WO2002010136A1 - 3-substituted isoquinolin-1-yl derivatives - Google Patents
3-substituted isoquinolin-1-yl derivatives Download PDFInfo
- Publication number
- WO2002010136A1 WO2002010136A1 PCT/GB2001/003429 GB0103429W WO0210136A1 WO 2002010136 A1 WO2002010136 A1 WO 2002010136A1 GB 0103429 W GB0103429 W GB 0103429W WO 0210136 A1 WO0210136 A1 WO 0210136A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- group
- optionally substituted
- compound according
- alk
- groups
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Definitions
- This invention relates to a series of 3-substituted isoquinolin-1 -yl derivatives, to compositions containing them, to processes for their preparation, and to their use in medicine.
- the adhesion molecules have been sub-divided into different groups on the basis of their structure.
- One family of adhesion molecules which is believed to play a particularly important role in regulating immune and inflammatory responses is the integrin family.
- This family of cell surface glycoproteins has a typical non-covalently linked heterodimer structure. At least 16 different integrin alpha chains and 8 different integrin beta chains have been identified [Newman, P. et al, Molecular Medicine Today, 304, (1996)].
- the members of the family are typically named according to their heterodimer composition although trivial nomenclature is widespread in the field.
- the integrin ⁇ 4 ⁇ 1 consists of the integrin alpha 4 chain associated with the integrin beta 1 chain, but is also widely referred to as ery Late Antigen 4 or VLA-4. Not all of the potential pairings of integrin alpha and beta chains have yet been observed in nature and the integrin family has been subdivided into a number of subgroups based on the pairings that have been recognised to date [Sonnenberg, A., Current Topics in Microbiology and Immunology, 184, 7, (1993)].
- LAD LAD
- Glanzman's thrombasthenia a defect in a member of the beta 3 integrin family
- blood clotting Hodivala-Dilke, K. M., J. Gin. Invest. 103, 229, (1999)
- Integrins recognize both cell surface and extracellular matrix ligands, and ligand specificity is determined by the particular alpha-beta subunit combination of the molecule [Newman, P., ibid .
- One particular integrin subgroup of interest involves the ⁇ 4 chain which can pair with two different beta chains ⁇ 1 and ⁇ 7 [Sonnenberg, A., ibid].
- the ⁇ 4 ⁇ 1 pairing occurs on many circulating leukocytes (for example lymphocytes, monocytes, eosinophils and basophils) although it is absent or only present at low levels on circulating neutrophils.
- VCAM-1 Vascular Cell Adhesion Molecule-1 also known as VCAM-1
- VCAM-1 an adhesion molecule
- the molecule has also been shown to bind to at least three sites in the matrix molecule fibronectin [Humphries, M. J. et al, Ciba " Foundation Symposium, 189, 177, (1995)].
- fibronectin a matrix molecule fibronectin
- the integrin generated by the pairing of 4 and ⁇ 7 has been termed LPAM-1 [Holzmann, B. and Weissman, I. L, EMBO J. 8, 1735, (1989)].
- the ⁇ 4 ⁇ 7 pairing is expressed on certain sub-populations of T and B lymphocytes and on eosinophils [Erie, D. J. et al, J. Immunol. 153. 517 (1994)].
- 4 ⁇ 7 binds to VCAM-1 and fibronectin.
- ⁇ 4 ⁇ 7 binds to an adhesion molecule believed to be involved in the homing of leukocytes to mucosal tissue termed MAdCAM-1 [Berlin, C.
- Regions of the peptide sequence recognizeded by ⁇ 4 ⁇ 1 and 4 ⁇ 7 when they bind to their ligands have been identified.
- ⁇ 4 ⁇ 1 seems to recognise LDV, IDA or REDV peptide sequences in fibronectin and a QIDSP sequence in VCAM-1 [Humphries, M. J. et al, ibid] whilst ⁇ 4 ⁇ 7 recognises a LDT sequence in MAdCAM-1 [Birskin, M. J. et al, J. Immunol. 156. 719, (1996)].
- inhibitors of these interactions being designed from modifications of these short peptide sequences [Cardarelli, P. M. et al, J. Biol.
- alpha 4 subgroup of integrins are predominantly expressed on leukocytes their inhibition can be expected to be beneficial in a number of immune or inflammatory disease states.
- the ubiquitous distribution and wide range of functions performed by other members of the integrin family it is important to be able to identify selective inhibitors of the alpha 4 subgroup.
- Members of the group are able to inhibit 4 integrins such as 4 ⁇ 1 and 4 ⁇ 7 at concentrations at which they generally have no or minimal inhibitory action on integrins of other subgroups.
- the 3-substituted isoquinlin-1-yl derivatives show unexpectedly high inhibition of ⁇ 4-integrins when compared to unsubstituted isoquinolin-1-yl derivatives. Additionally, the 3- substituted isoquinolin-1-yl derivatives of the invention show a surprisingly improved pharmacokinetic profile in comparison to unsubstituted isoquinolin-1 -yl derivatives, particularly improved bioavailability.
- the compounds are thus of use in medicine, for example in the prophylaxis and treatment of immune or inflammatory disorders as described hereinafter.
- R 1 is a hydrogen atom or a C-
- L 1 is a covalent bond or a linker atom or group
- Alk 1 is an optionally substituted aliphatic chain; n is zero or the integer 1 ;
- R 2 is a hydrogen atom or an optionally substitued heteroaliphatic, cycloaliphatic, heterocycloaliphatic, polycycloaliphatic, heteropolycyclo- aliphatic, aromatic or heteroaromatic group;
- Alk is a chain
- R is a carboxylic acid (-CO 2 H) or a derivative or biostere thereof;
- Ar 2 is an optionally substituted aromatic or heteroaromatic linking group;
- L 2 is a covalent bond or a linker atom or group;
- R 16 is the group -L 3 (Alk 2 )tL 4 R 20 in which L 3 and L 4 which may be the same or different is each a covalent bond or a linker atom or group, t is zero or the integer 1 , Alk 2 is an optionally substituted aliphatic or heteroaliphatic chain and R 20 is an optionally substituted aromatic or heteroaromatic group; g is zero or the integer 1 , 2, 3, 4 or 5; each R 17 which may be the same or different is a hydrogen or halogen atom or an optionally substituted straight or branched alkyl, alkoxy, alkylthio or cycloalkyl aromatic or heteroaromatic group or a thiol (-SH), hydroxyl (-OH), amino (-NH 2 ), -N(R )(R 4 ) [where R 3 and R 4 is each independently a hydrogen atom or an optionally substituted alkyl group or together with the N atom to which they are attached R 3 and R 4 alkyl
- compounds of formula (1) may have one or more chiral centres, and exist as enantiomers or diastereomers. The invention is to be understood to extend to all such enantiomers, diastereomers and mixtures thereof, including racemates.
- Formula (1) and the formulae hereinafter are intended to represent all individual isomers and mixtures thereof, unless stated or shown otherwise.
- Formula (1) and the formulae hereinafter are intended to represent all individual tautomers and mixtures thereof, unless stated otherwise.
- Optionally substituted aromatic and heteroaromatic groups represented by R 20 in the group -L 3 (Alk 3 )tL 4 R 20 include those optionally substituted aromatic and heteroaromatic groups as described hereinafter for the group R 2 , for example C6- ⁇ 2 monocyclic aromatic groups or C-i-gmonocyclic heteroaromatic groups.
- Optional substituents (R 18 ) that may be present on such aromatic and heteroaromatic groups include those optional substituents as described hereinafter for R 2 aromatic and heteroaromatic groups.
- L 3 and/or L 4 is present in these substituents as a linker atom or group it may be any divalent linking atom or group.
- Particular examples include -O- or -S- atoms or -C(O)-, -C(0)0-, -OC(O)-, -C(S)- ( -S(O)-, -S(0) 2 -, -N(R 8 )- [where R 8 is a hydrogen atom or an optionally substituted alkyl group], -N(R 8 )0-, -N(R 8 )N-, -CON(R 8 )-, -OC(0)N(R 8 )-, -CSN(R ⁇ )-, -N(R 8 )CO-, -N(R 8 )C(0)0-, -N(R 8 )CS-, -S(O) 2 N(R 8 )-, -N(R 8 )S(0) 2 -, -N(R 8 )CON
- R 8 When R 8 is present as an alkyl group it may be a straight or branched C ⁇ _ ⁇ alkyl group, e.g. a C ⁇ -3alkyl group such as a methyl or ethyl group or a C3-8cycloalkyl group particularly a C3-6cycloalkyl group e.g. a cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl group.
- C ⁇ _ ⁇ alkyl group e.g. a C ⁇ -3alkyl group such as a methyl or ethyl group or a C3-8cycloalkyl group particularly a C3-6cycloalkyl group e.g. a cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl group.
- Optional substituents which may be present on such groups include for example one, two or three substituents which may be the same or different selected from halogen atoms, for example fluorine, chlorine, bromine or iodine atoms, or hydroxy or C-
- halogen atoms for example fluorine, chlorine, bromine or iodine atoms, or hydroxy or C-
- Alk 2 is present as an aliphatic or heteroaliphatic chain it may be for example any divalent chain corresponding to the below-mentioned aliphatic chains described for Alk 1 or heteroaliphatic groups described for R 2 in which one of the terminal hydrogen atoms is replaced by a bond.
- Examples of the substituent represented by -L 3 (Alk )tL 4 R 20 which is present at the 3-position of the isoquinoline ring as the group R 16 in compounds of the invention include atoms or groups -L 3 Alk 2 L 4 R 20 , -L 3 Alk 2 R o, -L 3 R 2 0, -R 2 0 and -Alk 2 R o wherein L 3 , Alk 2 , L 4 and R ° are as defined above.
- substituents include -L 3 CH 2 L 4 R 2 0 , -L 3 CH(CH 3 )L 4 R 2 0 , -L 3 (CH 2 ) 2 L R 20 , -L 3 CH 2 R 2 0, -L 3 CH(CH 3 )R 2 0, -L 3 (CH 2 )2R 20 , -CH 2 R 0, -CH(CH 3 )R 2 0 , -(CH 2 ) 2 R 2 ° and -R 20 groups.
- R 20 optionally substituted aromatic and heteroaromatic groups when present in the group -L 3 (Alk 3 )tL 4 R 20 include optionally substituted phenyl, furyl, thienyl, triazolyl, imidazolyl, pyridyl, pyrimidinyl, thiazolyl, oxazolyl, isoxazolyl, isothiazolyl, pyrazolyl and triazinyl groups.
- R 16 substituents represented by -L 3 (Alk 2 )tL R 20 in compounds of the invention include optionally substitued phenyl, furyl, thienyl, triazolyl, imidazolyl, pyridyl, pyrimidinyl, thiazolyl, oxazolyl, isoxazolyl, isothiazolyl, pyrazolyl, triazinyl, benzyl, furylmethyl, thienylmethyl, imidazolylmethyl, pyridylmethyl, pyrimidinylmethyl, benzyloxy, furylmethyloxy, thienylmethyloxy, imidazolylmethyloxy, pyridylmethyloxy, pyrimidinylmethyloxy, phenyloxy, furyloxy, thienyloxy, pyridyloxy, pyrimidinyloxy, phenyltio, furylthio, thienylthio, pyri
- pyrimidinylamino phenylmethylamino, furylmethyl- amino, thienylmethylamino, pyridylmethylamiino, pyrimidinylmethylamino, ⁇ /-methyIphenylmethylamino, ⁇ /-methylfurylmethylamino, ⁇ /-methylthienyl- methylamino, /V-methylpyridylmethylamino, ⁇ /-methylpyridinylmethylamino, phenylcarbonyl, furylcarbonyl, thienylcarbonyl, pyridylcarbonyl and pyrimidinylcarbonyl groups.
