WO2002026297A1 - Device for administering an injectable product - Google Patents

Device for administering an injectable product Download PDF

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Publication number
WO2002026297A1
WO2002026297A1 PCT/CH2001/000469 CH0100469W WO0226297A1 WO 2002026297 A1 WO2002026297 A1 WO 2002026297A1 CH 0100469 W CH0100469 W CH 0100469W WO 0226297 A1 WO0226297 A1 WO 0226297A1
Authority
WO
WIPO (PCT)
Prior art keywords
metering
housing
product
reservoir
lubricant
Prior art date
Application number
PCT/CH2001/000469
Other languages
German (de)
French (fr)
Inventor
Stefan Gatti
Thomas Gurtner
Original Assignee
Disetronic Licensing Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AT01951309T priority Critical patent/ATE285262T1/en
Priority to EP01951309A priority patent/EP1324793B1/en
Priority to IL15493301A priority patent/IL154933A0/en
Priority to AU2001272293A priority patent/AU2001272293B2/en
Application filed by Disetronic Licensing Ag filed Critical Disetronic Licensing Ag
Priority to MXPA03002632A priority patent/MXPA03002632A/en
Priority to DK01951309T priority patent/DK1324793T3/en
Priority to JP2002530126A priority patent/JP2004508917A/en
Priority to KR1020037003976A priority patent/KR100770155B1/en
Priority to DE50104902T priority patent/DE50104902D1/en
Priority to CA002423267A priority patent/CA2423267C/en
Priority to AU7229301A priority patent/AU7229301A/en
Priority to BRPI0114151-1A priority patent/BR0114151B1/en
Publication of WO2002026297A1 publication Critical patent/WO2002026297A1/en
Priority to IL154933A priority patent/IL154933A/en
Priority to US10/396,537 priority patent/US7169131B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0222—Materials for reducing friction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M5/3135—Syringe barrels characterised by constructional features of the proximal end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31555—Mechanically operated dose setting member by purely axial movement of dose setting member, e.g. during setting or filling of a syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31561—Mechanically operated dose setting member using freely adjustable volume steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31563—Mechanically operated dose setting member interacting with a displaceable stop member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/31568—Means keeping track of the total dose administered, e.g. since the cartridge was inserted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir

Definitions

  • the invention relates to a device for administering an injectable product according to the preamble of claim 1.
  • An injection device as the invention also relates, is known from WO 97/36625 and DE 199 00 792 Cl.
  • the injection device comprises a housing, a product reservoir with a piston displaceably accommodated therein, the displacement of which displaces product from the reservoir, a drive device and a metering device.
  • the drive device comprises a drive member which is displaceable in the feed device and an output member which is prevented from moving against the feed direction, but is moved by the drive member when the drive member is displaced in the feed direction and thereby pushes the piston in the feed direction, so that Product is displaced from the reservoir.
  • the pourable product dose is set by means of a metering device.
  • the dosing device comprises the drive member and the dosing member for setting the distal end position of the drive member.
  • the dosing member is rotatably mounted in the housing about the displacement axis of the drive member. It preferably has a metering stop that rotates spirally about this axis of displacement, preferably with a continuous course with a constant slope relative to the axis of displacement of the drive member, against which the drive member strikes during a displacement into the distal position, ie the rotational angle position of the metering member determines the distal position of the drive member ,
  • the pourable product dose is preferably selected by rotating the metering element in discrete steps.
  • the dosing element locks in the rotational angle locking positions formed regularly between the housing and the dosing element. A rotation of the dosing member between two adjacent locking positions corresponds to an adjustable, smallest product dose.
  • the invention has set itself the task of creating a device for administering an injectable product, in particular of the aforementioned type, which enables easy dosing of the product for a user, the fineness and accuracy of the dosage of the previously known device being at least maintained.
  • the metering member should be easily rotatable.
  • a bearing surface is lubricated between the metering member and the housing and at least one lubricant reservoir is formed on the one bearing surface.
  • Lubricating the bearing surface reduces the friction between the metering element and the housing. Moving, preferably twisting, the metering element to be carried out for metering is made easier for a user. Sufficient lubricant can be made available by the arrangement of at least one lubricant reservoir, so that no subsequent lubricant supply is necessary during the entire service life of the device. Lifetime lubrication is provided. This simplifies the use of the device.
  • the lubricant reservoir is preferably formed in the immediate vicinity of the bearing surface. It is preferably formed by a cavity in the metering element or in the housing.
  • the metering member is preferably mounted in the housing such that it can be rotated about the axis of displacement of the drive member and is axially displaceable. There is particularly preferably no longitudinal play between the metering member and the housing. This will ensure accurate Dosage of the device is taken care of. As a result, there is a high surface pressure in the bearing surface between the metering element and the housing. This high surface pressure results in high torque, which is effectively reduced by lubrication.
  • the metering member is particularly preferably mounted on the housing in such a way that it is axially displaceably secure by means of an annular bead.
  • the annular bead is preferably arranged on that lateral surface of the metering member which is in contact with the housing, the annular bead protruding into a recess in the lateral surface of the housing. An undercut is thus created between the metering element and the housing.
  • the annular bead could also be formed on the housing.
  • a surface of the annular bead which is at an angle to the displacement axis forms a bearing surface for the axial mounting of the metering element.
  • This surface is preferably lubricated and at least one lubricant reservoir is formed on it.
  • the lubricant reservoir is arranged such that the lubricant located therein comes into contact with the bearing surface when the metering member rotates.
  • a second bearing surface for the axial mounting of the metering member is preferably also lubricated and at least one lubricant reservoir is formed on it.
  • This second bearing surface can be formed by a further surface of the annular bead or by another surface of the metering member or the housing.
  • the annular bead is preferably formed on the dosing member and held axially in a recess in the housing.
  • the dosing member is particularly preferably arranged within the housing, so that the annular bead protrudes radially from the outer lateral surface of the dosing member into an annular groove which is formed on the inner lateral surface of the housing.
  • the lubricant reservoir is preferably formed by flattening the annular bead.
  • the annular bead is particularly preferably interrupted at the point at which the lubricant reservoir is formed.
  • the interruption of the annular bead creates a cavity between the metering element and the annular groove in the housing. Lubricant can be stored in this cavity.
  • a plurality of lubricant reservoirs are preferably arranged evenly distributed over the circumference of the metering member or the housing. This results in better lubrication of the bearing surface.
  • Four lubricant reservoirs are particularly preferably provided.
  • Fat is preferably used as the lubricant, particularly preferably molykote fat.
  • the lubricant reservoirs are designed as fat pockets.
  • FIG. 1 shows an injection device with a metering device in a longitudinal section
  • FIG. 2 shows a metering member with a lubricant reservoir according to the invention according to detail A on FIG. 1.
  • FIG. 1 shows an injection device, in the exemplary embodiment an injection pen, in a longitudinal section.
  • FIG. 2 shows detail A from FIG. 1.
  • the injection device has a housing with a front housing sleeve 1 and a rear housing sleeve 10 firmly connected thereto.
  • the front housing sleeve serves as a receptacle for an ampoule 2.
  • the ampoule 2 contains a liquid product in the form of an active ingredient solution, for example insulin.
  • a piston 3 is accommodated in the ampoule 2. By moving the piston 3 in the feed direction towards an ampoule outlet 4, the product is displaced from the ampoule 2 through its outlet 4 and poured out through an injection needle, even at 3 IG and larger.
  • the front housing sleeve 1 is protected by a cap K.
  • the needle N is protected again by a needle cap.
  • the displacement of the piston 3 in the feed direction is brought about by a drive device which is accommodated in the rear housing sleeve 10.
  • the drive device comprises a toothed rack 5, which acts directly on the piston 3, and a drive member 6 as the output member.
  • a metering element designed as a sleeve body is secured against displacement with the rear housing sleeve 10, but is rotatably connected about the common longitudinal axis, which coincides with the displacement axis V.
  • the dosing member 15 projects with a front sleeve part 17 into the rear housing sleeve 10. Its rear sleeve part protrudes from the rear housing sleeve 10.
  • the rear sleeve part of the metering element 15 is provided with a profiling 16 in order to be able to manually rotate the metering element 15 in a hand-safe manner.
  • annular bead 20 which is formed on the front sleeve part 17 and is snapped into a recess 19 encircling the inner casing of the rear housing sleeve 10, is used for the secure fastening of the metering member 15.
  • a surface L1 of the annular bead 20 comes into contact with an undercut surface of the recess 19 of the rear housing sleeve 10.
  • a second bearing surface L2 is formed between the rear end of the rear housing sleeve 10 and a circumferential, radially projecting projection of the metering element 15.
  • the dosing member 15 is mounted axially displaceably in the housing between the bearing surfaces L1 and L2.
  • the metering member 15 In front of the profiling 16, the metering member 15 carries a clearly visible dose scale all around its outer circumferential surface, which is matched to fixed rotational angle positions in which the metering member 15 is locked against the rear housing sleeve 10.
  • the locking mechanism between the metering member 15 and the rear housing sleeve 10 is formed by elevations on the outer jacket of the front sleeve part 17 of the metering member 15 and recesses 23 are formed in the inner jacket of the rear housing sleeve 10.
  • the Recesses 23 are arranged circumferentially at the same height on the inner jacket of the rear housing sleeve 10 at equal angular intervals. In the fixed rotational angle locking positions of the metering element 15, the multiple elevations are recorded exactly in the respectively opposite recesses in the inner jacket of the rear housing sleeve 10.
  • the metering member 15 is penetrated by the drive member 6.
  • the dosing member 15 concentrically surrounds a distal part of the drive member 6 and also of the driven member 5.
  • the cover 9 projects with a sleeve part into an annular gap formed between the drive member 6 and the metering member 15.
  • the cover 9 also carries a marking in its jacket region protruding from the dosing member 15, which in cooperation with the marking of the dosing member 15 enables the exact determination of the total amount of product administered from the ampoule 2 even after several full rotations of the dosing member 15.
  • the maximum dose path length that can be covered in the feed direction by the drive member 6 and the rack 5 is set and thus also the maximum product dose that can be dispensed during an injection, even with 3 IG and greater.
  • the metering member 15 is preferably accommodated in the rear housing sleeve 10 without play. However, this increases the surface pressure in the bearing surfaces L1, L2, so that the user would need a higher torque to set the dose. This torque can be reduced by lubricating at least one of the slide bearing surfaces L1, L2. Since the lubricant would be displaced from the bearing surfaces L1, L2 during assembly or in operation at a high surface pressure, lubricant reservoirs F are provided which make contact between the bearing surface Ll or L2 and the lubricant.
  • a lubricant reservoir F is formed by interrupting the annular bead 20 in sections. This results in a gap between sections the metering element 15 and the housing sleeve 10. This intermediate space can be filled with lubricant, in particular grease, and serves as life-time lubrication for the bearing surface L1.
  • a plurality of lubricant reservoirs F are preferably arranged distributed uniformly over the circumference. The more lubricant reservoirs F are provided, the more often the bearing surface L1 sweeps over a lubricant reservoir F during rotation.
  • the section according to FIG. 2 runs through the annular bead 20 in the upper region of the drawing and through a lubricant reservoir F in the lower region of the drawing.
  • a development of a lubricant reservoir F is not shown in FIG. 2, in which the volume is increased by additionally providing a recess in the metering member 15 in the region of the interruption of the annular bead 20.
  • the variant in which the annular bead 20 is arranged on the rear housing sleeve 10 is also not shown in FIG.
  • the formation of the lubricant reservoirs F is carried out in an analogous manner.
  • lubricant reservoirs F can also be provided in the bearing surface L2. They are preferably formed by recesses in the radial end face of the metering member 15 or the rear end face of the rear housing sleeve 10.
  • Lubricant reservoirs F are preferably formed only in the bearing surface L1. However, they can also be formed in the bearing surface L2.
  • Lubricant reservoirs F are particularly preferably located in both bearing surfaces L1 and L2.
  • the area 22 of the rear housing sleeve 10 shown in broken lines in FIG. 2 is provided with lubricant. If the metering member 15 is pushed into the rear housing sleeve 10 for assembly, the lubricant remains in the areas of the lubricant reservoirs F and, when the metering member 15 is rotated, lubricates the bearing surfaces L.
  • the metering takes place in a foremost, proximal end position of the drive member 6 in relation to the feed direction, in which a stop cam or collar 13 protruding radially from the outer lateral surface of the drive member 6 bears against a stop formed by the rear housing sleeve 10.
  • the metering member 15 is rotated about the displacement axis V relative to the rear housing sleeve 10 until it has reached the desired metering or rotational angle locking position.
  • a clear metering distance remains between a further collar or cam, which also projects from the outer circumferential surface of the drive member 6 and forms a metering stop and is therefore referred to in the further metering cam 14, and the proximal end face 18 of the metering member 15 opposite this metering cam 14 ,
  • the drive member 6 can be retracted relative to the rear housing sleeve 10 and thus also relative to the piston 3 against the feed direction.
  • the withdrawal is done manually by pulling on the lid 9.
  • the dosing distance is equal to the dose path length in the subsequent administration.
  • the toothed rack 5 When the drive member 6 is displaced or retracted, the toothed rack 5 remains in its displacement position assumed during the metering process relative to the housing. It is secured against displacement against the feed direction by locking means 11 and 12 formed on the rear housing sleeve 10.
  • the locking means 11 and 12 are locking cams, which are each formed on one of the front ends of an elastically flexible tongue and project radially inward from the tongue onto the rack 5.
  • the locking means 11 and 12 each interact with a row of teeth of the rack 5 facing them in such a way that they allow the rack 5 to be displaced in the feed direction and allow a displacement against the feed direction and prevent a displacement against the feed direction by positive locking engagement.
  • the drive member 6 After the drive member 6 has been withdrawn, it can be moved in the feed direction by the dose path length, taking the toothed rack 5 and the piston 3 with it, so that a metered amount of the injectable product is displaced from the reservoir 2.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coating Apparatus (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

