WO2002016611A3 - Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders - Google Patents

Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders Download PDF

Info

Publication number
WO2002016611A3
WO2002016611A3 PCT/US2001/017443 US0117443W WO0216611A3 WO 2002016611 A3 WO2002016611 A3 WO 2002016611A3 US 0117443 W US0117443 W US 0117443W WO 0216611 A3 WO0216611 A3 WO 0216611A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptides
interleukin
methods
treatment
nucleic acids
Prior art date
Application number
PCT/US2001/017443
Other languages
French (fr)
Other versions
WO2002016611A2 (en
Inventor
Sudeepta Aggarwal
Jessica S Foster
Audrey Goddard
Austin L Gurney
Ellen M Maruoka
William I Wood
Ming-Hong Xie
Original Assignee
Genentech Inc
Sudeepta Aggarwal
Jessica S Foster
Audrey Goddard
Austin L Gurney
Ellen M Maruoka
William I Wood
Ming-Hong Xie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2000/023328 external-priority patent/WO2001016318A2/en
Application filed by Genentech Inc, Sudeepta Aggarwal, Jessica S Foster, Audrey Goddard, Austin L Gurney, Ellen M Maruoka, William I Wood, Ming-Hong Xie filed Critical Genentech Inc
Priority to DE60136281T priority Critical patent/DE60136281D1/en
Priority to AU2001268108A priority patent/AU2001268108A1/en
Priority to JP2002522282A priority patent/JP3886899B2/en
Priority to ES01946010T priority patent/ES2316454T3/en
Priority to DK01946010T priority patent/DK1311679T3/en
Priority to CA2419541A priority patent/CA2419541C/en
Priority to EP01946010A priority patent/EP1311679B1/en
Priority to PCT/US2001/017443 priority patent/WO2002016611A2/en
Priority to CA002648046A priority patent/CA2648046A1/en
Priority to CA002412211A priority patent/CA2412211A1/en
Priority to CA2709771A priority patent/CA2709771A1/en
Priority to AU2001278852A priority patent/AU2001278852A1/en
Priority to CA002648048A priority patent/CA2648048A1/en
Priority to PCT/US2001/019692 priority patent/WO2002000690A2/en
Priority to CA002648051A priority patent/CA2648051A1/en
Priority to EP09004417A priority patent/EP2077276A1/en
Priority to EP09004415A priority patent/EP2168980A1/en
Priority to EP01957073A priority patent/EP1309620A2/en
Priority to EP09004418A priority patent/EP2075253A1/en
Priority to JP2002505812A priority patent/JP2004506413A/en
Priority to PCT/US2001/021735 priority patent/WO2002008284A2/en
Priority to AU2001271973A priority patent/AU2001271973A1/en
Priority to JP2002514188A priority patent/JP2004516013A/en
Priority to CA002416538A priority patent/CA2416538A1/en
Priority to EP01951036A priority patent/EP1309685A2/en
Priority to US10/002,796 priority patent/US20030032057A1/en
Priority to US10/006,867 priority patent/US7160985B2/en
Priority to US10/066,203 priority patent/US20030180796A1/en
Priority to US10/066,211 priority patent/US20030044844A1/en
Priority to US10/066,193 priority patent/US20030044902A1/en
Priority to US10/066,269 priority patent/US20030040014A1/en
Priority to US10/066,500 priority patent/US20020177165A1/en
Priority to US10/066,273 priority patent/US7317092B2/en
Priority to US10/066,494 priority patent/US20030032063A1/en
Priority to US10/066,198 priority patent/US20030170721A1/en
Publication of WO2002016611A2 publication Critical patent/WO2002016611A2/en
Priority to US10/119,480 priority patent/US20040087769A1/en
Priority to US10/063,651 priority patent/US7193057B2/en
Priority to US10/226,739 priority patent/US7390879B2/en
Publication of WO2002016611A3 publication Critical patent/WO2002016611A3/en
Priority to US10/972,317 priority patent/US7208321B2/en
Priority to US11/240,891 priority patent/US20060246540A1/en
Priority to US11/263,278 priority patent/US20080286821A1/en
Priority to JP2008194721A priority patent/JP2009039118A/en
Priority to JP2008194678A priority patent/JP2009039117A/en
Priority to JP2008194764A priority patent/JP2009039119A/en
Priority to JP2011173336A priority patent/JP6033531B2/en
Priority to JP2014187275A priority patent/JP2015037408A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention is directed to interleukin-22 polypeptides and nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
PCT/US2001/017443 1997-08-26 2001-05-30 Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders WO2002016611A2 (en)