- R 17 is an optionally substituted alkyl group it may be for example an optionally substituted Ci- ⁇ alkyl group, e.g. an optionally substituted methyl, ethyl, propyl or isopropyl group.
- Optional substituents which may be present on R 7 alkyl groups include those optional substituents as described in relation to R 2 heteroaliphatic chains hereinafter.
- Particular examples of optionally substituted R 17 alkyl groups include -CF 3 , -CHF 2 , -CH 2 F, -CCI 3 , -CHCI 2 , -CH 2 CI, -CH 2 OCH 3 and -CH 2 OCH 2 CH 3 groups.
- R 1 7 When the substituent R 1 7 is an optionally substituted alkoxy group it may be for example an optionally substituted methoxy, ethoxy, propoxy or isopropoxy group.
- Optional substituents that may be present include those just described for R 17 alkyl groups.
- Particular examples of R 17 optionally substituted alkoxy groups include -OCF3, -OCHF 2 , -OCHF, -OCCI 3) -OCHCI 2 , -OCH 2 CI, -OCH 2 OCH 3 and -OCH 2 OCH 2 CH3 groups.
- R 17 When R 17 is an optionally substituted alkylthio group it may be for example an optionally substituted methylthio, ethylthio or isopropylthio group.
- Optional substituents which may be present include those optional substituents as just described for R 17 alkyl groups.
- R 17 is an optionally substituted cycloalkyl group it may be for example an optionally substituted C 3 -8cycloalkyl group, especialy a C3- ⁇ cycloalkyl group e.g. cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl.
- Optional substituents which may be present include those optional substituents just described for R 17 alkyl groups.
- R 17 is an optionally substituted aromatic or heteroaromatic group it may be any aromatic or heteroaromatic group as described hereinafter for the group R 2 .
- Optional substituents which may be present on R 17 aromatic and heteroaromatic groups include those optional substituents described for R 2 aromatic and heteroaromatic groups.
- Particular examples of optionally substituted aromatic groups include optionally substituted phenyl, furyl, thienyl, pyridyl and pyrimidinyl groups.
- R 3 , R 4 and/or R 5 is present in R 17 groups as an optionally substituted alkyl group it may be any optionally substituted alkyl group as previously described for R 8 .
- heterocyclic rings may be optionally interrupted by a further heteroatom selected from -0-, -S- or -N(R 3 )-.
- heterocyclic rings include piperidinyl, morpholinyl, thiomorpholinyl, pyrrolidinyl, imidazolidinyl and piperazinyl rings.
- two R 17 substituents may be linked together to form a cyclic group such as a cyclic ether e.g. a C-i- ⁇ alkylenedioxy group such as methylenedioxy or ethylenedioxy.
- L 2 when present in compounds of the invention may be a linker atom or group L 2a or a linker -Alk a (L 2a ) y -, where Alk a is an optionally substituted aliphatic or heteroaliphatic chain as previously defined for Alk 2 , L 2a is a covalent bond or a linker atom or group as described above for L 3 and L 4 , and y is zero or the integer 1.
- Optionally substituted aromatic or heteroaromatic linking groups represented by Ar 2 include those aromatic or heteroaromatic groups described hereinafter in relation to R 2 aromatic or heteroaromatic groups respectively where said groups become divalent linking groups, for example phenylene, pyridinylene or pyrimidinylene groups.
- the optional substituents which may be present on these groups include one, two, three or four optional substituents (R 17a , R 17b , R 17c and R 1 7d ) where said substituents include those R 17 optional substituents described hereinbefore.
- R When the group R is present in compounds of the invention as a derivative of a carboxylic acid it may be for example a carboxylic acid ester or amide. Particular esters and amides include -C0 2 Alk 7 and -CONR 3 R 4 groups as defined herein.
- R When R is a biostere of a carboxylic acid it may be for example a tetrazole or other acid such as phosphonic acid, phosphinic acid, sulphonic acid, sulphinic acid or boronic acid or an acylsulphonamide group.
- Esters (-C0 Alk 7 ) and amide (-CONR 3 R 4 ) derivatives of the carboxylic acid group (-C0 H) in compounds of formula (1) may advantageously be used as prodrugs of the active compound.
- Such prodrugs are compounds which undergo biotransformation to the corresponding carboxylic acid prior to exhibiting their pharmacological effects and the invention particularly extends to prodrugs of the acids of formula (1).
- Such prodrugs are well known in the art, see for example International Patent Application No. WO00/23419, Bodor, N. (Alfred Benzon Symposium, 1982, 17, 156-177), Singh, G. et al (J. Sci. Ind. Res., 1996, 55, 497-510) and Bundgaard, H., (Design of Prodrugs, 1985, Elsevier, Amsterdam).
- Esterified carboxyl groups represented by the group R 13a include groups of formula -C0 2 Alk 7 wherein Alk 7 is a straight or branched optionally substituted C-i-salkyl group such as a methyl, ethyl, n-propyl, i-propyl, n- butyl, i-butyl, s-butyl or t-butyl group; an optionally substituted C 2 -8alkenyl group such as a propenyl e.g. 2-propenyl or butenyl e.g.
- 2-butenyl or 3- butenyl group an optionally substituted C2-8a' ynyl group such as a ethynyl, propynyl e.g. 2-propynyl or butynyl e.g. 2-butynyl or 3-butynyl group, an optionally substituted C3-scycloalkyl group such as a cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl or cycloheptyl group; an optionally substituted Cs- ⁇ cycloalkylC-i -salky!
- -6alkyl group such as a morpholinyl-N-ethyl, thiomorpholinyl-N-methyl, pyrrolidinyl-N-ethyl, pyrrolidinyl-N-propyl, piperidinyl-N-ethyl, pyrazolidinyl-N-methyl or piperazinyl-N-ethyl group
- an optionally substituted C ⁇ -6alkyloxyC ⁇ _ 6 alkyl group such as a methyloxyethyl or propyloxyethyl group
- an optionally substituted C ⁇ -ealkylthioCi . ⁇ alkyl group such as an ethylthioethyl group
- an optionally substituted N-di-C-i-salkylaminoC-i- ⁇ alkyl group such as a N-dimethylaminoethyl or N-diethylaminoethyl group
- - 6 alkyl group such as a N-phenyl-N-methylaminomethyl group
- -8alkylcarbamoylC ⁇ _8alkyl group such as a N-diethylcarbamoyl- methyl group
- an optionally substituted C ⁇ -1 oarylCi - ⁇ l yl group such as an optionally substituted benzyl, phenylethyl, phenylpropyl, 1 - naphthylmethyl or 2-nap
- l oaryloxyCi - ⁇ alkyl group such as an optionally substituted phenyloxymethyl, phenyloxyethyl, 1-naphthyloxymethyl, or 2-naphthyloxy- methyl group; a C6- ⁇ 2 arylthioC-
- i 2 arylsulfonylC ⁇ -8alkyl group such as an optionally substituted phenylsulfonylmethyl group; an optionally substituted C-i-salkanoyloxyC-i- ⁇ alkyl group, such as a acetoxymethyl, ethoxycarbonyloxyethyl, pivaloyloxymethyl, propionyloxyethyl or propionyloxypropyl group; an optionally substituted C ⁇ si m i d oC i -salkyl group such as a succinimidomethyl or phthalamidoethyl group; a C6- ⁇ 2 aroyloxyC ⁇ -8alkyl group such as an optionally substituted benzoyloxyethyl or benzoyloxypropyl group or a triglyceride such as a 2-substituted triglyceride e.g.
- - 8 aIkylglyceroI-2-yl group such as a 1 ,3- diheptylglycerol-2-yl group.
- Optional substituents present on the Alk 7 group include R 13a substituents described above.
- alkyl groups may be replaced by alkenyl or alkynyl groups where such groups are as previously defined for Alk 1 . Additionally these alkyl, alkenyl or alkynyl groups may optionally be interrupted by one, two or three linker atoms or groups where such linker atoms and groups are as previously defined for L 3 .
- the group R 1 is present in compounds of the invention as a Ci-6alkyl group it may be for example a straight or branched C-i- ⁇ alkyl group, e.g. a C ⁇ -3alkyl group such as a methyl or ethyl group.
- the linker atom or group represented by L 1 in compounds of formula (1) may be any linker atom or group as described above for the linker atom or group L 3 .
- group Alk 1 is present in compounds of formula (1) as an optionally substituted aliphatic chain it may be an optionally substituted C-
- Particular examples include optionally substituted straight or branched chain C1 -6 alkylene, C 2 -6 alkenylene, or C -6 alkynylene chains.
- Particular examples of aliphatic chains represented by Alk 1 include optionally substituted -CH 2 -, -(CH 2 ) 2 -, -CH(CH 3 )CH 2 -, -(CH 2 )2CH2-, -(CH 2 )3CH 2 -, -CH(CH 3 )(CH 2 )2 ⁇ , -CH 2 CH(CH 3 )CH2-, -C(CH 3 )2CH2-, -CH 2 C(CH 3 )2CH2-, -(CH2)2C(CH 3 )2CH 2 -, -(CH 2 ) 4 CH 2 -, -(CH 2 ) 5 CH 2 -, -CHCH-, -CHCHCH2-, -CH 2 CHCH-, -CHCHCH2CH2-, -CH2CHCHCH 2 -, -(CH 2 )2CHCH-, -CC-, -CCCH 2 -, -CCCH 2 CH2-,
- Heteroaliphatic groups represented by the group R 2 in the compounds of formula (1) include the aliphatic chains just described for Alk 1 but with each containing a terminal hydrogen atom and additionally containing one, two, three or four heteroatoms or heteroatom-containing groups.
- Particular heteroatoms or groups include atoms or groups L 5 where L 5 is as defined above for L 3 when L 3 is a linker atom or group.
- Each L 5 atom or group may interrupt the aliphatic group, or may be positioned at its terminal carbon atom to connect the group to an adjoining atom or group.
- Particular examples include optionally substituted -L 5 CH3, -CH2L 5 CH3 , -L5CH 2 CH 3j -CH 2 L5CH2CH 3) -(CH 2 ) 2 L5CH 3 , -(CH 2 ) 3 L5CH 3 , -L5(CH 2 ) 3 CH 3 and -(CH 2 )2L 5 CH 2 CH3 groups.
- the optional substituents which may be present on aliphatic chains or heteroaliphatic groups represented by Alk 1 and R 2 respectively include one, two, three or more substituents where each substituent may be the same or different and is selected from halogen atoms, e.g. fluorine, chlorine, bromine or iodine atoms, or -OH, -CO 2 H, -CO 2 R 9 , where R 9 is an alkyl group as defined above for R 8 , -CONHR 9 , -C0N(R 9 ) 2 , -COCH 3 , C-
- halogen atoms e.g. fluorine, chlorine, bromine or iodine atoms
- R 9 is an alkyl group as defined above for R 8 , -CONHR 9 , -C0N(R 9 ) 2 , -COCH 3 , C-
- Substituted amino groups include -NHR 9 and -N(R 9 )2 groups . Where two R 9 groups are present in any of the above substituents these may be the same or different.
- Optionally substituted cycloaliphatic groups represented by the group R 2 in compounds of the invention include optionally substituted C3-1 0 cycloaliphatic groups.
- Particular examples include optionally substituted C3-1 0 cycloalkyl, e.g. C3.7 cycloalkyl or C3-10 cycloalkenyl, e.g C3-7 cycloalkenyl groups.