The invention relates to a device for the dosed administration of an injectable product. Said device comprises a housing with a reservoir for the product and a plunger that expels the product from the reservoir when displaced in an advance direction towards a reservoir outlet. A drive element can be displaced along an axis of displacement, thereby pushing the plunger in the direction of advance. A dosing element is mounted in the housing to be glidingly movable, preferably in a rotatable manner, along the axis of displacement in order to adjust a product dosis to be released during administration. The device according to the invention is further characterized in that a bearing surface between the dosing element and the housing is lubricated and that at least one lubricant reservoir is disposed on the one bearing surface.

Description

Vorrichtung zur Verabreichung eines injizierbaren Produkts Device for administering an injectable product
Die Erfindung betrifft eine Vorrichtung zur Verabreichung eines injizierbaren Produkts nach dem Oberbegriff von Anspruch 1.The invention relates to a device for administering an injectable product according to the preamble of claim 1.
Ein Injektionsgerät, wie die Erfindung es auch betrifft, ist aus der WO 97/36625 und der DE 199 00 792 Cl bekannt. Das Injektionsgerät umfasst ein Gehäuse, ein Produktreservoir mit einem darin verschiebbar aufgenommenen Kolben, bei dessen Verschiebung in eine Vorschubrichtung Produkt aus dem Reservoir verdrängt wird, eine Antriebseinrichtung und eine Dosiereinrichtung.An injection device, as the invention also relates, is known from WO 97/36625 and DE 199 00 792 Cl. The injection device comprises a housing, a product reservoir with a piston displaceably accommodated therein, the displacement of which displaces product from the reservoir, a drive device and a metering device.
Die Antriebseinrichtung umfasst ein Antriebsglied, das in die Vorschubeinrichtung verschiebbar ist, und ein Abtriebsglied, das an einer Verschiebung gegen die Vorschubrichtung gehindert ist, bei einer Verschiebung des Antriebsglieds in Vorschubrichtung jedoch von dem Antriebsglied mitgenommen wird und dabei den Kolben in Vorschubrichtung schiebt, so dass Produkt aus dem Reservoir verdrängt wird. Die ausschüttbare Produktdosis wird mittels einer Dosiereinrichtung eingestellt.The drive device comprises a drive member which is displaceable in the feed device and an output member which is prevented from moving against the feed direction, but is moved by the drive member when the drive member is displaced in the feed direction and thereby pushes the piston in the feed direction, so that Product is displaced from the reservoir. The pourable product dose is set by means of a metering device.
Die Dosiereinrichtung umfasst das Antriebsglied und das Dosierglied zur Einstellung der distalen Endposition des Antriebsglieds. Das Dosierglied ist um die Verschiebeachse des Antriebsglieds verdrehbar in dem Gehäuse gelagert. Es weist vorzugsweise einen um diese Verschiebeachse spiralig umlaufenden Dosieranschlag mit vorzugsweise einem kontinuierlichen Verlauf mit einer konstanten Steigung relativ zur Verschiebeachse des Antriebsglieds auf, an den das Antriebsglied bei einer Verschiebung in die distale Position anschlägt, d.h. die Drehwinkelposition des Dosierglieds bestimmt die distale Position des Antriebsglieds. Die ausschüttbare Produktdosis wird durch Verdrehen des Dosierglieds vorzugsweise in diskreten Schritten gewählt. Hierfür verrastet das Dosierglied in regelmäßig zwischen dem Gehäuse und dem Dosierglied gebildeten Drehwinkelrastpositionen. Eine Verdrehung des Dosierglieds zwischen zwei benachbarten Rastpositionen entspricht einer einstellbaren, kleinsten Produktdosis.The dosing device comprises the drive member and the dosing member for setting the distal end position of the drive member. The dosing member is rotatably mounted in the housing about the displacement axis of the drive member. It preferably has a metering stop that rotates spirally about this axis of displacement, preferably with a continuous course with a constant slope relative to the axis of displacement of the drive member, against which the drive member strikes during a displacement into the distal position, ie the rotational angle position of the metering member determines the distal position of the drive member , The pourable product dose is preferably selected by rotating the metering element in discrete steps. For this purpose, the dosing element locks in the rotational angle locking positions formed regularly between the housing and the dosing element. A rotation of the dosing member between two adjacent locking positions corresponds to an adjustable, smallest product dose.
Die Erfindung hat es sich zur Aufgabe gemacht, eine Vorrichtung zur Verabreichung eines injizierbaren Produkts, insbesondere der vorgenannten Art, zu schaffen, die für einen Anwender eine leichte Produktdosierung ermöglicht, wobei die Feinheit und Exaktheit der Dosierung der vorbekannten Vorrichtung zumindest beibehalten werden soll. Insbesondere soll für eine leichte Verdrehbarkeit des Dosierglieds gesorgt werden.The invention has set itself the task of creating a device for administering an injectable product, in particular of the aforementioned type, which enables easy dosing of the product for a user, the fineness and accuracy of the dosage of the previously known device being at least maintained. In particular, the metering member should be easily rotatable.
Diese Aufgabe wird durch den Gegenstand von Anspruch 1 gelöst, indem eine Lagerfläche zwischen dem Dosierglied und dem Gehäuse geschmiert wird und an der einen Lagerfläche wenigstens ein Schmiermittelreservoir ausgebildet ist.This object is achieved by the subject matter of claim 1 in that a bearing surface is lubricated between the metering member and the housing and at least one lubricant reservoir is formed on the one bearing surface.
Durch die Schmierung der Lagerfläche wird die Reibung zwischen Dosierglied und Gehäuse verringert. Für einen Anwender wird das für eine Dosierung durchzuführende Bewegen, vorzugsweise Verdrehen, des Dosierglieds erleichtert. Durch die Anordnung wenigstens eines Schmiermittelreservoirs kann genügend Schmiermittel zur Verfügung gestellt werden, so dass während der gesamten Gebrauchsdauer der Vorrichtung keine nachträgliche Schmiermittelzufuhr notwendig ist. Es wird für eine Lebenszeitschmierung gesorgt. Dies vereinfacht den Gebrauch der Vorrichtung.Lubricating the bearing surface reduces the friction between the metering element and the housing. Moving, preferably twisting, the metering element to be carried out for metering is made easier for a user. Sufficient lubricant can be made available by the arrangement of at least one lubricant reservoir, so that no subsequent lubricant supply is necessary during the entire service life of the device. Lifetime lubrication is provided. This simplifies the use of the device.
Das Schmiermittelreservoir ist vorzugsweise in unmittelbarer Nähe an der Lagerfläche ausgebildet. Es wird vorzugsweise von einem Hohlraum im Dosierglied oder im Gehäuse gebildet.The lubricant reservoir is preferably formed in the immediate vicinity of the bearing surface. It is preferably formed by a cavity in the metering element or in the housing.
Vorzugsweise wird das Dosierglied um die Verschiebeachse des Antriebsglieds drehbar und axialverschiebesicher im Gehäuse gelagert. Besonders bevorzugt ist zwischen dem Dosierglied und dem Gehäuse kein Längsspiel vorhanden. Dadurch wird für eine genaue Dosierung der Vorrichtung gesorgt. In der Lagerfläche zwischen dem Dosierglied und dem Gehäuse herrscht dadurch eine hohe Flächenpressung. Diese hohe Flächenpressung ergibt ein hohes Drehmoment, welches jedoch wirksam durch eine Schmierung reduziert wird.The metering member is preferably mounted in the housing such that it can be rotated about the axis of displacement of the drive member and is axially displaceable. There is particularly preferably no longitudinal play between the metering member and the housing. This will ensure accurate Dosage of the device is taken care of. As a result, there is a high surface pressure in the bearing surface between the metering element and the housing. This high surface pressure results in high torque, which is effectively reduced by lubrication.
Besonders bevorzugt wird das Dosierglied über einen Ringwulst axial verschiebesicher am Gehäuse gelagert. Der Ringwulst ist vorzugsweise an derjenigen Mantelfläche des Dosierglieds angeordnet, die mit dem Gehäuse in Berührung ist, wobei der Ringwulst in eine Ausnehmung in der Mantelfläche des Gehäuses hineinragt. Zwischen dem Dosierglied und dem Gehäuse wird somit eine Hinterschneidung erzeugt. Grundsätzlich könnte der Ringwulst jedoch auch am Gehäuse ausgebildet werden. Eine in einem Winkel zur Verschiebeachse stehende Fläche des Ringwulstes bildet eine Lagerfläche für die axiale Lagerung des Dosierglieds. Vorzugsweise wird diese Fläche geschmiert und an ihr wenigstens ein Schmiermittelreservoir ausgebildet. Das Schmiermittelreservoir wird derart angeordnet, dass das sich darin befindliche Schmiermittel bei einer Drehung des Dosierglieds mit der Lagerfläche in Kontakt kommt.The metering member is particularly preferably mounted on the housing in such a way that it is axially displaceably secure by means of an annular bead. The annular bead is preferably arranged on that lateral surface of the metering member which is in contact with the housing, the annular bead protruding into a recess in the lateral surface of the housing. An undercut is thus created between the metering element and the housing. In principle, however, the annular bead could also be formed on the housing. A surface of the annular bead which is at an angle to the displacement axis forms a bearing surface for the axial mounting of the metering element. This surface is preferably lubricated and at least one lubricant reservoir is formed on it. The lubricant reservoir is arranged such that the lubricant located therein comes into contact with the bearing surface when the metering member rotates.
Vorzugsweise wird auch eine zweite Lagerfläche für die axiale Lagerung des Dosierglieds geschmiert und an ihr wenigstens ein Schmiermittelreservoir ausgebildet. Diese zweite Lagerfläche kann von einer weiteren Fläche des Ringwulstes oder von einer anderen Fläche des Dosierglieds oder des Gehäuses gebildet werden.A second bearing surface for the axial mounting of the metering member is preferably also lubricated and at least one lubricant reservoir is formed on it. This second bearing surface can be formed by a further surface of the annular bead or by another surface of the metering member or the housing.
Vorzugsweise ist der Ringwulst am Dosierglied ausgebildet und in einer Ausnehmung im Gehäuse axial gehalten. Das Dosierglied ist besonders bevorzugt innerhalb des Gehäuses angeordnet, so dass der Ringwulst radial von der Außenmantelfläche des Dosierglieds in eine Ringnut, welche an der Innenmantelfläche des Gehäuses ausgebildet ist, abragt.The annular bead is preferably formed on the dosing member and held axially in a recess in the housing. The dosing member is particularly preferably arranged within the housing, so that the annular bead protrudes radially from the outer lateral surface of the dosing member into an annular groove which is formed on the inner lateral surface of the housing.
Das Schmiermittelreservoir wird vorzugsweise durch eine Abflachung des Ringwulstes gebildet. Besonders bevorzugt ist der Ringwulst an der Stelle, an der das Schmiermittelreservoir ausgebildet wird, unterbrochen. Durch die Unterbrechung des Ringwulstes entsteht ein Hohlraum zwischen dem Dosierglied und der Ringnut im Gehäuse. In diesen Hohlraum kann Schmiermittel eingelagert werden. Ein Vorteil des Schmiermittelreservoirs besteht darin, dass bei der Montage des Dosierglieds in das Gehäuse das Schmiermittel zwar von der Lagerfläche weggedrückt wird, bei einem Verdrehen die Lagerfläche jedoch über ein Schmiermittelreservoir läuft, so dass eine ständige Nachschmierung gewährleistet ist. Das Schmiermittel bleibt auch nach der Montage an der gewünschten Stelle.The lubricant reservoir is preferably formed by flattening the annular bead. The annular bead is particularly preferably interrupted at the point at which the lubricant reservoir is formed. The interruption of the annular bead creates a cavity between the metering element and the annular groove in the housing. Lubricant can be stored in this cavity. An advantage of the lubricant reservoir is that when the metering element is installed in the Although the lubricant is pressed away from the bearing surface, the bearing surface runs over a lubricant reservoir when it is turned, so that constant relubrication is ensured. The lubricant remains in the desired position even after assembly.
Vorzugsweise werden mehrere Schmiermittelreservoirs gleichmäßig über den Umfang des Dosierglieds oder des Gehäuses verteilt angeordnet. Dadurch wird eine bessere Schmierung der Lagerfläche erreicht. Besonders bevorzugt werden vier Schmiermittelreservoirs vorgesehen.A plurality of lubricant reservoirs are preferably arranged evenly distributed over the circumference of the metering member or the housing. This results in better lubrication of the bearing surface. Four lubricant reservoirs are particularly preferably provided.