Priority Applications (46)

Application Number Priority Date Filing Date Title
DE60136281T DE60136281D1 (en) 2000-08-24 2001-05-30 METHOD FOR INHIBITING IL-22-INDUCED PAP1
AU2001268108A AU2001268108A1 (en) 2000-08-24 2001-05-30 Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders
JP2002522282A JP3886899B2 (en) 2000-08-24 2001-05-30 Interleukin-22 polypeptide, nucleic acid encoding the same, and method for treating pancreatic disease
ES01946010T ES2316454T3 (en) 2000-08-24 2001-05-30 PAP1 INHIBITION METHOD INDUCED BY IL-22.
DK01946010T DK1311679T3 (en) 2000-08-24 2001-05-30 Method of Inhibiting IL-22-Induced PAP1
CA2419541A CA2419541C (en) 2000-08-24 2001-05-30 Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders
EP01946010A EP1311679B1 (en) 2000-08-24 2001-05-30 Method for inhibiting il-22 induced pap1
PCT/US2001/017443 WO2002016611A2 (en) 2000-08-24 2001-05-30 Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders
CA002648046A CA2648046A1 (en) 2000-06-23 2001-06-20 Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
CA002412211A CA2412211A1 (en) 2000-06-23 2001-06-20 Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
CA2709771A CA2709771A1 (en) 2000-06-23 2001-06-20 Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
AU2001278852A AU2001278852A1 (en) 2000-06-23 2001-06-20 Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
CA002648048A CA2648048A1 (en) 2000-06-23 2001-06-20 Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
PCT/US2001/019692 WO2002000690A2 (en) 2000-06-23 2001-06-20 Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
CA002648051A CA2648051A1 (en) 2000-06-23 2001-06-20 Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
EP09004417A EP2077276A1 (en) 2000-06-23 2001-06-20 Compositions and methods for the diagnosis and treatment of disorders involving angiogensis
EP09004415A EP2168980A1 (en) 2000-06-23 2001-06-20 Compositions and methods for the diagnosis and treatment of disorders involving angiogensis
EP01957073A EP1309620A2 (en) 2000-06-23 2001-06-20 Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
EP09004418A EP2075253A1 (en) 2000-06-23 2001-06-20 Compositions and methds for the diagnosis and treatment of disorders involving angiogensis
JP2002505812A JP2004506413A (en) 2000-06-23 2001-06-20 Compositions and methods for diagnosis and treatment of diseases involving angiogenesis
PCT/US2001/021735 WO2002008284A2 (en) 2000-07-20 2001-07-09 Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
AU2001271973A AU2001271973A1 (en) 2000-07-20 2001-07-09 Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
JP2002514188A JP2004516013A (en) 2000-07-20 2001-07-09 Compositions and methods for diagnosing and treating disorders associated with angiogenesis
CA002416538A CA2416538A1 (en) 2000-07-20 2001-07-09 Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
EP01951036A EP1309685A2 (en) 2000-07-20 2001-07-09 Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
US10/002,796 US20030032057A1 (en) 1997-08-26 2001-11-15 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/006,867 US7160985B2 (en) 1997-10-29 2001-12-06 Pro180 polypeptide
US10/066,203 US20030180796A1 (en) 1997-08-26 2002-02-01 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/066,211 US20030044844A1 (en) 1997-08-26 2002-02-01 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/066,193 US20030044902A1 (en) 1997-08-26 2002-02-01 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/066,269 US20030040014A1 (en) 1997-08-26 2002-02-01 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/066,500 US20020177165A1 (en) 1997-08-26 2002-02-01 Secreted and transmembrane polypeptides and nucleic acids encoding
US10/066,273 US7317092B2 (en) 1997-08-26 2002-02-01 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/066,494 US20030032063A1 (en) 1997-08-26 2002-02-01 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/066,198 US20030170721A1 (en) 1997-08-26 2002-02-01 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/119,480 US20040087769A1 (en) 1998-09-10 2002-04-09 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/063,651 US7193057B2 (en) 1997-10-29 2002-05-07 Antibodies to a polypeptide encoded by a nucleic acid underexpressed in rectal tumor
US10/226,739 US7390879B2 (en) 1999-06-15 2002-08-23 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US10/972,317 US7208321B2 (en) 1998-06-02 2004-10-22 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US11/240,891 US20060246540A1 (en) 1997-08-26 2005-09-29 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US11/263,278 US20080286821A1 (en) 1999-05-14 2005-10-31 Secreted and transmembrane polypeptides and nucleic acids encoding the same
JP2008194721A JP2009039118A (en) 2000-07-20 2008-07-29 Composition and method for diagnosing and treating lesion associated with angiogenesis
JP2008194678A JP2009039117A (en) 2000-07-20 2008-07-29 Composition and method for diagnosing and treating lesion associated with angiogenesis
JP2008194764A JP2009039119A (en) 2000-07-20 2008-07-29 Composition and method for diagnosing and treating lesion associated with angiogenesis
JP2011173336A JP6033531B2 (en) 2000-07-20 2011-08-08 Compositions and methods for diagnosing and treating disorders associated with angiogenesis
JP2014187275A JP2015037408A (en) 2000-07-20 2014-09-16 Compositions and methods for diagnosis and treatment of disorders involving angiogenesis