- Optionally substituted heterocycloaliphatic groups represented by the group R 2 include optionally substituted C3--
- Particular examples include optionally substituted C 3 - ⁇ rjheterocycloalkyl, e.g. C3-7 heterocycloalkyl, or C3- ⁇ oheterocycloalkenyl, e.g. C3.7 hetercyclo- alkenyl groups, each of said groups containing one, two, three or four heteroatoms or heteroatom-containing groups L 5 as defined above.
- Optionally substituted polycycloaliphatic groups represented by the group R 2 include optionally substitued C7-1 0 bi- or tricycloalkyl or C7-- ⁇ obi- or tricycloalkenyl groups.
- Optionally substituted heteropolycycloaliphatic groups represented by the group R 2 include the optionally substituted polycycloalkyl groups just described, but with each group additionally containing one, two, three or four L 5 atoms or groups.
- cycloaliphatic, polycycloaliphatic, heterocyclo- aliphatic and heteropolycycloaliphatic groups represented by the group R 2 include optionally substituted cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, 2-cyclobuten-1 -yl, 2-cyclopenten-1 -yl, 3- cyclopenten-1-yl, adamantyl, norbomyl, norbomenyl, tetrahydrofuranyl, pyrroline, e.g.
- o- or p-isoxazinyl oxathiazinyl, e.g. 1 ,2,5 or 1 ,2,6-oxathiazinyl, or 1 ,3,5,-oxadiazinyl groups.
- the optional substituents which may be present on the cycloaliphatic, polycycloaliphatic, heterocycloaliphatic or heteropolycycloaliphatic groups represented by the group R 2 include one, two, three or more substituents each selected from halogen atoms, e.g. fluorine, chlorine, bromine or iodine atoms, or Ci - ⁇ alkyl, e.g. methyl or ethyl, haloCi- ⁇ alkyl, e.g. halomethyl or haloethyl such as difluoromethyl or trifluoromethyl, optionally substituted by hydroxyl, e.g.
- halogen atoms e.g. fluorine, chlorine, bromine or iodine atoms
- Ci - ⁇ alkyl e.g. methyl or ethyl
- haloCi- ⁇ alkyl e.g. halomethyl or haloethyl such as di
- -C(OH)(CF3) 2 C-i- ⁇ alkoxy, e.g. methoxy or ethoxy, haloC-
- v is zero or an integer 1 and R 10 is a -OH, -SH,
- Optionally substituted phenyl groups include phenyl substituted by one, two or three of the R 13 groups described below Additionally, when the group R 2 is a heterocycloaliphatic group containing one or more nitrogen atoms each nitrogen atom may be optionally substituted by a group -(L 8 ) p (Alk 5 ) q R 12 in which L6 is -C(O)-, -C(0)0-, -C(S)-, -S(0)2-, -CON(R 1 1 )-, -CSN(R 1 1 )- or S0 2 N(R 1 1 )-; p is zero or an integer 1 ; Alk 5 is an optionally substituted aliphatic or heteroaliphatic chain; q is zero or an integer 1 ; and R 12 is a hydrogen atom or an optionally substituted cycloaliphatic, heterocycloaliphatic, polycycloaliphatic, heteropolycycloaliphatic, aromatic or heteroaromatic group.
- Optionally substituted aliphatic or heteroaliphatic chains represented by Alk 5 include those optionally substituted chains described above for Alk 2 .
- Cycloaliphatic, heterocycloaliphatic, polycycloaliphatic or heteropolycycloaliphatic groups represented by R 12 include those groups just described for the group R 2 .
- Optional substituents which may be present on these groups include those described above in relation to Alk 1 and R 2 aliphatic and heteroaliphatic chains.
- Optionally substituted aromatic or heteroaromatic groups represented by R 12 include those optionally substituted R 2 aromatic and heteroaromatic groups as described hereinafter.
- Optionally substituted aromatic groups represented by R 2 include for example optionally substituted monocyclic or bicyclic fused ring C ⁇ -12 aromatic groups, such as phenyl, 1 - or 2-naphthyI, 1 - or 2- tetrahydronaphthyl, indanyl or indenyl groups.
- Optionally substituted heteroaromatic groups represented by the group R 2 include for example optionally substituted C1-9 heteroaromatic groups containing for example one, two, three or four heteroatoms selected from oxygen, sulphur or nitrogen atoms.
- the heteroaromatic groups may be for example monocyclic or bicyclic fused ring heteroaromatic groups.
- Monocyclic heteroaromatic groups include for example five- or six-membered heteroaromatic groups containing one, two, three or four heteroatoms selected from oxygen, sulphur or nitrogen atoms.
- Bicyclic heteroaromatic groups include for example eight- to thirteen-membered fused-ring heteroaromatic groups containing one, two or more heteroatoms selected from oxygen, sulphur or nitrogen atoms.
- heteroaromatic groups of these types include pyrrolyl, furyl, thienyl, imidazolyl, N-C ⁇ - 6 alkylimidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyrazolyl, 1 ,2,3-triazolyl, 1 ,2,4-triazolyl, 1 ,2,3-oxadiazolyl, 1 ,2,4-oxadiazolyl, 1 ,2,5-oxadiazolyl, 1 ,3,4-oxadiazolyl, 1 ,3,4-thiadiazole, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, 1 ,3,5-triazinyl, 1 ,2,4-triazinyl, 1 ,2,3-triazinyl, benzofuryl, [2,3-dihydro]benzofuryl, [2,3-d
- Optional substituents which may be present on the aromatic or heteroaromatic groups represented by the group R 2 include one, two, three or more substituents, each selected from an atom or group R 13 in which R 13 is -R 3a or -Alk 6 (R 13a ) m , where R 13a is a halogen atom, or an amino (-NH2), substituted amino, nitro, cyano, amidino, hydroxyl (-OH), substituted hydroxyl, formyl, carboxyl (-CO2H), esterified carboxyl, thiol (-SH), substituted thiol, -COR 1 4 [where R 4 is an -Alk 6 (R 13a ) m , cycloaliphatic, heterocycloaliphatic, aryl or heteroaryl group], -CSR 14 , -SO3H, -SOR 14 , -S0 2 R 14 , -SO3R 14 -S0 2 NH 2) -S
- R 1 1 or R 1 4 groups may be the same or different.
- m is an integer 1 , 2 or 3, it is to be understood that the substituent or substituents R 13a may be present on any suitable carbon atom in -Alk 6 . Where more than one R 13a substituent is present these may be the same or different and may be present on the same or different atom in -Alk 6 . Clearly, when m is zero and no substituent R 13a is present the alkylene, alkenylene or alkynylene chain represented by Alk 6 becomes an alkyl, alkenyl or alkynyl group.
- R 13a is a substituted amino group it may be for example a group -NHR 14 [where R 14 is as defined above] or a group -N(R 14 ) 2 wherein each R 14 group is the same or different.
- R 1 a is a halogen atom it may be for example a fluorine, chlorine, bromine, or iodine atom.
- Esterified carboxyl groups represented by the group R 13a include groups of formula -C0 2 Alk 7 where Alk 7 is a group as defined hereinbefore.
- Alk 6 When Alk 6 is present in or as a substituent it may be for example a methylene, ethylene, n-propylene, i-propylene, n-butylene, i-butylene, s- butylene, t-butylene, ethenylene, 2-propenylene, 2-butenylene, 3- butenylene, ethynylene, 2-propynylene, 2-butynylene or 3-butynylene chain, optionally interrupted by one, two, or three -O- or -S-, atoms or -S(O)-, -S(0) 2 - or -N(R 9 )- groups.
- Cycloaliphatic or heterocycloaliphatic groups represented by the groups Ri3a or R14 include those optionally substituted C3- ⁇ ocycloaliphatic or C3-10 heterocycloaliphatic groups described above for R 2 .
- Aryl or heteroaryl groups represented by the groups R 13a or R 14 include mono- or bicyclic optionally substituted C6-12 aromatic or C1 -9 heteroaromatic groups as described above for the group R 2 .
- the aromatic and heteroaromatic groups may be attached to the remainder of the compound of formula (1) by any carbon or hetero e.g. nitrogen atom as appropriate.
- each may be for example an optionally substituted pyrrolidinyl, pyrazolidinyl, piperazinyl, morpholinyl, thiomorpholinyl, piperidinyl or thiazolidinyl group.
- Het 2 may represent for example, an optionally substituted cyclopentyl or cyclohexyl group.
- Optional substituents which may be present on -NHet 1 or -Het 2 include those optional substituents described hereinbefore for R 2 heterocycloaliphatic groups.
- Particularly useful atoms or groups represented by R 13 include fluorine, chlorine, bromine or iodine atoms, or Ci- ⁇ alkyl, e.g. methyl, ethyl, n-propyl, i-propyl, n-butyl or t-butyl, optionally substituted phenyl, pyridyl, pyrimidinyl, pyrrolyl, furyl, thiazolyl, thienyl, morpholinyl, thiomorpholinyl, piperazinyl, e.g.
- t-butyloxycarbonylpiperazinyl pyrrolidinyl, dioxolanyl, dioxanyl, oxazolidinyl, thiazolidinyl, imidazolidinyl or piperidinyl, C ⁇ -6hydroxyalkyl, e.g. hydroxymethyl or hydroxyethyl, carboxyC-i- ⁇ alkyl, e.g. carboxyethyl, C-
- -6alkoxy e.g. trifluoromethoxy
- C-j -6alkylamino e.g. methylamino, ethylamino or propylamino
- C6-12arylC1 -6alkylamino e.g.benzylamino, 4- fluorobenzylamino or 4-hydroxyphenylethylamino, amino (-NH 2 ), aminoC-i - ⁇ alkyl, e.g. aminomethyl or aminoethyl, C-
- aminoethylamino or aminopropylamino optionally substituted Het 1 NC-
- ⁇ alkylamino e.g. 3-morpholinopropylamino, C ⁇ -6alkylaminoC ⁇ -6alkyl, e.g. ethylaminoethyl, C ⁇ -6dialkyl-aminoC-
- C ⁇ _6alkylaminocarbonyl e.g. methylamino- carbonyl, ethylaminocarbonyl or propylaminocarbonyl
- Ci- ⁇ dialkylamino- carbonyl e.g. dimethylaminocarbonyl or diethylaminocarbonyl
- aminoCi- 6alkylaminocarbonyl e.g. aminoethylaminocarbonyl, C-
- methylaminoethylaminocarbonyl C ⁇ _6dialkyl- aminoCi _6alkylaminocarbonyl, e.g. diethylaminoethylaminocarbonyl, aminocarbonylamino, Ci- ⁇ alkylaminocarbonylamino, e.g. methylamino- carbonylamino or ethylaminocarbonylamino, C-
- Ci- ⁇ alkyl- sulphonylamino e.g. methylsulphonylamino or ethylsulphonylamino
- haloC ⁇ -6alkylsulphonylamino e.g. trifluoromethylsulphonylamino
- C ⁇ .Q dialkylsulphonylamino e.g.
- dimethylaminosulphonylamino or diethylaminosulphonylamino optionally substituted morpholinesulphonylamino or morpholinesulphonylC-
- acetylaminomethyl C ⁇ -6alkanoylaminoC-
- two R 1 3 substituents may be linked together to form a cyclic group such as a cyclic ether, e.g. a C-i- ⁇ alkylenedioxy group such as methylenedioxy or ethylenedioxy.
- a cyclic group such as a cyclic ether, e.g. a C-i- ⁇ alkylenedioxy group such as methylenedioxy or ethylenedioxy.
- R 13 substituents need not necessarily be the same atoms and/or groups.
- the substituent(s) may be present at any available ring position in the aromatic or heteroaromatic group represented by R 2 .
