WO2002030382A1 - Composition blanchissante et dentifrice - Google Patents

Composition blanchissante et dentifrice Download PDF

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Publication number
WO2002030382A1
WO2002030382A1 PCT/US2001/042643 US0142643W WO0230382A1 WO 2002030382 A1 WO2002030382 A1 WO 2002030382A1 US 0142643 W US0142643 W US 0142643W WO 0230382 A1 WO0230382 A1 WO 0230382A1
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WO
WIPO (PCT)
Prior art keywords
dentifrice
composition
present
sodium
whitening
Prior art date
Application number
PCT/US2001/042643
Other languages
English (en)
Inventor
Bala C. Nayar
Jin Xu
Original Assignee
Block Drug Company, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Block Drug Company, Inc. filed Critical Block Drug Company, Inc.
Publication of WO2002030382A1 publication Critical patent/WO2002030382A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention is directed to an oral care composition that effectively dissolves, disperses, detaches, and removes deposits and stains from teeth and other surfaces in the oral cavity.
  • the external surface of the teeth is covered by an organic film (i.e., the pellicle) formed of salivary protein, which is known to become stained and discolored by foods such as coffee, tea and berries, as well as tobacco smoke (i.e., tar), cationic bacterials and chromogenic bacteria.
  • an abrasive such as synthetic silicas for the removal of stained pellicle.
  • Synthetic silicas include both silica gels and precipitated silicas that are prepared by the neutralization of aqueous silica solutions with a strong mineral acid.
  • U.S. Patent No. 4,153,680 discloses the use of silica hydrogels or hydrated silica as a dentifrice polishing agent.
  • U.S. Patent Nos. 5,716,601 and 5,603,920 disclose a "novel abrasive" to remove stained pellicle with a precipitated silica resulting in dentifrice compositions "without undue abrasive.”
  • the dentifrice may further include about 0.1 to 2.5 wt.% of surfactants and 0.1 to 2.5 wt.% of chelating agents.
  • These two patents are assigned to Proctor and Gamble Corporation, the maker of Crest® Extra Whitening, which "contains a special enamel-safe polishing ingredient” and “works by gently polishing away stains, not bleaching.”
  • U.S. Patent Nos. 4,923,684 and 4,985,236 disclose a different approach to removing stain by using at least 4 wt.% of sodium tripolyphosphate in a storage stable fluoride toothpaste. These two patents are assigned to SmithKline Beecham Corporation, the maker of Aquafresh® Whitening with Triclene® (a registered trademark for sodium tripolyphosphate) to "gently break up stains to get teeth whiter.”
  • Patent application WO 99/12517 discloses a water-soluble alkali metal tripolyphosphate used in combination with an alkali metal pyrophosphate and polyvinyl pyrrolidone for preventing the build-up of stain and whitening tooth and dental prostheses.
  • WO 99/13851 discloses a dentifrice with improved cleaning performance comprising 2 to 12 wt.% of a condensed phosphate selected from tripolyphosphate, pyrophosphate and trimetaphosphate, 10 to 30 wt.% of a combination of silicic acid and aluminum oxide in a weight ratio of 10:(0.2-2), and between 20 to 50 wt.% of a moistening agent from the group containing sorbitol, glycerin, propylene glycol-1, 2, polyethylene glycol, and their mixtures.
  • a condensed phosphate selected from tripolyphosphate, pyrophosphate and trimetaphosphate
  • a moistening agent from the group containing sorbitol, glycerin, propylene glycol-1, 2, polyethylene glycol, and their mixtures.
  • JP 11021216 discloses a composition with a high cleaning effect comprising one or more of linear and cyclic water-soluble polyphosphates and phytates, and one or more 3-4 carbon monohydric alcohols.
  • U.S. Patent No. 6,086,372 discloses an oral composition comprising at least one nonionic surfactant and at least one essential oil for dissolving tobacco tar.
  • 5,662,888 discloses a toothpaste composition
  • a toothpaste composition comprising 0.3 to 6.5 wt.% of a non-ionic surfactant, 0.3 to 4.5 wt.% of at least one anionic surfactant; 0.06 to 0.20-wt.% of methyl salicylate, 0.3 to 2 wt.% of at least one essential oil, and 12 to 20 wt.% of ethyl alcohol.
  • the invention relates to a dentifrice composition having a pH of about 6.0 to 10.0 comprising (a) 5 to 50 wt.% of a combination of alumina and silica in the ratio of about 1:5 to 1:0.20; (b) 1 to 4 wt.% of a water soluble polyphosphate salt; and (c) about 1 to 20 wt.% of a humectant polyol as a solubilizing agent.
  • the composition further includes 0.3 to 5 wt.% of at least a surfactant.
  • the present invention further relates to a method to whiten teeth and remove stains using the above composition.
  • polishing materials are dentally acceptable polishing materials including alumina and silica.
  • silica is used to mean amorphous silica having particle sizes in the range from 1 to 50 microns.
  • Commercially available hydrated silica include Sorbosil AC-35 marketed by Crossfields Chemicals, Zeodent 165 marketed by Huber Company, or Sylodent 783 marketed by Grace Davidson.
  • Alumina abrasives include alumina trihydrate, aluminum silicate, calcined alumina and bentonite.
  • a preferred alumina abrasive is anhydrous calcined alumina having mean particle sizes in the range from 0.2 to 50 microns.
