WO2002000716A3 - Cell lines and cell-based assays for identification of androgen receptor modulators - Google Patents
Cell lines and cell-based assays for identification of androgen receptor modulators Download PDFInfo
- Publication number
- WO2002000716A3 WO2002000716A3 PCT/US2001/019609 US0119609W WO0200716A3 WO 2002000716 A3 WO2002000716 A3 WO 2002000716A3 US 0119609 W US0119609 W US 0119609W WO 0200716 A3 WO0200716 A3 WO 0200716A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cell
- androgen receptor
- receptor modulators
- identification
- based assays
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MXPA02012573A MXPA02012573A (en) | 2000-06-28 | 2001-06-20 | Cell lines and cell-based assays for identification of androgen receptor modulators. |
EP01944616A EP1297108A2 (en) | 2000-06-28 | 2001-06-20 | Cell lines and cell-based assays for identification of androgen receptor modulators |
IL15249101A IL152491A0 (en) | 2000-06-28 | 2001-06-20 | Stable muscle cell lines and cell-based assay methods for identification of androgen receptor modulations |
CA002413596A CA2413596A1 (en) | 2000-06-28 | 2001-06-20 | Cell lines and cell-based assays for identification of androgen receptor modulators |
JP2002505838A JP2004517606A (en) | 2000-06-28 | 2001-06-20 | Cell lines and cell-based assays for identification of androgen receptor modulators |
AU2001267008A AU2001267008A1 (en) | 2000-06-28 | 2001-06-20 | Cell lines and cell-based assays for identification of androgen receptor modulators |
PCT/US2001/019609 WO2002000716A2 (en) | 2000-06-28 | 2001-06-20 | Cell lines and cell-based assays for identification of androgen receptor modulators |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21439200P | 2000-06-28 | 2000-06-28 | |
US60/214,392 | 2000-06-28 | ||
PCT/US2001/019609 WO2002000716A2 (en) | 2000-06-28 | 2001-06-20 | Cell lines and cell-based assays for identification of androgen receptor modulators |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002000716A2 WO2002000716A2 (en) | 2002-01-03 |
WO2002000716A3 true WO2002000716A3 (en) | 2002-06-13 |
Family
ID=26680504
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/019609 WO2002000716A2 (en) | 2000-06-28 | 2001-06-20 | Cell lines and cell-based assays for identification of androgen receptor modulators |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1297108A2 (en) |
JP (1) | JP2004517606A (en) |
AU (1) | AU2001267008A1 (en) |
CA (1) | CA2413596A1 (en) |
MX (1) | MXPA02012573A (en) |
WO (1) | WO2002000716A2 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1359160A1 (en) * | 2002-02-28 | 2003-11-05 | Pfizer Products Inc. | Androgen receptor overexpressing skeletal myoblasts |
WO2004007753A2 (en) * | 2002-07-17 | 2004-01-22 | Bristol-Myers Squibb Company | Transgenic non-human mammals expressing a reporter nucleic acid under the regulation of androgen response elements |
WO2009136629A1 (en) * | 2008-05-09 | 2009-11-12 | あすか製薬株式会社 | Prophylactic/therapeutic agent for lifestyle-related diseases |
AR092982A1 (en) | 2012-10-11 | 2015-05-13 | Isis Pharmaceuticals Inc | MODULATION OF THE EXPRESSION OF ANDROGEN RECEIVERS |
CN105758916B (en) * | 2016-03-16 | 2018-04-13 | 济南大学 | A kind of preparation method and application of the decis optical electro-chemistry sensor based on electrochemical luminescence excitation |
CN115181748A (en) * | 2022-08-08 | 2022-10-14 | 湖州师范学院 | Biological detection method of male hormone |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1988003168A1 (en) * | 1986-10-24 | 1988-05-05 | The Salk Institute For Biological Studies | Hormone receptor compositions and methods |
WO1992016546A1 (en) * | 1991-03-19 | 1992-10-01 | The Salk Institute For Biological Studies | Response element compositions and assays employing same |
WO1996040958A1 (en) * | 1995-06-07 | 1996-12-19 | Baylor College Of Medicine | Nucleic acid transporters for delivery of nucleic acids into a cell |
WO1999054728A2 (en) * | 1998-04-23 | 1999-10-28 | Karo Bio Usa, Inc. | Method of predicting receptor modulating activity |
-
2001
- 2001-06-20 WO PCT/US2001/019609 patent/WO2002000716A2/en not_active Application Discontinuation
- 2001-06-20 AU AU2001267008A patent/AU2001267008A1/en not_active Abandoned
