WO2002024750A3 - Proteine membranaire humaine surexprimee dans une tumeur renale 1 (ktom1) - Google Patents

Proteine membranaire humaine surexprimee dans une tumeur renale 1 (ktom1) Download PDF

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Publication number
WO2002024750A3
WO2002024750A3 PCT/US2001/029656 US0129656W WO0224750A3 WO 2002024750 A3 WO2002024750 A3 WO 2002024750A3 US 0129656 W US0129656 W US 0129656W WO 0224750 A3 WO0224750 A3 WO 0224750A3
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WIPO (PCT)
Prior art keywords
human
ktom1
nucleic acids
antibodies
proteins
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Application number
PCT/US2001/029656
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English (en)
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WO2002024750A2 (fr
Inventor
Jian Zhang
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Aeomica Inc
Jian Zhang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0024263A external-priority patent/GB2360284B/en
Priority claimed from PCT/US2001/000662 external-priority patent/WO2001057271A2/fr
Priority claimed from US09/864,761 external-priority patent/US20020048763A1/en
Application filed by Aeomica Inc, Jian Zhang filed Critical Aeomica Inc
Priority to AU2001292957A priority Critical patent/AU2001292957A1/en
Publication of WO2002024750A2 publication Critical patent/WO2002024750A2/fr
Publication of WO2002024750A3 publication Critical patent/WO2002024750A3/fr

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    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/20—Polymerase chain reaction [PCR]; Primer or probe design; Probe optimisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
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    • C12Q2600/136—Screening for pharmacological compounds
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    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression

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  • Chemical & Material Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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Abstract

L'invention porte sur des acides nucléiques isolés codant la protéine KTOM1, et sur des fragments de ceux-ci, sur des vecteurs destinés à propager et exprimer les acides nucléiques de la protéine humaine KTOM1, sur des cellules hôtes comprenant les acides nucléiques et les vecteurs précités, sur des protéines et des fragments de protéine, et sur des fusions de protéines des nouveaux isoformes de la protéine KTOM1, et sur les anticorps contre ceux-ci. L'invention porte également sur des cellules transgéniques et sur des organismes non humains comprenant des acides nucléiques de la protéine humaine KTOM1, et sur des cellules transgéniques et des organismes non humains à rupture ciblée de l'orthologue endogène du gène de la protéine humaine KTOM1. L'invention porte aussi sur des formulations pharmaceutiques des acides nucléiques, des protéines et des anticorps précités, ainsi que sur des méthodes diagnostiques, thérapeutiques et d'investigation basées sur les acides nucléiques, les protéines et les anticorps de la protéine humaine KTOM1.
PCT/US2001/029656 2000-09-21 2001-09-21 Proteine membranaire humaine surexprimee dans une tumeur renale 1 (ktom1) WO2002024750A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001292957A AU2001292957A1 (en) 2000-09-21 2001-09-21 Human kidney tumor overexpressed membrane protein 1

Applications Claiming Priority (30)