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US2000/023328 WO2001016318A2 (en) 1999-09-01 2000-08-24 Secreted and transmembrane polypeptides and nucleic acids encoding the same
USPCT/US00/23328 2000-08-24
PCT/US2001/017443 WO2002016611A2 (en) 2000-08-24 2001-05-30 Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders

Related Parent Applications (3)

Application Number Title Priority Date Filing Date
US09/866,028 Continuation-In-Part US6642360B2 (en) 1996-11-06 2001-05-25 Secreted polypeptides that stimulate release of proteoglycans from cartilage
US09/870,574 Continuation US6551799B2 (en) 1997-08-26 2001-05-30 Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders
US09/870,574 Continuation-In-Part US6551799B2 (en) 1997-08-26 2001-05-30 Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders

Related Child Applications (4)

Application Number Title Priority Date Filing Date
PCT/US2001/017800 Continuation WO2001093983A1 (en) 1996-11-06 2001-06-01 Secreted and transmembrane polypeptides and nucleic acids encoding the same
PCT/US2001/017800 Continuation-In-Part WO2001093983A1 (en) 1996-11-06 2001-06-01 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US87203501A Continuation-In-Part 1996-11-06 2001-06-01
US10/119,480 Continuation US20040087769A1 (en) 1998-09-10 2002-04-09 Secreted and transmembrane polypeptides and nucleic acids encoding the same

Publications (2)

Publication Number Publication Date
WO2002016611A2 WO2002016611A2 (en) 2002-02-28
WO2002016611A3 true WO2002016611A3 (en) 2002-09-26

Family

ID=40513806

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/017443 WO2002016611A2 (en) 1997-08-26 2001-05-30 Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders

Country Status (1)

