WO2002014528A1 - Stereoselective reduction of substituted oxo-butanes - Google Patents
Stereoselective reduction of substituted oxo-butanes Download PDFInfo
- Publication number
- WO2002014528A1 WO2002014528A1 PCT/US2001/023113 US0123113W WO0214528A1 WO 2002014528 A1 WO2002014528 A1 WO 2002014528A1 US 0123113 W US0123113 W US 0123113W WO 0214528 A1 WO0214528 A1 WO 0214528A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- formula
- accordance
- substituted
- amino
- compound represented
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
Abstract
Description
Claims
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2001280698A AU2001280698B2 (en) | 2000-08-16 | 2001-07-20 | Stereoselective reduction of substituted oxo-butanes |
CA002417086A CA2417086A1 (en) | 2000-08-16 | 2001-07-20 | Stereoselective reduction of substituted oxo-butanes |
JP2002519654A JP3843255B2 (en) | 2000-08-16 | 2001-07-20 | Stereoselective reduction of substituted oxobutanes. |
IL15437601A IL154376A0 (en) | 2000-08-16 | 2001-07-20 | Stereoselective reduction of substituted oxo-butanes |
MXPA03001312A MXPA03001312A (en) | 2000-08-16 | 2001-07-20 | Stereoselective reduction of substituted oxo-butanes. |
HU0300873A HU229338B1 (en) | 2000-08-16 | 2001-07-20 | Stereoselective reduction of substituted oxo-butanes |
AU8069801A AU8069801A (en) | 2000-08-16 | 2001-07-20 | Stereoselective reduction of substituted oxo-butanes |
KR10-2003-7002257A KR20040031674A (en) | 2000-08-16 | 2001-07-20 | Stereoselective Reduction of Substituted Oxo-Butanes |
EP01959109A EP1309714B1 (en) | 2000-08-16 | 2001-07-20 | Stereoselective reduction of substituted oxo-butanes |
DE60138712T DE60138712D1 (en) | 2000-08-16 | 2001-07-20 | O-butanes |
BRPI0113236-9A BR0113236B1 (en) | 2000-08-16 | 2001-07-20 | Stereoselective process for the preparation of (3S, 2R) -1-halo-2-hydroxy-3- (protected) amino-4-substituted butanes |
AT01959109T ATE431422T1 (en) | 2000-08-16 | 2001-07-20 | STEREOSELECTIVE REDUCTION OF SUBSTITUTED OXO-BUTANES |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22569500P | 2000-08-16 | 2000-08-16 | |
US60/225,695 | 2000-08-16 | ||
US27753101P | 2001-03-21 | 2001-03-21 | |
US60/277,531 | 2001-03-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002014528A1 true WO2002014528A1 (en) | 2002-02-21 |
Family
ID=26919835
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/023113 WO2002014528A1 (en) | 2000-08-16 | 2001-07-20 | Stereoselective reduction of substituted oxo-butanes |
Country Status (18)
Country | Link |
---|---|
US (2) | US20020042124A1 (en) |
EP (1) | EP1309714B1 (en) |
JP (1) | JP3843255B2 (en) |
KR (1) | KR20040031674A (en) |
CN (1) | CN100335643C (en) |
AT (1) | ATE431422T1 (en) |
AU (2) | AU2001280698B2 (en) |
BR (1) | BR0113236B1 (en) |
CA (1) | CA2417086A1 (en) |
CZ (1) | CZ303884B6 (en) |
DE (1) | DE60138712D1 (en) |
ES (1) | ES2325309T3 (en) |
HU (1) | HU229338B1 (en) |
IL (1) | IL154376A0 (en) |
MX (1) | MXPA03001312A (en) |
PL (1) | PL366098A1 (en) |
TW (1) | TWI287579B (en) |
WO (1) | WO2002014528A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006127180A1 (en) * | 2005-05-25 | 2006-11-30 | Bristol-Myers Squibb Company | A process for preparing (2r,3s)-1,2-epoxy-3-(protected)amino-4-substituted butane and intermediates thereof |
US8222009B2 (en) | 2004-04-14 | 2012-07-17 | Bristol-Myers Squibb Company | Process for preparing dipeptidyl peptidase IV inhibitors and intermediates therefor |
