WO2002002758A3 - Crystallization and structure of staphylococcus aureus peptide deformylase - Google Patents

Crystallization and structure of staphylococcus aureus peptide deformylase Download PDF

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Publication number
WO2002002758A3
WO2002002758A3 PCT/US2001/020777 US0120777W WO0202758A3 WO 2002002758 A3 WO2002002758 A3 WO 2002002758A3 US 0120777 W US0120777 W US 0120777W WO 0202758 A3 WO0202758 A3 WO 0202758A3
Authority
WO
WIPO (PCT)
Prior art keywords
staphylococcus aureus
peptide deformylase
crystallization
aureus peptide
ray crystal
Prior art date
Application number
PCT/US2001/020777
Other languages
French (fr)
Other versions
WO2002002758A2 (en
Inventor
Eric T Baldwin
Melissa S Harris
Original Assignee
Upjohn Co
Eric T Baldwin
Melissa S Harris
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co, Eric T Baldwin, Melissa S Harris filed Critical Upjohn Co
Priority to AU71647/01A priority Critical patent/AU7164701A/en
Publication of WO2002002758A2 publication Critical patent/WO2002002758A2/en
Publication of WO2002002758A3 publication Critical patent/WO2002002758A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Abstract

Staphylococcus aureus peptide deformylase has been crystallized, and the three-dimensional x-ray crystal structure has been solved to 1.9 Å resolution. The x-ray crystal structure is useful for solving the structure of other molecules or molecular complexes, and designing modifiers of peptide deformylase activity.
PCT/US2001/020777 2000-06-30 2001-06-29 Crystallization and structure of staphylococcus aureus peptide deformylase WO2002002758A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU71647/01A AU7164701A (en) 2000-06-30 2001-06-29 Crystallization and structure of staphylococcus aureus peptide deformylase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21555000P 2000-06-30 2000-06-30
US60/215,550 2000-06-30

Publications (2)

Publication Number Publication Date
WO2002002758A2 WO2002002758A2 (en) 2002-01-10
WO2002002758A3 true WO2002002758A3 (en) 2002-08-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/020777 WO2002002758A2 (en) 2000-06-30 2001-06-29 Crystallization and structure of staphylococcus aureus peptide deformylase

Country Status (2)

Country Link
AU (1) AU7164701A (en)
WO (1) WO2002002758A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0879879A2 (en) * 1997-05-21 1998-11-25 Smithkline Beecham Corporation Polypeptide deformylase 1 (Def1)

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0879879A2 (en) * 1997-05-21 1998-11-25 Smithkline Beecham Corporation Polypeptide deformylase 1 (Def1)

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHEN DAWN Z ET AL: "Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor.", BIOCHEMISTRY, vol. 39, no. 6, 15 February 2000 (2000-02-15), pages 1256 - 1262, XP002202852, ISSN: 0006-2960 *
GREER J: "PROTEIN STRUCTURE AND FUNCTION BY COMPARATIVE MODEL BUILDING", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, NEW YORK ACADEMY OF SCIENCES, NEW YORK, NY, US, vol. 439, 1985, pages 44 - 63, XP001053165, ISSN: 0077-8923 *
HAO BING ET AL: "Structural basis for the design of antibiotics targeting peptide deformylase.", BIOCHEMISTRY, vol. 38, no. 15, 13 April 1999 (1999-04-13), pages 4712 - 4719, XP002202851, ISSN: 0006-2960 *
HUNTINGTON KRISTI M ET AL: "Synthesis and antibacterial activity of peptide deformylase inhibitors.", BIOCHEMISTRY, vol. 39, no. 15, 18 April 2000 (2000-04-18), pages 4543 - 4551, XP002202850, ISSN: 0006-2960 *
JANCARIK J ET AL: "SPARSE MATRIX SAMPLING: A SCREENING METHOD FOR CRYSTALLIZATION OF PROTEINS", JOURNAL OF APPLIED CRYSTALLOGRAPHY, COPENHAGEN, DK, vol. 24, 1991, pages 409 - 411, XP001053042, ISSN: 0021-8898 *
KUNTZ I D ET AL: "STRUCTURE-BASED MOLECULAR DESIGN", ACCOUNTS OF CHEMICAL RESEARCH, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 27, no. 5, May 1994 (1994-05-01), pages 117 - 123, XP000885741, ISSN: 0001-4842 *

Also Published As

Publication number Publication date
AU7164701A (en) 2002-01-14
WO2002002758A2 (en) 2002-01-10

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