WO2002013968A3 - Microarray placer unit - Google Patents

Microarray placer unit Download PDF

Info

Publication number
WO2002013968A3
WO2002013968A3 PCT/US2001/024996 US0124996W WO0213968A3 WO 2002013968 A3 WO2002013968 A3 WO 2002013968A3 US 0124996 W US0124996 W US 0124996W WO 0213968 A3 WO0213968 A3 WO 0213968A3
Authority
WO
WIPO (PCT)
Prior art keywords
microarray
processing device
workpiece
movable arm
support body
Prior art date
Application number
PCT/US2001/024996
Other languages
French (fr)
Other versions
WO2002013968A2 (en
Inventor
Joeben Bevirt
Eric J Rollins
Original Assignee
Incyte Genomics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc filed Critical Incyte Genomics Inc
Priority to AU2001279251A priority Critical patent/AU2001279251A1/en
Publication of WO2002013968A2 publication Critical patent/WO2002013968A2/en
Publication of WO2002013968A3 publication Critical patent/WO2002013968A3/en

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00Supporting devices; Holding devices
    • B01L9/52Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/34Microscope slides, e.g. mounting specimens on microscope slides
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00497Features relating to the solid phase supports
    • B01J2219/00527Sheets
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00497Features relating to the solid phase supports
    • B01J2219/00527Sheets
    • B01J2219/00533Sheets essentially rectangular
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00596Solid-phase processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00659Two-dimensional arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00677Ex-situ synthesis followed by deposition on the substrate
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00686Automatic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00686Automatic
    • B01J2219/00689Automatic using computers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00686Automatic
    • B01J2219/00691Automatic using robots
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0822Slides
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099Characterised by type of test elements
    • G01N2035/00158Elements containing microarrays, i.e. "biochip"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04Details of the conveyor system
    • G01N2035/0474Details of actuating means for conveyors or pipettes
    • G01N2035/0491Position sensing, encoding; closed-loop control
    • G01N2035/0494Detecting or compensating piositioning errors

Abstract

The present invention provides a placer unit (150) for a microarray processing device to transport a workpiece such as a microscope slide (32) before and after processing operations by the microarray processing device. The processing device is slidably attached to a gantry (166) and has a support carriage and a movable arm. The movable arm is slidably attached to the support carriage. The placer unit includes a main support body (188), a latching mechanism (171) and a vacuum chuck (184). The main support body is mounted on the support carriage and allowed to translate up and down. The latching mechanism enables the main support body to couple with the movable arm of the processing device. The vacuum chuck (184) is used to hold the workpiece for transportation. The present invention also includes a method within a microarray processing machine for transporting a workpiece such as a microscope slide (32) from one workstation to another workstation.
PCT/US2001/024996 2000-08-11 2001-08-09 Microarray placer unit WO2002013968A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001279251A AU2001279251A1 (en) 2000-08-11 2001-08-09 Microarray placer unit

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US22433800P 2000-08-11 2000-08-11
US22433700P 2000-08-11 2000-08-11
US22433500P 2000-08-11 2000-08-11
US22433600P 2000-08-11 2000-08-11
US60/224,338 2000-08-11
US60/224,337 2000-08-11
US60/224,335 2000-08-11
US60/224,336 2000-08-11
US63973200A 2000-08-15 2000-08-15
US63973100A 2000-08-15 2000-08-15
US63973400A 2000-08-15 2000-08-15
US63973300A 2000-08-15 2000-08-15
US09/639,734 2000-08-15
US09/638,733 2000-08-15
US09/639,732 2000-08-15
US09/639,731 2000-08-15

Publications (2)

Publication Number Publication Date
WO2002013968A2 WO2002013968A2 (en) 2002-02-21
WO2002013968A3 true WO2002013968A3 (en) 2003-01-16

Family

ID=27575221

Family Applications (4)

Application Number Title Priority Date Filing Date
PCT/US2001/024850 WO2002014877A2 (en) 2000-08-11 2001-08-08 Microarray retrieval unit
PCT/US2001/024844 WO2002013967A2 (en) 2000-08-11 2001-08-08 Microarray alignment mechanism
PCT/US2001/024996 WO2002013968A2 (en) 2000-08-11 2001-08-09 Microarray placer unit
PCT/US2001/024994 WO2002014531A2 (en) 2000-08-11 2001-08-09 Microarray platen

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PCT/US2001/024850 WO2002014877A2 (en) 2000-08-11 2001-08-08 Microarray retrieval unit
PCT/US2001/024844 WO2002013967A2 (en) 2000-08-11 2001-08-08 Microarray alignment mechanism

