 A3 WO2002038185 A3 WO 2002038185A3 US 0147116 W US0147116 W US 0147116W WO 0238185 A3 WO0238185 A3 WO 0238185A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
loperamide
delivery system
sustained release
release delivery
flowable composition
Prior art date
Application number
PCT/US2001/047116
Other languages
French (fr)
Other versions
WO2002038185A2 (en )
Inventor
Richard L Dunn
David W Osborne
Original Assignee
Atrix Lab Inc
Richard L Dunn
David W Osborne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/451Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

Abstract

The present invention provides for a flowable composition suitable for use as a controlled release implant, a method for forming a flowable composition for use as a controlled release implant, and methods for using the flowable composition. The composition comprises a biodegradable thermoplastic polyester that is at least substantially insoluble in aqueous medium or body fluid; a biocompatible organic solvent that is miscible to dispersible in aqueous medium or body fluid and can effectively dissolve the thermoplastic polyester; and an antihyperalgesic opiate.
PCT/US2001/047116 2000-11-13 2001-11-13 Injectable sustained release delivery system with loperamide WO2002038185A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US71082500 true 2000-11-13 2000-11-13
US09/710,825 2000-11-13

Publications (2)

Publication Number Publication Date
WO2002038185A2 true WO2002038185A2 (en) 2002-05-16
WO2002038185A3 true true WO2002038185A3 (en) 2003-01-16

Family

ID=24855703

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/047116 WO2002038185A3 (en) 2000-11-13 2001-11-13 Injectable sustained release delivery system with loperamide

Country Status (1)

Country Link
WO (1) WO2002038185A3 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8133968B2 (en) 2006-06-29 2012-03-13 Medtronic, Inc. Poly(orthoester) polymers, and methods of making and using same
US8475823B2 (en) 2008-04-18 2013-07-02 Medtronic, Inc. Baclofen formulation in a polyorthoester carrier
US8956642B2 (en) 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
US10022367B2 (en) 2014-03-10 2018-07-17 Indivior Uk Limited Sustained-release buprenorphine solutions
US10058554B2 (en) 2005-09-30 2018-08-28 Indivior Uk Limited Sustained release small molecule drug formulation

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2320321C2 (en) * 2002-06-25 2008-03-27 Алза Корпорейшн Depot compositions of shot-term action
CA2494400A1 (en) * 2002-07-31 2004-02-05 Alza Corporation Injectable multimodal polymer depot compositions and uses thereof
JP2006508127A (en) * 2002-11-06 2006-03-09 アルザ・コーポレーション Controlled-release depot formulation
US7202259B2 (en) 2002-11-18 2007-04-10 Euro-Celtique S.A. Therapeutic agents useful for treating pain
CA2527664A1 (en) * 2003-05-30 2004-12-16 Alza Corporation Implantable elastomeric depot compositions, uses thereof and method of manufacturing
EP1951718B9 (en) 2005-11-21 2012-08-15 Purdue Pharma LP 4-oxadiazolyl-piperidine compounds and use thereof
JP5087629B2 (en) 2006-11-01 2012-12-05 パーデュー、ファーマ、リミテッド、パートナーシップ Phenylpropionamide compounds and their uses
CA2687979C (en) 2007-05-25 2017-07-04 Tolmar Therapeutics, Inc. Sustained delivery formulations of risperidone compounds
EP2309982A2 (en) 2008-06-03 2011-04-20 Tolmar Therapeutics, Inc. Controlled release copolymer formulation with improved release kinetics
EP2394663A1 (en) 2010-05-31 2011-12-14 Laboratorios Farmaceuticos Rovi, S.A. Compositions for injectable in-situ biodegradable implants

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018940A1 (en) * 1990-06-04 1991-12-12 Nova Pharmaceutical Corporation Branched polyanhydrides
WO2000024374A1 (en) * 1998-10-28 2000-05-04 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
WO2001035929A2 (en) * 1999-11-16 2001-05-25 Atrix Laboratories, Inc. Biodegradable polymer composition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018940A1 (en) * 1990-06-04 1991-12-12 Nova Pharmaceutical Corporation Branched polyanhydrides
WO2000024374A1 (en) * 1998-10-28 2000-05-04 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
WO2001035929A2 (en) * 1999-11-16 2001-05-25 Atrix Laboratories, Inc. Biodegradable polymer composition

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10058554B2 (en) 2005-09-30 2018-08-28 Indivior Uk Limited Sustained release small molecule drug formulation
US8133968B2 (en) 2006-06-29 2012-03-13 Medtronic, Inc. Poly(orthoester) polymers, and methods of making and using same
US8475823B2 (en) 2008-04-18 2013-07-02 Medtronic, Inc. Baclofen formulation in a polyorthoester carrier
US8940315B2 (en) 2008-04-18 2015-01-27 Medtronic, Inc. Benzodiazepine formulation in a polyorthoester carrier
US8956642B2 (en) 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
US10022367B2 (en) 2014-03-10 2018-07-17 Indivior Uk Limited Sustained-release buprenorphine solutions

Also Published As

Publication number Publication date Type
WO2002038185A2 (en) 2002-05-16 application

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