- Suitable salts include pharmaceutically acceptable salts, for example acid addition salts derived from inorganic or organic acids, and salts derived from inorganic and organic bases.
- Acid addition salts include hydrochlorides, hydrobromides, hydroiodides, alkylsulphonates, e.g. methanesulphonates, ethanesulphonates, or isothionates, arylsulphonates, e.g. p-toluenesulphonates, besylates or napsylates, phosphates, sulphates, hydrogen sulphates, acetates, trifluoroacetates, propionates, citrates, maleates, fumarates, malonates, succinates, lactates, oxalates, tartrates and benzoates.
- Salts derived from inorganic or organic bases include alkali metal salts such as sodium or potassium salts, alkaline earth metal salts such as magnesium or calcium salts, and organic amine salts such as morpholine, piperidine, dimethylamine or diethylamine salts.
- Particularly useful salts of compounds according to the invention include pharmaceutically acceptable salts, especially acid addition pharmaceutically acceptable salts.
- R 16 is a L 3 (Alk 2 )tL 4 R 20 group.
- R 20 is preferably an optionally substituted aromatic group such as an optionally substituted phenyl group or an optionally substituted monocyclic hetero-aromatic group.
- Particularly useful monocyclic heteroaromatic groups are optionally substituted five- or six-membered heteroaromatic groups as previously described, especially five- or six-membered heteroaromatic groups containing one, two, three or four heteroatoms selected from oxygen, sulphur or nitrogen atoms.
- Patrticularly useful optional substituents that may be present on these R 20 groups include halogen atoms or optionally substituted alkyl, alkoxy, alkylthio, -NR 3 R 4 , -CN, -C0 2 R 3 , -COR 3 or -N(R 3 )COR 4 groups, as described above in relation to the compounds of formula (1 ).
- a particularly useful group of compounds according to the invention has the formula (2):
- R 17a and R 17b is each a hydrogen atom or an optional substituent as previously defined for R 17 ;
- R 16 > R 17 , g, L 1 , L 2 , Ar 2 , Alk, R 1 , Alk 1 , n and R 2 are as defined for formula
- Particularly useful optionally substituted monocyclic heteroaromatic groups represented by R 20 in the group R 6 include optionally substituted furyl, thienyl, imidazolyl, pyridyl and pyrimidinyl groups.
- Most especially useful R 20 aromatic groups include optionally substituted phenyl groups and most especially useful R 20 monocyclic heteroaromatic groups include thienyl and pyridyl groups.
- R 16 is the group -L 3 (Alk 2 )tL 4 R 20 in which R 20 is preferably a group as just defined, L 3 is preferably an -O- or -S- atom or a -C(O)- or -N(R 8 )- group in which R 8 is preferably a hydrogen atom or a methyl group, t is the integer 1 and Alk 2 is preferably an optionally substituted aliphatic chain, most preferably an optionally substitued Ci - ⁇ alkylene chain, especially an optionally substituted -CH 2 -, -(CH 2 ) 2 - or -CH(CH )CH 2 - chain , and L 4 is preferably a covalent bond.
- R 16 is the group -L 3 (Alk 2 )tL 4 R 20 in which R 20 is preferably a group as just defined, t is zero and L 3 and L 4 is each a covalent bond.
- R 20 aromatic and heteroaromatic grops include halogen atoms, especially fluorine and chlorine atoms, and Ci- ⁇ alkyl groups, especially methyl, ethyl and i-propyl groups and -CF3 -OCH3 -OCH2CH3, -OCH(CH3) , -OCF3, -SCH3, -NHCH 3) -N(CH 3 )2, -CN, -C0 2 CH 3 , -COCH3 and -N(CH 3 )COCH 3 groups.
- halogen atoms especially fluorine and chlorine atoms
- Ci- ⁇ alkyl groups especially methyl, ethyl and i-propyl groups and -CF3 -OCH3 -OCH2CH3, -OCH(CH3) , -OCF3, -SCH3, -NHCH 3) -N(CH 3 )2, -CN, -C0 2 CH 3 , -COCH3 and -N(CH 3
- Alk in compounds of the invention is preferably: -CH- or, especially, -CH 2 CH(R)-.
- R is a -C0 2 H group.
- R is an esterified carboxyl group of formula -C0 2 Alk 7 .
- Alk 7 is preferably a Ci-salkyl group, especially a methyl, ethyl, propyl or i- propyl group, an optionally substituted C6- ⁇ ⁇ aryl group, especially a phenyl group, an optionally substituted C6- ⁇ o rylC ⁇ _6alkyl group, especially a benzyl group, a C-3-8heterocycloalkylC ⁇ -6alkyl group, especially a morpholinyl-N-ethyl group or a C-
- Especially preferred esterified carboxyl groups include -C0 2 CH 3 , -C0 2 CH 2 CH 3 , -C0 2 CH 2 CH 2 CH3 and -C0 2 CH
- R 1 is preferably a hydrogen atom.
- L 2 is preferably L 2a where L 2a is a -O- atom or -N(R 8 )- group in which R 8 is preferably a hydrogen atom or methyl group.
- R 8 is preferably a hydrogen atom or methyl group.
- An especially useful -N(R 8 )- group is -NH-.
- R 17 , R 17a and R 7b when present as an optional substituent is each preferably a halogen atom, especially a fluorine or chlorine atom or an Ci- ⁇ alkyl group, especially methyl, ethyl, propyl or isopropyl group, a haloCi-ealkyl group, especially -CF3, a C ⁇ - ⁇ al oxy group, especially a methoxy, ethoxy, propoxy or isopropoxy group a haloC ⁇ -6alkoxy group, especially a trifluoromethoxy or difluoromethoxy group, -CN, -COR 3 , especially -COCH3, a Ci- ⁇ alkylthio group especially a methylthio or ethylthio group, a C3-8cycloalkyl group, especially a cyclopentyl or cyclohexyl group or a C ⁇ _6alkylenedioxy group, especially a methyl
- g is the integer 1 and 2.
- the group R 2 may especially be an optionally substituted heteroaliphatic, cycloaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group as defined herein.
- Particularly useful groups of this type include optionally substituted C2-6heteroalkyl, particularly O
- 3alkoxyC ⁇ -3alkyl especially methoxypropyl, optionally substituted C3- 7cycloalkyl, especially optionally substituted cyclopropyl, cyclobutyl cyclopropyl or cyclohexyl, optionally substituted C5-7heterocycloaliphatic, especially optionally substituted pyrrolidinyl or thiazolidinyl, especially optionally substituted phenyl and optionally substituted Cs ⁇ hetero- aromatic, especially optionally substituted pyridyl groups.
- Optional substituents on these groups include in particular R 3 atoms or groups where the group is an aromatic or heteroaromatic group and -(L 6 ) p (Alk 5 )qR 12 groups as described earlier where the group is a nitrogen- containing heterocycloaliphatic group such as a pyrrolidinyl, thiazolidinyl pyrrolidinoyl, piperidinyl, homopiperidinyl, heptamethyleneiminyl, morpholinyl, piperazinyl or homopiperazinyl group.
- Particularly useful -(L 6 ) p (Alk 5 )qR 12 groups include those in which L 6 is a -CO- group.
- Alk 5 in these groups is preferably present (i.e. q is preferably an integer 1) and in particular is a -CH2-chain.
- R 1 2 is a hydrogen atom or an optionally substituted aromatic or heteroaromatic group, especially an optionally substituted phenyl, pyridyl or imidazolyl group are particularly preferred.
- L 1 is present as a -N(R 8 )- group.
- Particularly useful -N(R 8 )- groups include -NH-, -N(CH 3 )-, -N(CH 2 CH 3 )- and -N(CH 2 CH 2 CH 3 )- groups.
- n is preferably the integer 1 and Alk 1 is preferably an optionally substituted straight or branched Ci- ⁇ alkylene chain.
- Particularly useful Alk 1 chains include -CH 2 -, -CH 2 CH 2 -, -CH2 CH2CH2-, -CH(CH3)CH 2 - and -C(CH3)2CH 2 -.
- R 2 in this class of compounds is preferably a hydrogen atom.
- L 1 is a covalent bond
- n is the integer 1
- Alk 1 is an optionally substituted straight or branched C ⁇ -6alkylene chain.
- Particularly useful Alk 1 chains ' include optionally substituted -CH2-, -CH 2 CH 2 -, -CH 2 CH 2 CH 2 - ⁇ ' -CH(CH3)CH 2 - and especially -C(CH 3 ) 2 CH2- chains.
- R 2 in this class of compounds is preferably a hydrogen atom.
- a most especially useful optionally substituted Alk 1 R 2 group is -C(CH 3 )3.
- L 1 is a covalent bond
- n is zero
- R 2 is an optionally substituted C5- 7 heterocycloaliphatic group.
- Especially useful C5-7heterocycloaliphatic groups include optionally substituted piperidinyl, homopiperidinyl, heptamethyleneiminyl, pyrrolidinyl, piperazinyl, homopiperazinyl, morpholinyl and thiomorpholinyl groups.
- Most preferred C5- 7 hetero- cycloaliphatic groups are those linked via a ring nitrogen atom to the remainder of the compund of formulae (1) or (2).
- C5- 7 heterocycloaIiphatic groups include optionally substituted pyrolidin-1- yl, piperidin-1-yl and homopiperidin-1-yl groups.
- Especially useful optional substituents on these Cs ⁇ heterocycloaliphatic groups include optionally substituted C - ⁇ alkyl groups, especially methyl, ethyl or i-propyl groups.
- C5-7heterocycloaliphatic groups include 2-methylpyrrolidin-1-yl, cis and trans 2,5-dimethylpyrrolidin-1-yl, 2- methylpiperidin-yl and 2,6-dimethylpiperidin ⁇ 1-yl, homopiperidin-1-yl, 2- methylhomopiperidin-1-yl and c/ ' s and trans 2,7-dimethy
- Particularly useful compounds of the invention include:
- Compounds according to the inventions are potent and selective inhibitors of ⁇ 4 integrins and have advantageous clearance properties, especially those compounds where R is a carboxylic ester or amide.
- the ability of the compounds to act in this way may be simply determined by employing tests such as those described in the Examples hereinafter.
- the compounds are of use in modulating cell adhesion and in particular are of use in the prophylaxis and treatment of diseases or disorders involving inflammation in which the extravasation of leukocytes plays a role and the invention extends to such a use and to the use of the compounds for the manufacture of a medicament for treating such diseases or disorders.
- Diseases or disorders of this type include inflammatory arthritis such as rheumatoid arthritis vasculitis or polydermatomyositis, multiple sclerosis, allograft rejection, diabetes, inflammatory dermatoses such as psoriasis or dermatitis, asthma and inflammatory bowel disease.
- inflammatory arthritis such as rheumatoid arthritis vasculitis or polydermatomyositis, multiple sclerosis, allograft rejection, diabetes, inflammatory dermatoses such as psoriasis or dermatitis, asthma and inflammatory bowel disease.
- the compounds according to the invention may be administered as pharmaceutical compositions, and according to a further aspect of the invention we provide a pharmaceutical composition which comprises a compound of formula (1) together with one or more pharmaceutically acceptable carriers, excipients or diluents.
- compositions according to the invention may take a form suitable for oral, buccal, parenteral, nasal, topical or rectal administration, or a form suitable for administration by inhalation or insufflation.
- oral administration the pharmaceutical compositions may take the form of, for example, tablets, lozenges or capsules prepared by conventional means with pharmaceutically acceptable excipients such as binding agents (e.g. pregelatinised maize starch, polyvinylpyrrolidone or hydroxypropyl methylcellulose); fillers (e.g. lactose, microcrystalline cellulose or calcium hydrogen phosphate); lubricants (e.g. magnesium stearate, talc or silica); disintegrants (e.g.
