WO2002011894A1 - Diaphragme - Google Patents

Diaphragme Download PDF

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Publication number
WO2002011894A1
WO2002011894A1 PCT/GB2001/003578 GB0103578W WO0211894A1 WO 2002011894 A1 WO2002011894 A1 WO 2002011894A1 GB 0103578 W GB0103578 W GB 0103578W WO 0211894 A1 WO0211894 A1 WO 0211894A1
Authority
WO
WIPO (PCT)
Prior art keywords
delivery device
aerosol delivery
valve
inhaler
medicament
Prior art date
Application number
PCT/GB2001/003578
Other languages
English (en)
Inventor
Philip Braithwaite
Original Assignee
Innovata Biomed Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innovata Biomed Limited filed Critical Innovata Biomed Limited
Priority to AU2001284156A priority Critical patent/AU2001284156A1/en
Publication of WO2002011894A1 publication Critical patent/WO2002011894A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A61M15/0093—Inhalators mechanically breath-triggered without arming or cocking, e.g. acting directly on the delivery valve
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
    • B05B11/06—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump
    • B05B11/062—Gas or vapour producing the flow, e.g. from a compressible bulb or air pump designed for spraying particulate material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/14—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas designed for spraying particulate materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Definitions

  • This invention relates to a novel method of producing an aerosol, to novel devices utilising such a method, e.g. using a flexible valve and to methods of treatment related thereto.
  • European Patent Application No. 0 160 336 describes a flexible container e.g. a shower gel container including a self-sealing dispensing valve.
  • the valve comprises a flexible resilient diaphragm with at least one slot. This valve is closed until pressure is applied to the flexible container which causes the valve to take up a convex shape and the slit opens.
  • the self-sealing valve described in the prior art is known to be used in, for example, containers for storage and dispensing of gels and/or viscous liquids since the resilient valve member will close when pressure is removed from the walls of the dispensing container. Such a valve is ideally suited for dispensing devices which are inverted in use.
  • valves have considerably extended the use of such valves. Not only have we found that they may be used with solid materials, such as powders, but upon opening of the valve, the ingress of air through the open valve is an aid to the dispersion of such solid materials.
  • valve of the prior art is especially advantageous in that it allows a mixture of air and powder, e.g. an aerosolised powder, to be ejected from a medicament delivery device.
  • a mixture of air and powder e.g. an aerosolised powder
  • a valve is especially suitable for use in generating an aerosol and especially a powder/air aerosol. Therefore, such a valve especially finds utility in an inhaler e.g. a dry powder inhaler (DPI) and may be suited to the delivery of a medicament into, for example, a holding chamber.
  • DPI dry powder inhaler
  • medicaments administered by inhalation may be administered in the form of a dry powder with the use of a dry powder inhaler (DPI) or in the form of a solution or suspension with the use of a pressurised metered dose inhaler (MDI).
  • DPI dry powder inhaler
  • MDI pressurised metered dose inhaler
  • a holding chamber such that an aerosolised medicament is dispensed from an inhaler and the medicament is momentarily held in the chamber before the patient inhales.
  • One disadvantage of such holding chambers is that, due to, ter alia, electrostatic charges, agglomeration of the aerosolised particles may occur and/or particles may be attached to the surfaces of the chamber.
  • a method of producing an aerosol which comprises placing a dispersible material adjacent the surface of a resiliently flexible diaphragm valve member and causing the valve member to flex and disperse the material.
  • the resiliently flexible diaphragm valve member is preferentially a valve such as described in EP 0 160 336.
  • the preferred valve comprises a resiliently deformable, concave shaped portion with its perimeter optionally sealingly secured across a discharge orifice.
  • the valve which will generally be self-sealing, may be secured across the orifice so that it is in a closed position.
  • the valve may be placed in an arrangement whereby it is inwardly concave or, alternatively, it may be outwardly concave when in the closed position.
  • the concave shaped portion of the valve may include at least one substantially linear slit extending through the thickness of the wall that comprises the concave portion of the valve.
  • the valve requires the attainment of a threshold opening pressure to effect inversion from the concave, at rest, position in order to dispense the material.
