WO2002017888A3 - Controlled and sustained release properties of polyelectrolyte multilayer capsules - Google Patents

Controlled and sustained release properties of polyelectrolyte multilayer capsules Download PDF

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Publication number
WO2002017888A3
WO2002017888A3 PCT/EP2001/009908 EP0109908W WO0217888A3 WO 2002017888 A3 WO2002017888 A3 WO 2002017888A3 EP 0109908 W EP0109908 W EP 0109908W WO 0217888 A3 WO0217888 A3 WO 0217888A3
Authority
WO
WIPO (PCT)
Prior art keywords
polyelectrolyte
release
fluorescein
shell
fluorescence
Prior art date
Application number
PCT/EP2001/009908
Other languages
French (fr)
Other versions
WO2002017888A9 (en
WO2002017888A2 (en
Inventor
Alexei Antipov
Euridice Vieira
Gemma Ibarz
Gleb Sukhorukov
Lars Daehne
Changyou Gao
Edwin Donath
Helmuth Moehwald
Original Assignee
Max Planck Gesellschaft
Alexei Antipov
Euridice Vieira
Gemma Ibarz
Gleb Sukhorukov
Lars Daehne
Changyou Gao
Edwin Donath
Helmuth Moehwald
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft, Alexei Antipov, Euridice Vieira, Gemma Ibarz, Gleb Sukhorukov, Lars Daehne, Changyou Gao, Edwin Donath, Helmuth Moehwald filed Critical Max Planck Gesellschaft
Priority to AT01980290T priority Critical patent/ATE295156T1/en
Priority to US10/363,472 priority patent/US20040013721A1/en
Priority to EP01980290A priority patent/EP1313455B1/en
Priority to JP2002522862A priority patent/JP2004507488A/en
Priority to CA2420523A priority patent/CA2420523C/en
Priority to DE60110809T priority patent/DE60110809T2/en
Publication of WO2002017888A2 publication Critical patent/WO2002017888A2/en
Publication of WO2002017888A3 publication Critical patent/WO2002017888A3/en
Publication of WO2002017888A9 publication Critical patent/WO2002017888A9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening

Abstract

Method of layer-by-layer (LbL) assembly of oppositely charged polyelectrolytes was applied to coat fluorescein particles. These particles with a size of 4-9 νm were prepared by precipitation of fluorescein at pH 2. Polysterensulfonate (PSS) and polyallylamine (PAH) were used to compose the polyelectrolyte shell on the fluorescein core. The release of fluorescein molecules through the polyelectrolyte shell core dissolution was monitored at pH 8 by increasing fluorescence intensity. The number of polyelectrolyte layers sufficient to sustain fluorescence release was found to be 8-10. Sequentially adsorbed layers prolong core dissolution time for minutes. The permeability of polyelectrolyte multilayers of the thickness of 20 nm is about 10-8 m/s. Mechanism of fluorescence diffusion and osmotically supported release is under discussion. The features of release profile and possible applications of LbL method for shell formation in order to control release properties for entrapped materials are outlined. Also ambient conditions of pH, temperature and salt concentration were changed to control the permeability of polyelectrolyte multilayer capsules.
PCT/EP2001/009908 2000-08-28 2001-08-28 Controlled and sustained release properties of polyelectrolyte multilayer capsules WO2002017888A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AT01980290T ATE295156T1 (en) 2000-08-28 2001-08-28 MULTI-LAYER POLYELECTROLYTE CAPSULES WITH CONTROLLED AND SUSTAINED RELEASE
US10/363,472 US20040013721A1 (en) 2000-08-28 2001-08-28 Controlled and sustained release properties of polyelectrolyte multilayer capsules
EP01980290A EP1313455B1 (en) 2000-08-28 2001-08-28 Controlled and sustained release properties of polyelectrolyte multilayer capsules
JP2002522862A JP2004507488A (en) 2000-08-28 2001-08-28 Controlled and sustained release characteristics of polyelectrolyte multilayer capsules
CA2420523A CA2420523C (en) 2000-08-28 2001-08-28 Controlled and sustained release properties of polyelectrolyte multilayer capsules
DE60110809T DE60110809T2 (en) 2000-08-28 2001-08-28 Multi-layer controlled and sustained release polyelectrolyte capsules

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP00118615.4 2000-08-28
EP00118615 2000-08-28
EP01112600 2001-05-23
EP01112600.0 2001-05-23

Publications (3)

Publication Number Publication Date
WO2002017888A2 WO2002017888A2 (en) 2002-03-07
WO2002017888A3 true WO2002017888A3 (en) 2002-07-25
WO2002017888A9 WO2002017888A9 (en) 2003-05-15

Family

ID=26071336

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/009908 WO2002017888A2 (en) 2000-08-28 2001-08-28 Controlled and sustained release properties of polyelectrolyte multilayer capsules

Country Status (7)

Country Link
US (1) US20040013721A1 (en)
EP (1) EP1313455B1 (en)
JP (1) JP2004507488A (en)
AT (1) ATE295156T1 (en)
CA (1) CA2420523C (en)
DE (1) DE60110809T2 (en)
WO (1) WO2002017888A2 (en)

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Also Published As

Publication number Publication date
DE60110809T2 (en) 2005-10-06
ATE295156T1 (en) 2005-05-15
EP1313455B1 (en) 2005-05-11
US20040013721A1 (en) 2004-01-22
EP1313455A2 (en) 2003-05-28
JP2004507488A (en) 2004-03-11
CA2420523A1 (en) 2002-03-07
WO2002017888A9 (en) 2003-05-15
WO2002017888A2 (en) 2002-03-07
DE60110809D1 (en) 2005-06-16
CA2420523C (en) 2010-05-25

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