WO2002011761A3 - Vaccin contre le virus respiratoire syncytial (rs) - Google Patents

Vaccin contre le virus respiratoire syncytial (rs) Download PDF

Info

Publication number
WO2002011761A3
WO2002011761A3 PCT/US2001/041633 US0141633W WO0211761A3 WO 2002011761 A3 WO2002011761 A3 WO 2002011761A3 US 0141633 W US0141633 W US 0141633W WO 0211761 A3 WO0211761 A3 WO 0211761A3
Authority
WO
WIPO (PCT)
Prior art keywords
vaccine
protein
vaccine against
against rsv
rsv
Prior art date
Application number
PCT/US2001/041633
Other languages
English (en)
Other versions
WO2002011761A2 (fr
Inventor
James J Mond
Gregory Prince
Dennis M Klinman
Original Assignee
Jackson H M Found Military Med
James J Mond
Gregory Prince
Dennis M Klinman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jackson H M Found Military Med, James J Mond, Gregory Prince, Dennis M Klinman filed Critical Jackson H M Found Military Med
Priority to AU2001285421A priority Critical patent/AU2001285421A1/en
Publication of WO2002011761A2 publication Critical patent/WO2002011761A2/fr
Publication of WO2002011761A3 publication Critical patent/WO2002011761A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un vaccin comprenant des oligodidésoxynucléotides (ODN) adjuvants, renfermant au moins un dinucléotide CpG et un antigène qui comporte une séquence peptidique porteuse d'au moins un épitope de protéine F de Paramyxoviridae. Selon une variante, l'ODN est mélangé et conjugué à une protéine F de virus RS. Le vaccin peut être administré directement au tissu des muqueuses des voies respiratoires, par inhalation ou voie intranasale.
PCT/US2001/041633 2000-08-10 2001-08-09 Vaccin contre le virus respiratoire syncytial (rs) WO2002011761A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001285421A AU2001285421A1 (en) 2000-08-10 2001-08-09 Vaccine against rsv

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22401100P 2000-08-10 2000-08-10
US60/224,011 2000-08-10
US22930700P 2000-09-01 2000-09-01
US60/229,307 2000-09-01

Publications (2)

Publication Number Publication Date
WO2002011761A2 WO2002011761A2 (fr) 2002-02-14
WO2002011761A3 true WO2002011761A3 (fr) 2003-01-23

Family

ID=26918345

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/041633 WO2002011761A2 (fr) 2000-08-10 2001-08-09 Vaccin contre le virus respiratoire syncytial (rs)

Country Status (2)

Country Link
AU (1) AU2001285421A1 (fr)
WO (1) WO2002011761A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8466116B2 (en) * 2001-12-20 2013-06-18 The Unites States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of CpG oligodeoxynucleotides to induce epithelial cell growth
SE0201701D0 (sv) * 2002-06-05 2002-06-05 Gotovax Ab Treatment of epithelial tumors and infections

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996002555A1 (fr) * 1994-07-15 1996-02-01 The University Of Iowa Research Foundation Oligonucleotides immunomodulateurs
WO1999061056A2 (fr) * 1998-05-22 1999-12-02 Loeb Health Research Institute At The Ottawa Hospital Methodes et produits permettant d'induire une immunite au niveau des muqueuses
WO2000062802A2 (fr) * 1999-04-20 2000-10-26 Smithkline Beecham Biologicals Sa Vaccin

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996002555A1 (fr) * 1994-07-15 1996-02-01 The University Of Iowa Research Foundation Oligonucleotides immunomodulateurs
WO1999061056A2 (fr) * 1998-05-22 1999-12-02 Loeb Health Research Institute At The Ottawa Hospital Methodes et produits permettant d'induire une immunite au niveau des muqueuses
WO2000062802A2 (fr) * 1999-04-20 2000-10-26 Smithkline Beecham Biologicals Sa Vaccin

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HANCOCK G E ET AL: "CpG containing oligodeoxynucleotides are potent adjuvants for parenteral vaccination with the fusion (F) protein of respiratory syncytial virus (RSV)", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 19, no. 32, 14 September 2001 (2001-09-14), pages 4874 - 4882, XP004303185, ISSN: 0264-410X *
TEBBEY P W ET AL: "A NOVEL AND EFFECTIVE INTRANASAL IMMUNIZATION STRATEGY FOR RESPIRATORY SYNCYTIAL VIRUS", VIRAL IMMUNOLOGY, MARY ANN LIEBERT, INC., NEW YORK, US, vol. 12, no. 1, 1999, pages 41 - 45, XP001055775, ISSN: 0882-8245 *

Also Published As

Publication number Publication date
WO2002011761A2 (fr) 2002-02-14
AU2001285421A1 (en) 2002-02-18

Similar Documents

Publication Publication Date Title
WO2001068116A3 (fr) Prevention et traitement d'infections respiratoires virales au moyen de sequences polynucleotidiques immunomodulatoires
WO2002028422A3 (fr) Vaccin
ATE250937T1 (de) Chitosan und influenza-antigen(e) enthaltende impfstoff-zubereitungen zur verabreichung durch eine mukosa
WO2001060402A3 (fr) Vaccin antigrippal a base de proteosomes
DE69426077D1 (de) Adjuvantien für impfstoffe gegen das respiratorische synzitialvirus
PT1409692E (pt) Novos péptidos do derivados da proteína g do vírus respiratório sincicial (vrs) e sua utilização numa vacina
WO2004080403A3 (fr) Vaccin contre le virus de la grippe
WO2002028426A8 (fr) Vaccin
WO2001092470A3 (fr) Vecteurs d'expression d'adn et procedes d'utilisation
WO2003039595A3 (fr) Modeles ameliores de vaccins administrables par voie muqueuse et modes d'utilisation
AU2001263443A1 (en) F-protein epitope-based vaccine for respiratory syncytial virus infection
WO2002087494A3 (fr) Nouveau vaccin
AU2238597A (en) Iscom or iscom-matrix comprising a mucus targetting substance and optionally, an antigen
WO2000035481A3 (fr) Composition immunogene polyvalente contenant une composition de sous-unite de rsv et une preparation d'influenzavirus
WO2006076587A3 (fr) Peptides destines a l'administration de vaccins muqueux
WO2001095934A3 (fr) Utilisation de corps lipidiques vegetaux dans des systemes d'administration vaccinaux
ATE287957T1 (de) Peptide abgeleitet vom bindungs (g) protein des respiratorisches synzytialvirus
WO2006114312A3 (fr) Vaccin
WO2002058725A3 (fr) Peptides non glycosyles derives de la proteine g du vrs et leur utilisation dans un vaccin
WO2002011761A3 (fr) Vaccin contre le virus respiratoire syncytial (rs)
AUPQ797700A0 (en) Vaccine
DK0682950T3 (da) Slimhindeadministration af pneumokok-antigener
WO2001070265A3 (fr) Adjuvants lipopeptidiques
WO2002009749A3 (fr) Vaccin contre le virus respiratoire syncytial
WO2000062802A3 (fr) Vaccin

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU CA JP US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP