WO2002012346A3 - A new slit-like protein obtained from a cdna library from hs-5 stromal cell line - Google Patents

A new slit-like protein obtained from a cdna library from hs-5 stromal cell line Download PDF

Info

Publication number
WO2002012346A3
WO2002012346A3 PCT/US2001/025242 US0125242W WO0212346A3 WO 2002012346 A3 WO2002012346 A3 WO 2002012346A3 US 0125242 W US0125242 W US 0125242W WO 0212346 A3 WO0212346 A3 WO 0212346A3
Authority
WO
WIPO (PCT)
Prior art keywords
slit
cell line
cdna library
stromal cell
protein
Prior art date
Application number
PCT/US2001/025242
Other languages
French (fr)
Other versions
WO2002012346A2 (en
WO2002012346A8 (en
Inventor
Porul D Doshi
Martin F Meier
Cynthia L Woods
Original Assignee
Pharmacia Corp
Porul D Doshi
Martin F Meier
Cynthia L Woods
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp, Porul D Doshi, Martin F Meier, Cynthia L Woods filed Critical Pharmacia Corp
Priority to CA002423519A priority Critical patent/CA2423519A1/en
Priority to JP2002518317A priority patent/JP2004523210A/en
Priority to AU2001286446A priority patent/AU2001286446A1/en
Priority to EP01965890A priority patent/EP1307559A2/en
Publication of WO2002012346A2 publication Critical patent/WO2002012346A2/en
Publication of WO2002012346A8 publication Critical patent/WO2002012346A8/en
Publication of WO2002012346A3 publication Critical patent/WO2002012346A3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Pain & Pain Management (AREA)
  • AIDS & HIV (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)

Abstract

The present invention relates to a new Slit-like protein obtained from a cDNA library from HS-5 stromal cell line, nucleic acid molecules that encode the Slit-like protein or a fragment thereof and nucleic acid molecules that are useful as probes or primers for detecting or amplifying the Slit-like protein, respectively. The invention further relates to uses of the Slit-like protein. The invention also relates to applications of the factor or fragment such as forming antibodies capable of binding the factor or fragments thereof.
PCT/US2001/025242 2000-08-10 2001-08-10 A new slit-like protein obtained from a cdna library from hs-5 stromal cell line WO2002012346A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002423519A CA2423519A1 (en) 2000-08-10 2001-08-10 A new slit-like protein obtained from a cdna library from hs-5 stromal cell line
JP2002518317A JP2004523210A (en) 2000-08-10 2001-08-10 Novel Slit-like protein obtained from cDNA library from HS-5 stromal cell line
AU2001286446A AU2001286446A1 (en) 2000-08-10 2001-08-10 A new slit-like protein obtained from a cdna library from hs-5 stromal cell line
EP01965890A EP1307559A2 (en) 2000-08-10 2001-08-10 Slit-like protein obtained from a cdna library from hs-5 stromal cell line

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63616900A 2000-08-10 2000-08-10
US09/636,169 2000-08-10

Publications (3)

Publication Number Publication Date
WO2002012346A2 WO2002012346A2 (en) 2002-02-14
WO2002012346A8 WO2002012346A8 (en) 2002-07-04
WO2002012346A3 true WO2002012346A3 (en) 2002-09-12

Family

ID=24550722

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/025242 WO2002012346A2 (en) 2000-08-10 2001-08-10 A new slit-like protein obtained from a cdna library from hs-5 stromal cell line

Country Status (5)

Country Link
EP (1) EP1307559A2 (en)
JP (1) JP2004523210A (en)
AU (1) AU2001286446A1 (en)
CA (1) CA2423519A1 (en)
WO (1) WO2002012346A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2007010586A1 (en) * 2005-07-14 2009-01-29 国立大学法人 東京大学 Hematopoietic stem cell identification agent
MX2010002716A (en) * 2007-09-14 2010-07-05 Scil Technology Gmbh Neuroendocrine factors for treatment of degenerative diseases.