  • the valve When opened, the valve will generally move to a convex arrangement, thus the valve may present an outwardly facing convex surface or an inwardly facing convex surface when open.
  • the circumferential wall of the valve member may be provided with a plurality of circumferential spaced apart pimples on the inside surface of the wall.
  • the pimples are especially advantageous in the embodiment in which the valve is in an inwardly concave position at rest and an inwardly convex position when open.
  • the pimples may react against distortion of the side wall and therefore urge the valve back to a closed position.
  • a pressure differential is essential to reopen the valve member of the invention.
  • the valve used in the method of the invention has utility in a variety of areas, and is particularly suited for the generation of aerosols, e.g. powder aerosols, including, for. example, medicament delivery devices, such as inhalers, air fresheners or any other devices which rely upon an aerosol generation and especially a powder aerosol.
  • aerosols e.g. powder aerosols
  • medicament delivery devices such as inhalers, air fresheners or any other devices which rely upon an aerosol generation and especially a powder aerosol.
  • the valve and/or the method of the present invention are especially suited to use in conjunction with an inhaler, including an MDI, a DPI, an insufflator and a nebuliser.
  • an inhaler including an MDI, a DPI, an insufflator and a nebuliser.
  • the inhaler of the invention comprises a DPI.
  • dispersible material we particularly include a material which is aerosolisable e.g. an aerosolisable powder.
  • the dispersible material may be positioned on or near the surface of the diaphragm valve member and the term adjacent should be construed accordingly.
  • valve used herein is not novel per se, the use of a valve in aerosol generation is new and therefore any aerosol delivery device including such a valve is novel.
  • aerosol delivery device comprising a material reservoir, a metering member and a material outlet characterised in that the delivery device is provided with a valve as hereinbefore described.
  • the aerosol delivery device is provided with a resiliently flexible diaphragm valve member comprising a resiliently deformable, concave shaped member with its perimeter sealed across a discharge orifice so that it is inwardly concave in the closed position, the concave portion including at least one slit extending through the thickness of the concave portion of the valve.
  • aerosol delivery device is a medicament delivery device which comprises a medicament reservoir, a metering member and a medicament outlet characterised in that the delivery device is provided with a valve as hereinbefore described.
  • the medicament reservoir may be a bulk reservoir, in which a separate metering mechanism is provided. Such an arrangement is described in International Patent application No. WO 92/00771, which is incorporated herein by reference.
  • the medicament reservoir and metering member e.g. a metering mechanism, may comprise a single unit. Such an arrangement is described in European Patent No. 0 664 239, which is also incorporated herein by reference.
  • the medicament delivery device is an inhaler.
  • the valve is positioned adjacent to the metering mechanism.
  • a predetermined amount of medicament is dispensed adjacent to a non-dispensing surface of the diaphragm valve member when the metering mechanism is actuated.
  • the diaphragm valve member is then flexed by a change in pressure experienced by the diaphragm valve.
  • the pressure may be introduced by an increase in pressure on the non-dispensing surface of the valve member or, alternatively, by a decrease in pressure on the dispensing surface of the concave valve member, e.g. when a patient inhales.
  • the medicament is ejected through the outlet of the inhaler.
  • the process of aerosolisation may occur by the mechanical flexing of the diaphragm or the influx of air allowed through the open valve.
  • the process of aerosolisation may comprise a combination of the aforementioned steps.
  • the valve may be mechanically or electromechanically flexed.
  • the diaphragm may be flexed manually, for example, by the use of a flexible portion of the inhaler.
  • the pressure may be introduced by an increase in pressure on the non-dispensing surface of the valve member or, alternatively, by a decrease in pressure on the dispensing surface of the concave valve member, e.g. when a patient inhales.
  • the actuation of the metering mechanism and the flexing of the valve may occur separately, sequentially or together.
  • the inhaler of the invention may be provided with a holding chamber.
  • This may be a holding chamber which is conventionally know per se.
  • it may be an electrically charged holding chamber such as is described by our co-pending International application No. PCT/GBO 1/01993.
