WO2003020200A8 - A novel pharmaceutical compound and methods of making and using same - Google Patents

A novel pharmaceutical compound and methods of making and using same

Info

Publication number
WO2003020200A8
WO2003020200A8 PCT/US2001/043117 US0143117W WO03020200A8 WO 2003020200 A8 WO2003020200 A8 WO 2003020200A8 US 0143117 W US0143117 W US 0143117W WO 03020200 A8 WO03020200 A8 WO 03020200A8
Authority
WO
WIPO (PCT)
Prior art keywords
making
methods
same
pharmaceutical compound
novel pharmaceutical
Prior art date
Application number
PCT/US2001/043117
Other languages
French (fr)
Other versions
WO2003020200A2 (en
WO2003020200A3 (en
Inventor
Thomas Picariello
Original Assignee
New River Pharmaceuticals Inc
Thomas Picariello
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New River Pharmaceuticals Inc, Thomas Picariello filed Critical New River Pharmaceuticals Inc
Priority to JP2003524514A priority Critical patent/JP2006516947A/en
Priority to ES01273387T priority patent/ES2373641T3/en
Priority to AU2001297565A priority patent/AU2001297565B2/en
Priority to IL15592801A priority patent/IL155928A0/en
Priority to EP01273387A priority patent/EP1357928B1/en
Priority to AT01273387T priority patent/ATE533512T1/en
Publication of WO2003020200A2 publication Critical patent/WO2003020200A2/en
Publication of WO2003020200A3 publication Critical patent/WO2003020200A3/en
Priority to US10/923,088 priority patent/US7427600B2/en
Priority to US11/392,878 priority patent/US20070060500A1/en
Publication of WO2003020200A8 publication Critical patent/WO2003020200A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6867—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of a blood cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6839—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting material from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6839—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting material from viruses
    • A61K47/6841—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting material from viruses the antibody targeting a RNA virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell

Abstract

A pharmaceutical composition comprising : a polypeptide; and an active agent attached to said polypeptide.
PCT/US2001/043117 2000-08-22 2001-11-16 A novel pharmaceutical compound and methods of making and using same WO2003020200A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
JP2003524514A JP2006516947A (en) 2000-11-16 2001-11-16 Novel pharmaceutical compound and method for producing and using the same
ES01273387T ES2373641T3 (en) 2000-11-16 2001-11-16 A NEW PHARMACEUTICAL COMPOUND AND METHODS TO MANUFACTURE AND USE.
AU2001297565A AU2001297565B2 (en) 2000-11-16 2001-11-16 A novel pharmaceutical compound and methods of making and using same
IL15592801A IL155928A0 (en) 2000-11-16 2001-11-16 A novel pharmaceutical compound and methods of making and using same
EP01273387A EP1357928B1 (en) 2000-11-16 2001-11-16 A novel pharmaceutical compound and methods of making and using same
AT01273387T ATE533512T1 (en) 2000-11-16 2001-11-16 NOVEL PHARMACEUTICAL COMPOUND AND METHOD FOR THE PRODUCTION AND USE OF THE SAME
US10/923,088 US7427600B2 (en) 2000-08-22 2004-08-23 Active agent delivery systems and methods for protecting and administering active agents
US11/392,878 US20070060500A1 (en) 2000-08-22 2006-03-30 Pharmaceutical compositions for prevention of overdose or abuse

Applications Claiming Priority (327)