US8932835B2 (en) | 2007-09-27 | 2015-01-13 | Iep Gmbh | Process for the enantioselective enzymatic reduction of intermediates |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003000290A (en) * | 2001-06-25 | 2003-01-07 | Kanegafuchi Chem Ind Co Ltd | Method for producing optically active (r)-2-chloro-1-(3'- chlorophenyl)ethanol |
ES2310143B1 (en) * | 2007-06-15 | 2010-02-08 | Universitat Jaume I | CISTEINE PROTEASES INHIBITORS. |
DE602008005462D1 (en) * | 2007-06-22 | 2011-04-21 | Bristol Myers Squibb Co | TABLETTED ATAZANA-CONTAINING COMPOSITIONS |
DK2170292T3 (en) * | 2007-06-22 | 2014-04-07 | Bristol Myers Squibb Holdings Ireland | Tablet-containing Atazanavir Compositions |
US20100183716A1 (en) * | 2007-06-22 | 2010-07-22 | Bristo-Meyers Squibb Company | Tableted compositions containing atazanavir |
WO2009002823A2 (en) * | 2007-06-22 | 2008-12-31 | Bristol-Myers Squibb Company | Tableted compositions containing atazanavir |
WO2011005527A2 (en) | 2009-06-22 | 2011-01-13 | Codexis, Inc. | Ketoreductase-mediated stereoselective route to alpha chloroalcohols |
US9080192B2 (en) | 2010-02-10 | 2015-07-14 | Codexis, Inc. | Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system |
CN113026036B (en) * | 2021-03-11 | 2022-06-07 | 南京工业大学 | Method for synthesizing sulfur ylide compounds by using continuous flow electrochemical oxidation |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5391495A (en) * | 1992-11-05 | 1995-02-21 | Bristol-Myers Squibb Company | Stereoselective reduction of ketones |
US5726047A (en) * | 1995-06-19 | 1998-03-10 | Kaneka Corporation | Process for stereoselectively reducing 1-halo-3-amino-4-phenyl-2-butanone to the corresponding alcohol with microorganisms |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61108394A (en) | 1984-10-30 | 1986-05-27 | Sumitomo Chem Co Ltd | Biochemical production of optically active 1-(4-fenoxyphenoxy)-propane-2-ol |
JPH02295970A (en) | 1989-05-10 | 1990-12-06 | Asahi Chem Ind Co Ltd | Preparation of optically active propane-2-ol derivative |
JPH02295969A (en) | 1989-05-10 | 1990-12-06 | Asahi Chem Ind Co Ltd | Preparation of optically active aminoalcohol derivative |
JP3814766B2 (en) | 1996-02-28 | 2006-08-30 | 日本農薬株式会社 | Process for producing optically active 2-halo-1- (substituted phenyl) ethanol |
US5849911A (en) | 1996-04-22 | 1998-12-15 | Novartis Finance Corporation | Antivirally active heterocyclic azahexane derivatives |
JP3941184B2 (en) | 1997-10-06 | 2007-07-04 | 三菱化学株式会社 | Process for producing optically active 1-acyloxy-3-chloro-2-propanol and optically active 3-chloro-1,2-propanediol |
-
2001
- 2001-07-20 AU AU2001280698A patent/AU2001280698B2/en not_active Expired
- 2001-07-20 AU AU8069801A patent/AU8069801A/en active Pending
- 2001-07-20 EP EP01959109A patent/EP1309714B1/en not_active Expired - Lifetime
- 2001-07-20 JP JP2002519654A patent/JP3843255B2/en not_active Expired - Lifetime
- 2001-07-20 MX MXPA03001312A patent/MXPA03001312A/en active IP Right Grant
- 2001-07-20 WO PCT/US2001/023113 patent/WO2002014528A1/en active IP Right Grant
- 2001-07-20 AT AT01959109T patent/ATE431422T1/en not_active IP Right Cessation
- 2001-07-20 IL IL15437601A patent/IL154376A0/en unknown
- 2001-07-20 PL PL01366098A patent/PL366098A1/en not_active Application Discontinuation
- 2001-07-20 CN CNB01814196XA patent/CN100335643C/en not_active Expired - Lifetime
- 2001-07-20 CA CA002417086A patent/CA2417086A1/en not_active Abandoned
- 2001-07-20 HU HU0300873A patent/HU229338B1/en unknown
- 2001-07-20 DE DE60138712T patent/DE60138712D1/en not_active Expired - Lifetime