  • the concentration of abrasive in composition of the present invention will normally be in the range of about 5 to 50 wt.% and the ratio of alumina to silica is in the range of about 1:5 to 1:0.20. In one embodiment, the concentration is in the range of 10 to 40 wt.%.
  • the cleaning agents of the invention are polyphosphate salts, especially linear polyphosphate salts. They also function as anti-tartar agents. They are well known, being generally employed in the form of their wholly or partially neutralized water soluble alkali metal (e.g., potassium or preferably sodium) or ammonium salts, and any mixtures thereof.
  • polyphosphate salts are the water soluble alkali metal tripolyphosphates such as sodium tripolyphosphate (STPP), potassium tripolyphosphate, sodium hexametaphosphate (SHMP), disodium pyrophosphate, dipotassium pyrophosphate, tetrasodium pyrophosphate, tetrapotassium pyrophosphate (TKPP), and mixtures of these salts.
  • Amounts of the polyphosphate salts may range from 1 to 4 wt.% and typically are 1 to 3.5 wt.% of the oral composition.
  • Materials that substantially dissolve the stains, i.e., solubilizing materials, of the invention include humectant polyols such as polyethylene glycol, propylene glycol, dipropylene glycol and hexylene glycol, cellosolves such as methyl cellosolve and ethyl cellosolve, and mixtures thereof.
  • humectant polyols such as polyethylene glycol, propylene glycol, dipropylene glycol and hexylene glycol
  • cellosolves such as methyl cellosolve and ethyl cellosolve
  • Polyethylene glycol is preferred.
  • the average molecular weight of the polyethylene glycols used in the practice of the present invention is about 200-2000, preferably 400-800.
  • the amount of solubilizing agent used in the present invention is about 1 to 10 wt.%.
  • polyethylene glycol is used in the range of about 3 to 7 wt.%.
  • Surfactants are used in the compositions of the present invention to provide foaming properties in dispersing the dentifrice composition throughout the oral cavity and also as a cleansing agent. They also aid in producing a uniform composition in which the ingredients of the composition are evenly distributed and more cosmetically acceptable.
  • the surface-active material is preferably anionic, nonionic or ampholytic in nature, and most preferably is anionic.
  • Suitable examples of anionic surfacants are higher alkyl sulfates such as potassium or sodium lauryl sulfate, sodium ether lauryl sulfate, sodium lauryl sulfoacetate, higher fatty acid monoglyceride monosulfates, such as the potassium salt of the monosulfated monoglyceride of hydrogenated coconut oil fatty acids, alkyl aryl sulfonates such as potassium dodecyl benzene sulfonate, higher fatty sulfoacetates, higher fatty acid esters of 1,2 dihydroxy propane sulfonate, and the substantially saturated higher aliphatic acyl amides of lower aliphatic amino carboxylic acid compounds, such as those having 12 to 16 carbons in the fatty acid, alkyl or acyl radicals, and the like.
  • higher alkyl sulfates such as potassium or sodium lauryl sulfate, sodium ether lauryl sulfate
  • amides examples include N-lauroyl sarcosine, and the potassium salts of N-lauroyl, N-myristoyl, or N-palmitoyl sarcosine.
  • the surfactant is typically present in the whitening dentifrice compositions, of the present invention in an amount of about 0.3 to about 5 wt.%, preferably about 0.5 to about 2 wt.%. Mixtures of two or more surfactants can be used if desired to obtain desired properties.
  • Optional thickeners may be used to provide bulk and a suitable consistency for the compositions of the present invention.
  • compositions of the present invention include natural and synthetic gums and colloids, examples of which include carrageenan, xanthan gum, sodium carboxymethyl cellulose, starch, polyvinylpyrrolidone, hydroxyethylpropyl cellulose, hydroxybutyl methyl cellulose, hydroxyproplymethyl cellulose, hydroxyethyl cellulose, other cellulosic ethers, and carboxypolymethlene.
  • Thickening materials will preferably be incorporated in the compositions of the present invention in a concentration ranging from about 0.05 to about 25 wt.% of the composition, and preferably in a range from about 0.1 to about 10 wt.%.
  • the dentifrice composition of the present invention may also contain a source of fluoride ions or a fluorine-providing component, as an anticaries agent in an amount sufficient to supply about 25 ppm to 5,000 ppm of fluoride ions and include inorganic fluoride salts, such as soluble alkali metal salts, for example, sodium fluoride, potassium fluoride, sodium fluorosilicate, ammonium fluorosilicate, sodium monofluorophosphate, as well as tin fluorides, such as stannous fluoride.
  • desensitizing agents such as potassium nitrate, potassium chloride, potassium citrate, and mixtures thereof.
  • antibacterials agents may also be included in the composition of this invention.
  • Antibacterials if present, are in the range of 0.2 to 1.0 wt.% of the dentifrice composition.
  • Useful antibacterial agents include chlorohexidene, non-cationic antibacterial agents which are based on phenolic or bisphenolic compounds, such as halogenated diphenyl ethers like triclosan (2,4,4 '-trichloro-2'-hydroxydiphenyl ether), benzoate esters or carbanilides.