  • the inhaler of the invention may optionally include a conventionally known breath actuated mechanism.
  • the valve mechanism may comprise a membrane with a single aperture or a plurality of apertures.
  • the preferred valve mechanism is such as that described in European Patent Application No. 0 160 336, which is incorporated herein by reference.
  • an inhaler system comprising an inhaler in conjunction with a chamber as hereinbefore described.
  • the inhaler and chamber of the invention may be provided separately, together or as a kit of parts.
  • the particle size of the medicament may be varied depending, ter alia, on the type of aerosol being formed.
  • the particle size of the medicament, and the carrier, if one is present, may be varied.
  • the nature of the carrier may also be varied.
  • the particle size of the medicament may be substantially between 1 and 100 ⁇ m. That is, at least 90% w/w of the medicament should have a particle size of between 1 and 100 ⁇ m.
  • the preferred particle size may also depend upon the nature of the medicament being delivered. Thus, for example, for the treatment of respiratory disorders a particle size of 4 to 8 ⁇ m may be preferred, e.g. 6 ⁇ m. However, for the delivery of systematically active medicaments a smaller particle size may be desirable, for example from 1 to 5 ⁇ m, e.g. 3 ⁇ m.
  • a variety of carriers may be used.
  • Certain carriers may be mentioned, by way of example only, such as sugars, e.g. dextran, mannitol and lactose, for example ⁇ -lactose monohydrate.
  • the particle size of the carrier may be across a wide range, between 0.1 and 500 ⁇ m, preferably between 50 and 500 ⁇ m, more preferably between 50 and 400 ⁇ m.
  • the carrier may itself comprise a mixture of fine and coarse particles.
  • a method of drug delivery to a patient which comprises administering a medicament to a patient suffering a respiratory disorder which comprises administering a therapeutically effective amount of a medicament using an inhaler as hereinbefore described.
  • a flexible diaphragm valve in the manufacture of an inhaler as hereinbefore described.
  • a valve as described in EP 0 160 336.
  • the diaphragm valve member may vary depending upon the nature of the material intended to pass through the valve. Most importantly it should be a flexible, resilient and/or elastomeric. The material may preferentially be non-porous. More particularly when the valve mechanism is used such it is actuated by a gas pressure differential, as in a breath actuated MDI, then the membrane material should be non-gas permeable.
  • plastics materials are well suited for use as the valve member material, an elastomer such as silicone rubber being one example of such a plastics material.
  • Other examples include, but are not limited to, polyvinyl chloride, urethane, ethylene vinyl acetate and styrene butadiene copolymer.
  • the inhaler of the invention is advantageous in that, ter alia, it enables the delivery of dispersions of finely divided forms of medicament and avoids some if the disadvantageous of agglomeration experienced with some known DPIs.
  • conventionally known DPIs operate as passive systems, i.e. they generally act independently of a patient's inspiratory flow rate.
  • the inhalers of the present invention provide an active system which is dependent on inspiratory flow rate.
  • medicaments may be administered by using the inhaler of the invention, such medicaments may have a systemic or non-systemic activity on the patient.
  • medicaments are generally (but not limiting) antibiotics, bronchodilators or other anti-asthma drugs.
  • medicaments include, but are not limited to ⁇ 2 -agonists, e.g. fenoterol, formoterol, pirbuterol, reproterol, rimiterol, salbutamol, salmeterol and terbutaline; non-selective beta-stimulants such as isoprenaline; xanthine bronchodilators, e.g.
  • anticholinergics e.g. ipratropium bromide
  • mast cell stabilisers e.g. sodium cromoglycate and ketotifen
  • bronchial anti-inflammatory agents e.g. nedocromil sodium
  • steroids e.g. beclomethasone dipropionate, fmticasone, budesonide and flunisolide; and combinations thereof.
  • medicaments which may be mentioned include combinations of steroids, such as, beclomethasone dipropionate, fluticasone, budesonide and flunisolide; and combinations of to ⁇ -agonists, such as, formoterol and salmeterol. It is also within the scope of this invention to include combinations of one or more of the aforementioned steroids with one or more of the aforementioned ⁇ 2 -agonists.
  • steroids such as, beclomethasone dipropionate, fluticasone, budesonide and flunisolide
  • to ⁇ -agonists such as, formoterol and salmeterol. It is also within the scope of this invention to include combinations of one or more of the aforementioned steroids with one or more of the aforementioned ⁇ 2 -agonists.
  • medicaments which may be mentioned include systemically active materials, such as, proteinaceous compounds and or macromolecules, for example, hormones, such as insulin, human growth hormone, leuprolide and alpha interferon; growth factors, anticoagulants, immunomodulators, cytokines and nucleic acids.
