WO2002004601A3 - Mammalian mdm2 binding proteins and uses thereof - Google Patents

Mammalian mdm2 binding proteins and uses thereof Download PDF

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Publication number
WO2002004601A3
WO2002004601A3 PCT/US2001/022053 US0122053W WO0204601A3 WO 2002004601 A3 WO2002004601 A3 WO 2002004601A3 US 0122053 W US0122053 W US 0122053W WO 0204601 A3 WO0204601 A3 WO 0204601A3
Authority
WO
WIPO (PCT)
Prior art keywords
mdm2 binding
mammalian mdm2
binding protein
mammalian
binding proteins
Prior art date
Application number
PCT/US2001/022053
Other languages
French (fr)
Other versions
WO2002004601A2 (en
Inventor
Mark Thomas Boyd
Dale Stewart Haines
Nikolina Vlatkovic
Original Assignee
Philadelphia Health & Educatio
Mark Thomas Boyd
Dale Stewart Haines
Nikolina Vlatkovic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Philadelphia Health & Educatio, Mark Thomas Boyd, Dale Stewart Haines, Nikolina Vlatkovic filed Critical Philadelphia Health & Educatio
Priority to AU2001276899A priority Critical patent/AU2001276899A1/en
Priority to US10/312,954 priority patent/US7166712B2/en
Publication of WO2002004601A2 publication Critical patent/WO2002004601A2/en
Publication of WO2002004601A3 publication Critical patent/WO2002004601A3/en
Priority to US11/650,159 priority patent/US7304142B2/en
Priority to US11/876,901 priority patent/US7732577B2/en
Priority to US12/759,906 priority patent/US20100286362A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Isolated nucleic acid sequences encoding mammalian MDM2 binding protein and polypeptide sequences for the mammalian MDM2 binding protein are provided. Also provided are vectors containing these nucleic acid sequences, host cells which express these proteins and antibodies targeted to these proteins. In addition, methods and compositions for modulating the G1 phase of the cell cycle via altering expression and/or activity of a mammalian MDM2 binding protein are provided.
PCT/US2001/022053 2000-07-12 2001-07-12 Mammalian mdm2 binding proteins and uses thereof WO2002004601A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2001276899A AU2001276899A1 (en) 2000-07-12 2001-07-12 Mammalian mdm2 binding proteins and uses thereof
US10/312,954 US7166712B2 (en) 2000-07-12 2001-07-12 Mammalian MDM2 binding proteins and uses thereof
US11/650,159 US7304142B2 (en) 2000-07-12 2007-01-05 Mammalian MDM2 binding proteins
US11/876,901 US7732577B2 (en) 2000-07-12 2007-10-23 Isolated antibody specific for a mammalian MDM2 binding protein comprising SEQ ID No. 2 or 4
US12/759,906 US20100286362A1 (en) 2000-07-12 2010-04-14 Mammalian MDM2 Binding Proteins and Uses Thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US21783500P 2000-07-12 2000-07-12
US60/217,835 2000-07-12
US23089400P 2000-09-05 2000-09-05
US60/230,894 2000-09-05

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10312954 A-371-Of-International 2001-07-12
US11/650,159 Division US7304142B2 (en) 2000-07-12 2007-01-05 Mammalian MDM2 binding proteins

Publications (2)

Publication Number Publication Date
WO2002004601A2 WO2002004601A2 (en) 2002-01-17
WO2002004601A3 true WO2002004601A3 (en) 2002-06-27

Family

ID=26912305

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/022053 WO2002004601A2 (en) 2000-07-12 2001-07-12 Mammalian mdm2 binding proteins and uses thereof

Country Status (2)

Country Link
AU (1) AU2001276899A1 (en)
WO (1) WO2002004601A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004319946A1 (en) * 2004-04-22 2005-12-01 3-Dimensional Pharmaceuticals, Inc. HDM2-inhibitor complexes and uses thereof
GB0428187D0 (en) * 2004-12-23 2005-01-26 Univ Liverpool Cancer treatment
EP4337676A1 (en) 2021-05-10 2024-03-20 Entrada Therapeutics, Inc. Antigen-binding and antigen degradation constructs

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BOYD ET AL.: "A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 14, 13 October 2000 (2000-10-13), pages 31883 - 31890, XP002908459 *
JUVEN-GERSHON ET AL.: "The MDM2 oncoprotein interacts with the cell fate regulator numb.", MOLECULAR AND CELLULAR BIOLOGY, vol. 18, no. 7, July 1988 (1988-07-01), pages 3974 - 3982, XP001031399 *
SHARP ET AL.: "Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 53, 31 December 1999 (1999-12-31), pages 38189 - 38196, XP002908461 *
VLATKOVIC ET AL.: "A novel MDM2 binding protein (MTBP) induces a G1 arrest that is suppressed by MDM2", BRITISH J. CANCER, vol. 83, no. 3A, 11 July 2000 (2000-07-11), pages 60, XP002908460 *

Also Published As

Publication number Publication date
AU2001276899A1 (en) 2002-01-21
WO2002004601A2 (en) 2002-01-17

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