WO2002006280A3 - Inhibiteurs du facteur xa - Google Patents

Inhibiteurs du facteur xa Download PDF

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Publication number
WO2002006280A3
WO2002006280A3 PCT/US2001/022077 US0122077W WO0206280A3 WO 2002006280 A3 WO2002006280 A3 WO 2002006280A3 US 0122077 W US0122077 W US 0122077W WO 0206280 A3 WO0206280 A3 WO 0206280A3
Authority
WO
WIPO (PCT)
Prior art keywords
factor
inhibitors
compounds
vitro
vivo
Prior art date
Application number
PCT/US2001/022077
Other languages
English (en)
Other versions
WO2002006280A2 (fr
Inventor
Bing-Yan Zhu
Hua Yang
Robert M Scarborough
Original Assignee
Millennium Pharamaceuticals In
Bing-Yan Zhu
Hua Yang
Robert M Scarborough
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharamaceuticals In, Bing-Yan Zhu, Hua Yang, Robert M Scarborough filed Critical Millennium Pharamaceuticals In
Priority to AU2002222933A priority Critical patent/AU2002222933A1/en
Publication of WO2002006280A2 publication Critical patent/WO2002006280A2/fr
Publication of WO2002006280A3 publication Critical patent/WO2002006280A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

L'invention concerne des nouveaux composés, des sels de ceux-ci, ainsi que des compositions associées à ces composés et possédant une activité contre le facteur mammifère Xa. Ces composés sont utiles in vitro ou in vivo pour prévenir ou traiter les troubles de la coagulation.
PCT/US2001/022077 2000-07-13 2001-07-13 Inhibiteurs du facteur xa WO2002006280A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002222933A AU2002222933A1 (en) 2000-07-13 2001-07-13 Inhibitors of factor xa

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21805100P 2000-07-13 2000-07-13
US60/218,051 2000-07-13

Publications (2)

Publication Number Publication Date
WO2002006280A2 WO2002006280A2 (fr) 2002-01-24
WO2002006280A3 true WO2002006280A3 (fr) 2003-07-17

Family

ID=22813543

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/022077 WO2002006280A2 (fr) 2000-07-13 2001-07-13 Inhibiteurs du facteur xa

Country Status (2)

Country Link
AU (1) AU2002222933A1 (fr)
WO (1) WO2002006280A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE50310038D1 (de) 2002-03-11 2008-08-07 Curacyte Ag Hemmstoffe der urokinase, ihre herstellung und verwendung
DE10301300B4 (de) 2003-01-15 2009-07-16 Curacyte Chemistry Gmbh Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein
DE10342108A1 (de) 2003-09-11 2005-04-14 Curacyte Chemistry Gmbh Basisch-substituierte Benzylaminanaloga als Inhibitoren des Gerinnungsfaktors Xa, ihre Herstellung und Verwendung
DE102005044319A1 (de) * 2005-09-16 2007-03-22 Curacyte Chemistry Gmbh 2-(Aminomethyl)-5-Chlor-Benzylamid-Derivate und ihre Verwendung als Hemmstoffe des Gerinnungsfaktors Xa
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
BRPI0719883A2 (pt) 2006-10-09 2015-05-05 Takeda Pharmaceutical Inibidores de quinase
DE102006050672A1 (de) 2006-10-24 2008-04-30 Curacyte Discovery Gmbh Hemmstoffe des Plasmins und des Plasmakallikreins
AU2017282651B2 (en) 2016-06-21 2021-08-12 Orion Ophthalmology LLC Heterocyclic prolinamide derivatives
EP3472151A4 (fr) 2016-06-21 2020-03-04 Orion Ophthalmology LLC Dérivés de prolinamide carbocycliques