Application Number Priority Date Filing Date Title
US23468700P 2000-09-21 2000-09-21
US60/234,687 2000-09-21
US23635900P 2000-09-27 2000-09-27
US60/236,359 2000-09-27
GB0024263A GB2360284B (en) 2000-02-04 2000-10-04 Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human heart
GB0024263.6 2000-10-04
USPCT/US01/00661 2001-01-30
USPCT/US01/00665 2001-01-30
USPCT/US01/00662 2001-01-30
PCT/US2001/000662 WO2001057271A2 (fr) 2000-02-04 2001-01-30 Sondes d'acide nucleique a un seul exon derivees du genome humain utiles pour analyser l'expression genique dans des cellules bt 474
USPCT/US01/00664 2001-01-30
PCT/US2001/000668 WO2001057276A2 (fr) 2000-02-04 2001-01-30 Sondes d'acide nucleique a un seul exon derivees du genome humain utiles pour analyser l'expression genique dans la moelle osseuse humaine
PCT/US2001/000669 WO2001057277A2 (fr) 2000-02-04 2001-01-30 Sondes d'acide nucleique a un seul exon derivees du genome humain utiles pour analyser l'expression genique dans le foie foetal humain
USPCT/US01/00669 2001-01-30
USPCT/US01/00666 2001-01-30
USPCT/US01/00663 2001-01-30
PCT/US2001/000667 WO2001057275A2 (fr) 2000-02-04 2001-01-30 Sondes d'acide nucleique a un seul exon derivees du genome humain utiles pour analyser l'expression genique dans le cerveau humain
USPCT/US01/00667 2001-01-30
PCT/US2001/000665 WO2001086003A2 (fr) 2000-02-04 2001-01-30 Sondes d'acide nucleique a un seul exon derivees du genome humain utiles pour analyser l'expression genique dans le poumon humain
PCT/US2001/000670 WO2001057278A2 (fr) 2000-02-04 2001-01-30 Sondes d'acide nucleique a un seul exon derivees du genome humain utiles pour analyser l'expression genique dans des cellules hela humaines ou d'autres cellules epitheliales humaines du col de l'uterus
USPCT/US01/00668 2001-01-30
USPCT/US01/00670 2001-01-30
PCT/US2001/000664 WO2001057273A2 (fr) 2000-02-04 2001-01-30 Sondes d'acide nucleique a un seul exon derivees du genome humain utiles pour analyser l'expression genique dans le foie adulte humain
PCT/US2001/000663 WO2001057272A2 (fr) 2000-02-04 2001-01-30 Sondes d'acide nucleique a un seul exon derivees du genome humain utiles pour analyser l'expression genique dans le placenta humain
PCT/US2001/000666 WO2001057274A2 (fr) 2000-02-04 2001-01-30 Sondes d'acide nucleique a un seul exon derivees du genome humain utiles pour analyser l'expression genique dans le coeur humain
PCT/US2001/000661 WO2001057270A2 (fr) 2000-02-04 2001-01-30 Sondes d'acide nucleique a un seul exon derivees du genome humain utiles pour analyser l'expression genique dans des cellules hbl 100
US09/864,761 US20020048763A1 (en) 2000-02-04 2001-05-23 Human genome-derived single exon nucleic acid probes useful for gene expression analysis
US09/864,761 2001-05-23
US31567601P 2001-08-28 2001-08-28
US60/315,676 2001-08-28

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WO2002024750A2 WO2002024750A2 (fr) 2002-03-28
WO2002024750A3 true WO2002024750A3 (fr) 2003-11-06

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Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030215916A1 (en) * 2000-08-18 2003-11-20 Feder John N. Novel imidazoline receptor homologs
WO2002016585A2 (fr) * 2000-08-18 2002-02-28 Bristol-Myers Squibb Company Nouveaux homologues du recepteur de l'imidazoline
DE102007022457A1 (de) 2007-05-09 2008-11-13 Durtec Gmbh Plasmamodifizierte natürliche Minerale mit nanoskaligen Eigenschaften, Verfahren zu ihrer Herstellung und ihre Verwendung

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999006548A2 (fr) * 1997-08-01 1999-02-11 Genset Est 5' pour proteines secretees sans specificite tissulaire
WO2002016585A2 (fr) * 2000-08-18 2002-02-28 Bristol-Myers Squibb Company Nouveaux homologues du recepteur de l'imidazoline

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999006548A2 (fr) * 1997-08-01 1999-02-11 Genset Est 5' pour proteines secretees sans specificite tissulaire
WO2002016585A2 (fr) * 2000-08-18 2002-02-28 Bristol-Myers Squibb Company Nouveaux homologues du recepteur de l'imidazoline

Non-Patent Citations (5)

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Title
DATABASE EMBL [online] DUCLERT ET AL., XP002242111, retrieved from EBI Database accession no. AAY12436 *
DATABASE EMBL [online] HILLIER ET AL.: "zm79g08.r1 Stratagene neuroepithelium", XP002242044, retrieved from EBI Database accession no. AA134712 *
DATABASE EMBL [online] STRAUSBERG ET AL.: "Al307255.1tb24c07.x1NCI_CGAP", XP002242046, retrieved from EBI Database accession no. AI307255 *
DATABASE EMBL [online] STRAUSBERG ET AL.: "NIH_MGC_21 cDNA clone", XP002242045, retrieved from EBI Database accession no. BE408715 *
PEARSON MATTHEW A ET AL: "Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain.", CELL, vol. 101, no. 3, 28 April 2000 (2000-04-28), pages 259 - 270, XP001148051, ISSN: 0092-8674 *

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