Application Number Priority Date Filing Date Title
USUNKNOWN 1999-06-07
US24871300P 2000-11-16 2000-11-16
US24871600P 2000-11-16 2000-11-16
US24874300P 2000-11-16 2000-11-16
US24869900P 2000-11-16 2000-11-16
US24869700P 2000-11-16 2000-11-16
US24859600P 2000-11-16 2000-11-16
US24853700P 2000-11-16 2000-11-16
US24868800P 2000-11-16 2000-11-16
US24872400P 2000-11-16 2000-11-16
US24874600P 2000-11-16 2000-11-16
US24852700P 2000-11-16 2000-11-16
US24872300P 2000-11-16 2000-11-16
US24885200P 2000-11-16 2000-11-16
US24872100P 2000-11-16 2000-11-16
US24870900P 2000-11-16 2000-11-16
US24875600P 2000-11-16 2000-11-16
US24871400P 2000-11-16 2000-11-16
US24860600P 2000-11-16 2000-11-16
US24860700P 2000-11-16 2000-11-16
US24871800P 2000-11-16 2000-11-16
US24870400P 2000-11-16 2000-11-16
US24870100P 2000-11-16 2000-11-16
US24861100P 2000-11-16 2000-11-16
US24853100P 2000-11-16 2000-11-16
US24885100P 2000-11-16 2000-11-16
US24874400P 2000-11-16 2000-11-16
US24860400P 2000-11-16 2000-11-16
US24859400P 2000-11-16 2000-11-16
US24853300P 2000-11-16 2000-11-16
US24870200P 2000-11-16 2000-11-16
US24885500P 2000-11-16 2000-11-16
US24860800P 2000-11-16 2000-11-16
US24870700P 2000-11-16 2000-11-16
US24869600P 2000-11-16 2000-11-16
US24853800P 2000-11-16 2000-11-16
US24859700P 2000-11-16 2000-11-16
US24870600P 2000-11-16 2000-11-16
US24885800P 2000-11-16 2000-11-16
US24869500P 2000-11-16 2000-11-16
US24869800P 2000-11-16 2000-11-16
US24873200P 2000-11-16 2000-11-16
US24872900P 2000-11-16 2000-11-16
US24869400P 2000-11-16 2000-11-16
US24872700P 2000-11-16 2000-11-16
US24872500P 2000-11-16 2000-11-16
US24859500P 2000-11-16 2000-11-16
US24860300P 2000-11-16 2000-11-16
US24872600P 2000-11-16 2000-11-16
US24884900P 2000-11-16 2000-11-16
US24852800P 2000-11-16 2000-11-16
US24885300P 2000-11-16 2000-11-16
US24860900P 2000-11-16 2000-11-16
US24873300P 2000-11-16 2000-11-16
US24853000P 2000-11-16 2000-11-16
US24871200P 2000-11-16 2000-11-16
US24872800P 2000-11-16 2000-11-16
US24885700P 2000-11-16 2000-11-16
US24872200P 2000-11-16 2000-11-16
US24854000P 2000-11-16 2000-11-16
US24871100P 2000-11-16 2000-11-16
US24885600P 2000-11-16 2000-11-16
US24853900P 2000-11-16 2000-11-16
US24853500P 2000-11-16 2000-11-16
US24885000P 2000-11-16 2000-11-16
US24870300P 2000-11-16 2000-11-16
US24873000P 2000-11-16 2000-11-16
US24869200P 2000-11-16 2000-11-16
US24870000P 2000-11-16 2000-11-16
US24859900P 2000-11-16 2000-11-16
US24868600P 2000-11-16 2000-11-16
US24874500P 2000-11-16 2000-11-16
US24853600P 2000-11-16 2000-11-16
US24885400P 2000-11-16 2000-11-16
US24874800P 2000-11-16 2000-11-16
US24859800P 2000-11-16 2000-11-16
US24852600P 2000-11-16 2000-11-16
US24868900P 2000-11-16 2000-11-16
US24860100P 2000-11-16 2000-11-16
US24872000P 2000-11-16 2000-11-16
US24871700P 2000-11-16 2000-11-16
US24869100P 2000-11-16 2000-11-16
US24878900P 2000-11-16 2000-11-16
US24869300P 2000-11-16 2000-11-16
US24853200P 2000-11-16 2000-11-16
US24867000P 2000-11-16 2000-11-16
