WO2002038143A3 - Enhanced efficacy and safety of genotoxic therapy by p38 mapk modulation - Google Patents

Enhanced efficacy and safety of genotoxic therapy by p38 mapk modulation Download PDF

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Publication number
WO2002038143A3
WO2002038143A3 PCT/US2001/047669 US0147669W WO0238143A3 WO 2002038143 A3 WO2002038143 A3 WO 2002038143A3 US 0147669 W US0147669 W US 0147669W WO 0238143 A3 WO0238143 A3 WO 0238143A3
Authority
WO
WIPO (PCT)
Prior art keywords
mapk
modulation
safety
enhanced efficacy
genotoxic
Prior art date
Application number
PCT/US2001/047669
Other languages
French (fr)
Other versions
WO2002038143A2 (en
Inventor
Dmitry V Bulavin
Albert J Fornace Jr
Original Assignee
Us Gov Health & Human Serv
Dmitry V Bulavin
Albert J Fornace Jr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv, Dmitry V Bulavin, Albert J Fornace Jr filed Critical Us Gov Health & Human Serv
Priority to AU2002239578A priority Critical patent/AU2002239578A1/en
Publication of WO2002038143A2 publication Critical patent/WO2002038143A2/en
Publication of WO2002038143A3 publication Critical patent/WO2002038143A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2440/00—Post-translational modifications [PTMs] in chemical analysis of biological material
    • G01N2440/14—Post-translational modifications [PTMs] in chemical analysis of biological material phosphorylation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Methods of enhancing the efficacy of genotoxic agents are provided. The methods include inhibiting p38 mitogen activated protein kinase in cells exposed to genotoxic agents, such as UV radiation and chemotherapeutic agents. Methods are also provided to protect non-tumor cells from genotoxin-induced cell death, by inhibiting p38 mitogen activated protein kinase in the cells.
PCT/US2001/047669 2000-11-07 2001-11-06 Enhanced efficacy and safety of genotoxic therapy by p38 mapk modulation WO2002038143A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002239578A AU2002239578A1 (en) 2000-11-07 2001-11-06 Enhanced efficacy and safety of genotoxic therapy by p38 mapk modulation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24691200P 2000-11-07 2000-11-07
US60/246,912 2000-11-07

Publications (2)

Publication Number Publication Date
WO2002038143A2 WO2002038143A2 (en) 2002-05-16
WO2002038143A3 true WO2002038143A3 (en) 2003-12-31

Family

ID=22932754

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/047669 WO2002038143A2 (en) 2000-11-07 2001-11-06 Enhanced efficacy and safety of genotoxic therapy by p38 mapk modulation

Country Status (2)

Country Link
AU (1) AU2002239578A1 (en)
WO (1) WO2002038143A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1709965A3 (en) 2001-07-11 2006-12-27 Boehringer Ingelheim Pharmaceuticals, Inc. Methods of treating cytokine mediate diseases
WO2005077983A2 (en) * 2004-02-05 2005-08-25 Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Modulating p38 kinase activity
FR2874619B1 (en) * 2004-08-25 2006-11-17 Centre Nat Rech Scient Cnrse NOVEL PHOSPHORYLATED PHOSPHATASE SEQUENCES OF CDC25B PHOSPHATASE, ANTIBODIES DIRECTED THEREFROM AND USES THEREOF
CN110624108B (en) * 2019-01-08 2022-04-05 浙江大学 Application of Fas or ligand FasL thereof as target in preparation of antitumor drugs

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5863729A (en) * 1996-07-09 1999-01-26 Washington University DNA sequences encoding human TcAK1 kinase
WO2001009373A2 (en) * 1999-07-30 2001-02-08 Basf Bioresearch Corporation Native cdc25 substrates, compositions and uses related thereto
WO2001057206A2 (en) * 2000-02-03 2001-08-09 Ribozyme Pharmaceuticals, Inc. Method and reagent for the inhibition of checkpoint kinase-1 (chk 1) enzyme

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5863729A (en) * 1996-07-09 1999-01-26 Washington University DNA sequences encoding human TcAK1 kinase
WO2001009373A2 (en) * 1999-07-30 2001-02-08 Basf Bioresearch Corporation Native cdc25 substrates, compositions and uses related thereto
WO2001057206A2 (en) * 2000-02-03 2001-08-09 Ribozyme Pharmaceuticals, Inc. Method and reagent for the inhibition of checkpoint kinase-1 (chk 1) enzyme

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BULAVIN D V ET AL: "Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation.", THE EMBO JOURNAL. ENGLAND 1 DEC 1999, vol. 18, no. 23, 1 December 1999 (1999-12-01), pages 6845 - 6854, XP002224351, ISSN: 0261-4189 *
FURNARI B ET AL: "Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase.", SCIENCE. UNITED STATES 5 SEP 1997, vol. 277, no. 5331, 5 September 1997 (1997-09-05), pages 1495 - 1497, XP002224352, ISSN: 0036-8075 *
GRAVES P R ET AL: "The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. UNITED STATES 25 FEB 2000, vol. 275, no. 8, 25 February 2000 (2000-02-25), pages 5600 - 5605, XP002224350, ISSN: 0021-9258 *
LEE J C ET AL: "P38 MITOGEN-ACTIVATED PROTEIN KINASE INHIBITORS-MECHANISMS AND THERAPEUTIC POTENTIALS", PHARMACOLOGY AND THERAPEUTICS, ELSEVIER, GB, vol. 82, no. 2/3, May 1999 (1999-05-01), pages 389 - 397, XP000972766, ISSN: 0163-7258 *
MORRIS M C ET AL: "An essential phosphorylation-site domain of human cdc25C interacts with both 14-3-3 and cyclins.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. UNITED STATES 15 SEP 2000, vol. 275, no. 37, 15 September 2000 (2000-09-15), pages 28849 - 28857, XP001118987, ISSN: 0021-9258 *
PENG C Y ET AL: "Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216.", SCIENCE. UNITED STATES 5 SEP 1997, vol. 277, no. 5331, 5 September 1997 (1997-09-05), pages 1501 - 1505, XP002224349, ISSN: 0036-8075 *
SANCHEZ Y ET AL: "Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms.", SCIENCE. UNITED STATES 5 NOV 1999, vol. 286, no. 5442, 5 November 1999 (1999-11-05), pages 1166 - 1171, XP002224353, ISSN: 0036-8075 *
WANG X ET AL: "Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest.", MOLECULAR AND CELLULAR BIOLOGY. UNITED STATES JUL 2000, vol. 20, no. 13, July 2000 (2000-07-01), pages 4543 - 4552, XP002224348, ISSN: 0270-7306 *

Also Published As

Publication number Publication date
AU2002239578A1 (en) 2002-05-21
WO2002038143A2 (en) 2002-05-16

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