WO2002028431A1 - Remedies for hepatic diseases containing calcium channel antagonist as the active ingredient - Google Patents

Remedies for hepatic diseases containing calcium channel antagonist as the active ingredient Download PDF

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Publication number
WO2002028431A1
WO2002028431A1 PCT/JP2001/008407 JP0108407W WO0228431A1 WO 2002028431 A1 WO2002028431 A1 WO 2002028431A1 JP 0108407 W JP0108407 W JP 0108407W WO 0228431 A1 WO0228431 A1 WO 0228431A1
Authority
WO
WIPO (PCT)
Prior art keywords
calcium channel
remedies
active ingredient
hepatic diseases
containing calcium
Prior art date
Application number
PCT/JP2001/008407
Other languages
French (fr)
Japanese (ja)
Inventor
Toshihiro Okamoto
Yuji Takahashi
Jun Goto
Ichiro Kanazawa
Original Assignee
Nippon Chemiphar Co.,Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co.,Ltd. filed Critical Nippon Chemiphar Co.,Ltd.
Priority to JP2002532255A priority Critical patent/JPWO2002028431A1/en
Priority to AU2001292258A priority patent/AU2001292258A1/en
Publication of WO2002028431A1 publication Critical patent/WO2002028431A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

As useful remedies for hepatic diseases with little side effects on the vascular system, use is made of a calcium channel antagonist having a low affinity for a calcium channel wherein the a1 subunit type is a1C but a high affinity for a calcium channel wherein the a1 subunit type is a1D.
PCT/JP2001/008407 2000-10-02 2001-09-27 Remedies for hepatic diseases containing calcium channel antagonist as the active ingredient WO2002028431A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2002532255A JPWO2002028431A1 (en) 2000-10-02 2001-09-27 A therapeutic agent for liver disease containing a calcium channel antagonist as an active ingredient
AU2001292258A AU2001292258A1 (en) 2000-10-02 2001-09-27 Remedies for hepatic diseases containing calcium channel antagonist as the active ingredient

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000-301637 2000-10-02
JP2000301637 2000-10-02

Publications (1)

Publication Number Publication Date
WO2002028431A1 true WO2002028431A1 (en) 2002-04-11

Family

ID=18783139

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2001/008407 WO2002028431A1 (en) 2000-10-02 2001-09-27 Remedies for hepatic diseases containing calcium channel antagonist as the active ingredient

Country Status (3)

Country Link
JP (1) JPWO2002028431A1 (en)
AU (1) AU2001292258A1 (en)
WO (1) WO2002028431A1 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997048396A1 (en) * 1996-06-20 1997-12-24 Pharmacy & Therapeutic Advisory Consultancy Ltd. A method of treating liver disease and like indications with vasodilating agents
WO1999028342A2 (en) * 1997-12-03 1999-06-10 Merck & Co., Inc. Low-voltage activated calcium channel compositions and methods
JP2000026315A (en) * 1998-07-09 2000-01-25 Dai Ichi Seiyaku Co Ltd Evaluation of calcium channel activator

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997048396A1 (en) * 1996-06-20 1997-12-24 Pharmacy & Therapeutic Advisory Consultancy Ltd. A method of treating liver disease and like indications with vasodilating agents
WO1999028342A2 (en) * 1997-12-03 1999-06-10 Merck & Co., Inc. Low-voltage activated calcium channel compositions and methods
JP2000026315A (en) * 1998-07-09 2000-01-25 Dai Ichi Seiyaku Co Ltd Evaluation of calcium channel activator

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ATSUKO TANAKA ET AL.: "Nifedipine nite hatsunetsu, hishin, kan-shougai wo shoujita 1rei", SHINDAN TO CHIRYOU, vol. 84, 1996, pages 226, XP002907966 *
DATABASE MEDLINE [online] BETHESDA, MARYLAND, USA, UNITED STATES NATIONAL LIBRARY OF MEDICINE; 13 December 2001 (2001-12-13), accession no. STN Database accession no. 2001514623 *
G. ROMERO ET AL.: "Protective effects of calcium channel blockers in carbon tetrachloride-induced liver toxicity", LIFE SCI., vol. 55, no. 13, 1994, pages 981 - 990, XP002907962 *
M.E. WILLIAMS ET AL.: "Structure and functional expression of alpha2 and beta subunits of a novel human neuronal calcium channel subtype", NEURON, vol. 8, no. 1, 1992, pages 71 - 84, XP002907964 *
T. OKAMOTO ET AL.: "Expression of the alpha1D subunit of the L-type voltage gated calcium channel in human liver", INT. J. MOL. MED., vol. 8, no. 4, October 2001 (2001-10-01), pages 413 - 416, XP002907965 *
TOSHIKO GOTO ET AL.: "Rat halothane kanen ni taisuru calcium kikkou-yaku no yobou kouka ni tsuite", MASUI, vol. 39, no. 2, 1990, pages 204 - 209, XP002907963 *

Also Published As

Publication number Publication date
JPWO2002028431A1 (en) 2004-02-12
AU2001292258A1 (en) 2002-04-15

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