US24860200P 2000-11-16 2000-11-16
US24871000P 2000-11-16 2000-11-16
US24874700P 2000-11-16 2000-11-16
US24852500P 2000-11-16 2000-11-16
US24852900P 2000-11-16 2000-11-16
US24870800P 2000-11-16 2000-11-16
US24860000P 2000-11-16 2000-11-16
US24871500P 2000-11-16 2000-11-16
US24871900P 2000-11-16 2000-11-16
US24873100P 2000-11-16 2000-11-16
US24870500P 2000-11-16 2000-11-16
US24852400P 2000-11-16 2000-11-16
US60/248,760 2000-11-16
US60/248,532 2000-11-16
US60/248,622 2000-11-16
US60/248,731 2000-11-16
US60/248,699 2000-11-16
US60/248,665 2000-11-16
US60/248,597 2000-11-16
US60/248,856 2000-11-16
US60/248,629 2000-11-16
US60/248,770 2000-11-16
US60/248,594 2000-11-16
US60/248,854 2000-11-16
US60/248,720 2000-11-16
US60/248,721 2000-11-16
US60/248,669 2000-11-16
US60/248,694 2000-11-16
US60/248,737 2000-11-16
US60/248,858 2000-11-16
US60/248,599 2000-11-16
US60/248,692 2000-11-16
US60/248,595 2000-11-16
US60/248,703 2000-11-16
US60/248,609 2000-11-16
US60/248,602 2000-11-16
US60/248,649 2000-11-16
US60/248,778 2000-11-16
US60/248,752 2000-11-16
US60/248,637 2000-11-16
US60/248,616 2000-11-16
US60/248,792 2000-11-16
US60/248,614 2000-11-16
US60/248,651 2000-11-16
US60/248,761 2000-11-16
US60/248,530 2000-11-16
US60/248,753 2000-11-16
US60/248,615 2000-11-16
US60/248,613 2000-11-16
US60/248,668 2000-11-16
US60/248,660 2000-11-16
US60/248,717 2000-11-16
US60/248,785 2000-11-16
US60/248,663 2000-11-16
US60/248,671 2000-11-16
US60/248,682 2000-11-16
US60/248,626 2000-11-16
US60/248,536 2000-11-16
US60/248,659 2000-11-16
US60/248,535 2000-11-16
US60/248,642 2000-11-16
US60/248,619 2000-11-16
US60/248,627 2000-11-16
US60/248,531 2000-11-16
US60/248,625 2000-11-16
US60/248,780 2000-11-16
US60/248,708 2000-11-16
US60/248,618 2000-11-16
US60/248,738 2000-11-16
US60/248,657 2000-11-16
US60/248,724 2000-11-16
US60/248,754 2000-11-16
US60/248,775 2000-11-16
US60/248,601 2000-11-16
US60/248,735 2000-11-16
US60/248,722 2000-11-16
US60/248,782 2000-11-16
US60/248,608 2000-11-16
US60/248,746 2000-11-16
US60/248,704 2000-11-16
US60/248,675 2000-11-16
US60/248,691 2000-11-16
US60/248,848 2000-11-16
US60/248,670 2000-11-16
US60/248,700 2000-11-16
US60/248,672 2000-11-16
US60/248,632 2000-11-16
US60/248,777 2000-11-16
US60/248,650 2000-11-16
US60/248,528 2000-11-16
US60/248,638 2000-11-16
US60/248,715 2000-11-16
US60/248,779 2000-11-16
US60/248,736 2000-11-16
US60/248,662 2000-11-16
US60/248,716 2000-11-16
US60/248,789 2000-11-16
US60/248,757 2000-11-16
US60/248,635 2000-11-16
US60/248,696 2000-11-16
US60/248,833 2000-11-16
US60/248,688 2000-11-16
US60/248,667 2000-11-16
US60/248,851 2000-11-16
US60/248,733 2000-11-16
US60/248,539 2000-11-16
US60/248,712 2000-11-16
US60/248,648 2000-11-16
US60/248,857 2000-11-16
US60/248,655 2000-11-16
US60/248,710 2000-11-16
US60/248,748 2000-11-16
US60/248,695 2000-11-16
US60/248,652 2000-11-16
US60/248,600 2000-11-16
US60/248,793 2000-11-16
US60/248,707 2000-11-16
US60/248,774 2000-11-16