  • a preferred antibacterial agent is triclosan, which is a broad-spectrum antibacterial agent, marketed for use in oral products under the trademarks Irgacare MP or Irgasan DP3000 by CIBA-Geigy Corporation, Greensboro, N.C. 27419.
  • Various other materials may be incorporated in the dentifrice compositions of this invention, including whitening agents, such as hydrogen peroxide, calcium peroxide and urea peroxide; preservatives; silicones; and chlorophyll compounds. These additives, when present, are incorporated in the dentifrice composition in amounts which do not substantially adversely affect the properties and characteristics desired.
  • pigments and dyes may be used in the practice of the present invention.
  • Pigments include non-toxic, water soluble inorganic pigments such as titanium dioxide and chromium oxide greens, ultramarine blues and pinks and ferric oxides as well as water insoluble dye lakes prepared by extending calcium or aluminum salts of FD&C dyes on alumina such as FD&C Green#l lake, FD&C Blue #2 lake, FD&C B&D #30 lake and FD&C #Yellow 15 lake.
  • the pigments have a particle size in the range of 5-1000 microns, preferably 250-500 microns, and are present at a concentration of 0.5 to 3 wt.%.
  • Dyes used in the practice of the present invention are generally food color additives presently certified in the Food Drug & Cosmetic Act for use in food and ingested drugs, including dyes such as FD&C red No. 3 (sodium salt of tetraiodofluorescein), FD&C Yellow No. 5 (sodium salt of 4-p-sulfophenylazo-l-p- sulfophenyl-5-hydroxypyrazole-3-carboxylic acid), FD&C Yellow No.
  • FD&C red No. 3 sodium salt of tetraiodofluorescein
  • FD&C Yellow No. 5 sodium salt of 4-p-sulfophenylazo-l-p- sulfophenyl-5-hydroxypyrazole-3-carboxylic acid
  • the concentration of the dye for the most effective result in the present invention is an amount from about 0.05 to about 10 wt.%, and preferably from about 0 ⁇ 05 to about 2 wt.% of the total composition.
  • the dentifrice composition of the present invention may also contain a flavoring agent.
  • Flavoring agents which are used in the practice of the present invention include essential oils as well as various flavoring aldehydes, esters, alcohols, and similar materials.
  • the essential oils include oils of spearmint, peppermint, wintergreen, sassafras, clove, sage, eucalyptus, marjoram, cinnamon, lemon, lime, grapefruit, and orange. Also useful are such chemicals as menthol, carvone, and anethol. Of these, the most commonly employed are the oils of peppermint and spearmint.
  • Suitable sweetening agepts include sucrose, lactose, maltose, sorbitol, sodium cyclamate, perillartine, and sodium saccharin.
  • flavor and sweetening agents may together comprise from about 0.01 to 5 wt.% of the compositions described herein.
  • the pH of dentifrice of the invention is generally in the range of about 6 to about 10 and preferably about 7 to about 9. The pH can be controlled with acid (e.g., citric acid or benzoic acid) or base (e.g., sodium hydroxide) or buffered (as with sodium citrate, benzoate, carbonate, or bicarbonate, disodium hydrogen phosphate, sodium dihydrogen phosphate, and the like).
  • the preparation of dentifrices is well known in the art.
  • the humectants e.g., glycerin, sorbitol, propylene glycol, and polyethylene glycol
  • the organic thickeners such as carboxymethyl cellulose (CMC), carrageenan, or xanthan gum, etc.
  • any salts such as sodium fluoride anticaries agents
  • sweeteners any sweeteners.
  • the resultant mixture is agitated until a homogeneous gel phase is formed.
  • a pigment such as TiO 2 and any acid or base required to adjust the pH.
  • dentifrice compositions prepared according to the present invention in Examples 1-3 were compared with a control dentifrice, Crest® Extra Whitening with Tartar Protection which is protected under U.S. Patent No. 5,603,920 and 5,716,601.
  • a number of hydroxy appetite disks were smoked with cigarettes and aged overnight.
  • the disks were shaken in 35mL of the supernatant of 1:3 diluted slurry (lOgm in 30mL of water) dentifrice compositions for 1 hour in a 140mL beaker using a multi-wrist®" Shaker, manufactured by Lab-Line Instruments, Inc., and operated at Speed 4.5.
  • the cleaning properties of dentifrice compositions are typically expressed in terms of Pellicale Cleaning Ratios ("PCR") and Radioactive Dentin Abrasion (“RDA”) values, respectively.
  • PCR Pellicale Cleaning Ratios
  • RDA Radioactive Dentin Abrasion
  • the PCR test measures the ability of a dentifrice composition to remove pellicle film from a tooth under fixed brushing conditions.
  • the PCR test is described generally in "In Vitro Removal of Stain With Dentifrice", G. K. Stookey, T. A.Burkhard and B. R. Schemehorn, J. Dental Research, 61, 1236-1239, 1982.
  • the RDA test is the standard measurement for predicting the performance of a given toothpaste formulation in terms of its abrasivity by measuring the amount of radio- labeled dentin removed from a tooth under fixed brushing conditions.
  • Example 3 of the present invention was compared with two known and commercially available control dentifrices, Crest® Extra Whitening with Tartar Protection protected under U.S. Patent No. 5,603,920 and 5,716,601, and Aquafresh® Whitening with Triclene® to "gently break up stains to get teeth whiter," protected under U.S. Patent Nos. 4,923,684 and 4,985,236.
  • the result of the RDA and PCR tests are as follows:

Abstract

Cette invention se rapporte à une préparation orale servant à éliminer les dépôts et les taches sur les surfaces de la cavité buccale en association avec une brosse à dents. Cette invention contient environ 5 à 50 % en poids d'une combinaison d'alumine et de silice, selon un rapport compris entre 1/5 et 1/0,20, un sel de polyphosphate soluble dans l'eau, un polyol humectant; et un agent tensioactif anionique; cette composition ayant un pH compris entre environ 6 et 10.
PCT/US2001/042643 2000-10-10 2001-10-10 Composition blanchissante et dentifrice WO2002030382A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68673800A 2000-10-10 2000-10-10
US09/686,738 2000-10-10

Publications (1)

Publication Number Publication Date
WO2002030382A1 true WO2002030382A1 (fr) 2002-04-18

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PCT/US2001/042643 WO2002030382A1 (fr) 2000-10-10 2001-10-10 Composition blanchissante et dentifrice

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1961452A1 (fr) * 2007-02-23 2008-08-27 The Procter and Gamble Company Compositions orales de polyphosphate
US11471388B2 (en) 2018-11-07 2022-10-18 The Procter & Gamble Company Oral care compositions comprising medium length polyphosphates

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4822599A (en) * 1987-08-26 1989-04-18 The Procter & Gamble Company Oral compositions
US5698182A (en) * 1994-11-14 1997-12-16 Colgate Palmolive Company Dentifrice composition containing calcium peroxide having heightened tooth whitening effect

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4822599A (en) * 1987-08-26 1989-04-18 The Procter & Gamble Company Oral compositions
US5698182A (en) * 1994-11-14 1997-12-16 Colgate Palmolive Company Dentifrice composition containing calcium peroxide having heightened tooth whitening effect

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1961452A1 (fr) * 2007-02-23 2008-08-27 The Procter and Gamble Company Compositions orales de polyphosphate
RU2443407C2 (ru) * 2007-02-23 2012-02-27 Дзе Проктер Энд Гэмбл Компани Композиции для ухода за полостью рта, содержащие полифосфат
US11471388B2 (en) 2018-11-07 2022-10-18 The Procter & Gamble Company Oral care compositions comprising medium length polyphosphates

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