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999035170A2 (en) * 1998-01-05 1999-07-15 Genentech, Inc. Compositions and methods for the treatment of tumor
WO2000042170A1 (en) * 1998-04-21 2000-07-20 Millennium Pharmaceuticals, Inc. Novel lrsg protein and nucleic acid molecules and uses therefor
WO2000061623A1 (en) * 1999-04-09 2000-10-19 Human Genome Sciences, Inc. 62 human secreted proteins
WO2001046418A1 (en) * 1999-12-21 2001-06-28 Zymogenetics, Inc. Human slit polypeptide zslit3

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999035170A2 (en) * 1998-01-05 1999-07-15 Genentech, Inc. Compositions and methods for the treatment of tumor
WO2000042170A1 (en) * 1998-04-21 2000-07-20 Millennium Pharmaceuticals, Inc. Novel lrsg protein and nucleic acid molecules and uses therefor
WO2000061623A1 (en) * 1999-04-09 2000-10-19 Human Genome Sciences, Inc. 62 human secreted proteins
WO2001046418A1 (en) * 1999-12-21 2001-06-28 Zymogenetics, Inc. Human slit polypeptide zslit3

Also Published As

Publication number Publication date
CA2423519A1 (en) 2002-02-14
WO2002012346A2 (en) 2002-02-14
JP2004523210A (en) 2004-08-05
WO2002012346A8 (en) 2002-07-04
AU2001286446A1 (en) 2002-02-18
EP1307559A2 (en) 2003-05-07

Similar Documents

Publication Publication Date Title
WO2002004523A3 (en) Artificial antibody polypeptides
WO2004035170A3 (en) Composition for separating molecules
WO2004058990A3 (en) Genetic polymorphisms associated with stenosis, methods of detection and uses thereof
WO2003104418A3 (en) Reconstituted polypeptides
WO2004029220A3 (en) Synthetic genes
WO2002014485A3 (en) Kallikrein gene
WO2002074928A3 (en) Fusion peptides isolatable by phase transition
WO2005005462A3 (en) Blys antagonists and uses thereof
WO2005111241A3 (en) Genetic polymorphisms associated with liver fibrosis methods of detection and uses thereof
EP1379693A4 (en) Bio-barcodes based on oligonucleotide-modified particles
WO2002055562A3 (en) Cyclodextrin sulfonates, guest inclusion complexes, methods of making the same and related materials
WO2002024912A3 (en) Isolated nucleic acid molecules which encode a soluble il-tif/il-22 receptor or binding protein which binds to il-tif/il-22, and uses thereof
WO2001036641A3 (en) DOUBLE-STRANDED RNA RECEPTOR (dsRNA-R) AND METHODS RELATING THERETO
WO2003046148A8 (en) Polypeptide quantitation
WO2002010393A3 (en) Isolated nucleic acid molecules which encode t cell inducible factors, or interleukin-21, the proteins encoded, and uses thereof
WO2004106367A3 (en) Enterococcus antigens
WO2004077038A3 (en) Stationary phase for use in capillary electrophoresis, capillary electrochromatography, microfluidics, and related methods
WO2002049625A3 (en) Compounds that affect cd83 expression, pharmaceutical compositions comprising said compounds and methods for identifying said compounds
WO2002012346A8 (en) A new slit-like protein obtained from a cdna library from hs-5 stromal cell line
WO2006135738A3 (en) Devices from prion-like proteins
WO2006060823A3 (en) Apoptosis-specific eif-5a and polynucleotides encoding same
WO2003018631A3 (en) Nogo receptor homologues and their use
WO2002061046A3 (en) Novel nucleic acid and polypeptide molecules
WO2005033286A3 (en) Compositions and methods for synthesizing, purifying and detecting biomolecules
WO2002012335A3 (en) A NEW EGF MOTIF REPEAT PROTEIN OBTAINED FROM A cDNA LIBRARY FROM HS-5 STROMAL CELL LINE

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: C1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: C1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i
WWE Wipo information: entry into national phase

Ref document number: 2423519

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2001965890

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2002518317

Country of ref document: JP

WWP Wipo information: published in national office

Ref document number: 2001965890

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 2001965890

Country of ref document: EP