- 2001-07-20 BR BRPI0113236-9A patent/BR0113236B1/en not_active IP Right Cessation
- 2001-07-20 KR KR10-2003-7002257A patent/KR20040031674A/en not_active Application Discontinuation
- 2001-07-20 US US09/909,684 patent/US20020042124A1/en not_active Abandoned
- 2001-07-20 ES ES01959109T patent/ES2325309T3/en not_active Expired - Lifetime
- 2001-07-20 CZ CZ20030758A patent/CZ303884B6/en not_active IP Right Cessation
- 2001-08-16 TW TW090120123A patent/TWI287579B/en not_active IP Right Cessation
-
2003
- 2003-09-12 US US10/661,893 patent/US7083973B2/en not_active Expired - Lifetime
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5391495A (en) * | 1992-11-05 | 1995-02-21 | Bristol-Myers Squibb Company | Stereoselective reduction of ketones |
US5726047A (en) * | 1995-06-19 | 1998-03-10 | Kaneka Corporation | Process for stereoselectively reducing 1-halo-3-amino-4-phenyl-2-butanone to the corresponding alcohol with microorganisms |
Non-Patent Citations (2)
Title |
---|
ALBECK ET AL.: "Functionalized erythro N-protected alpha-amino epoxides. Stereocontrolled synthesis and biological activity", TETRAHEDRON, vol. 53, no. 14, 1997, pages 5325 - 5338, XP002946858 * |
PATEL R.: "Biocatalytic synthesis of chiral intermediates for antiviral and antihypertensive drugs", JOURNAL AMERICAN OIL CHEMICAL SOCIETY, vol. 76, no. 11, 1999, pages 1275 - 1281, XP002946859 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8222009B2 (en) | 2004-04-14 | 2012-07-17 | Bristol-Myers Squibb Company | Process for preparing dipeptidyl peptidase IV inhibitors and intermediates therefor |
US8361761B2 (en) | 2004-04-14 | 2013-01-29 | Bristol Myers-Squibb Company | Process for preparing dipeptidyl peptidase IV inhibitors and intermediates therefor |
US8809024B2 (en) | 2004-04-14 | 2014-08-19 | Astrazeneca Ab | Process for preparing dipeptidyl peptidase IV inhibitors and intermediates therefor |
WO2006127180A1 (en) * | 2005-05-25 | 2006-11-30 | Bristol-Myers Squibb Company | A process for preparing (2r,3s)-1,2-epoxy-3-(protected)amino-4-substituted butane and intermediates thereof |
US7582468B2 (en) | 2005-05-25 | 2009-09-01 | Bristol-Myers Squibb Company | Process for preparing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane and intermediates thereof |
US8119389B2 (en) | 2005-05-25 | 2012-02-21 | Bristol-Myers Squibb Company | Rhodococcus erythropolis strain |
US8932835B2 (en) | 2007-09-27 | 2015-01-13 | Iep Gmbh | Process for the enantioselective enzymatic reduction of intermediates |
Also Published As
Publication number | Publication date |
---|---|
IL154376A0 (en) | 2003-09-17 |
TWI287579B (en) | 2007-10-01 |
CA2417086A1 (en) | 2002-02-21 |
CZ2003758A3 (en) | 2003-11-12 |
EP1309714A1 (en) | 2003-05-14 |
CZ303884B6 (en) | 2013-06-12 |
HUP0300873A3 (en) | 2006-02-28 |
AU8069801A (en) | 2002-02-25 |
ATE431422T1 (en) | 2009-05-15 |
MXPA03001312A (en) | 2003-10-06 |
US20020042124A1 (en) | 2002-04-11 |
CN1492932A (en) | 2004-04-28 |
EP1309714A4 (en) | 2006-04-05 |
CN100335643C (en) | 2007-09-05 |
KR20040031674A (en) | 2004-04-13 |
BR0113236B1 (en) | 2014-04-22 |
JP3843255B2 (en) | 2006-11-08 |
PL366098A1 (en) | 2005-01-24 |
HUP0300873A2 (en) | 2003-12-29 |
US20040058431A1 (en) | 2004-03-25 |
AU2001280698B2 (en) | 2005-08-25 |
HU229338B1 (en) | 2013-11-28 |
JP2004511225A (en) | 2004-04-15 |
BR0113236A (en) | 2005-12-13 |
US7083973B2 (en) | 2006-08-01 |
EP1309714B1 (en) | 2009-05-13 |
ES2325309T3 (en) | 2009-09-01 |
DE60138712D1 (en) | 2009-06-25 |
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