WO2002036630A3 - Proteine recepteur de la renine et/ou de la prorenine, acide nucleique codant pour ce recepteur et leurs applications - Google Patents
Proteine recepteur de la renine et/ou de la prorenine, acide nucleique codant pour ce recepteur et leurs applications Download PDFInfo
- Publication number
- WO2002036630A3 WO2002036630A3 PCT/FR2001/003374 FR0103374W WO0236630A3 WO 2002036630 A3 WO2002036630 A3 WO 2002036630A3 FR 0103374 W FR0103374 W FR 0103374W WO 0236630 A3 WO0236630 A3 WO 0236630A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- renin
- nucleic acid
- acid coding
- proprenin
- same
- Prior art date
Links
- 102100028255 Renin Human genes 0.000 title abstract 2
- 108090000783 Renin Proteins 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 102000005962 receptors Human genes 0.000 title 1
- 108020003175 receptors Proteins 0.000 title 1
- 102100028254 Renin receptor Human genes 0.000 abstract 2
- 101710152859 Renin receptor Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000015427 Angiotensins Human genes 0.000 abstract 1
- 108010064733 Angiotensins Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000003734 kidney Anatomy 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Cette invention concerne une protéine isolée à activité de récepteur de la rénine, un acide nucléique codant pour cette protéine et leurs applications, notamment pour le criblage de composés antagonistes ou agonistes de la liaison rénine-récepteur, utiles notamment dans le traitement d'affections impliquant le système rénine/angiotensine, et atteignant en particulier le coeur, les reins et le cerveau.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR00/13943 | 2000-10-30 | ||
FR0013943A FR2815964A1 (fr) | 2000-10-30 | 2000-10-30 | Proteine recepteur de la renine et/ou de la prorenine, acide nucleique codant pour ce recepteur et leur applications |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002036630A2 WO2002036630A2 (fr) | 2002-05-10 |
WO2002036630A3 true WO2002036630A3 (fr) | 2003-10-23 |
Family
ID=8855910
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2001/003374 WO2002036630A2 (fr) | 2000-10-30 | 2001-10-30 | Proteine recepteur de la renine et/ou de la prorenine, acide nucleique codant pour ce recepteur et leurs applications |
Country Status (2)
Country | Link |
---|---|
FR (1) | FR2815964A1 (fr) |
WO (1) | WO2002036630A2 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1890152A1 (fr) * | 2006-08-14 | 2008-02-20 | Charite Universitätsmedizin-Berlin | Détermination de l'activité du récepteur rénine/prorénine |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998021328A2 (fr) * | 1996-11-13 | 1998-05-22 | Sagami Chemical Research Center | Proteines humaines possedant des domaines de transmembrane et adn codant ces proteines |
WO1999040189A2 (fr) * | 1998-02-09 | 1999-08-12 | Genset | ADNc CODANT DES PROTEINES SECRETEES |
WO2001021658A1 (fr) * | 1999-09-24 | 2001-03-29 | Human Genome Sciences, Inc. | 32 proteines humaines secretees |
WO2001077137A1 (fr) * | 2000-04-12 | 2001-10-18 | Human Genome Sciences, Inc. | Proteines de fusion d'albumine |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1514933A1 (fr) * | 1999-07-08 | 2005-03-16 | Research Association for Biotechnology | Protéine sécrétoire ou protéine de membrane |
-
2000
- 2000-10-30 FR FR0013943A patent/FR2815964A1/fr not_active Withdrawn
-
2001
- 2001-10-30 WO PCT/FR2001/003374 patent/WO2002036630A2/fr active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998021328A2 (fr) * | 1996-11-13 | 1998-05-22 | Sagami Chemical Research Center | Proteines humaines possedant des domaines de transmembrane et adn codant ces proteines |
WO1999040189A2 (fr) * | 1998-02-09 | 1999-08-12 | Genset | ADNc CODANT DES PROTEINES SECRETEES |
WO2001021658A1 (fr) * | 1999-09-24 | 2001-03-29 | Human Genome Sciences, Inc. | 32 proteines humaines secretees |
WO2001077137A1 (fr) * | 2000-04-12 | 2001-10-18 | Human Genome Sciences, Inc. | Proteines de fusion d'albumine |
Non-Patent Citations (8)
Title |
---|
ASN;San Francisco, CA, USA; October 10-17, 2001. * |
DATABASE EM_PAT [online] EMBL; 30 May 2001 (2001-05-30), OTA, T. ET AL.: "Sequence 61 from EP1067182", XP002171373, Database accession no. AX136139 * |
EP-A-1067182 (HELIX RESEARCH INST.) * |
INOUE H ET AL: "MOLECULAR CLONING AND SEQUENCE ANALYSIS OF A COMPLEMENTARY DNA ENCODING A PORCINE KIDNEY RENIN-BINDING PROTEIN", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 265, no. 12, 1990, pages 6556 - 6561, XP002227436, ISSN: 0021-9258 * |
NGUYEN G ET AL: "Mise en évidence d'un récepteur de la rénine sur les cellules mésangiales humaines: effets sur le PAI1 et sur le GMPc.", NEPHROLOGIE, vol. 19, no. 7, 1998, pages 411 - 416, XP002171372, ISSN: 0250-4960 * |
NGUYEN GENEVIEVE ET AL: "Molecular cloning of the human receptor of renin: A new protein playing pivotal role in cell surface generation of angiotensin II and mediating renin cellular effects.", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 12, no. Program and Abstract Issue, September 2001 (2001-09-01), pages 573A - 574A, XP008012415, ISSN: 1046-6673 * |
NGUYEN GENEVIEVE ET AL: "Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin.", JOURNAL OF CLINICAL INVESTIGATION, vol. 109, no. 11, June 2002 (2002-06-01), pages 1417 - 1427, XP002227437, ISSN: 0021-9738 * |
SEALEY JEAN E ET AL: "Specific prorenin/renin binding (ProBP): Identification and characterization of a novel membrane site.", AMERICAN JOURNAL OF HYPERTENSION, vol. 9, no. 5, 1996, pages 491 - 502, XP001010230, ISSN: 0895-7061 * |
Also Published As
Publication number | Publication date |
---|---|
FR2815964A1 (fr) | 2002-05-03 |
WO2002036630A2 (fr) | 2002-05-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
122 | Ep: pct application non-entry in european phase | ||
NENP | Non-entry into the national phase |
Ref country code: JP |