  • hormones such as insulin, human growth hormone, leuprolide and alpha interferon
  • growth factors such as anticoagulants, immunomodulators, cytokines and nucleic acids.
  • the device of the invention When the device of the invention is used for the delivery of macromolecules, such as insulin, it is important that they be provided in a moisture resistant system.
  • a moisture resistant coating e.g. a paraxylylene coating.
  • FIG. 1 is a perspective drawing of a valve of the invention in the closed position
  • Figure 2 is a cross-sectional view of a valve of the invention in the closed position
  • Figure 3 is a perspective drawing of a valve of the invention in the open position
  • Figure 4 is a cross-sectional view of a valve of the invention in the open position
  • Figure 5 is a cross-sectional view of a valve of the invention in the closed position with a powdered medicament in place
  • Figure 6 is a cross-sectional view of a valve of the invention in the open position with medicament being discharged;
  • Figure 7 is a cross-sectional view of an inverted valve of the invention in the closed position with a powdered medicament in place;
  • Figure 8 is a cross-sectional view of an inverted valve of the invention in the open position with medicament being discharged;
  • Figures 9a and 9b are perspective views of a valve of the invention illustrating the pimples on the valve; and Figure 10 is a schematic representation of an inhaler comprising a valve of the invention.
  • a diaphragm valve (1) comprises a circular peripheral flange (2) surrounding a concave valve member (3).
  • the flange is connected to an annular portion (4).
  • the concave valve member (3) comprises a flexible material and is provided with a slit (5) or a pair of slits in its body.
  • the version illustrated shows a pair of slits in the form of a cross, although it will be appreciated that a variety of slit arrangements may be suitable for the invention to perform satisfactorily.
  • the concave valve member (3) is provided with a dispensing surface (6) and a non-dispensing surface (7). Generally the dispensing surface (6) is the upper surface and the non-dispensing surface (7) is the lower surface.
  • valve (1) when the valve (1) is actuated pressure is applied either directly or indirectly to the non-dispensing surface (7) of the valve member (3). This causes the concave valve member (3) to flex and take up a concave form.
  • the slit (5) opens to create an aperture (8).
  • a powdered medicament (9) is dispensed onto the dispensing surface (6) of the concave valve member (3). Pressure is applied to the non-dispensing surface (7) of the valve member (3) causing the slit (5) to open to form aperture (8).
  • the pressure may be introduced by an increase in pressure on the non-dispensing surface (7) of the valve member (3) or, alternatively, by a decrease in pressure on the dispensing surface (6) of the concave valve member (3), e.g. when a patient inhales.
  • the flexing on the valve member (3) itself can cause the medicament (9) to be dispersed, alternatively, as the slit (5) opens to form an aperture (8) air is allow through the aperture (8) and the rush of air facilitates dispersion of the medicament (9).
  • the dispersion of the aerosolised powder may utilise a combination of the flexing of the valve member and the rush of air through the aperture.
  • a powdered medicament (9) is dispensed onto a concave dispensing surface (10) of the valve member (3). Pressure is applied to the non-dispensing surface (11) of the valve member (3) causing the slit (5) to open to form aperture (8).
  • the valve member of the invention is provided with a plurality of circumferential spaced apart pimples (12) on the inside surface (13) of the wall (4) of the valve member (3).
  • the pimples (12) are especially advantageous in the embodiment of Figures 7 and 8.
  • the pimples (12) react against distortion of the side wall and therefore urge the valve back to a closed position.
  • a pressure differential is essential to reopen the valve member of the invention.
  • an inhaler (14) comprises an inhalation passage (15) which comprises at one end (16) a piston (17) adjacent to a valve member (18). Downstream (in the direction of the arrow) of the valve member (18) is a medicament dispenser (19) in the form of a spool, e.g. as described in European Patent Application No. 0 626 689, in a spool cavity (20) and further downstream, the inhalation passage is provided with an outlet (21).
  • a medicament containing spool (19) is brought into coincidence with the inhalation passage (15) and medicament is dispensed into the passage (15).
  • the piston (17) is urged towards the valve (18), which is caused by the pressure differential to flex to an open position.
  • the medicament is therefore aerosolised and exits at an outlet (21).