- 2001-06-20 JP JP2002505838A patent/JP2004517606A/en active Pending
- 2001-06-20 CA CA002413596A patent/CA2413596A1/en not_active Abandoned
- 2001-06-20 EP EP01944616A patent/EP1297108A2/en not_active Withdrawn
- 2001-06-20 MX MXPA02012573A patent/MXPA02012573A/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1988003168A1 (en) * | 1986-10-24 | 1988-05-05 | The Salk Institute For Biological Studies | Hormone receptor compositions and methods |
WO1992016546A1 (en) * | 1991-03-19 | 1992-10-01 | The Salk Institute For Biological Studies | Response element compositions and assays employing same |
WO1996040958A1 (en) * | 1995-06-07 | 1996-12-19 | Baylor College Of Medicine | Nucleic acid transporters for delivery of nucleic acids into a cell |
WO1999054728A2 (en) * | 1998-04-23 | 1999-10-28 | Karo Bio Usa, Inc. | Method of predicting receptor modulating activity |
Non-Patent Citations (11)
Title |
---|
EVANS R M: "THE STERIOD AND THYROID HORMONE RECEPTOR SUPERFAMILY", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 240, no. 4854, 13 May 1988 (1988-05-13), pages 889 - 895, XP000574469, ISSN: 0036-8075 * |
FUHRMANN U ET AL: "STABLE TRANSFECTION OF ANDROGEN RECEPTOR AND MMTV-CAT INTO MAMMALIAN CELLS: INHIBITION OF CAT EXPRESSION BY ANTI-ANDROGENS", JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, ELSEVIER SCIENCE LTD., OXFORD, GB, vol. 42, no. 8, September 1992 (1992-09-01), pages 787 - 793, XP000884986, ISSN: 0960-0760 * |
GERDES MICHAEL J ET AL: "Transforming growth factor-beta1 induces nuclear to cytoplasmic distribution of androgen receptor and inhibits androgen response in prostate smooth muscle cells.", ENDOCRINOLOGY, vol. 139, no. 8, August 1998 (1998-08-01), pages 3569 - 3577, XP002193244, ISSN: 0013-7227 * |
HOFBAUER LORENZ C ET AL: "Development and characterization of a conditionally immortalized human osteoblastic cell line stably transfected with the human androgen receptor gene.", JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 66, no. 4, 1997, pages 542 - 551, XP002193246, ISSN: 0730-2312 * |
NEGRO-VILAR ANDRES: "Selective androgen receptor modulators (SARMs): A novel approach to androgen therapy for the new millennium.", JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 84, no. 10, October 1999 (1999-10-01), pages 3459 - 3462, XP002193249, ISSN: 0021-972X * |
SALM SARAH N ET AL: "Transforming growth factor-beta is an autocrine mitogen for a novel androgen-responsive murine prostatic smooth muscle cell line, PSMC1.", JOURNAL OF CELLULAR PHYSIOLOGY, vol. 185, no. 3, December 2000 (2000-12-01), pages 416 - 424, XP001056974, ISSN: 0021-9541 * |
SYMS A J ET AL: "MECHANISM OF ANDROGEN-RECEPTOR AUGMENTATION ANALYSIS OF RECEPTOR SYNTHESIS AND DEGRADATION BY THE DENSITY-SHIFT TECHNIQUE", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 260, no. 1, 1985, pages 455 - 461, XP001057030, ISSN: 0021-9258 * |
TABB JOEL S ET AL: "Suppression of sodium channel function in differentiating C2 muscle cells stably overexpressing rat androgen receptors.", JOURNAL OF NEUROSCIENCE, vol. 14, no. 2, 1994, pages 763 - 773, XP001056898, ISSN: 0270-6474 * |
TEROUANNE BEATRICE ET AL: "A stable prostatic bioluminescent cell line to investigate androgen and antiandrogen effects.", MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 160, no. 1-2, 25 February 2000 (2000-02-25), pages 39 - 49, XP002193245, ISSN: 0303-7207 * |
YARBROUGH W G ET AL: "A SINGLE BASE MUTATION IN THE ANDROGEN RECEPTOR GENE CAUSES ANDROGEN INSENSITIVITY IN THE TESTICULAR FEMINIZED RAT", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 265, no. 15, 1990, pages 8893 - 8900, XP001062675, ISSN: 0021-9258 * |
ZHOU ZHIFENG ET AL: "Identification and characterization of a novel androgen response element composed of a direct repeat.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 13, 1997, pages 8227 - 8235, XP002193247, ISSN: 0021-9258 * |
Also Published As
Publication number | Publication date |
---|---|
WO2002000716A2 (en) | 2002-01-03 |
MXPA02012573A (en) | 2003-05-14 |
AU2001267008A1 (en) | 2002-01-08 |
EP1297108A2 (en) | 2003-04-02 |
JP2004517606A (en) | 2004-06-17 |
CA2413596A1 (en) | 2002-01-03 |
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