Country Link
WO (1) WO2002016611A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6939545B2 (en) 1999-04-28 2005-09-06 Genetics Institute, Llc Composition and method for treating inflammatory disorders
US7307161B1 (en) 1999-04-28 2007-12-11 Genetics Institute, Llc Human Gil-19/AE289 polynucleotides
US20030170823A1 (en) 1999-12-23 2003-09-11 Presnell Scott R. Novel cytokine ZCYTO18
US7638604B2 (en) 2001-02-23 2009-12-29 Genetics Institute, Llc Monoclonal antibodies against interleukin-22
US7265211B2 (en) 2002-03-22 2007-09-04 Zymogenetics, Inc. Anti-IL-TIF antibodies and methods of making
ES2354693T3 (en) * 2003-06-23 2011-03-17 Genetics Institute, Llc ANTIBODIES AGAINST INTERLEUCINE-22 AND USES FOR THEM.
TW200744634A (en) 2006-02-21 2007-12-16 Wyeth Corp Methods of using antibodies against human IL-22
TWI417301B (en) 2006-02-21 2013-12-01 Wyeth Corp Antibodies against human il-22 and uses therefor
WO2011087986A1 (en) * 2010-01-13 2011-07-21 Amgen Inc. Il-22-fc and hepcidin activity
JP6456356B2 (en) 2013-03-15 2019-01-23 ジェネンテック， インコーポレイテッド IL-22 polypeptides and IL-22 Fc fusion proteins and methods of use
KR102536314B1 (en) * 2018-05-23 2023-05-25 주식회사 휴벳바이오 Composition for diagnosing disease
KR102226826B1 (en) * 2020-08-06 2021-03-11 주식회사 휴벳바이오 Composition for Diagnosing Pancreatic Cancer for Use in Buffy Coat Sample

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000024758A1 (en) * 1998-10-26 2000-05-04 Ludwig Institute For Cancer Research ISOLATED NUCLEIC ACID MOLECULES WHICH ENCODE T CELL INDUCIBLE FACTORS (TIFs), THE PROTEINS ENCODED, AND USES THEREOF
WO2000065027A2 (en) * 1999-04-28 2000-11-02 Genetics Institute, Inc. Human gil-19/ae289 proteins and polynucleotides encoding same
WO2000070049A2 (en) * 1999-05-19 2000-11-23 Incyte Genomics, Inc. Extracellular signaling molecules
WO2000073457A1 (en) * 1999-05-27 2000-12-07 Schering-Corporation Mammalian interleukin-10 homologs: il-d110 and il-d210
WO2000077037A2 (en) * 1999-06-15 2000-12-21 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2001040467A1 (en) * 1999-12-03 2001-06-07 Zymogenetics, Inc. Human cytokine receptor
WO2001046422A1 (en) * 1999-12-23 2001-06-28 Zymogenetics, Inc. Novel cytokine zcyto18

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000024758A1 (en) * 1998-10-26 2000-05-04 Ludwig Institute For Cancer Research ISOLATED NUCLEIC ACID MOLECULES WHICH ENCODE T CELL INDUCIBLE FACTORS (TIFs), THE PROTEINS ENCODED, AND USES THEREOF
WO2000065027A2 (en) * 1999-04-28 2000-11-02 Genetics Institute, Inc. Human gil-19/ae289 proteins and polynucleotides encoding same
WO2000070049A2 (en) * 1999-05-19 2000-11-23 Incyte Genomics, Inc. Extracellular signaling molecules
WO2000073457A1 (en) * 1999-05-27 2000-12-07 Schering-Corporation Mammalian interleukin-10 homologs: il-d110 and il-d210
WO2000077037A2 (en) * 1999-06-15 2000-12-21 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2001040467A1 (en) * 1999-12-03 2001-06-07 Zymogenetics, Inc. Human cytokine receptor
WO2001046422A1 (en) * 1999-12-23 2001-06-28 Zymogenetics, Inc. Novel cytokine zcyto18