- binding agents e.g. pregelatinised maize starch, polyvinylpyrrolidone or hydroxypropyl methylcellulose
- fillers e.g. lactose, microcrystalline cellulose or calcium hydrogen phosphate
- lubricants e.g. magnesium stearate,
- liquid preparations for oral administration may take the form of, for example, solutions, syrups or suspensions, or they may be presented as a dry product for constitution with water or other suitable vehicle before use.
- Such liquid preparations may be prepared by conventional means with pharmaceutically acceptable additives such as suspending agents, emulsifying agents, non-aqueous vehicles and preservatives.
- the preparations may also contain buffer salts, flavouring, colouring and sweetening agents as appropriate.
- Preparations for oral administration may be suitably formulated to give controlled release of the active compound.
- compositions may take the form of tablets or lozenges formulated in conventional manner.
- the compounds for formula (1) may be formulated for parenteral administration by injection e.g. by bolus injection or infusion.
- Formulations for injection may be presented in unit dosage form, e.g. in glass ampoule or multi dose containers, e.g. glass vials.
- the compositions for injection may take such forms as suspensions, solutions or emulsions in oily or aqueous vehicles, and may contain formulatory agents such as suspending, stabilising, preserving and/or dispersing agents.
- the active ingredient may be in powder form for constitution with a suitable vehicle, e.g. sterile pyrogen-free water, before use.
- the compounds of formula (1) may be coated on particles such as microscopic gold particles.
- the compounds of formula (1) may also be formulated as a depot preparation. Such long acting formulations may be administered by implantation or by intramuscular injection.
- the compounds for use according to the present invention are conveniently delivered in the form of an aerosol spray presentation for pressurised packs or a nebuliser, with the use of suitable propellant, e.g. dichlorodifluoromethane, trichloro- fluoromethane, dichlorotetrafluoroethane, carbon dioxide or other suitable gas or mixture of gases.
- suitable propellant e.g. dichlorodifluoromethane, trichloro- fluoromethane, dichlorotetrafluoroethane, carbon dioxide or other suitable gas or mixture of gases.
- compositions may, if desired, be presented in a pack or dispenser device which may contain one or more unit dosage forms containing the active ingredient.
- the pack or dispensing device may be accompanied by instructions for administration.
- daily dosages may range from around 100ng/kg to 100mg/kg e.g. around 0.01 mg/kg to 40mg/kg body weight for oral or buccal administration, from around 10ng/kg to 50mg/kg body weight for parenteral administration and around 0.05mg to around 1000mg e.g. around 0.5mg to around 1000mg for nasal administration or administration by inhalation or insufflation.
- the compounds of the invention may be prepared by a number of processes as generally described below and more specifically in the Examples hereinafter.
- the symbols Ar 2 , Alk, R 1 , R 2 , L 1 , L 2 , Alk 1 and n when used in the formulae depicted are to be understood to represent those groups described above in relation to formula (1 ) unless otherwise indicated.
- reactive functional groups for example hydroxy, amino, thio or carboxy groups, where these are desired in the final product, to avoid their unwanted participation in the reactions.
- Conventional protecting groups may be used in accordance with standard practice [see, for example, Green, T. W. in "Protective Groups in Organic Synthesis", John Wiley and Sons, 1999].
- deprotection may be the final step in the synthesis of a compound of formula (1) and the processes according to the invention described hereinafter are to be understood to extend to such removal of protecting groups.
- the processes described below all refer to a preparation of a compound of formula (1) but clearly the description applies equally to the preparation of compounds of formula (2).
- a compound of formula (1) in which R is a -C0 2 H group may be obtained by hydrolysis of an ester of formula (3):
- Ar 1 represents a group:
- the hydrolysis may be performed using either an acid or a base depending on the nature of Ry, for example an organic acid such as trifluoroacetic acid or an inorganic base such as lithium, sodium or potassium hydroxide optionally in an aqueous organic solvent such as an amide e.g. a substituted amide such as dimethylformamide, an ether e.g. a cyclic ether such as tetrahydrofuran or dioxane or an alcohol e.g. methanol at a temperature from ambient to the reflux temperature. Where desired, mixtures of such solvents may be used.
- an organic acid such as trifluoroacetic acid or an inorganic base such as lithium, sodium or potassium hydroxide
- an aqueous organic solvent such as an amide e.g. a substituted amide such as dimethylformamide, an ether e.g. a cyclic ether such as tetrahydrofuran or dioxane or an alcohol e.g. methanol
- a compound of formula (1) may be prepared by displacement of a leaving group from a compound of formula (4):
- R a is a leaving group, with an amine Ar 1 L 2 Ar 2 AlkN(R 1 )H or a salt thereof.
- Suitable leaving groups represented by R a include halogen atoms, especially chlorine and bromine atoms, or alkoxy, e.g. methoxy, ethoxy or isopropoxy, aryloxy, e.g. dinitrophenyloxy, or aralkoxy, e.g. benzyloxy, groups.
- the reaction may be performed in an inert solvent or mixture of solvents, for example a substituted amide such as dimethylformamide, an alcohol such as ethanol and/or a halogenated hydrocarbon such as dichloromethane, at a temperature from 0°C to the reflux temperature.
- a substituted amide such as dimethylformamide
- an alcohol such as ethanol
- a halogenated hydrocarbon such as dichloromethane
- an organic base such as diisopropyl- ethylamine can be added.
- Any carboxylic acid group present in the intermediate of formula (4) or the amine Ar 1 L 2 Ar 2 AlkN(R 1 )H may need to be protected during the displacement reaction, for example as an ethyl ester.
- the desired acid may then be obtained through subsequent hydrolysis, for example as particularly described above and generally described below.
- R b is a leaving group as defined for R a using an intermediate R 2 (Alk 1 ) n L 1 H where -L 1 H is a functional group such as an amine (-NH2) using the reaction conditions just described.
- the displacement reaction may also be performed on an intermediate of formulae (4) or (5), Ar 1 L 2 Ar 2 AlkN(R 1 )H or R (Alk 1 ) n L 1 H which is linked, for example via its Ar 1 or R 2 group, to a solid support, such as a polystyrene resin.
- a solid support such as a polystyrene resin.
- R a and R b are as previously defined and an amine Ar 1 L Ar AlkN(R 1 )H or R (Alk 1 ) n N(R 6 )H by displacement as just described for the preparation of compounds of formula (1).
- Intermediates of formulae Ar 1 L 2 Ar AlkN(R 1 )H and R (Alk ) n N(R 8 )H may be obtained from simpler, known compounds by one or more standard synthetic methods employing substitution, oxidation, reduction or cleavage reactions. Particular substitution approaches include conventional alkylation, arylation, heteroarylation, acylation, thioacylation, halogenation, sulphonylation, nitration, formylation and coupling procedures. It will be appreciated that these methods may also be used to obtain or modify other compounds of formulae (1) and (2) where appropriate functional groups exist in these compounds.
- compounds of the invention and intermediates thereto may be prepared by alkylation, arylation or heteroarylation.
- compounds containing a -L 1 H or -L 2 H group may be treated with a coupling agent R 2 (Alk 1 ) n X 1 or Ar 1 X 1 respectively in which X 1 is a leaving atom or group such as a halogen atom, e.g. a fluorine, bromine, iodine or chlorine atom or a sulphonyloxy group such as an alkylsulphonyloxy, e.g. trifluoromethylsulphonyloxy or arylsulphonyloxy, e.g. p-toluene- sulphonyloxy group.
- a halogen atom e.g. a fluorine, bromine, iodine or chlorine atom
- a sulphonyloxy group such as an alkylsulphonyloxy, e.
- the reaction may be carried out in the presence of a base such as a carbonate, e.g. caesium or potassium carbonate, an alkoxide, e.g. potassium t-butoxide, or a hydride, e.g. sodium hydride, or an organic amine e.g. triethylamine or N,N-diisopropylethylamine or a cyclic amine, such as N-methylmorpholine or pyridine, in a dipolar aprotic solvent such as an amide, e.g. a substituted amide such as dimethylformamide or an ether, e.g. a cyclic ether such as tetrahydrofuran.
- a base such as a carbonate, e.g. caesium or potassium carbonate, an alkoxide, e.g. potassium t-butoxide, or a hydride, e.g. sodium hydride, or an organic amine e
- Intermediate alcohols of formula Ar 1 OH in which Ar 1 represents a 3- substituted isoquinolin-1-yl group may be prepared by methods well known to a person skilled in the art, e.g. by the methods of Wu M.-J. et al Tetrahedron, 55, 13193-200 (1999), Hiebl J. et al Tetrahedron Lett. 40, 7935-8 (1999), Nagarajan A. et al Indian J. Chem., Sect. B, 28B. 67-78 (1989), Brun E. M. et a/ Synlett, 7, 1088-90 (1999) and Brun, E. M. et al Synthesis, 273-280 (2000).
- intermediates of formula Ar 1 L 2 Ar 2 AlkN(R 1 )H may be obtained by reaction of a compound of formula Ar 1 L H with a compound of formula X 1 Ar 2 AlkN(R 1 )H under the reaction conditions just described
- compounds containing a -L 1 H or -L 2 H or group as defined above may be functionalised by acylation or thioacylation, for example by reaction with one of the alkylating agents just described but in which X 1 is replaced by a -C(0)X 2 , C(S)X 2 , -N(R 8 )COX or -N(R 8 )C(S)X 2 group in which X 2 is a leaving atom or group as described for X 1 .
- the reaction may be performed in the presence of a base, such as a hydride, e.g. sodium hydride or an amine, e.g.
- a solvent such as a halogenated hydrocarbon, e.g. dichloromethane or carbon tetrachloride or an amide, e.g. dimethylformamide, at for example ambient temperature.
- a halogenated hydrocarbon e.g. dichloromethane or carbon tetrachloride
- an amide e.g. dimethylformamide
- the acylation may be carried out under the same conditions with an acid (for example one of the alkylating agents described above in which X 1 is replaced by a -CO2H group) in the presence of a condensing agent, for example a diimide such as 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide or N,N'-dicyclohexylcarbodiimide, advantageously in the presence of a catalyst such as a N-hydroxy compound e.g. a N-hydroxytriazole such as 1 -hydroxybenzotriazole.
- the acid may be reacted with a chloroformate, for example ethylchloroformate, prior to the desired acylation reaction
- compounds may be obtained by sulphonylation of a compound containing an -OH group by reaction with one of the above alkylating agents but in which X 1 is replaced by a -S(O)Hal or -SU2Hal group in which Hal is a halogen atom such as chlorine atom] in the presence of a base, for example an inorganic base such as sodium hydride in a solvent such as an amide, e.g. a substituted amide such as dimethylformamide at for example ambient temperature.
- a base for example an inorganic base such as sodium hydride in a solvent such as an amide, e.g. a substituted amide such as dimethylformamide at for example ambient temperature.
- compounds containing a -L 1 H or -L 2 H group as defined above may be coupled with one of the alkylation agents just described but in which X 1 is replaced by an -OH group in a solvent such as tetrahydrofuran in the presence of a phosphine, e.g. triphenylphosphine and an activator such as diethyl, diisopropyl- or dimethylazodicarboxylate.
- a phosphine e.g. triphenylphosphine and an activator such as diethyl, diisopropyl- or dimethylazodicarboxylate.