Als Schmiermittels wird vorzugsweise Fett besonders bevorzugt Molykote-Fett verwendet. Die Schmiermittelreservoirs werden als Fettaschen ausgebildet.Fat is preferably used as the lubricant, particularly preferably molykote fat. The lubricant reservoirs are designed as fat pockets.
Ein bevorzugtes Ausführungsbeispiel der Erfindung wird nachfolgend anhand von Figuren erläutert. Es zeigen:A preferred embodiment of the invention is explained below with reference to figures. Show it:
Fig. 1 eine Injektions Vorrichtung mit einer Dosiereinrichtung in einem Längsschnitt und Fig. 2 ein Dosierglied mit einem erfindungsgemäßen Schmiermittelreservoir gemäß Detail A on Fig. 1.1 shows an injection device with a metering device in a longitudinal section, and FIG. 2 shows a metering member with a lubricant reservoir according to the invention according to detail A on FIG. 1.
Figur 1 zeigt ein Injektionsgerät, im Ausführungsbeispiel ein Injektionspen, in einem Längsschnitt. Die Figur 2 zeigt Detail A von Fig. 1.FIG. 1 shows an injection device, in the exemplary embodiment an injection pen, in a longitudinal section. FIG. 2 shows detail A from FIG. 1.
Da Injektionsgerät weist ein Gehäuse mit einer vorderen Gehäusehülse 1 und einer damit fest verbundenen hinteren Gehäusehülse 10 auf. Die vordere Gehäusehülse dient als Aufnahme für eine Ampulle 2. In der Ampulle 2 ist ein flüssiges Produkt in Form einer Wirkstofflösung, beispielsweise Insulin, enthalten. Ferner ist in der Ampulle 2 ein Kolben 3 aufgenommen. Durch Verschiebung des Kolbens 3 in Vorschubrichtung auf einen AmpuUenauslass 4 zu wird das Produkt aus der Ampulle 2 durch deren Auslass 4 hindurch verdrängt und durch eine Injektionsnadel n, auch bei 3 IG und grösser ausgeschüttet. Die vordere Gehäusehülse 1 ist durch eine Kappe K geschützt. Die Nadel N ist durch eine Nadelkappe nochmals geschützt. Die Verschiebung des Kolbens 3 in Vorschubrichtung wird durch eine Antriebseinrichtung bewirkt, die in der hinteren Gehäusehülse 10 aufgenommen ist. Die Antriebseinrichtung umfasst als Abtriebsglied eine Zahnstange 5, die unmittelbar auf den Kolben 3 wirkt, und ein Antriebsglied 6. Das Antriebsglied 6 ist in der hinteren Gehäusehülse 10 in und gegen die Vorschubrichtung des Kolbens 3 entlang einer Verschiebeachse V geradverschiebbar gelagert. Ein Deckel 9, der mit dem Antriebsglied 6 verschiebe- und frei verdrehbar verbunden ist, ragt aus dem Gehäuse nach hinten heraus.The injection device has a housing with a front housing sleeve 1 and a rear housing sleeve 10 firmly connected thereto. The front housing sleeve serves as a receptacle for an ampoule 2. The ampoule 2 contains a liquid product in the form of an active ingredient solution, for example insulin. Furthermore, a piston 3 is accommodated in the ampoule 2. By moving the piston 3 in the feed direction towards an ampoule outlet 4, the product is displaced from the ampoule 2 through its outlet 4 and poured out through an injection needle, even at 3 IG and larger. The front housing sleeve 1 is protected by a cap K. The needle N is protected again by a needle cap. The displacement of the piston 3 in the feed direction is brought about by a drive device which is accommodated in the rear housing sleeve 10. The drive device comprises a toothed rack 5, which acts directly on the piston 3, and a drive member 6 as the output member. A cover 9, which is connected to the drive member 6 so as to be displaceable and freely rotatable, projects out of the housing to the rear.
Ein als Hülsenkörper ausgebildetes Dosierglied ist mit der hinteren Gehäusehülse 10 verschiebegesichert, jedoch um die gemeinsame Längsachse, die mit der Verschiebeachse V zusammenfällt, verdrehbar verbunden. Das Dosierglied 15 ragt mit einem vorderen Hülsenteil 17 in die hintere Gehäusehülse 10. Sein hinterer Hülsenteil ragt aus der hinteren Gehäusehülse 10 heraus. Das hintere Hülsenteil des Dosierglieds 15 ist mit einer Profilierung 16 versehen, um das Dosierglied 15 griffsicher manuell verdrehen zu können.A metering element designed as a sleeve body is secured against displacement with the rear housing sleeve 10, but is rotatably connected about the common longitudinal axis, which coincides with the displacement axis V. The dosing member 15 projects with a front sleeve part 17 into the rear housing sleeve 10. Its rear sleeve part protrudes from the rear housing sleeve 10. The rear sleeve part of the metering element 15 is provided with a profiling 16 in order to be able to manually rotate the metering element 15 in a hand-safe manner.
Wie am besten aus der Zusammenschau der Figuren 1 und 2 zu erkennen ist dient zur verschiebesicheren Befestigung des Dosierglieds 15 ein an dem vorderen Hülsenteil 17 ausgebildeter Ringwulst 20, der in einer an dem Innenmantel der hinteren Gehäusehülse 10 umlaufenden Ausnehmung 19 eingeschnappt ist. Eine Fläche Ll des Ringwulstes 20 kommt mit einer hinterschnittenen Fläche der Ausnehmung 19 der hinteren Gehäusehülse 10 in Kontakt. Eine zweite Lagerfläche L2 wird zwischen dem hinteren Ende der hinteren Gehäusehülse 10 und einem umlaufenden, radial abstehenden Vorsprung des Dosierglieds 15 gebildet. Das Dosierglied 15 wird zwischen den Lagerflächen Ll und L2 axial verschiebesicher im Gehäuse gelagert.As can best be seen from the overview of FIGS. 1 and 2, an annular bead 20, which is formed on the front sleeve part 17 and is snapped into a recess 19 encircling the inner casing of the rear housing sleeve 10, is used for the secure fastening of the metering member 15. A surface L1 of the annular bead 20 comes into contact with an undercut surface of the recess 19 of the rear housing sleeve 10. A second bearing surface L2 is formed between the rear end of the rear housing sleeve 10 and a circumferential, radially projecting projection of the metering element 15. The dosing member 15 is mounted axially displaceably in the housing between the bearing surfaces L1 and L2.