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993025574A1 (fr) * 1992-06-12 1993-12-23 Pfizer Inc. Inhibiteurs d'angiotensine i-chymase(s), comprenant la chymase cardiaque humaine
WO1994015956A1 (fr) * 1993-01-04 1994-07-21 The Wellcome Foundation Limited Inhibiteurs de l'enzyme transformant l'endotheline
EP0611756A2 (fr) * 1993-02-19 1994-08-24 Takeda Chemical Industries, Ltd. Alcool et aldéhyde dérivés comme inhibiteur de cathepsin L et comme inhibiteur de la résorption osseuse
WO1995024914A1 (fr) * 1994-03-15 1995-09-21 Myogenics, Inc. Inhibiteurs du complexe proteolytique 26s et du proteasome 20s contenu dans ce dernier
JPH0820597A (ja) * 1994-07-07 1996-01-23 Meiji Seika Kaisha Ltd トロンビン阻害作用を有する複素環カルボニル化合物
WO1996040743A2 (fr) * 1995-06-07 1996-12-19 Cor Therapeutics, Inc. INHIBITEURS DU FACTEUR Xa
WO1996040741A1 (fr) * 1995-06-07 1996-12-19 Ortho Pharmaceutical Corporation Heterocycles peptidyliques utiles dans le traitement de pathologies associees a la thrombine
WO1996040744A1 (fr) * 1995-06-07 1996-12-19 Cor Therapeutics, Inc. INHIBITEURS CETOHETEROCYCLIQUES DU FACTEUR Xa
WO1997031939A1 (fr) * 1996-03-01 1997-09-04 Akzo Nobel N.V. Inhibiteurs de la serine-protease
WO2001010894A2 (fr) * 1999-08-04 2001-02-15 Agouron Pharmaceuticals, Inc. Composes et compositions anti-picornavirus; utilisations pharmaceutiques et materiaux employes pour leur synthese

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993025574A1 (fr) * 1992-06-12 1993-12-23 Pfizer Inc. Inhibiteurs d'angiotensine i-chymase(s), comprenant la chymase cardiaque humaine
WO1994015956A1 (fr) * 1993-01-04 1994-07-21 The Wellcome Foundation Limited Inhibiteurs de l'enzyme transformant l'endotheline
EP0611756A2 (fr) * 1993-02-19 1994-08-24 Takeda Chemical Industries, Ltd. Alcool et aldéhyde dérivés comme inhibiteur de cathepsin L et comme inhibiteur de la résorption osseuse
WO1995024914A1 (fr) * 1994-03-15 1995-09-21 Myogenics, Inc. Inhibiteurs du complexe proteolytique 26s et du proteasome 20s contenu dans ce dernier
JPH0820597A (ja) * 1994-07-07 1996-01-23 Meiji Seika Kaisha Ltd トロンビン阻害作用を有する複素環カルボニル化合物
WO1996040743A2 (fr) * 1995-06-07 1996-12-19 Cor Therapeutics, Inc. INHIBITEURS DU FACTEUR Xa
WO1996040741A1 (fr) * 1995-06-07 1996-12-19 Ortho Pharmaceutical Corporation Heterocycles peptidyliques utiles dans le traitement de pathologies associees a la thrombine
WO1996040744A1 (fr) * 1995-06-07 1996-12-19 Cor Therapeutics, Inc. INHIBITEURS CETOHETEROCYCLIQUES DU FACTEUR Xa
WO1997031939A1 (fr) * 1996-03-01 1997-09-04 Akzo Nobel N.V. Inhibiteurs de la serine-protease
WO2001010894A2 (fr) * 1999-08-04 2001-02-15 Agouron Pharmaceuticals, Inc. Composes et compositions anti-picornavirus; utilisations pharmaceutiques et materiaux employes pour leur synthese

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
B.J. HALL ET AL, TETRAHEDRON LETT., vol. 39, no. 36, 1998, pages 6593 - 6596, XP004132554 *
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002235421, retrieved from STN Database accession no. 1996:281614 *
M. IQBAL ET AL, BIOORG. MED. CHEM. LETT., vol. 7, no. 5, 1997, pages 539 - 544, XP004136061 *
M. TAO ET AL, BIOORG. MED. CHEM. LETT., vol. 6, no. 24, 1996, pages 3009 - 3012, XP002161620 *
S. BAJUSZ ET AL, BIOORG. MED. CHEM. LETT., vol. 8, no. 12, 1998, pages 1477 - 1482, XP004137067 *

Also Published As

Publication number Publication date
AU2002222933A1 (en) 2002-01-30
WO2002006280A2 (fr) 2002-01-24

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