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DUMOUTIER L ET AL: "CLONING AND CHARACTERIZATION OF IL-10-RELATED T CELL-DERIVED INDUCIBLE BY IL-9", JOURNAL OF IMMUNOLOGY, BLACKWELL SCIENTIFIC PUBLICATIONS, GB, vol. 164, 15 February 2000 (2000-02-15), pages 1814 - 1819, XP000946156, ISSN: 0019-2805 *
DUMOUTIER L ET AL: "HUMAN INTERLEUKIN-10-RELATED T CELL-DERIVED INDUCIBLE FACTOR: MOLECULAR CLONING AND FUNCTIONAL CHARACTERIZATION AS AN HEPATOCYTE-STIMULATING FACTOR", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 97, no. 18, 29 August 2000 (2000-08-29), pages 10144 - 10149, XP000946025, ISSN: 0027-8424 *
KOTENKO SERGEI V ET AL: "Identification of the functional interleukin-22 (IL-22) receptor complex. The IL-10R2 chain (IL-10Rbeta) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 4, 26 January 2001 (2001-01-26), pages 2725 - 2732, XP002186669, ISSN: 0021-9258 *
SPENCER S D ET AL: "THE ORPHAN RECEPTOR CRF2-4 IS AN ESSENTIAL SUBUNIT OF THE INTERLEUKIN 10 RECEPTOR", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 187, no. 4, 16 February 1998 (1998-02-16), pages 571 - 578, XP002922011, ISSN: 0022-1007 *
XIE M-H ET AL: "Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 275, no. 40, 6 October 2000 (2000-10-06), pages 31335 - 31339, XP002164307, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
WO2002016611A2 (en) 2002-02-28

Similar Documents

Publication Publication Date Title
WO2001007611A3 (en) Novel polynucleotides and method for the use thereof
WO2001046420A8 (en) Il-17 and il-17r homologous polypeptides and therapeutic uses thereof
WO2001068848A3 (en) Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2002008288A3 (en) Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO1999028462A3 (en) Polypeptides and nucleic acids encoding the same
WO2001016318A3 (en) Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2001040466A3 (en) Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2000053756A3 (en) Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2000077037A3 (en) Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO1999060127A3 (en) Il-17 homologous polypeptides and therapeutic uses thereof
WO1999063088A3 (en) Membrane-bound proteins and nucleic acids encoding the same
WO1999061469A3 (en) Prostate growth-associated membrane proteins
WO2002024888A3 (en) Secreted and transmembrane polypeptides and nucleic acids encoding the same
AU3774300A (en) Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2000015796A3 (en) Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2000036102A3 (en) Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2000032776A3 (en) Secreted amd transmembrane polypeptides and nucleic acids encoding the same
WO2000056889A3 (en) Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2002016611A3 (en) Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders
WO2000039297A3 (en) Il-1 related polypeptides
WO2000068376A8 (en) Novel chimpanzee erythropoietin (chepo) polypeptides and nucleic acids encoding the same
WO2003076569A3 (en) Novel polypeptides having sequence similarity to gdnfr and nucleic acids encoding the same
EP1241179A3 (en) Human cornichon-like protein and nucleic acids encoding it
EP1251139A3 (en) Human mindin-like protein and nucleic acids encoding it
EP1283215A3 (en) Secreted polypeptide and nucleic acids encoding it

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 10002796

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 10066198

Country of ref document: US

Ref document number: 10066193

Country of ref document: US

Ref document number: 10066203

Country of ref document: US

Ref document number: 10066494

Country of ref document: US

Ref document number: 10066269

Country of ref document: US

Ref document number: 10066211

Country of ref document: US

Ref document number: 10066273

Country of ref document: US

Ref document number: 10066500

Country of ref document: US

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 10119480

Country of ref document: US

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 10226739

Country of ref document: US

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2419541

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2002522282

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2001946010

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2001946010

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)