WO2002000836A3 - Spinigerin variants, an antibacterial and antifungal peptide derived from pseudacanthotermes spiniger, preparation method and compositions containing same - Google Patents

Spinigerin variants, an antibacterial and antifungal peptide derived from pseudacanthotermes spiniger, preparation method and compositions containing same Download PDF

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Publication number
WO2002000836A3
WO2002000836A3 PCT/FR2001/002100 FR0102100W WO0200836A3 WO 2002000836 A3 WO2002000836 A3 WO 2002000836A3 FR 0102100 W FR0102100 W FR 0102100W WO 0200836 A3 WO0200836 A3 WO 0200836A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibacterial
spinigerin
pseudacanthotermes
spiniger
variants
Prior art date
Application number
PCT/FR2001/002100
Other languages
French (fr)
Other versions
WO2002000836A2 (en
Inventor
Philippe Bulet
Jules Hoffmann
Mireille Lamberty
Original Assignee
Centre Nat Rech Scient
Entomed
Philippe Bulet
Jules Hoffmann
Mireille Lamberty
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient, Entomed, Philippe Bulet, Jules Hoffmann, Mireille Lamberty filed Critical Centre Nat Rech Scient
Priority to AU2001270722A priority Critical patent/AU2001270722A1/en
Publication of WO2002000836A2 publication Critical patent/WO2002000836A2/en
Publication of WO2002000836A3 publication Critical patent/WO2002000836A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/50—Isolated enzymes; Isolated proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8281—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for bacterial resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
    • C12N15/8282—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance for fungal resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Insects & Arthropods (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Virology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)

Abstract

The invention concerns peptides of formula: β1 ζ2 υ3 β4 β5 ζ6 σ7 υ8 β9 ζ10 ζ11 ζ12 ζ13 β14 υ15 ζ16 β17 ζ18 ζ19 β20 ζ21 ζ22 σ23 β24 ζ25 wherein: β is a basic amino acid, ζ is a hydrophobic amino acid, υ is a negatively charged or polar/large type amino acid, σ is an amino acid selected among glycine, serine, alanine or threonine. The invention also concerns antibacterial and antifungal compositions for use in man, animal or plants comprising at least said peptides.
PCT/FR2001/002100 2000-06-29 2001-06-29 Spinigerin variants, an antibacterial and antifungal peptide derived from pseudacanthotermes spiniger, preparation method and compositions containing same WO2002000836A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001270722A AU2001270722A1 (en) 2000-06-29 2001-06-29 Spinigerin variants, an antibacterial and antifungal peptide derived from pseudacanthotermes spiniger, preparation method and compositions containing same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR00/08436 2000-06-29
FR0008436A FR2810986B1 (en) 2000-06-29 2000-06-29 ANTIBACTERIAL AND ANTIFUNGAL PEPTIDES, THEIR PREPARATION PROCESS AND THE COMPOSITIONS CONTAINING THEM

Publications (2)

Publication Number Publication Date
WO2002000836A2 WO2002000836A2 (en) 2002-01-03
WO2002000836A3 true WO2002000836A3 (en) 2002-08-29

Family

ID=8851898

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2001/002100 WO2002000836A2 (en) 2000-06-29 2001-06-29 Spinigerin variants, an antibacterial and antifungal peptide derived from pseudacanthotermes spiniger, preparation method and compositions containing same

Country Status (3)

Country Link
AU (1) AU2001270722A1 (en)
FR (1) FR2810986B1 (en)
WO (1) WO2002000836A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988005826A1 (en) * 1987-02-06 1988-08-11 International Genetic Engineering, Inc. Polypeptides with activity against gram-positive and gram-negative bacteria

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988005826A1 (en) * 1987-02-06 1988-08-11 International Genetic Engineering, Inc. Polypeptides with activity against gram-positive and gram-negative bacteria

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LAMBERTY, M. ET AL.: "Insect Immunity - Constitutive Expression of a Cysteine-Rich Antifungal and a Linear Antibacterial Peptide in a Termite Insect", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 6, 9 February 2001 (2001-02-09), pages 4085 - 4092, XP002162835 *
LOWENBERGER, C. ET AL.: "Antimicrobial Activity Spectrum, cDNA Cloning, and mRNA Expression of a Newly Isolated Member of the Cecropin Family from Mosquito Vector Aedes aegypti", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 29, 16 July 1999 (1999-07-16), pages 20092 - 20097, XP002165176 *

Also Published As

Publication number Publication date
FR2810986B1 (en) 2002-09-27
FR2810986A1 (en) 2002-01-04
AU2001270722A1 (en) 2002-01-08
WO2002000836A2 (en) 2002-01-03

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