WO2002024610A3 - Method for producing an antineoplastic - Google Patents

Method for producing an antineoplastic Download PDF

Info

Publication number
WO2002024610A3
WO2002024610A3 PCT/RU2001/000396 RU0100396W WO0224610A3 WO 2002024610 A3 WO2002024610 A3 WO 2002024610A3 RU 0100396 W RU0100396 W RU 0100396W WO 0224610 A3 WO0224610 A3 WO 0224610A3
Authority
WO
WIPO (PCT)
Prior art keywords
solution
humic substances
platinite
tetra
chloro
Prior art date
Application number
PCT/RU2001/000396
Other languages
French (fr)
Russian (ru)
Other versions
WO2002024610A2 (en
Inventor
Valery Afanasievich D Trofimov
Valery Pavlovich Shipov
Aleksandr Ivanovich Popov
Evgeny Sergeevich Pigarev
Viktor Nikolaevich Ivanov
Original Assignee
Nobel Ltd Liability Company
Trofimova Nadezhda Vasilievich
Valery Pavlovich Shipov
Aleksandr Ivanovich Popov
Evgeny Sergeevich Pigarev
Viktor Nikolaevich Ivanov
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nobel Ltd Liability Company, Trofimova Nadezhda Vasilievich, Valery Pavlovich Shipov, Aleksandr Ivanovich Popov, Evgeny Sergeevich Pigarev, Viktor Nikolaevich Ivanov filed Critical Nobel Ltd Liability Company
Priority to AU2001294449A priority Critical patent/AU2001294449A1/en
Publication of WO2002024610A2 publication Critical patent/WO2002024610A2/en
Publication of WO2002024610A3 publication Critical patent/WO2002024610A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

The inventive method for producing an antineoplastic based on tetra-chloro-platinite of potassium consists in treating a water solution containing humic substances with a solution of tetra-chloro-platinite of potassium. Said treatment is carried out by exposing to the action of ultrasound having a radiation power of 40 W/cm2 and a frequency of 22 Hz during 4-8 minutes. The humic substances can be exuded by treating a humified material with an alkaline solution at standard conditions. Moss peat and transition peat, or composts, or sapropels, or the humus horizons of various soils can be used as the humified material. The humic substances can be also produced from oxidised wood lignin. It is rational to produce humic acids by oxidising the wood lignin in an alkaline medium with the aid of an oxygen-containing gas at a temperature of 170 20 °C, a pressure ranging from 1.9 to 2.5 MPa during a time period ranging from 1 to 3 hours, aftercooling the stock, separating a solid phase from the solution and acidulating it till pH =2-3 is obtained.
PCT/RU2001/000396 2000-09-19 2001-09-19 Method for producing an antineoplastic WO2002024610A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001294449A AU2001294449A1 (en) 2000-09-19 2001-09-19 Method for producing an antineoplastic

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2000123815 2000-09-19
RU2000123815/14A RU2182482C1 (en) 2000-09-19 2000-09-19 Method to obtain antitumor preparation

Publications (2)

Publication Number Publication Date
WO2002024610A2 WO2002024610A2 (en) 2002-03-28
WO2002024610A3 true WO2002024610A3 (en) 2002-10-24

Family

ID=20240137

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2001/000396 WO2002024610A2 (en) 2000-09-19 2001-09-19 Method for producing an antineoplastic

Country Status (3)

Country Link
AU (1) AU2001294449A1 (en)
RU (1) RU2182482C1 (en)
WO (1) WO2002024610A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2178702C1 (en) * 2001-02-21 2002-01-27 Общество с ограниченной ответственностью "Нобель" Anticancer agent
RU2368379C2 (en) * 2005-02-17 2009-09-27 РДИнновейшн Апс Anti-cancer remedy obtaining method
UA116535C2 (en) 2012-03-30 2018-04-10 Рдінновейшн Апс Benzene polycarboxylic acid compounds and their use as drug
RU2667128C2 (en) 2016-12-29 2018-09-14 Герман Петрович Беккер Composition for preparation of anti-tumor medication and method for preparation of anti-tumor medication based on it

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1701323A1 (en) * 1989-04-28 1991-12-30 Институт Физической Химии Им.Л.В.Писаржевского Method for obtaining antitumor agents
WO1992005803A1 (en) * 1990-10-04 1992-04-16 The Scripps Research Institute Self-assembling ion pair drugs
EP0517225A1 (en) * 1991-06-05 1992-12-09 Ferrer Internacional, S.A. Aminopyrrolidine platinum compounds, a process for preparing them and pharmaceutical compositions containing them
RU96116096A (en) * 1996-08-05 1998-11-20 Н.Н. Желиговская METHOD FOR PRODUCING CIS-DIAMMINDICHLOROPLATIN / P /

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1701323A1 (en) * 1989-04-28 1991-12-30 Институт Физической Химии Им.Л.В.Писаржевского Method for obtaining antitumor agents
WO1992005803A1 (en) * 1990-10-04 1992-04-16 The Scripps Research Institute Self-assembling ion pair drugs
EP0517225A1 (en) * 1991-06-05 1992-12-09 Ferrer Internacional, S.A. Aminopyrrolidine platinum compounds, a process for preparing them and pharmaceutical compositions containing them
RU96116096A (en) * 1996-08-05 1998-11-20 Н.Н. Желиговская METHOD FOR PRODUCING CIS-DIAMMINDICHLOROPLATIN / P /

Also Published As

Publication number Publication date
WO2002024610A2 (en) 2002-03-28
AU2001294449A1 (en) 2002-04-02
RU2182482C1 (en) 2002-05-20

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