WO2002030406A3 - Use of antagonists or partial agonists of 5ht1a receptors for the preparation of a medicament for treatment and prevention of gastrointestinal diseases - Google Patents

Use of antagonists or partial agonists of 5ht1a receptors for the preparation of a medicament for treatment and prevention of gastrointestinal diseases Download PDF

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Publication number
WO2002030406A3
WO2002030406A3 PCT/IB2001/002759 IB0102759W WO0230406A3 WO 2002030406 A3 WO2002030406 A3 WO 2002030406A3 IB 0102759 W IB0102759 W IB 0102759W WO 0230406 A3 WO0230406 A3 WO 0230406A3
Authority
WO
WIPO (PCT)
Prior art keywords
antagonists
medicament
prevention
gastrointestinal diseases
preparation
Prior art date
Application number
PCT/IB2001/002759
Other languages
French (fr)
Other versions
WO2002030406A2 (en
Inventor
T G Dinan
P W N Keeling
Original Assignee
T G Dinan
P W N Keeling
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/687,384 external-priority patent/US7098232B1/en
Application filed by T G Dinan, P W N Keeling filed Critical T G Dinan
Priority to CA002425910A priority Critical patent/CA2425910A1/en
Priority to EP01986602A priority patent/EP1408937A2/en
Priority to JP2002533849A priority patent/JP2004510814A/en
Publication of WO2002030406A2 publication Critical patent/WO2002030406A2/en
Publication of WO2002030406A3 publication Critical patent/WO2002030406A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)

Abstract

The present invention provides a method for preventing and treating gastrointestinal diseases such as dyspepsia, irritable bowel disease and chemotherapy-associated nausea by administering an antagonist or partial agonist of 5HT1a receptors.
PCT/IB2001/002759 2000-10-13 2001-10-11 Use of antagonists or partial agonists of 5ht1a receptors for the preparation of a medicament for treatment and prevention of gastrointestinal diseases WO2002030406A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002425910A CA2425910A1 (en) 2000-10-13 2001-10-11 Treatment and prevention of gastrointestinal disease using antagonists or partial agonists of 5ht1a receptors
EP01986602A EP1408937A2 (en) 2000-10-13 2001-10-11 Use of antagonists or partial agonists of 5ht1a receptors for the preparation of a medicament for treatment and prevention of gastrointestinal diseases
JP2002533849A JP2004510814A (en) 2000-10-13 2001-10-11 Treatment and prevention of gastrointestinal diseases using 5HT1a receptor antagonists or partial agonists

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/687,384 US7098232B1 (en) 1999-10-22 2000-10-13 Treatment and prevention of gastrointestinal disease using antagonists of partial agonists of 5HT1a receptors
US09/687,384 2000-10-13

Publications (2)

Publication Number Publication Date
WO2002030406A2 WO2002030406A2 (en) 2002-04-18
WO2002030406A3 true WO2002030406A3 (en) 2004-02-12

Family

ID=24760250

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2001/002759 WO2002030406A2 (en) 2000-10-13 2001-10-11 Use of antagonists or partial agonists of 5ht1a receptors for the preparation of a medicament for treatment and prevention of gastrointestinal diseases

Country Status (4)

Country Link
EP (1) EP1408937A2 (en)
JP (1) JP2004510814A (en)
CA (1) CA2425910A1 (en)
WO (1) WO2002030406A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100563648C (en) * 2003-04-25 2009-12-02 田边三菱制药株式会社 The Orally administered composition that comprises alkylene dioxybenzene derivative
JP4912145B2 (en) * 2004-02-26 2012-04-11 あすか製薬株式会社 Pyrimidine derivatives

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO92436A2 (en) * 1985-04-19 1987-09-30 Intreprinderea De Medicamente,Ro SINERGIC MEDICINAL COMPOSITION FOR TREATMENT OF GASTRODUODENITES AND GASTRODUODENAL ULTRAS

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO92436A2 (en) * 1985-04-19 1987-09-30 Intreprinderea De Medicamente,Ro SINERGIC MEDICINAL COMPOSITION FOR TREATMENT OF GASTRODUODENITES AND GASTRODUODENAL ULTRAS

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 198804, Derwent World Patents Index; Class B04, AN 1988-026750, XP002211972 *

Also Published As

Publication number Publication date
WO2002030406A2 (en) 2002-04-18
EP1408937A2 (en) 2004-04-21
JP2004510814A (en) 2004-04-08
CA2425910A1 (en) 2002-04-18

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