WO2002024752A3 - Monoclonal antibodies against lipid structures different from the double layer of cell membranes for defining physiological states in different cell types and detecting anti lipid particle antibodies in human beings and/or animals suffering from certain antiphospholipid antibody-related diseases - Google Patents

Monoclonal antibodies against lipid structures different from the double layer of cell membranes for defining physiological states in different cell types and detecting anti lipid particle antibodies in human beings and/or animals suffering from certain antiphospholipid antibody-related diseases Download PDF

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Publication number
WO2002024752A3
WO2002024752A3 PCT/MX2001/000069 MX0100069W WO0224752A3 WO 2002024752 A3 WO2002024752 A3 WO 2002024752A3 MX 0100069 W MX0100069 W MX 0100069W WO 0224752 A3 WO0224752 A3 WO 0224752A3
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WO
WIPO (PCT)
Prior art keywords
different
monoclonal antibodies
double layer
antibodies
certain
Prior art date
Application number
PCT/MX2001/000069
Other languages
Spanish (es)
French (fr)
Other versions
WO2002024752A2 (en
Inventor
Pierres Maria Guadalupe Ortega
Linan Sara Rocio Fonseca
Original Assignee
Ct Investig Y Estudios Del Ipn
Pierres Maria Guadalupe Ortega
Linan Sara Rocio Fonseca
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from MXPA/A/2000/008567A external-priority patent/MXPA00008567A/en
Application filed by Ct Investig Y Estudios Del Ipn, Pierres Maria Guadalupe Ortega, Linan Sara Rocio Fonseca filed Critical Ct Investig Y Estudios Del Ipn
Priority to AU2001288136A priority Critical patent/AU2001288136A1/en
Publication of WO2002024752A2 publication Critical patent/WO2002024752A2/en
Publication of WO2002024752A3 publication Critical patent/WO2002024752A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention relates to the obtention of murine hybridomas that produce monoclonal antibodies against non double layer lipid particles also known as lipid particles in liposomes. The monoclonal antibodies are isotype IgM. Said antibodies were obtained by fusing spleen cells of female BALB/c mice that were immunized with liposomes of unilamellar phosphatidylcholine: phosphatidate (2:1) containing lipid particles induced by Mn+2 and P3X63AGBU.1 myeloma cell line. In the present invention, the use of said antibodies has been tested in ELISA assays to detect non dual layer lipid associations both in animal and plant cells. Hence its potential use in the prevention and treatment of diseases associated with the production of antiphospholipid antibodies.
PCT/MX2001/000069 2000-09-01 2001-08-31 Monoclonal antibodies against lipid structures different from the double layer of cell membranes for defining physiological states in different cell types and detecting anti lipid particle antibodies in human beings and/or animals suffering from certain antiphospholipid antibody-related diseases WO2002024752A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001288136A AU2001288136A1 (en) 2000-09-01 2001-08-31 Monoclonal antibodies against lipid structures different from the double layer of cell membranes for defining physiological states in different cell types and detecting anti lipid particle antibodies in human beings and/or animals suffering from certain antiphospholipid antibody-related diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MX008567 2000-09-01
MXPA/A/2000/008567A MXPA00008567A (en) 2000-09-01 Monoclonal antibodies against lipid structures different from the two-layer of cellular membranes to define phsycological states in different cellular types and for the detection of antiparticles antibodies

Publications (2)

Publication Number Publication Date
WO2002024752A2 WO2002024752A2 (en) 2002-03-28
WO2002024752A3 true WO2002024752A3 (en) 2002-07-18

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/MX2001/000069 WO2002024752A2 (en) 2000-09-01 2001-08-31 Monoclonal antibodies against lipid structures different from the double layer of cell membranes for defining physiological states in different cell types and detecting anti lipid particle antibodies in human beings and/or animals suffering from certain antiphospholipid antibody-related diseases

Country Status (2)

Country Link
AU (1) AU2001288136A1 (en)
WO (1) WO2002024752A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104155451B (en) * 2014-08-20 2016-01-06 厦门大学附属中山医院 IgM antibody to treponema pallidum biotin-labeled pentylamine enzyme-linked immunologic detecting kit and preparation method thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983002672A1 (en) * 1982-02-02 1983-08-04 Hana Biolog Inc Immunologic assay for determining presence of a phospholipid in biological fluid
US4666831A (en) * 1985-02-19 1987-05-19 The Liposome Company, Inc. Lipid-dependent diagnostic assays
US4698299A (en) * 1985-02-19 1987-10-06 The Liposome Company, Inc. Lipid-dependent diagnostic assays
WO1997039736A1 (en) * 1996-04-19 1997-10-30 Pasteur Sanofi Diagnostics, S.A. Liposome reagents for immunoassays
WO1997040387A1 (en) * 1996-04-19 1997-10-30 Pasteur Sanofi Diagnostics, S.A. Immunoassays to detect antiphospholipid antibodies
WO1999002992A1 (en) * 1997-07-11 1999-01-21 The Mount Sinai School Of Medicine Of The City University Of New York Assays for diagnosis of thrombophilic disease

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983002672A1 (en) * 1982-02-02 1983-08-04 Hana Biolog Inc Immunologic assay for determining presence of a phospholipid in biological fluid
US4666831A (en) * 1985-02-19 1987-05-19 The Liposome Company, Inc. Lipid-dependent diagnostic assays
US4698299A (en) * 1985-02-19 1987-10-06 The Liposome Company, Inc. Lipid-dependent diagnostic assays
WO1997039736A1 (en) * 1996-04-19 1997-10-30 Pasteur Sanofi Diagnostics, S.A. Liposome reagents for immunoassays
WO1997040387A1 (en) * 1996-04-19 1997-10-30 Pasteur Sanofi Diagnostics, S.A. Immunoassays to detect antiphospholipid antibodies
WO1999002992A1 (en) * 1997-07-11 1999-01-21 The Mount Sinai School Of Medicine Of The City University Of New York Assays for diagnosis of thrombophilic disease

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Publication number Publication date
WO2002024752A2 (en) 2002-03-28
AU2001288136A1 (en) 2002-04-02

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