Vor der Profilierung 16 trägt das Dosierglied 15 um seine äußere Mantelfläche umlaufend eine gut sichtbare Dosisskala, die auf festgelegte Drehwinkelpositionen, in denen das Dosierglied 15 gegen die hintere Gehäusehülse 10 verrastet, abgestimmt ist. Der Rastmechanismus zwischen dem Dosierglied 15 und der hinteren Gehäusehülse 10 wird durch Erhebungen an dem Außenmantel des vorderen Hülsenteils 17 des Dosierglieds 15 und Vertiefungen 23 sind in dem Innmantel der hinteren Gehäusehülse 10 gebildet. Die Vertiefungen 23 sind in gleichen Winkelabständen nebeneinander auf gleicher Höhe umlaufend an dem Innenmantel der hinteren Gehäusehülse 10 angeordnet. In den fixen Drehwinkelrastpositionen des Dosierglieds 15 werden die mehreren Erhebungen exakt in den jeweils gegenüberliegenden Vertiefungen in dem Innenmantel der hinteren Gehäusehülse 10 aufgenommen.In front of the profiling 16, the metering member 15 carries a clearly visible dose scale all around its outer circumferential surface, which is matched to fixed rotational angle positions in which the metering member 15 is locked against the rear housing sleeve 10. The locking mechanism between the metering member 15 and the rear housing sleeve 10 is formed by elevations on the outer jacket of the front sleeve part 17 of the metering member 15 and recesses 23 are formed in the inner jacket of the rear housing sleeve 10. The Recesses 23 are arranged circumferentially at the same height on the inner jacket of the rear housing sleeve 10 at equal angular intervals. In the fixed rotational angle locking positions of the metering element 15, the multiple elevations are recorded exactly in the respectively opposite recesses in the inner jacket of the rear housing sleeve 10.
Im komplett montierten Zustand des Injektionsgerätes, wie es in Figur 1 dargestellt ist, wird das Dosierglied 15 von dem Antriebsglied 6 durchragt. Das Dosierglied 15 umgibt einen distalen Teil des Antriebsglieds 6 und auch des Abtriebglieds 5 konzentrisch. Der Deckel 9 ragt mit einem Hülsenteil in einem zwischen dem Antriebsglied 6 und dem Dosierglied 15 gebildeten Ringspalt hinein. Auch der Deckel 9 trägt in seinem aus dem Dosierglied 15 herausragenden Mantelbereich eine Markierung, die im Zusammenwirken mit der Markierung des Dosierglieds 15 auch nach mehreren vollen Drehungen des Dosierglieds 15 die genaue Bestimmung der aus der Ampulle 2 insgesamt verabreichten Produktmenge ermöglicht.In the fully assembled state of the injection device, as shown in Figure 1, the metering member 15 is penetrated by the drive member 6. The dosing member 15 concentrically surrounds a distal part of the drive member 6 and also of the driven member 5. The cover 9 projects with a sleeve part into an annular gap formed between the drive member 6 and the metering member 15. The cover 9 also carries a marking in its jacket region protruding from the dosing member 15, which in cooperation with the marking of the dosing member 15 enables the exact determination of the total amount of product administered from the ampoule 2 even after several full rotations of the dosing member 15.
Durch Verdrehen des Dosierglieds 15 wird die in Vorschubrichtung von dem Antriebsglied 6 und der Zahnstange 5 maximal zurücklegbare Dosisweglänge eingestellt und damit auch die bei einer Injektion, auch bei 3 IG und grösser maximal ausschüttbare Produktdosis.By turning the metering member 15, the maximum dose path length that can be covered in the feed direction by the drive member 6 and the rack 5 is set and thus also the maximum product dose that can be dispensed during an injection, even with 3 IG and greater.
Je geringer das axiale Spiel des Dosierglieds 15 in der hinteren Gehäusehülse 10 ist, desto genauer ist die Dosierung der Vorrichtung. Vorzugsweise ist das Dosierglied 15 ohne Spiel in der hinteren Gehäusehülse 10 aufgenommen. Damit steigt jedoch die Flächenpressung in den Lagerflächen Ll, L2, so dass vom Verwender ein höheres Drehmoment zum Einstellen der Dosis notwendig wäre. Durch die Schmierung wenigstens einer der Gleitlagerflächen Ll, L2 kann dieses Drehmoment reduziert werden. Da bei einer hohen Flächenpressung das Schmiermittel von den Lagerflächen Ll, L2 bei der Montage oder im Betrieb verdrängt würde, werden Schmiermittelreservoirs F vorgesehen, die einen Kontakt zwischen der Lagerfläche Ll oder L2 und dem Schmiermittel herstellen.The smaller the axial play of the metering element 15 in the rear housing sleeve 10, the more precise the metering of the device. The metering member 15 is preferably accommodated in the rear housing sleeve 10 without play. However, this increases the surface pressure in the bearing surfaces L1, L2, so that the user would need a higher torque to set the dose. This torque can be reduced by lubricating at least one of the slide bearing surfaces L1, L2. Since the lubricant would be displaced from the bearing surfaces L1, L2 during assembly or in operation at a high surface pressure, lubricant reservoirs F are provided which make contact between the bearing surface Ll or L2 and the lubricant.
Ein Schmiermittelreservoir F wird durch eine abschnittsweise Unterbrechung des Ringwulstes 20 gebildet. Dadurch ergibt sich ein abschnittsweiser Zwischenraum zwischen dem Dosierglied 15 und der Gehäusehülse 10. Dieser Zwischenraum kann mit Schmiermittel, insbesondere Fett, gefüllt werden und dient als Lebensdauerschmierung für die Lagerfläche Ll. Vorzugsweise werden mehrere Schmiermittelreservoirs F gleichmäßig über den Umfang verteilt angeordnet. Je mehr Schmiermittelreservoirs F vorgesehen werden, desto öfter überstreicht die Lagerfläche Ll bei einer Drehung ein Schmiermittelreservoir F. Der Schnitt gemäß Fig. 2 verläuft im oberen Berreich der Zeichnung durch den Ringwulst 20 und im unteren Bereich der Zeichnung durch ein Schmiermittelreservoir F.A lubricant reservoir F is formed by interrupting the annular bead 20 in sections. This results in a gap between sections the metering element 15 and the housing sleeve 10. This intermediate space can be filled with lubricant, in particular grease, and serves as life-time lubrication for the bearing surface L1. A plurality of lubricant reservoirs F are preferably arranged distributed uniformly over the circumference. The more lubricant reservoirs F are provided, the more often the bearing surface L1 sweeps over a lubricant reservoir F during rotation. The section according to FIG. 2 runs through the annular bead 20 in the upper region of the drawing and through a lubricant reservoir F in the lower region of the drawing.
Nicht in Figur 2 dargestellt ist eine Weiterbildung eines Schmiermittelreservoirs F, bei dem das Volumen dadurch erhöht wird, dass im Bereich der Unterbrechung des Ringwulstes 20 zusätzlich eine Vertiefung in dem Dosierglied 15 vorgesehen ist. Nicht in Figur 2 dargestellt ist ebenfalls die Variante, bei der der Ringwulst 20 an der hinteren Gehäusehülse 10 angeordnet ist. Die Ausbildung der Schmiermittelreservoirs F erfolgt dabei in analoger Weise. Analog zu den Schmiermittelreservoirs im Ringwulst 20 können auch Schmiermittelreservoirs F in der Lagerfläche L2 vorgesehen werden. Vorzugsweise werden sie durch Ausnehmungen in der radialen Stirnfläche des Dosierglieds 15 oder der hinteren Endfläche der hinteren Gehäusehülse 10 gebildet. Vorzugsweise werden Schmiermittelreservoirs F nur in der Lagerfläche Ll ausgebildet. Sie können jedoch auch in der Lagerfläche L2 ausgebildet werden. Besonders bevorzugt befinden sich in beiden Lagerflächen Ll und L2 Schmiermittelreservoirs F.A development of a lubricant reservoir F is not shown in FIG. 2, in which the volume is increased by additionally providing a recess in the metering member 15 in the region of the interruption of the annular bead 20. The variant in which the annular bead 20 is arranged on the rear housing sleeve 10 is also not shown in FIG. The formation of the lubricant reservoirs F is carried out in an analogous manner. Analogous to the lubricant reservoirs in the annular bead 20, lubricant reservoirs F can also be provided in the bearing surface L2. They are preferably formed by recesses in the radial end face of the metering member 15 or the rear end face of the rear housing sleeve 10. Lubricant reservoirs F are preferably formed only in the bearing surface L1. However, they can also be formed in the bearing surface L2. Lubricant reservoirs F are particularly preferably located in both bearing surfaces L1 and L2.
Vor der Montage des Dosierglieds 15 wird der in Figur 2 gestrichelt eingezeichnete Bereich 22 der hinteren Gehäusehülse 10 mit Schmiermittel versehen. Wird zur Montage das Dosierglied 15 in die hintere Gehäusehülse 10 geschoben, bleibt in den Bereichen der Schmiermittelreservoirs F das Schmiermittel zurück und sorgt bei einer Verdrehung des Dosierglieds 15 für eine Schmierung der Lagerflächen L.Before the metering member 15 is installed, the area 22 of the rear housing sleeve 10 shown in broken lines in FIG. 2 is provided with lubricant. If the metering member 15 is pushed into the rear housing sleeve 10 for assembly, the lubricant remains in the areas of the lubricant reservoirs F and, when the metering member 15 is rotated, lubricates the bearing surfaces L.
Die Dosierung erfolgt in einer in Bezug auf die Vorschubrichtung vordersten, proximalen Endposition des Antriebsglieds 6, in der ein von der äußeren Mantelfläche des Antriebsglieds 6 radial abstehender Anschlagnocken oder -kragen 13 an einem durch die hintere Gehäusehülse 10 gebildeten Anschlag anliegt. In dieser proximalen Endposition des Antriebsglieds 6 wird das Dosierglied 15 um die Verschiebeachse V relativ zur hinteren Gehäusehülse 10 verdreht, bis es die gewünschte Dosier bzw. Drehwinkelrastposition erreicht hat. In dieser Dosierposition verbleibt zwischen einem ebenfalls von der äußeren Mantelfläche des Antriebsglieds 6 abragenden weiteren Kragen bzw. Nocken, der einen Dosieranschlag bildet und daher im weiteren Dosiernocken 14 genannt wird, und der diesem Dosiernocken 14 gegenüberliegenden, proximalen Stirnseite 18 des Dosierglieds 15 ein lichter Dosierabstand. Um den Dosierabstand kann das Antriebsglied 6 relativ zur hinteren Gehäusehülse 10 und damit auch relativ zum Kolben 3 gegen die Vorschubrichtung zurückgezogen werden. Das Zurückziehen erfolgt manuell durch Ziehen an dem Deckel 9. Der Dosierabstand ist gleich der Dosisweglänge bei der nachfolgenden Verabreichung.The metering takes place in a foremost, proximal end position of the drive member 6 in relation to the feed direction, in which a stop cam or collar 13 protruding radially from the outer lateral surface of the drive member 6 bears against a stop formed by the rear housing sleeve 10. In this proximal end position of the drive member 6, the metering member 15 is rotated about the displacement axis V relative to the rear housing sleeve 10 until it has reached the desired metering or rotational angle locking position. In this metering position, a clear metering distance remains between a further collar or cam, which also projects from the outer circumferential surface of the drive member 6 and forms a metering stop and is therefore referred to in the further metering cam 14, and the proximal end face 18 of the metering member 15 opposite this metering cam 14 , By the metering distance, the drive member 6 can be retracted relative to the rear housing sleeve 10 and thus also relative to the piston 3 against the feed direction. The withdrawal is done manually by pulling on the lid 9. The dosing distance is equal to the dose path length in the subsequent administration.
Bei einer Zurückverschiebung bzw. Zurückziehen des Antriebsgliedes 6 verbleibt die Zahnstange 5 in ihrer bei dem Dosiervorgang eingenommenen Verschiebelage relativ zum Gehäuse. Sie wird durch an der hinteren Gehäusehülse 10 ausgebildete Sperrmittel 11 und 12 gegen eine Verschiebung gegen die Vorschubrichtung gesichert. Die Sperrmittel 11 und 12 sind Rastnocken, die je an einem der vorderen Ende einer elastisch nachgiebigen Zunge ausgebildet sind und von ihrer Zunge radial nach innen auf die Zahnstange 5 zu ragen. Die Sperrmittel 11 und 12 wirken je mit einer ihnen zugewandten Zahnreihe der Zahnstange 5 zusammen, derart, dass sie eine Verschiebung der Zahnstange 5 in Vorschubrichtung zulassen und eine Verschiebung gegen die Vorschubrichtung zulassen und eine Verschiebung gegen die Vorschubrichtung durch formschlüssigen Sperreingriff verhindern. Nach dem Zurückziehen des Antriebsglieds 6 kann es um die Dosisweglänge in Vorschubrichtung verschoben werden, wobei es die Zahnstange 5 und den Kolben 3 mitnimmt, so dass eine dosierte Menge des injizierbaren Produkts aus dem Reservoir 2 verdrängt wird. When the drive member 6 is displaced or retracted, the toothed rack 5 remains in its displacement position assumed during the metering process relative to the housing. It is secured against displacement against the feed direction by locking means 11 and 12 formed on the rear housing sleeve 10. The locking means 11 and 12 are locking cams, which are each formed on one of the front ends of an elastically flexible tongue and project radially inward from the tongue onto the rack 5. The locking means 11 and 12 each interact with a row of teeth of the rack 5 facing them in such a way that they allow the rack 5 to be displaced in the feed direction and allow a displacement against the feed direction and prevent a displacement against the feed direction by positive locking engagement. After the drive member 6 has been withdrawn, it can be moved in the feed direction by the dose path length, taking the toothed rack 5 and the piston 3 with it, so that a metered amount of the injectable product is displaced from the reservoir 2.