US60/248,742 2000-11-16
US60/248,673 2000-11-16
US60/248,734 2000-11-16
US60/248,607 2000-11-16
US60/248,850 2000-11-16
US60/248,739 2000-11-16
US60/248,537 2000-11-16
US60/248,540 2000-11-16
US60/248,603 2000-11-16
US60/248,643 2000-11-16
US60/248,702 2000-11-16
US60/248,786 2000-11-16
US60/248,646 2000-11-16
US60/248,701 2000-11-16
US60/248,605 2000-11-16
US60/248,796 2000-11-16
US60/248,849 2000-11-16
US60/248,612 2000-11-16
US60/248,621 2000-11-16
US60/248,693 2000-11-16
US60/248,640 2000-11-16
US60/248,689 2000-11-16
US60/248,741 2000-11-16
US60/248,767 2000-11-16
US60/248,772 2000-11-16
US60/248,768 2000-11-16
US60/248,610 2000-11-16
US60/248,606 2000-11-16
US60/248,624 2000-11-16
US60/248,797 2000-11-16
US60/248,763 2000-11-16
US60/248,751 2000-11-16
US60/248,697 2000-11-16
US60/248,744 2000-11-16
US60/248,641 2000-11-16
US60/248,680 2000-11-16
US60/248,794 2000-11-16
US60/248,679 2000-11-16
US60/248,647 2000-11-16
US60/248,623 2000-11-16
US60/248,749 2000-11-16
US60/248,773 2000-11-16
US60/248,633 2000-11-16
US60/248,527 2000-11-16
US60/248,762 2000-11-16
US60/248,787 2000-11-16
US60/248,636 2000-11-16
US60/248,639 2000-11-16
US60/248,723 2000-11-16
US60/248,674 2000-11-16
US60/248,596 2000-11-16
US60/248,611 2000-11-16
US60/248,706 2000-11-16
US60/248,714 2000-11-16
US60/248,729 2000-11-16
US60/248,732 2000-11-16
US60/248,676 2000-11-16
US60/248,853 2000-11-16
US60/248,766 2000-11-16
US60/248,769 2000-11-16
US60/248,783 2000-11-16
US60/248,771 2000-11-16
US60/248,630 2000-11-16
US60/248,795 2000-11-16
US60/248,604 2000-11-16
US60/248,713 2000-11-16
US60/248,617 2000-11-16
US60/248,730 2000-11-16
US60/248,711 2000-11-16
US60/248,728 2000-11-16
US60/248,755 2000-11-16
US60/248,526 2000-11-16
US60/248,759 2000-11-16
US60/248,683 2000-11-16
US60/248,658 2000-11-16
US60/248,685 2000-11-16
US60/248,740 2000-11-16
US60/248,745 2000-11-16
US60/248,718 2000-11-16
US60/248,661 2000-11-16
US60/248,750 2000-11-16
US60/248,719 2000-11-16
US60/248,677 2000-11-16
US60/248,684 2000-11-16
US60/248,765 2000-11-16
US60/248,743 2000-11-16
US60/248,791 2000-11-16
US60/248,620 2000-11-16
US60/248,756 2000-11-16
US60/248,598 2000-11-16
US60/248,678 2000-11-16
US60/248,654 2000-11-16
US60/248,747 2000-11-16
US60/248,656 2000-11-16
US60/248,686 2000-11-16
US60/248,698 2000-11-16
US60/248,852 2000-11-16
US60/248,790 2000-11-16
US60/248,645 2000-11-16
US60/248,764 2000-11-16
US60/248,681 2000-11-16
US60/248,525 2000-11-16
US60/248,529 2000-11-16
US60/248,628 2000-11-16
US60/248,524 2000-11-16
US60/248,727 2000-11-16
US60/248,726 2000-11-16
US60/248,709 2000-11-16
US60/248,666 2000-11-16
US60/248,725 2000-11-16
US60/248,705 2000-11-16
US60/248,533 2000-11-16
US60/248,538 2000-11-16
US60/248,644 2000-11-16
US60/248,784 2000-11-16
US60/248,664 2000-11-16
US60/248,631 2000-11-16
US60/248,634 2000-11-16
US60/248,653 2000-11-16
US60/248,776 2000-11-16
US60/248,855 2000-11-16
US60/248,781 2000-11-16
US60/248,758 2000-11-16