- ester groups -CO2R 3 , -CO2R 1 1 or -CO2Alk 7 in the compounds may be converted to the corresponding acid [-CO 2 H] by acid- or base-catalysed hydrolysis depending on the nature of the groups R 3 , R 1 or Alk 7 .
- Acid- or base-catalysed hydrolysis may be achieved for example by treatment with an organic or inorganic acid, e.g. trifluoroacetic acid in an aqueous solvent or a mineral acid such as hydrochloric acid in a solvent such as dioxan or an alkali metal hydroxide, e.g. lithium hydroxide in an aqueous alcohol, e.g. aqueous methanol.
- -OR 5 or -OR 14 groups [where R 5 or R 14 each represents an alkyl group such as methyl group] in compounds of formula (1) may be cleaved to the corresponding alcohol -OH by reaction with boron tribromide in a solvent such as a halogenated hydrocarbon, e.g. dichloromethane at a low temperature, e.g. around -78°C.
- a solvent such as a halogenated hydrocarbon, e.g. dichloromethane at a low temperature, e.g. around -78°C.
- Alcohol [-OH] groups may also be obtained by hydrogenation of a corresponding -OCH 2 R 14 group (where R 14 is an aryl group) using a metal catalyst, for example palladium on a support such as carbon in a solvent such as ethanol in the presence of ammonium formate, cyclohexadiene or hydrogen, from around ambient to the reflux temperature.
- a metal catalyst for example palladium on a support such as carbon in a solvent such as ethanol in the presence of ammonium formate, cyclohexadiene or hydrogen, from around ambient to the reflux temperature.
- -OH groups may be generated from the corresponding ester [C0 2 R 3 or CO2R 11 ] or aldehyde [-CHO] by reduction, using for example a complex metal hydride such as lithium aluminium hydride or sodium borohydride in a solvent such as methanol.
- alcohol -OH groups in the compounds may be converted to a corresponding -OR 5 or -OR 14 group by coupling with a reagent R 5 OH or R 1 4 OH in a solvent such as tetrahydrofuran in the presence of a phosphine, e.g. triphenylphosphine and an activator such as diethyl-, diisopropyl-, or dimethylazodicarboxylate.
- a phosphine e.g. triphenylphosphine and an activator such as diethyl-, diisopropyl-, or dimethylazodicarboxylate.
- Aminosulphonylamino [-NHSO2NHR 2 or -NHS02NHAr 1 ] groups in the compounds may be obtained, in another example, by reaction of a corresponding amine [-NH2] with a sulphamide R 2 NHS02NH 2 or Ar 1 NHS0 2 NH 2 in the presence of an organic base such as pyridine at an elevated temperature, e.g. the reflux temperature.
- compounds containing a -NHCSAr 1 , -CSNHAr 1 , -NHCSR 2 or -CSNHR 2 may be prepared by treating a corrsponding compound containing a -NHCOAr 1 , -CONHAr 1 , -NHCOR 2 or -CONHR 2 group with a thiation reagent, such as Lawesson's Reagent, in an anhydrous solvent, for example a cyclic ether such as tetrahydrofuran, at an elevated temperature such as the reflux temperature.
- a thiation reagent such as Lawesson's Reagent
- amine (-NH ) groups may be alkylated using a reductive alkylation process employing an aldehyde and a borohydride, for example sodium triacetoxyborohyride or sodium cyanoborohydride, in a solvent such as a halogenated hydrocarbon, e.g. dichloromethane, a ketone such as acetone, or an alcohol, e.g. ethanol, where necessary in the presence of an acid such as acetic acid at around ambient temperature.
- amine [-NH 2 ] groups in compounds of formula (1) may be obtained by hydrolysis from a corresponding imide by reaction with hydrazine in a solvent such as an alcohol, e.g. ethanol at ambient temperature.
- a nitro [-N0 2 ] group may be reduced to an amine [- NH 2 ], for example by catalytic hydrogenation using for example hydrogen in the presence of a metal catalyst, for example palladium on a support such as carbon in a solvent such as an ether, e.g. tetrahydrofuran or an alcohol e.g. methanol, or by chemical reduction using for example a metal, e.g. tin or iron, in the presence of an acid such as hydrochloric acid.
- a metal catalyst for example palladium on a support such as carbon in a solvent such as an ether, e.g. tetrahydrofuran or an alcohol e.g. methanol
- an acid such as hydrochloric acid
- Aromatic halogen substituents in the compounds may be subjected to halogen-metal exchange with a base, for example a lithium base such as n-butyl or t-butyl lithium, optionally at a low temperature, e.g. around -78°C, in a solvent such as tetrahydrofuran and then quenched with an electrophile to introduce a desired substituent.
- a base for example a lithium base such as n-butyl or t-butyl lithium
- a solvent such as tetrahydrofuran
- an electrophile to introduce a desired substituent.
- a formyl group may be introduced by using dimethylformamide as the electrophile
- a thiomethyl group may be introduced by using dimethyldisulphide as the electrophile.
- sulphur atoms in the compounds may be oxidised to the corresponding sulphoxide or sulphone using an oxidising agent such as a peroxy acid, e.g. 3-chloroperoxybenzoic acid, in an inert solvent such as a halogenated hydrocarbon, e.g. dichloromethane, at around ambient temperature.
- an oxidising agent such as a peroxy acid, e.g. 3-chloroperoxybenzoic acid
- an inert solvent such as a halogenated hydrocarbon, e.g. dichloromethane
- compounds of formula Ar 1 X 1 may be converted to such compounds as Ar 1 C0 2 R 20 (in which R 20 is an optionally substituted alkyl, aryl or heteroaryl group), Ar 1 CHO, Ar 1 CHCHR 2 o, Ar 1 CCR 2 0, Ar 1 N(R 20 )H, Ar 1 N(R 20 ) 2 , for use in the synthesis of for example compounds of formula Ar 1 L Ar 2 AIkN(R 1 )H, using such well know and commonly used palladium mediated reaction conditions as are to be found in the general reference texts Rodd's Chemistry of Carbon Compounds, Volumes 1-15 and Supplementals (Elsevier Science Publishers, 1989), Fieser and Fieser's Reagents for Organic Synthesis, Volumes 1-19 (John Wiley and Sons, 1999), Comprehensive Heterocyclic Chemistry, Ed.
- N-oxides of compounds of formula (1) may be prepared for example by oxidation of the corresponding nitrogen base using an oxidising agent such as hydrogen peroxide in the presence of an acid such as acetic acid, at an elevated temperature, for example around 70°C to 80°C, or alternatively by reaction with a peracid such as peracetic acid in a solvent, e.g. dichloromethane, at ambient temperature.
- an oxidising agent such as hydrogen peroxide in the presence of an acid such as acetic acid
- an elevated temperature for example around 70°C to 80°C
- a peracid such as peracetic acid in a solvent, e.g. dichloromethane
- Salts of compounds of formula (1) may be prepared by reaction of a compound of formula (1) with an appropriate base in a suitable solvent or mixture of solvents e.g. an organic solvent such as an ether e.g. diethylether, or an alcohol, e.g. ethanol using conventional procedures.
- a suitable solvent or mixture of solvents e.g. an organic solvent such as an ether e.g. diethylether, or an alcohol, e.g. ethanol using conventional procedures.
- diastereomeric derivatives may be produced by reaction of a mixture of enantiomers of formula (1) e.g. a racemate, and an appropriate chiral compound, e.g. a chiral base.
- the diastereomers may then be separated by any convenient means, for example by crystallisation and the desired enantiomer recovered, e.g. by treatment with an acid in the instance where the diastereomer is a salt.
- a racemate of formula (1) may be separated using chiral High Performance Liquid Chromatography.
- a particular enantiomer may be obtained by using an appropriate chiral intermediate in one of the processes described above.
- the following assays can be used to demonstrate the potency and selectivity of the compounds according to the invention.
- the blocked plates were washed (3x in PBS) and the assay then performed at 37°C in a total volume of 200 ⁇ l containing 2.5x 10 5 K562 cells, phorbol-12- myristate-13-acetate at 10ng/ml, and in the presence or absence of titrated test compounds. Incubation time was 30 minutes. Each plate was fixed and stained as described in the ⁇ 4 ⁇ assay above.
- 96 well tissue culture plates were coated with RPMI 1640/10% FCS for 2h at 37°C.
- 2 x 10 5 freshly isolated human venous polymorphonuclear neutrophils (PMN) were added to the wells in a total volume of 200 ⁇ l in the presence of 10ng/ml phorbol-12-myristate-13-acetate, and in the presence or absence of test compounds, and incubated for 20min at 37°C followed by 30min at room temperature.
- the plates were washed in medium and 100 ⁇ l 0.1 % (w/v) HMB (hexadecyl trimethyl ammonium bromide, Sigma H5882) in 0.05M potassium phosphate buffer, pH 6.0 added to each well.
- HMB hexadecyl trimethyl ammonium bromide
- TMB tetramethyl benzidine
- Human platelet aggregation was assessed using impedance aggregation on the Chronolog Whole Blood Lumiaggregometer.
- Human platelet-rich plasma (PRP) was obtained by spinning fresh human venous blood anticoagulated with 0.38% (v/v) tri-sodium citrate at 220xg for 10 min and diluted to a cell density of 6 x 10 8 /ml in autologous plasma.
- Cuvettes contained equal volumes of PRP and filtered Tyrode's buffer (g/liter: NaCI 8.0; MgCI 2 .H 2 0 0.427; CaCl 2 0.2; KCI 0.2; D-glucose 1.0; NaHC0 3 1.0; NaHP04.2H 2 0 0.065).
- Hepatic clearance can make a substantial contribution to the total plasma clearance of a drug.
- the total plasma clearance is a principal parameter of the pharmacokinetic properties of a medicine. It has a direct impact on the dose required to achieve effective plama concentrations and has a major impact on the elimination half-life and therefore the dose-interval. Furthermore, high hepatic clearance is an indicator of high first-pass hepatic clearance after oral administration and therefore low oral bioavailability.
- peptidic and non-peptidic carboxylic acids of therapeutic interest are subject to high hepatic clearance from plasma. Except for drugs which function in the liver, hepatic uptake from blood or plasma is undesirable because it leads to high hepatic clearance if the compound is excreted in bile or metabolised, or if the substance is not cleared from the liver, it may accumulate in the liver and interfere with the normal function of the liver.