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2001/024994 WO2002014531A2 (en) 2000-08-11 2001-08-09 Microarray platen

Country Status (2)

Country Link
AU (4) AU2001281179A1 (en)
WO (4) WO2002014877A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6955788B2 (en) 2001-09-07 2005-10-18 Affymetrix, Inc. Apparatus and method for aligning microarray printing head
DE10261533A1 (en) * 2002-12-23 2004-07-15 BioChip Technologies GmbH Gesellschaft für Entwicklung und Produktion von Detektionssystemen Holder for slide onto which droplet array is deposited, includes locating stops on long side of slide support surface, used in conjunction with clamping system
JP2006126204A (en) * 2004-10-29 2006-05-18 Affymetrix Inc Automated method for manufacturing polymer array
HUP0700404A2 (en) * 2007-06-08 2009-03-30 3D Histech Kft Catch frame for slide and slide feeding unit
US10746752B2 (en) 2009-11-13 2020-08-18 Ventana Medical Systems, Inc. Opposables and automated specimen processing systems with opposables
US10509216B2 (en) 2012-12-26 2019-12-17 Ventana Medical Systems, Inc. Specimen processing systems and methods for aligning slides
CN102010817B (en) * 2010-08-06 2013-05-22 博奥生物有限公司 Chip automatic loading device of microarray chip scanner
JP6080860B2 (en) * 2011-11-16 2017-02-15 ライカ・バイオシステムズ・メルボルン・プロプライエタリー・リミテッドLeica Biosystems Melbourne Pty Ltd Automated system and method for processing tissue samples on slides
US10036690B2 (en) 2011-11-16 2018-07-31 Leica Biosystems Melbourne Pty Ltd Biological sample treatment apparatus
US9989448B2 (en) 2012-12-26 2018-06-05 Ventana Medical Systems, Inc. Specimen processing systems and methods for holding slides
JP6117938B2 (en) * 2012-12-26 2017-04-19 ベンタナ メディカル システムズ, インコーポレイテッド Sample processing system and method for aligning glass slides
US11274998B2 (en) 2012-12-26 2022-03-15 Ventana Medical Systems, Inc. Specimen processing systems and methods for holding slides
CN104007274B (en) * 2014-06-04 2016-02-03 上海宏莘科技发展有限公司 Folder off-type digital-code type fully-automatic intelligent sampler
DE102016125691B4 (en) 2016-12-23 2018-10-25 Leica Microsystems Cms Gmbh Holder for microscope slide, microscope and method for controlling a microscope
JP7126809B2 (en) 2017-04-13 2022-08-29 浜松ホトニクス株式会社 Image acquisition device and image acquisition method

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WO1992012233A1 (en) * 1991-01-11 1992-07-23 Medical Research Council Transfer of biological samples
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WO1998041531A2 (en) * 1997-03-20 1998-09-24 University Of Washington Solvent for biopolymer synthesis, solvent microdroplets and methods of use
US5958342A (en) * 1996-05-17 1999-09-28 Incyte Pharmaceuticals, Inc. Jet droplet device
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Publication number Priority date Publication date Assignee Title
FR2630216A1 (en) * 1988-04-14 1989-10-20 Ibal Robotised installation for analyses, in particular medical analyses
WO1992012233A1 (en) * 1991-01-11 1992-07-23 Medical Research Council Transfer of biological samples
US5591402A (en) * 1993-07-09 1997-01-07 Dade Microscan Inc. Fluid dispensing apparatus
US5958342A (en) * 1996-05-17 1999-09-28 Incyte Pharmaceuticals, Inc. Jet droplet device
WO1998041531A2 (en) * 1997-03-20 1998-09-24 University Of Washington Solvent for biopolymer synthesis, solvent microdroplets and methods of use
WO1999049295A1 (en) * 1998-03-24 1999-09-30 Biogenex Laboratories Automated staining apparatus

Also Published As

Publication number Publication date
WO2002014531A2 (en) 2002-02-21
WO2002014531A3 (en) 2003-01-16
WO2002013967A2 (en) 2002-02-21
AU2001281217A1 (en) 2002-02-25
AU2001281182A1 (en) 2002-02-25
WO2002014877A3 (en) 2003-01-03
WO2002013967A3 (en) 2002-08-08
AU2001279251A1 (en) 2002-02-25
AU2001281179A1 (en) 2002-02-25
WO2002013968A2 (en) 2002-02-21
WO2002014877A2 (en) 2002-02-21

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