WO2002009649A3 - Conjugues peptides-medicaments integres dans des cellules - Google Patents

Conjugues peptides-medicaments integres dans des cellules Download PDF

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Publication number
WO2002009649A3
WO2002009649A3 PCT/US2001/024088 US0124088W WO0209649A3 WO 2002009649 A3 WO2002009649 A3 WO 2002009649A3 US 0124088 W US0124088 W US 0124088W WO 0209649 A3 WO0209649 A3 WO 0209649A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug conjugates
lfa
icam
leukocytes
side effects
Prior art date
Application number
PCT/US2001/024088
Other languages
English (en)
Other versions
WO2002009649A8 (fr
WO2002009649A2 (fr
Inventor
Teruna J Siahaan
Helena Yusuf-Makagiansar
Meagan Anderson
Rong Christine Xu
Original Assignee
Univ Kansas
Teruna J Siahaan
Yusuf Makagiansar Helena
Meagan Anderson
Rong Christine Xu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Kansas, Teruna J Siahaan, Yusuf Makagiansar Helena, Meagan Anderson, Rong Christine Xu filed Critical Univ Kansas
Priority to CA002417885A priority Critical patent/CA2417885A1/fr
Priority to EP01956077A priority patent/EP1311280A4/fr
Priority to JP2002515204A priority patent/JP2004505029A/ja
Priority to AU2001278113A priority patent/AU2001278113A1/en
Publication of WO2002009649A2 publication Critical patent/WO2002009649A2/fr
Publication of WO2002009649A3 publication Critical patent/WO2002009649A3/fr
Publication of WO2002009649A8 publication Critical patent/WO2002009649A8/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

Des peptides se fixant à des leucocytes sont conjugués à des médicaments. Ces conjugués peptides-médicaments jouent un rôle dans les interactions ICAM-1/LFA-1 et sont intégrés par les leucocytes, ce qui permet à la partie médicament du conjugué d'exercer des effets secondaires toxiques puissants contre des cellules ciblées, tout en minimisant les effets secondaires négatifs. Les conjugués préférés comprennent des peptides 4-30 mer dérivés de ICAM-1 ou LFA-1 couplés à des médicaments efficaces contre des maladies apparentées aux leucocytes.
PCT/US2001/024088 2000-08-01 2001-08-01 Conjugues peptides-medicaments integres dans des cellules WO2002009649A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002417885A CA2417885A1 (fr) 2000-08-01 2001-08-01 Conjugues peptides-medicaments integres dans des cellules
EP01956077A EP1311280A4 (fr) 2000-08-01 2001-08-01 Conjugues peptides-medicaments integres dans des cellules
JP2002515204A JP2004505029A (ja) 2000-08-01 2001-08-01 細胞内に取り込まれるペプチド−薬剤複合体
AU2001278113A AU2001278113A1 (en) 2000-08-01 2001-08-01 Cell internalized peptide-drug conjugates

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62971900A 2000-08-01 2000-08-01
US09/629,719 2000-08-01

Publications (3)

Publication Number Publication Date
WO2002009649A2 WO2002009649A2 (fr) 2002-02-07
WO2002009649A3 true WO2002009649A3 (fr) 2002-04-11
WO2002009649A8 WO2002009649A8 (fr) 2002-08-01

Family

ID=24524196

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/024088 WO2002009649A2 (fr) 2000-08-01 2001-08-01 Conjugues peptides-medicaments integres dans des cellules

Country Status (5)

Country Link
EP (1) EP1311280A4 (fr)
JP (1) JP2004505029A (fr)
AU (1) AU2001278113A1 (fr)
CA (1) CA2417885A1 (fr)
WO (1) WO2002009649A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006102395A2 (fr) * 2005-03-22 2006-09-28 Medstar Health Inc Systemes et methodes d'administration pour le diagnostic et le traitement de maladies cardio-vasculaires
KR101615161B1 (ko) * 2011-02-02 2016-04-25 메디포스트(주) 신경질환의 예방 또는 치료를 위한 icam-1의 용도
US11266717B2 (en) 2016-08-12 2022-03-08 Immunowork, Llc Diagnosis, prevention, and/or treatment of autoimmune diseases

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5183805A (en) * 1990-08-13 1993-02-02 Board Of Regents, The University Of Texas System Bioactive egf peptides for promotion of tissue regeneration and cancer therapy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2188287A1 (fr) * 1994-04-19 1995-10-26 Stephen Benedict Peptides a chaine courte a base d'icam-1/lfa-1 et leur methode d'utilisation
WO1997041149A1 (fr) * 1996-04-26 1997-11-06 The University Of Kansas Compositions de petpides entraînant une tolerance immunitaire et leurs procedes d'utilisation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5183805A (en) * 1990-08-13 1993-02-02 Board Of Regents, The University Of Texas System Bioactive egf peptides for promotion of tissue regeneration and cancer therapy

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GURSOY ET AL.: "Binding and internalization of an ECAM-1 peptide by the surface receptor of T cells", J. PEPTIDES RES, vol. 53, April 1999 (1999-04-01), pages 414 - 421, XP002905947 *
JOIS ET AL.: "Inhibition of homotypic adhesion of T cells: secondary structure of an ICAM-1-derived cyclic peptide", J. PEPTIDE RES., vol. 49, June 1997 (1997-06-01), pages 517 - 526, XP000657593 *
See also references of EP1311280A4 *

Also Published As

Publication number Publication date
EP1311280A2 (fr) 2003-05-21
AU2001278113A1 (en) 2002-02-13
JP2004505029A (ja) 2004-02-19
WO2002009649A8 (fr) 2002-08-01
CA2417885A1 (fr) 2002-02-07
WO2002009649A2 (fr) 2002-02-07
EP1311280A4 (fr) 2005-02-23

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