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01953234A EP1305291A1 (en) | 2000-08-02 | 2001-07-30 | 3-substituted isoquinolin-1-yl derivatives |
JP2002516268A JP2004505110A (en) | 2000-08-02 | 2001-07-30 | 3-position substituted isoquinolin-1-yl derivative |
CA002417059A CA2417059A1 (en) | 2000-08-02 | 2001-07-30 | 3-substituted isoquinolin-1-yl derivatives |
AU2001275724A AU2001275724A1 (en) | 2000-08-02 | 2001-07-30 | 3-substituted isoquinolin-1-yl derivatives |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0018969A GB0018969D0 (en) | 2000-08-02 | 2000-08-02 | Chemical compounds |
GB0018969.6 | 2000-08-02 | ||
GB0028837.3 | 2000-11-27 | ||
GB0028837A GB0028837D0 (en) | 2000-11-27 | 2000-11-27 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002010136A1 true WO2002010136A1 (en) | 2002-02-07 |
Family
ID=26244781
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2001/003429 WO2002010136A1 (en) | 2000-08-02 | 2001-07-30 | 3-substituted isoquinolin-1-yl derivatives |
Country Status (6)
Country | Link |
---|---|
US (1) | US6469025B1 (en) |
EP (1) | EP1305291A1 (en) |
JP (1) | JP2004505110A (en) |
AU (1) | AU2001275724A1 (en) |
CA (1) | CA2417059A1 (en) |
WO (1) | WO2002010136A1 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005534684A (en) * | 2002-07-30 | 2005-11-17 | シェーリング コーポレイション | 3,4-Disubstituted cyclobutene-1,2-diones as CXC chemokine receptor ligands |
WO2008125210A1 (en) * | 2007-04-12 | 2008-10-23 | Ucb Pharma, S.A. | Quinoline and naphthalene derivatives, processes for their preparation and their use in treatment of inflammatory diseases |
EP2096107A1 (en) | 2004-12-23 | 2009-09-02 | GPC Biotech AG | Derivatives of squaric acid with anti-proliferative activity |
US8450348B2 (en) | 2007-02-21 | 2013-05-28 | Forma Tm, Llc | Derivatives of squaric acid with anti-proliferative activity |
RU2529468C2 (en) * | 2008-06-24 | 2014-09-27 | Топотаргет А/С | 1, 2-dihydrocyclobutanedione derivatives as nicotinamide phosphoribosyltransferase inhibitors |
US9624195B2 (en) | 2014-12-24 | 2017-04-18 | Gilead Sciences, Inc. | Isoquinoline compounds |
US9701677B2 (en) | 2014-12-24 | 2017-07-11 | Gilead Sciences, Inc. | Fused pyrimidine compounds |
US9730936B2 (en) | 2014-12-24 | 2017-08-15 | Gilead Sciences, Inc. | Quinazoline compounds |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002004426A1 (en) | 2000-07-07 | 2002-01-17 | Celltech R & D Limited | Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3417651A1 (en) * | 1984-05-12 | 1985-11-14 | Arthur H. Prof. Dr. 6200 Wiesbaden Schmidt | Betaines of squaric acid and a process for their preparation |
WO1994025437A1 (en) * | 1993-04-30 | 1994-11-10 | American Home Products Corporation | N-acyl substituted phenyl piperidines as bronchodilators and anti-inflammatory agents |
WO1998018460A1 (en) * | 1996-10-30 | 1998-05-07 | Merck & Co., Inc. | Integrin antagonists |
WO2000035855A1 (en) * | 1998-12-14 | 2000-06-22 | American Home Products Corporation | 3,4-diamino-3-cyclobutene-1,2-dione derivatives which inhibit leukocyte adhesion mediated by vla-4 |
WO2000073260A1 (en) * | 1999-05-28 | 2000-12-07 | Celltech R&D Limited | Squaric acid derivatives as cell adhesion molecules |
Family Cites Families (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1437781A (en) | 1972-04-04 | 1976-06-03 | Beecham Group Ltd | Pyridine derivatives having hypoglycaemic activity |
JPS609718B2 (en) | 1977-08-25 | 1985-03-12 | 塩野義製薬株式会社 | Thiadiazolylthiosephalosporin related antibiotics |
JPS5683483A (en) | 1979-12-13 | 1981-07-08 | Santen Pharmaceut Co Ltd | Thiazolidine compound |
JPS5690045A (en) | 1979-12-25 | 1981-07-21 | Tokuyama Soda Co Ltd | Alpha*alpha**di substituted amino phenylenediacetic acid |
JPS56139455A (en) | 1980-04-02 | 1981-10-30 | Santen Pharmaceut Co Ltd | Sulfur-containing acylaminoacid |
US4470973A (en) | 1982-07-19 | 1984-09-11 | E. R. Squibb & Sons, Inc. | Substituted peptide compounds |
FR2540871B1 (en) | 1983-02-16 | 1986-01-10 | Lipha | AMINO-2 PHENYL-5 BENZODIAZEPINES-1,3; PREPARATION PROCESS AND MEDICINES CONTAINING THEM |
GB8332704D0 (en) | 1983-12-07 | 1984-01-11 | Pfizer Ltd | Growth promotants for animals |
IT1176983B (en) | 1984-10-16 | 1987-08-26 | Zambon Spa | DIPEPTIDES WITH PHARMACOLOGICAL ACTIVITY |
CN1030415A (en) | 1987-02-20 | 1989-01-18 | 山之内制药株式会社 | Saturated heterocycle carboxamide derivatives and its preparation method |
JPH0784424B2 (en) | 1987-04-15 | 1995-09-13 | 味の素株式会社 | Tyrosine derivative and its use |
US5510346A (en) | 1987-12-07 | 1996-04-23 | Hoechst Marion Roussel, Inc. | 4-heteroaryl-1,3-benzodiazepines and 2-substituted-gamma-(heteroaryl)benzeneethanamines |
IT1223565B (en) | 1987-12-21 | 1990-09-19 | Zambon Spa | THIAZOLIDIN 4 CARBOXYLIC ACID DERIVATIVES FOR PHARMACEUTICAL ACTIVITIES |
US5256812A (en) | 1989-01-31 | 1993-10-26 | Hoffmann-La Roche Inc. | Carboxamides and sulfonamides |
US5164372A (en) | 1989-04-28 | 1992-11-17 | Fujisawa Pharmaceutical Company, Ltd. | Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same |
JPH07121917B2 (en) | 1989-07-31 | 1995-12-25 | 四国化成工業株式会社 | 4 (5) -thiocarbamoyl-imidazole compound and method for synthesizing the same |
US5260277A (en) | 1990-09-10 | 1993-11-09 | Tanabe Seiyaku Co., Ltd. | Guanidinyl and related cell adhesion modulation compounds |
IT1244548B (en) | 1991-02-06 | 1994-07-15 | Poli Ind Chimica Spa | 5-OXO-L-PROLIN DERIVATIVES AND THEIR PHARMACEUTICAL APPLICATIONS |
AU666318B2 (en) | 1991-06-28 | 1996-02-08 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
US5296486A (en) | 1991-09-24 | 1994-03-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | Leukotriene biosynthesis inhibitors |
US5250679A (en) | 1991-10-18 | 1993-10-05 | Genentech, Inc. | Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor |
AU3141693A (en) | 1991-11-22 | 1993-06-15 | Friedman, Mark M. | Non-peptidic surrogates of the arg-gly-asp sequence and pharmaceutical compositions comprising them |
US5227490A (en) | 1992-02-21 | 1993-07-13 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
AU686115B2 (en) | 1992-11-02 | 1998-02-05 | Fujisawa Pharmaceutical Co., Ltd. | Imidazo (I,2-a) pyridine derivatives as bradykinin antagonists, pharmaceuticals and processes for their preparation |
FR2700168B1 (en) | 1993-01-07 | 1995-02-03 | Rhone Poulenc Rorer Sa | Thiazolidine derivatives, their preparation and the drugs containing them. |
FR2700167B1 (en) | 1993-01-07 | 1995-02-03 | Rhone Poulenc Rorer Sa | Pyrrolidine and thiazolidine derivatives, their preparation and the drugs containing them. |
GB9311661D0 (en) | 1993-06-05 | 1993-07-21 | Smithkline Beecham Plc | Novel compounds |
AU678503B2 (en) | 1993-09-24 | 1997-05-29 | Takeda Chemical Industries Ltd. | Condensed heterocyclic compounds and their use as squalene synthetase inhibitors |
WO1995013811A1 (en) | 1993-11-17 | 1995-05-26 | Byk Nederland Bv | Use of substituted thiazolidine derivatives in the treatment of raised intraocular pressure |
WO1995015973A1 (en) | 1993-12-06 | 1995-06-15 | Cytel Corporation | Cs-1 peptidomimetics, compositions and methods of using the same |
JP2973271B2 (en) | 1994-01-18 | 1999-11-08 | 参天製薬株式会社 | Endopeptidase 24.15 inhibitor |
FR2721608B1 (en) | 1994-06-22 | 1996-07-19 | Rhone Poulenc Rorer Sa | Thiazolidine derivatives, their preparation and the drugs containing them. |
DE4429597A1 (en) | 1994-08-20 | 1996-02-22 | Basf Ag | Use of low molecular weight or polymeric organic compounds with liquid crystalline properties present in the columnar helical phase |
ES2123889T3 (en) | 1994-11-02 | 1999-01-16 | Merck Patent Gmbh | ADHESION RECEPTOR ANTAGONISTS. |
TW403748B (en) | 1994-11-02 | 2000-09-01 | Takeda Chemical Industries Ltd | An oxazolidinedione derivative, its production and a pharmaceutical composition for lowering blood sugar and lipid in blood comprising the same |
US6306840B1 (en) | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
WO1996026190A1 (en) | 1995-02-22 | 1996-08-29 | Smithkline Beecham Corporation | Integrin receptor antagonists |
US6248713B1 (en) | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
GB9515073D0 (en) | 1995-07-22 | 1995-09-20 | Blair Neil | Securement device and method |
ATE203234T1 (en) | 1995-08-30 | 2001-08-15 | Searle & Co | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINOBENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS |
US5714488A (en) | 1995-10-03 | 1998-02-03 | Abbott Laboratories | Bis-heteroarylylmethoxyphenyl ketone derivatives as inhibitors of leukotriene biosynthesis |
EP0939757A1 (en) | 1995-12-22 | 1999-09-08 | Dupont Pharmaceuticals Company | Novel integrin receptor antagonists |
PL327626A1 (en) | 1995-12-29 | 1998-12-21 | Smithkline Beecham Corp | Antagonists of vitronectin receptor |
GB9604242D0 (en) | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
EP0889876B1 (en) | 1996-03-29 | 2001-07-25 | G.D. SEARLE & CO. | Meta-substituted phenylene sulphonamide derivatives |
EP0889875B1 (en) | 1996-03-29 | 2001-06-20 | G.D. Searle & Co. | Cyclopropyl alkanoic acid derivatives |
ATE204857T1 (en) | 1996-03-29 | 2001-09-15 | Searle & Co | META-SUBSTITUTED PHENYLENDER DERIVATIVES AND THEIR USE AS ALPHAVBETA3 INTERGRIN ANTAGONISTS OR INHIBITORS |
EP0891325B1 (en) | 1996-03-29 | 2002-02-06 | G.D. Searle & Co. | Para-substituted phenylpropanoic acid derivatives as integrin antagonists |
DE19620041A1 (en) | 1996-05-17 | 1998-01-29 | Merck Patent Gmbh | Adhesion receptor antagonists |
JP3418624B2 (en) | 1996-06-10 | 2003-06-23 | メルク エンド カンパニー インコーポレーテッド | Substituted imidazoles having cytokine inhibitory activity |
SK176898A3 (en) | 1996-06-28 | 1999-05-07 | Merck Patent Gmbh | Phenylalamine derivatives as integrin inhibitors |
DE19654483A1 (en) | 1996-06-28 | 1998-01-02 | Merck Patent Gmbh | Phenylalanine derivatives |
WO1998004913A1 (en) | 1996-07-25 | 1998-02-05 | Biogen, Inc. | Molecular model for vla-4 inhibitors |
DE19647381A1 (en) | 1996-11-15 | 1998-05-20 | Hoechst Ag | New heterocycles as leukocyte adhesion inhibitors and VLA-4 antagonists |