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
US98807101A Continuation-In-Part 2000-08-22 2001-11-16
PCT/US2001/043115 Continuation-In-Part WO2002051432A1 (en) 2000-08-22 2001-11-16 A novel pharmaceutical compound and methods of making and using same

Related Child Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2001/043089 Continuation-In-Part WO2003034980A2 (en) 2000-08-22 2001-11-14 A novel pharmaceutical compound containing abacavir sulfate and methods of making and using same
PCT/US2001/043115 Continuation-In-Part WO2002051432A1 (en) 2000-08-22 2001-11-16 A novel pharmaceutical compound and methods of making and using same
US10/156,527 Continuation-In-Part US7060708B2 (en) 1999-03-10 2002-05-29 Active agent delivery systems and methods for protecting and administering active agents

Publications (3)

Publication Number Publication Date
WO2003020200A2 WO2003020200A2 (en) 2003-03-13
WO2003020200A3 WO2003020200A3 (en) 2003-09-12
WO2003020200A8 true WO2003020200A8 (en) 2007-01-18

Family

ID=37649252

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/043117 WO2003020200A2 (en) 2000-08-22 2001-11-16 A novel pharmaceutical compound and methods of making and using same

Country Status (2)

Country Link
AU (1) AU2008201969A1 (en)
WO (1) WO2003020200A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003079972A2 (en) * 2002-02-22 2003-10-02 New River Parmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US7666445B2 (en) 2000-10-20 2010-02-23 The Trustees Of The University Of Pennsylvania Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use
US7375083B2 (en) * 2003-09-30 2008-05-20 Shire Llc Pharmaceutical compositions for prevention of overdose or abuse
US8221778B2 (en) 2005-01-12 2012-07-17 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
WO2007011955A2 (en) * 2005-07-18 2007-01-25 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
WO2006019760A1 (en) * 2004-07-14 2006-02-23 Gpc Biotech Ag Variable-dose packaging system
CN1988889A (en) * 2004-07-22 2007-06-27 株式会社太平洋 Sustained-release preparations containing topiramate and the producing method thereof
ATE555657T1 (en) 2005-09-29 2012-05-15 Syngenta Participations Ag FUNGICIDE COMPOSITIONS
CA2767987A1 (en) 2009-07-17 2011-01-20 Shire Llc Novel carbamate amino acid and peptide prodrugs of opioids and uses thereof
CA3042642A1 (en) 2013-08-12 2015-02-19 Pharmaceutical Manufacturing Research Services, Inc. Extruded immediate release abuse deterrent pill
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US10172797B2 (en) 2013-12-17 2019-01-08 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
CA2941867A1 (en) 2014-03-14 2015-09-17 Cutispharma, Inc. Composition and method for vancomycin oral liquid
EP3169315B1 (en) 2014-07-17 2020-06-24 Pharmaceutical Manufacturing Research Services, Inc. Immediate release abuse deterrent liquid fill dosage form
AU2015336065A1 (en) 2014-10-20 2017-05-04 Pharmaceutical Manufacturing Research Services, Inc. Extended release abuse deterrent liquid fill dosage form
US9695138B1 (en) 2016-10-17 2017-07-04 Acenda Pharma, Inc. Phenothiazine derivatives and methods of use thereof
DK3678705T3 (en) 2018-09-14 2023-06-26 Enlitisa Shanghai Pharmaceutical Co Ltd Conjugates of montelukast and peptides