Claims

Patentansprüche claims
1. Vorrichtung zur dosierten Verabreichung eines injizierbaren Produkts, die Vorrichtung umfassend: a) ein Gehäuse (1), mit einem Reservoir (2) für das Produkt, b) einen Kolben (3), der bei einer Verschiebung in eine Vorschubrichtung auf einen Reservoirauslass (4) zu Produkt aus dem Reservoir (2) verdrängt, c) ein Antriebsglied (6), welches entlang einer Verschiebeachse (V) verschiebbar ist und dabei den Kolben (3) in Vorschubrichtung schiebt, d) ein Dosierglied (15), das zur Einstellung einer bei einer Verabreichung ausschüttbaren Produktdosis um die Verschiebeachse (V) des Antriebsglieds (6) gleitend bewegbar, vorzugsweise drehbar, im Gehäuse (1) gelagert ist, dadurch gekennzeichnet, dass e) eine Lagerfläche (L) zwischen dem Dosierglied (15) und dem Gehäuse (1) geschmiert wird und f) an der einen Lagerfläche (L) wenigstens ein Schmiermittelreservoir (F) ausgebildet ist.1. Device for the metered administration of an injectable product, the device comprising: a) a housing (1), with a reservoir (2) for the product, b) a piston (3), which is displaced in a feed direction onto a reservoir outlet (4) displaced to product from the reservoir (2), c) a drive member (6) which is displaceable along an axis of displacement (V) and thereby pushes the piston (3) in the direction of advance, d) a metering member (15) which for setting a product dose to be dispensed during administration, is slidably movable, preferably rotatable, about the displacement axis (V) of the drive member (6) in the housing (1), characterized in that e) a bearing surface (L) between the metering member (15) and the housing (1) is lubricated and f) at least one lubricant reservoir (F) is formed on the one bearing surface (L).
2. Vorrichtung nach dem vorhergehenden Anspruch, dadurch gekennzeichnet, dass das Dosierglied (15) über einen Ringwulst (20) axial verschiebesicher am Gehäuse (1) gelagert ist und die Lagerfläche (L) durch wenigstens eine Fläche des Ringwulstes (20) gebildet wird.2. Device according to the preceding claim, characterized in that the metering member (15) via an annular bead (20) is axially displaceably mounted on the housing (1) and the bearing surface (L) is formed by at least one surface of the annular bead (20).
3. Vorrichtung nach dem vorhergehenden Anspruch, dadurch gekennzeichnet, dass der Ringwulst (20) am Dosierglied (15) ausgebildet ist und in einer Ringnut im Gehäuse (1) axial gehalten wird.3. Device according to the preceding claim, characterized in that the annular bead (20) is formed on the metering member (15) and is held axially in an annular groove in the housing (1).
4. Vorrichtung nach einem der beiden vorhergehenden Ansprüche, dadurch gekennzeichnet, dass das wenigstens ein Schmiermittelreservoir (F) durch eine Abflachung des Ringwulstes (20) gebildet wird. 4. Device according to one of the two preceding claims, characterized in that the at least one lubricant reservoir (F) is formed by flattening the annular bead (20).
PCT/CH2001/000469 2000-09-26 2001-07-31 Device for administering an injectable product WO2002026297A1 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
DK01951309T DK1324793T3 (en) 2000-09-26 2001-07-31 Apparatus for administering an injectable product
IL15493301A IL154933A0 (en) 2000-09-26 2001-07-31 Device for administering an injectable product
AU2001272293A AU2001272293B2 (en) 2000-09-26 2001-07-31 Device for administering an injectable product
KR1020037003976A KR100770155B1 (en) 2000-09-26 2001-07-31 Device for administering an injectable product
MXPA03002632A MXPA03002632A (en) 2000-09-26 2001-07-31 Device for administering an injectable product.
EP01951309A EP1324793B1 (en) 2000-09-26 2001-07-31 Device for administering an injectable product
JP2002530126A JP2004508917A (en) 2000-09-26 2001-07-31 Device for administering injectable products
AT01951309T ATE285262T1 (en) 2000-09-26 2001-07-31 DEVICE FOR ADMINISTRATION OF AN INJECTABLE PRODUCT
DE50104902T DE50104902D1 (en) 2000-09-26 2001-07-31 DEVICE FOR ADMINISTERING AN INJECTABLE PRODUCT
CA002423267A CA2423267C (en) 2000-09-26 2001-07-31 Device for administering an injectable product
AU7229301A AU7229301A (en) 2000-09-26 2001-07-31 Device for administering an injectable product
BRPI0114151-1A BR0114151B1 (en) 2000-09-26 2001-07-31 device to apply an injectable product.
IL154933A IL154933A (en) 2000-09-26 2003-03-16 Device for administering an injectable product
US10/396,537 US7169131B2 (en) 2000-09-26 2003-03-25 Device for administering an injectable product

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10047637A DE10047637A1 (en) 2000-09-26 2000-09-26 Device for administering an injectable product
DE10047637.6 2000-09-26

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/396,537 Continuation US7169131B2 (en) 2000-09-26 2003-03-25 Device for administering an injectable product

Publications (1)

Publication Number Publication Date
WO2002026297A1 true WO2002026297A1 (en) 2002-04-04

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ID=7657670

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PCT/CH2001/000469 WO2002026297A1 (en) 2000-09-26 2001-07-31 Device for administering an injectable product

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US (1) US7169131B2 (en)
EP (1) EP1324793B1 (en)
JP (1) JP2004508917A (en)
KR (1) KR100770155B1 (en)
CN (1) CN1250300C (en)
AT (1) ATE285262T1 (en)
AU (2) AU2001272293B2 (en)
BR (1) BR0114151B1 (en)
CA (1) CA2423267C (en)
DE (2) DE10047637A1 (en)
ES (1) ES2234857T3 (en)
IL (2) IL154933A0 (en)
MX (1) MXPA03002632A (en)
PT (1) PT1324793E (en)
WO (1) WO2002026297A1 (en)

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US20030187405A1 (en) 2003-10-02
CN1250300C (en) 2006-04-12
KR20030045076A (en) 2003-06-09
CN1469761A (en) 2004-01-21
IL154933A0 (en) 2003-10-31
ES2234857T3 (en) 2005-07-01
EP1324793B1 (en) 2004-12-22
KR100770155B1 (en) 2007-10-25
PT1324793E (en) 2005-04-29
EP1324793A1 (en) 2003-07-09
ATE285262T1 (en) 2005-01-15
BR0114151A (en) 2003-07-29
JP2004508917A (en) 2004-03-25
DE50104902D1 (en) 2005-01-27
MXPA03002632A (en) 2004-09-10
DE10047637A1 (en) 2002-04-25
US7169131B2 (en) 2007-01-30
CA2423267A1 (en) 2003-03-24
CA2423267C (en) 2007-08-14
IL154933A (en) 2010-03-28
AU7229301A (en) 2002-04-08
AU2001272293B2 (en) 2006-02-02
BR0114151B1 (en) 2009-12-01

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