WO2002022800A3 - Cassettes d'expression et vecteurs d'adenovirus - Google Patents

Cassettes d'expression et vecteurs d'adenovirus Download PDF

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Publication number
WO2002022800A3
WO2002022800A3 PCT/EP2001/010654 EP0110654W WO0222800A3 WO 2002022800 A3 WO2002022800 A3 WO 2002022800A3 EP 0110654 W EP0110654 W EP 0110654W WO 0222800 A3 WO0222800 A3 WO 0222800A3
Authority
WO
WIPO (PCT)
Prior art keywords
expression cassettes
adenovirus vectors
expression
adenovirus
dna
Prior art date
Application number
PCT/EP2001/010654
Other languages
German (de)
English (en)
Other versions
WO2002022800A2 (fr
Inventor
Leopold Doehner
Dietmar Becher
Salah Salim
Original Assignee
Micromun Privates Inst Fuer Mi
Leopold Doehner
Dietmar Becher
Salah Salim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micromun Privates Inst Fuer Mi, Leopold Doehner, Dietmar Becher, Salah Salim filed Critical Micromun Privates Inst Fuer Mi
Priority to AU2002221595A priority Critical patent/AU2002221595A1/en
Publication of WO2002022800A2 publication Critical patent/WO2002022800A2/fr
Publication of WO2002022800A3 publication Critical patent/WO2002022800A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Abstract

L'invention concerne des cassettes d'expression renfermant, en liaison coopérante avec l'ADN pour un ADN étranger à exprimer, les séquences régulatrices du gène IX polypeptide de l'adénovirus, ainsi que les vecteurs d'expression les renfermant, et un procédé de préparation de celles-ci.
PCT/EP2001/010654 2000-09-15 2001-09-14 Cassettes d'expression et vecteurs d'adenovirus WO2002022800A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002221595A AU2002221595A1 (en) 2000-09-15 2001-09-14 Expression cassettes and adenovirus vectors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10045687.1 2000-09-15
DE2000145687 DE10045687B4 (de) 2000-09-15 2000-09-15 Expressionskassetten und Adenovirusvektoren

Publications (2)

Publication Number Publication Date
WO2002022800A2 WO2002022800A2 (fr) 2002-03-21
WO2002022800A3 true WO2002022800A3 (fr) 2002-10-24

Family

ID=7656330

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/010654 WO2002022800A2 (fr) 2000-09-15 2001-09-14 Cassettes d'expression et vecteurs d'adenovirus

Country Status (3)

Country Link
AU (1) AU2002221595A1 (fr)
DE (1) DE10045687B4 (fr)
WO (1) WO2002022800A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL164802A0 (en) 2002-04-25 2005-12-18 Crucell Holland Bv Stable adenoviral vectors and methods for propagation thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994012649A2 (fr) * 1992-12-03 1994-06-09 Genzyme Corporation Therapie genique de la fibrose kystique
WO1995011984A2 (fr) * 1993-10-25 1995-05-04 Canji, Inc. Vecteur recombinant d'adenovirus et procedes d'utilisation
WO1996030534A1 (fr) * 1995-03-24 1996-10-03 Genzyme Corporation Vecteurs d'adenovirus pour therapie genique
WO2000052187A2 (fr) * 1999-03-05 2000-09-08 Merck & Co., Inc. Systeme evolue destine a la creation de vecteurs d'adenovirus
WO2001025462A1 (fr) * 1999-10-01 2001-04-12 Genovo, Incorporated Production de virus associes a l'adenovirus (aav) recombinants mettant en oeuvre un adenovirus comprenant des genes rep/cap associes a l'adenovirus

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW442569B (en) * 1993-10-25 2001-06-23 Canji Inc Recombinant adenoviral vector
FR2774699B1 (fr) * 1997-11-17 2003-10-03 Rhone Poulenc Rorer Sa Methode de reduction des evenements de recombinaison homologue

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994012649A2 (fr) * 1992-12-03 1994-06-09 Genzyme Corporation Therapie genique de la fibrose kystique
WO1995011984A2 (fr) * 1993-10-25 1995-05-04 Canji, Inc. Vecteur recombinant d'adenovirus et procedes d'utilisation
WO1996030534A1 (fr) * 1995-03-24 1996-10-03 Genzyme Corporation Vecteurs d'adenovirus pour therapie genique
WO2000052187A2 (fr) * 1999-03-05 2000-09-08 Merck & Co., Inc. Systeme evolue destine a la creation de vecteurs d'adenovirus
WO2001025462A1 (fr) * 1999-10-01 2001-04-12 Genovo, Incorporated Production de virus associes a l'adenovirus (aav) recombinants mettant en oeuvre un adenovirus comprenant des genes rep/cap associes a l'adenovirus

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BABISS L E ET AL: "PROMOTER OF THE ADENOVIRUS POLYPEPTIDE IX GENE: SIMILARITY TO E1B AND INACTIVATION BY SUBSTITUTION OF THE SIMIAN VIRUS 40 TATA ELEMENT", JOURNAL OF VIROLOGY, vol. 65, no. 2, February 1991 (1991-02-01), pages 598 - 605, XP002943494, ISSN: 0022-538X *
FIRE A ET AL: "IN-VITRO TRANSCRIPTION OF ADENOVIRUS", JOURNAL OF VIROLOGY, vol. 40, no. 3, 1981, pages 703 - 719, XP001055787, ISSN: 0022-538X *
FU Y ET AL: "EXPRESSION OF CIRCULAR PLASMIDS WHICH CONTAIN BACTERIAL CHLORAMPHENICOL ACETYLTRANSFERASE GENE CONNECTED TO THE PROMOTER OF POLYPEPTIDE IX GENE OF HUMAN ADENOVIRUS TYPE 12 IN OOCYTES EGGS AND EMBRYOS OF XENOPUS LAEVIS", ZOOLOGICAL SCIENCE (TOKYO), vol. 7, no. 2, 1990, pages 195 - 200, XP001055807, ISSN: 0289-0003 *
HITT M M ET AL: "STRUCTURE AND GENETIC ORGANIZATION OF ADENOVIRUS VECTORS", COLD SPRING HARBOR MONOGRAPH SERIES, COLD SPRING HARBOR LABORATORY, US, 1999, pages 61 - 86, XP000938159, ISSN: 0270-1847 *
MATSUI T: "CIS-ACTING ELEMENT AND TRANS-ACTING FACTORS OF THE ADENOVIRUS 2 PEPTIDE IX GENE", JOURNAL OF CELLULAR BIOCHEMISTRY SUPPLEMENT, no. 12 PART D, 1988, pages 213, XP001055877, ISSN: 0733-1959 *

Also Published As

Publication number Publication date
AU2002221595A1 (en) 2002-03-26
WO2002022800A2 (fr) 2002-03-21
DE10045687B4 (de) 2006-07-06
DE10045687A1 (de) 2002-04-04

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