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un procédé de fabrication d'un aérosol consistant à placer une matière dispersable (9) de manière que celle-ci soit adjacente à une surface (10) d'un élément de vanne à diaphragme élastiquement souple (3) et à contraindre l'élément de vanne de s'incurver et de dissiper la matière. L'invention concerne également un dispositif d'administration d'aérosol comprenant un élément de forme concave pouvant être élastiquement déformé et dont le périmètre est scellé à travers un orifice de décharge, de manière que celui-ci soit concave vers l'intérieur dans la position fermée, la partie concave comprenant au moins une fente (5) s'étendant à travers l'épaisseur de la vanne.
PCT/GB2001/003578 2000-08-09 2001-08-09 Diaphragme WO2002011894A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001284156A AU2001284156A1 (en) 2000-08-09 2001-08-09 Diaphragm

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0019429.0A GB0019429D0 (en) 2000-08-09 2000-08-09 Diaphragm
GB0019429.0 2000-08-09

Publications (1)

Publication Number Publication Date
WO2002011894A1 true WO2002011894A1 (fr) 2002-02-14

Family

ID=9897185

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/003578 WO2002011894A1 (fr) 2000-08-09 2001-08-09 Diaphragme

Country Status (3)

Country Link
AU (1) AU2001284156A1 (fr)
GB (1) GB0019429D0 (fr)
WO (1) WO2002011894A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008034504A2 (fr) * 2006-09-20 2008-03-27 Boehringer Ingelheim International Gmbh Inhalateur
US8448534B2 (en) 2007-05-18 2013-05-28 Malvern Instruments Incorporated Method and apparatus for dispersing a sample of particulate material
US9179691B2 (en) 2007-12-14 2015-11-10 Aerodesigns, Inc. Delivering aerosolizable food products

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0160336A2 (fr) 1984-04-27 1985-11-06 The Procter & Gamble Company Récipient souple muni d'une valve auto-refermable pour assurer une fermeture automatique et empêcher les fuites lors d'un rangement en position inversée
WO1992000771A1 (fr) 1990-07-13 1992-01-23 Innovata Biomed Limited Inhalateur
EP0514085A1 (fr) * 1991-05-14 1992-11-19 Scott Dibben Pty Limited Inhalateur pour aerosol
EP0664239A1 (fr) 1994-01-21 1995-07-26 Mittelhäuser, Bernhard Rétroviseur extérieur pour véhicules
US5437271A (en) * 1993-04-06 1995-08-01 Minnesota Mining And Manufacturing Company Deagglomerators for dry powder inhalers
WO2001001993A1 (fr) 1999-07-02 2001-01-11 Greither, Peter Preparation de sulfate de glucosamine

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0160336A2 (fr) 1984-04-27 1985-11-06 The Procter & Gamble Company Récipient souple muni d'une valve auto-refermable pour assurer une fermeture automatique et empêcher les fuites lors d'un rangement en position inversée
WO1992000771A1 (fr) 1990-07-13 1992-01-23 Innovata Biomed Limited Inhalateur
EP0514085A1 (fr) * 1991-05-14 1992-11-19 Scott Dibben Pty Limited Inhalateur pour aerosol
US5437271A (en) * 1993-04-06 1995-08-01 Minnesota Mining And Manufacturing Company Deagglomerators for dry powder inhalers
EP0664239A1 (fr) 1994-01-21 1995-07-26 Mittelhäuser, Bernhard Rétroviseur extérieur pour véhicules
WO2001001993A1 (fr) 1999-07-02 2001-01-11 Greither, Peter Preparation de sulfate de glucosamine

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008034504A2 (fr) * 2006-09-20 2008-03-27 Boehringer Ingelheim International Gmbh Inhalateur
WO2008034504A3 (fr) * 2006-09-20 2008-06-05 Boehringer Ingelheim Int Inhalateur
US8528548B2 (en) 2006-09-20 2013-09-10 Boehringer Ingelheim International Gmbh Inhaler
US8448534B2 (en) 2007-05-18 2013-05-28 Malvern Instruments Incorporated Method and apparatus for dispersing a sample of particulate material
US9179691B2 (en) 2007-12-14 2015-11-10 Aerodesigns, Inc. Delivering aerosolizable food products

Also Published As

Publication number Publication date
GB0019429D0 (en) 2000-09-27
AU2001284156A1 (en) 2002-02-18

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