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4427660A (en) * 1982-03-03 1984-01-24 Research Corporation Formyl-methionyl chemotatic peptide antibiotic conjugates useful in treating infections
US4801575A (en) * 1986-07-30 1989-01-31 The Regents Of The University Of California Chimeric peptides for neuropeptide delivery through the blood-brain barrier
US4902505A (en) * 1986-07-30 1990-02-20 Alkermes Chimeric peptides for neuropeptide delivery through the blood-brain barrier
IL107400A0 (en) 1992-11-10 1994-01-25 Cortech Inc Bradykinin antagonists
US6048736A (en) * 1998-04-29 2000-04-11 Kosak; Kenneth M. Cyclodextrin polymers for carrying and releasing drugs
US6652864B1 (en) 1998-12-21 2003-11-25 Asilomar Pharmaceuticals, Inc. Compounds for intracellular delivery of therapeutic moieties to nerve cells

Also Published As

Publication number Publication date
AU2008201969A1 (en) 2008-05-29
WO2003020200A2 (en) 2003-03-13
WO2003020200A3 (en) 2003-09-12

Similar Documents

Publication Publication Date Title
WO2003020200A8 (en) A novel pharmaceutical compound and methods of making and using same
AU2001263229A1 (en) Compositions and methods for administration of pharmacologically active compounds
AU2002243277A1 (en) Methods and compositions for encapsulating active agents
AU2002235140A1 (en) Fluidic self-assembly of active antenna
WO2003002136A3 (en) Stable formulation of modified glp-1
WO2000055124A3 (en) Novel compounds and compositions as protease inhibitors
AU2268301A (en) Novel urea compounds, compositions and methods of use and preparation
AU2001234114A1 (en) Drugs containing combined active ingredients
AU2001248215A1 (en) Cosmetically active composition
WO2001007049A3 (en) Ophthalmic composition comprising ketotifen
AU2001239363A1 (en) Method for fighting against arthropods destructive of crops and composition therefor
AU2002327097A1 (en) Novel glycolipid and remedial agent for autoimmune disease containing the same as active ingredient
AU2003228658A1 (en) Conjugates of membrane translocating agents and pharmaceutically active agents
AU2001268131A1 (en) Stabilized compositions containing oxygen-labile active agents
AU2001286242A1 (en) Urea derivative and adhesive-molecule inhibitor containing the same as active ingredient
WO2002015933A3 (en) Combination comprising an at1-receptor antagonist and an insulin secretion enhancer or an insulin sensitiser
CA2411787A1 (en) Stable gabapentin having ph within a controlled range
AU2001270626A1 (en) Floating type formulation of agricultural agents
PL367957A1 (en) Use of a copolymer to produce a galenic form containing a peptide or a protein as active agent
AU2002316200A1 (en) Compound and composition for delivering active agents
WO2002064093A3 (en) Stabilized pharmaceutical and thyroid hormone compositions and method of preparation
AU2001260089A1 (en) Pharmaceutical compositions comprising desglymidodrine as an active drug substance
WO2001041734A3 (en) Stable galenic preparations comprising a benzimidazol and method for the production thereof
AU2001277696A1 (en) Novel physiologically active peptide and use thereof
AU2001235976A1 (en) An antidiabetic composition of amino acids

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BY BZ CA CH CN CO CR CU CZ DE DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KP KR LC LK LR LS LT LU LV MA MD MG MN MW MX MZ NO NZ OM PH PL PT RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZA

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE CH CY DE DK FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ ML MR NE SN TD TG

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 155928

Country of ref document: IL

Ref document number: 2003524514

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2429345

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2001273387

Country of ref document: EP

Ref document number: 2001297565

Country of ref document: AU

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 2001273387

Country of ref document: EP

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)