DE19647380A1 (en) | 1996-11-15 | 1998-05-20 | Hoechst Ag | 5-ring heterocycles as inhibitors of leukocyte adhesion and VLA-4 antagonists |
CA2272090A1 (en) | 1996-12-09 | 1998-06-18 | Matthew J. Fisher | Integrin antagonists |
CA2277273C (en) | 1997-01-17 | 2008-03-25 | Merck & Co., Inc. | Integrin antagonists |
US6034136A (en) | 1997-03-20 | 2000-03-07 | Novartis Ag | Certain cyclic thio substituted acylaminoacid amide derivatives |
AU728435B2 (en) | 1997-05-29 | 2001-01-11 | Merck & Co., Inc. | Sulfonamides as cell adhesion inhibitors |
WO1998053814A1 (en) | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Heterocyclic amide compounds as cell adhesion inhibitors |
WO1998053817A1 (en) | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Biarylalkanoic acids as cell adhesion inhibitors |
WO1998054207A1 (en) | 1997-05-30 | 1998-12-03 | Celltech Therapeutics Limited | Anti-inflammatory tyrosine derivatives |
JP2001517246A (en) | 1997-06-23 | 2001-10-02 | 田辺製薬株式会社 | α ▲ Lower 4 ▼ β ▲ Lower 1 ▼ Inhibitor of cell adhesion |
KR20010022423A (en) | 1997-07-31 | 2001-03-15 | 진 엠. 듀발 | Compounds which inhibit leukocyte adhesion mediated by VLA-4 |
AU8584698A (en) | 1997-07-31 | 1999-02-22 | American Home Products Corporation | 4-amino-phenylalanine type compounds which inhibit leukocyte adhesion mediated by vla-4 |
EP1001972A1 (en) | 1997-07-31 | 2000-05-24 | Elan Pharmaceuticals, Inc. | Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by vla-4 |
PL338373A1 (en) | 1997-07-31 | 2000-10-23 | Elan Pharm Inc | Dipeptide and its affinite compounds inhibiting adhesion of leucocytes occurring through mediation of vla-4 |
AR016133A1 (en) | 1997-07-31 | 2001-06-20 | Wyeth Corp | CARBAMILOXI COMPOUND INHIBITING THE ADHESION OF LEUKOCYTES THROUGH VLA-4, COMPOUNDS THAT ARE DRUGS OF THESE COMPOUNDS, PHARMACEUTICAL COMPOSITION, METHOD FOR SETTING VLA-4 TO A BIOLOGICAL SAMPLE, METHOD FOR THE TREATMENT OF A TREATMENT |
HUP0003921A3 (en) | 1997-07-31 | 2001-03-28 | Wyeth Corp | Sulfonylated dipeptide compounds which inhibit leukocyte adhesion mediated by vla-4, pharmaceutical compositions comprising thereof and their use |
BR9811573A (en) | 1997-07-31 | 2000-09-19 | Elan Pharm Inc | Benzyl compounds that inhibit vla-4 mediated leukocyte adhesion |
ZA986834B (en) | 1997-07-31 | 2000-05-02 | Athena Neurosciences Inc | Compounds which inhibit leukocyte adhesion mediated by VLA-4. |
JP3555876B2 (en) | 1997-08-22 | 2004-08-18 | エフ.ホフマン−ラ ロシュ アーゲー | N-aroylphenylalanine derivative |
DK1005446T3 (en) | 1997-08-22 | 2004-06-07 | Hoffmann La Roche | N-aroylphenylalanine derivatives |
AU1361499A (en) | 1997-10-21 | 1999-05-10 | Merck & Co., Inc. | Azapeptide acids as cell adhesion inhibitors |
AU1463499A (en) | 1997-11-21 | 1999-06-15 | Merck & Co., Inc. | Substituted pyrrole derivatives as cell adhesion inhibitors |
CA2309341A1 (en) | 1997-11-24 | 1999-06-03 | Merck & Co., Inc. | Substituted .beta.-alanine derivatives as cell adhesion inhibitors |
CA2309204A1 (en) | 1997-11-26 | 1999-06-03 | Dupont Pharmaceuticals Company | 1,3,4-thiadiazoles and 1,3,4-oxadiazoles as .alpha.v.beta.3 antagonists |
CA2315370A1 (en) | 1997-12-17 | 1999-06-24 | Merck & Co., Inc. | Integrin receptor antagonists |
CN1284944A (en) | 1997-12-17 | 2001-02-21 | 麦克公司 | Integrin receptor antagonists |
EP1040111B1 (en) | 1997-12-17 | 2005-06-22 | Merck & Co., Inc. | Integrin receptor antagonists |
EP0933367A1 (en) | 1997-12-19 | 1999-08-04 | Hoechst Marion Roussel Deutschland GmbH | Novel acylguanidine derivates as inhibitors of bone resorption and as vitronectin receptor antagonists |
US6197794B1 (en) | 1998-01-08 | 2001-03-06 | Celltech Therapeutics Limited | Phenylalanine derivatives |
MY153569A (en) | 1998-01-20 | 2015-02-27 | Mitsubishi Tanabe Pharma Corp | Inhibitors of ?4 mediated cell adhesion |
US6329372B1 (en) | 1998-01-27 | 2001-12-11 | Celltech Therapeutics Limited | Phenylalanine derivatives |
DE69919334T2 (en) | 1998-02-26 | 2005-08-04 | Celltech Therapeutics Ltd., Slough | PHENYLALANINE DERIVATIVES AS INHIBITORS OF ALPHA4 INTEGRINEN |
ZA994406B (en) | 1998-03-04 | 2000-02-11 | Searle & Co | Meta-azacyclic amino benzoic acid and derivatives thereof. |
US6521626B1 (en) | 1998-03-24 | 2003-02-18 | Celltech R&D Limited | Thiocarboxamide derivatives |
EP1070060A1 (en) | 1998-04-10 | 2001-01-24 | G.D. Searle & Co. | Heterocyclic glycyl beta-alanine derivatives as vitronectin antagonists |
AU3561099A (en) | 1998-04-14 | 1999-11-01 | American Home Products Corporation | Acylresorcinol derivatives as selective vitronectin receptor inhibitors |
PL346220A1 (en) | 1998-04-16 | 2002-01-28 | Texas Biotechnology Corp | Compounds that inhibit the binding of integrins to their receptors |
DE19821483A1 (en) | 1998-05-14 | 1999-11-18 | Hoechst Marion Roussel De Gmbh | New imidazolidine derivatives useful as leukocyte adhesion and migration inhibitors and/or VLA-4 receptor antagonists for treating E.G. inflammatory and allergic disorders |
GB9811159D0 (en) | 1998-05-22 | 1998-07-22 | Celltech Therapeutics Ltd | Chemical compounds |
WO1999064395A1 (en) | 1998-06-11 | 1999-12-16 | Merck & Co., Inc. | Heterocyclic amide compounds as cell adhesion inhibitors |
US6166050A (en) | 1998-12-14 | 2000-12-26 | American Home Products Corporation | 3,4-diamino-3-cyclobutene-1,2-dione derivatives which inhibit leukocyte adhesion mediated by VLA-4 |
-
2001
- 2001-07-30 EP EP01953234A patent/EP1305291A1/en not_active Withdrawn
- 2001-07-30 AU AU2001275724A patent/AU2001275724A1/en not_active Abandoned
- 2001-07-30 JP JP2002516268A patent/JP2004505110A/en active Pending
- 2001-07-30 CA CA002417059A patent/CA2417059A1/en not_active Abandoned
- 2001-07-30 WO PCT/GB2001/003429 patent/WO2002010136A1/en not_active Application Discontinuation
- 2001-08-01 US US09/920,206 patent/US6469025B1/en not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3417651A1 (en) * | 1984-05-12 | 1985-11-14 | Arthur H. Prof. Dr. 6200 Wiesbaden Schmidt | Betaines of squaric acid and a process for their preparation |
WO1994025437A1 (en) * | 1993-04-30 | 1994-11-10 | American Home Products Corporation | N-acyl substituted phenyl piperidines as bronchodilators and anti-inflammatory agents |
WO1998018460A1 (en) * | 1996-10-30 | 1998-05-07 | Merck & Co., Inc. | Integrin antagonists |
WO2000035855A1 (en) * | 1998-12-14 | 2000-06-22 | American Home Products Corporation | 3,4-diamino-3-cyclobutene-1,2-dione derivatives which inhibit leukocyte adhesion mediated by vla-4 |
WO2000073260A1 (en) * | 1999-05-28 | 2000-12-07 | Celltech R&D Limited | Squaric acid derivatives as cell adhesion molecules |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005534684A (en) * | 2002-07-30 | 2005-11-17 | シェーリング コーポレイション | 3,4-Disubstituted cyclobutene-1,2-diones as CXC chemokine receptor ligands |
EP2096107A1 (en) | 2004-12-23 | 2009-09-02 | GPC Biotech AG | Derivatives of squaric acid with anti-proliferative activity |
US8450348B2 (en) | 2007-02-21 | 2013-05-28 | Forma Tm, Llc | Derivatives of squaric acid with anti-proliferative activity |
WO2008125210A1 (en) * | 2007-04-12 | 2008-10-23 | Ucb Pharma, S.A. | Quinoline and naphthalene derivatives, processes for their preparation and their use in treatment of inflammatory diseases |
RU2529468C2 (en) * | 2008-06-24 | 2014-09-27 | Топотаргет А/С | 1, 2-dihydrocyclobutanedione derivatives as nicotinamide phosphoribosyltransferase inhibitors |
US9006426B2 (en) | 2008-06-24 | 2015-04-14 | Topotarget A/S | Squaric acid derivatives as inhibitors of the nicotinamide |
US9624195B2 (en) | 2014-12-24 | 2017-04-18 | Gilead Sciences, Inc. | Isoquinoline compounds |
US9701677B2 (en) | 2014-12-24 | 2017-07-11 | Gilead Sciences, Inc. | Fused pyrimidine compounds |
US9730936B2 (en) | 2014-12-24 | 2017-08-15 | Gilead Sciences, Inc. | Quinazoline compounds |
US10206926B2 (en) | 2014-12-24 | 2019-02-19 | Gilead Sciences, Inc. | Quinazoline compounds |
US10548898B2 (en) | 2014-12-24 | 2020-02-04 | Gilead Sciences Inc. | Quinazoline compounds |
US11304948B2 (en) | 2014-12-24 | 2022-04-19 | Gilead Sciences, Inc. | Quinazoline compounds |
Also Published As
Publication number | Publication date |
---|---|
AU2001275724A1 (en) | 2002-02-13 |
CA2417059A1 (en) | 2002-02-07 |
US20020177605A1 (en) | 2002-11-28 |
JP2004505110A (en) | 2004-02-19 |
US6469025B1 (en) | 2002-10-22 |
EP1305291A1 (en) | 2003-05-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1135371A1 (en) | Beta-alanine derivatives as alpha 4 integrin inhibitors | |
EP1332132B1 (en) | Enamine derivatives as cell adhesion molecules | |
EP1244611B1 (en) | Squaric acid derivatives as integrin antagonists | |
US6469025B1 (en) | 3-substituted isoquinolin-1-yl derivatives | |
US6593338B2 (en) | 3-substituted 2,7-naphthyridin-1-yl derivatives | |
EP1066316B1 (en) | Cinnamic acid derivatives having cell adhesion modulating activity | |
EP1117646A1 (en) | Phenylalkanoic acid derivatives as inhibitors of alpha4 integrins | |
EP1095036B1 (en) | Cinnamic acid derivatives as cell adhesion molecules | |
WO2003011815A1 (en) | Bicyclic heteroaromatic alanines | |
US6545013B2 (en) | 2,7-naphthyridine derivatives | |
US6403608B1 (en) | 3-Substituted isoquinolin-1-yl derivatives | |
WO2002004426A1 (en) | Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists | |
WO2000018760A1 (en) | 1,3-benzodiazepines with integrin inhibitory activity for use in the treatment of inflammatory disorders | |
US6603041B2 (en) | Bicyclic enamide derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2001275724 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2417059 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2002516268 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2001953234 Country of ref document: EP |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWP | Wipo information: published in national office |
Ref document number: 2001953234 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 2001953234 Country of ref document: EP |