WO2002038185A3 - Injectable sustained release delivery system with loperamide - Google Patents

Injectable sustained release delivery system with loperamide Download PDF

Info

Publication number
WO2002038185A3
WO2002038185A3 PCT/US2001/047116 US0147116W WO0238185A3 WO 2002038185 A3 WO2002038185 A3 WO 2002038185A3 US 0147116 W US0147116 W US 0147116W WO 0238185 A3 WO0238185 A3 WO 0238185A3
Authority
WO
WIPO (PCT)
Prior art keywords
loperamide
delivery system
sustained release
release delivery
flowable composition
Prior art date
Application number
PCT/US2001/047116
Other languages
French (fr)
Other versions
WO2002038185A2 (en
Inventor
Richard L Dunn
David W Osborne
Original Assignee
Atrix Lab Inc
Richard L Dunn
David W Osborne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US71082500A priority Critical
Priority to US09/710,825 priority
Application filed by Atrix Lab Inc, Richard L Dunn, David W Osborne filed Critical Atrix Lab Inc
Publication of WO2002038185A2 publication Critical patent/WO2002038185A2/en
Publication of WO2002038185A3 publication Critical patent/WO2002038185A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/451Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

Abstract

The present invention provides for a flowable composition suitable for use as a controlled release implant, a method for forming a flowable composition for use as a controlled release implant, and methods for using the flowable composition. The composition comprises a biodegradable thermoplastic polyester that is at least substantially insoluble in aqueous medium or body fluid; a biocompatible organic solvent that is miscible to dispersible in aqueous medium or body fluid and can effectively dissolve the thermoplastic polyester; and an antihyperalgesic opiate.
PCT/US2001/047116 2000-11-13 2001-11-13 Injectable sustained release delivery system with loperamide WO2002038185A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US71082500A true 2000-11-13 2000-11-13
US09/710,825 2000-11-13

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AU2600002A AU2600002A (en) 2000-11-13 2001-11-13 Injectable sustained release delivery system with loperamide

Publications (2)

Publication Number Publication Date
WO2002038185A2 WO2002038185A2 (en) 2002-05-16
WO2002038185A3 true WO2002038185A3 (en) 2003-01-16

Family

ID=24855703

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/047116 WO2002038185A2 (en) 2000-11-13 2001-11-13 Injectable sustained release delivery system with loperamide

Country Status (2)

Country Link
AU (1) AU2600002A (en)
WO (1) WO2002038185A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8133968B2 (en) 2006-06-29 2012-03-13 Medtronic, Inc. Poly(orthoester) polymers, and methods of making and using same
US8475823B2 (en) 2008-04-18 2013-07-02 Medtronic, Inc. Baclofen formulation in a polyorthoester carrier
US8956642B2 (en) 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
AR039729A1 (en) * 2002-06-25 2005-03-09 Alza Corp Depot formulations of short duration
US8501215B2 (en) * 2002-07-31 2013-08-06 Guohua Chen Injectable multimodal polymer depot compositions and uses thereof
CA2504608C (en) * 2002-11-06 2013-01-08 Alza Corporation Controlled release depot formulations
US7202259B2 (en) 2002-11-18 2007-04-10 Euro-Celtique S.A. Therapeutic agents useful for treating pain
CA2527664A1 (en) * 2003-05-30 2004-12-16 Alza Corporation Implantable elastomeric depot compositions, uses thereof and method of manufacturing
US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
WO2007057229A1 (en) 2005-11-21 2007-05-24 Purdue Pharma L.P. 4-oxadiazolyl-piperidine compounds and use thereof
CA2666750C (en) 2006-11-01 2014-02-04 Purdue Pharma L.P. Phenylpropionamide compounds and the use thereof
MX337286B (en) 2007-05-25 2016-02-22 Indivior Uk Ltd Sustained delivery formulations of risperidone compounds.
EP2309982A2 (en) 2008-06-03 2011-04-20 Tolmar Therapeutics, Inc. Controlled release copolymer formulation with improved release kinetics
EP2394663A1 (en) 2010-05-31 2011-12-14 Laboratorios Farmaceuticos Rovi, S.A. Compositions for injectable in-situ biodegradable implants
US9272044B2 (en) 2010-06-08 2016-03-01 Indivior Uk Limited Injectable flowable composition buprenorphine
GB2481017B (en) 2010-06-08 2015-01-07 Rb Pharmaceuticals Ltd Microparticle buprenorphine suspension
GB201404139D0 (en) 2014-03-10 2014-04-23 Rb Pharmaceuticals Ltd Sustained release buprenorphine solution formulations

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018940A1 (en) * 1990-06-04 1991-12-12 Nova Pharmaceutical Corporation Branched polyanhydrides
WO2000024374A1 (en) * 1998-10-28 2000-05-04 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
WO2001035929A2 (en) * 1999-11-16 2001-05-25 Atrix Laboratories, Inc. Biodegradable polymer composition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018940A1 (en) * 1990-06-04 1991-12-12 Nova Pharmaceutical Corporation Branched polyanhydrides
WO2000024374A1 (en) * 1998-10-28 2000-05-04 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
WO2001035929A2 (en) * 1999-11-16 2001-05-25 Atrix Laboratories, Inc. Biodegradable polymer composition

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8133968B2 (en) 2006-06-29 2012-03-13 Medtronic, Inc. Poly(orthoester) polymers, and methods of making and using same
US8475823B2 (en) 2008-04-18 2013-07-02 Medtronic, Inc. Baclofen formulation in a polyorthoester carrier
US8940315B2 (en) 2008-04-18 2015-01-27 Medtronic, Inc. Benzodiazepine formulation in a polyorthoester carrier
US8956642B2 (en) 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier

Also Published As

Publication number Publication date
AU2600002A (en) 2002-05-21
WO2002038185A2 (en) 2002-05-16

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