WO2001098367A3 - Neuroactive peptides for treatment of hypoxia and related conditions - Google Patents

Neuroactive peptides for treatment of hypoxia and related conditions Download PDF

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Publication number
WO2001098367A3
WO2001098367A3 PCT/US2001/019839 US0119839W WO0198367A3 WO 2001098367 A3 WO2001098367 A3 WO 2001098367A3 US 0119839 W US0119839 W US 0119839W WO 0198367 A3 WO0198367 A3 WO 0198367A3
Authority
WO
WIPO (PCT)
Prior art keywords
hypoxia
treatment
related conditions
neuroactive peptides
neuroactive
Prior art date
Application number
PCT/US2001/019839
Other languages
French (fr)
Other versions
WO2001098367A2 (en
Inventor
Joseph R Moskal
Hirotaka Yamamoto
Patrica A Colley
Original Assignee
Nyxis Neurotherapies Inc
Joseph R Moskal
Hirotaka Yamamoto
Patrica A Colley
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nyxis Neurotherapies Inc, Joseph R Moskal, Hirotaka Yamamoto, Patrica A Colley filed Critical Nyxis Neurotherapies Inc
Priority to CA002413974A priority Critical patent/CA2413974A1/en
Priority to AU2001271366A priority patent/AU2001271366A1/en
Priority to EP01950368A priority patent/EP1296999A2/en
Priority to JP2002504322A priority patent/JP2004500874A/en
Publication of WO2001098367A2 publication Critical patent/WO2001098367A2/en
Publication of WO2001098367A3 publication Critical patent/WO2001098367A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Compositions and methods are provided for the treatment of hypoxia. In a preferred embodiment, compositions and methods are provided for the treatment of the effects of hypoxia or ischemia on the central nervous system.
PCT/US2001/019839 2000-06-22 2001-06-22 Neuroactive peptides for treatment of hypoxia and related conditions WO2001098367A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002413974A CA2413974A1 (en) 2000-06-22 2001-06-22 Neuroactive peptides for treatment of hypoxia and related conditions
AU2001271366A AU2001271366A1 (en) 2000-06-22 2001-06-22 Neuroactive peptides for treatment of hypoxia and related conditions
EP01950368A EP1296999A2 (en) 2000-06-22 2001-06-22 Neuroactive peptides for treatment of hypoxia and related conditions
JP2002504322A JP2004500874A (en) 2000-06-22 2001-06-22 Neuroactive peptides for the treatment of hypoxia and related conditions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21361400P 2000-06-22 2000-06-22
US60/213,614 2000-06-22

Publications (2)

Publication Number Publication Date
WO2001098367A2 WO2001098367A2 (en) 2001-12-27
WO2001098367A3 true WO2001098367A3 (en) 2002-08-01

Family

ID=22795793

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/019839 WO2001098367A2 (en) 2000-06-22 2001-06-22 Neuroactive peptides for treatment of hypoxia and related conditions

Country Status (5)

Country Link
EP (1) EP1296999A2 (en)
JP (1) JP2004500874A (en)
AU (1) AU2001271366A1 (en)
CA (1) CA2413974A1 (en)
WO (1) WO2001098367A2 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2553968T3 (en) 2008-09-18 2015-12-15 Northwestern University NMDA receiver modulators and their uses
US8951968B2 (en) 2009-10-05 2015-02-10 Northwestern University Methods of treating depression and other related diseases
MX2012009388A (en) 2010-02-11 2012-10-01 Univ Northwestern Secondary structure stabilized nmda receptor modulators and uses thereof.
KR101692275B1 (en) 2010-02-11 2017-01-04 노오쓰웨스턴 유니버시티 Secondary structure stabilized nmda receptor modulators and uses thereof
CN105026401A (en) 2013-01-29 2015-11-04 诺雷克斯股份有限公司 Spiro-lactam NMDA receptor modulators and uses thereof
CN105229010A (en) 2013-01-29 2016-01-06 阿普廷伊克斯股份有限公司 Spiral shell-lactan nmda receptor conditioning agent and uses thereof
MX2015009772A (en) 2013-01-29 2016-05-31 Aptinyx Inc Spiro-lactam nmda receptor modulators and uses thereof.
KR102280616B1 (en) 2013-01-29 2021-07-21 앱티닉스 인크. Spiro-lactam nmda receptor modulators and uses thereof
US9708335B2 (en) 2013-01-29 2017-07-18 Apytinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
WO2017201285A1 (en) 2016-05-19 2017-11-23 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
CA3024606C (en) 2016-05-19 2019-09-03 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
SG11201900558RA (en) 2016-08-01 2019-02-27 Aptinyx Inc Spiro-lactam nmda receptor modulators and uses thereof
AU2017305240B2 (en) 2016-08-01 2021-12-09 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
SG10202101055VA (en) 2016-08-01 2021-03-30 Aptinyx Inc Spiro-lactam nmda receptor modulators and uses thereof
CN109661398B (en) 2016-08-01 2022-07-05 阿普廷伊克斯股份有限公司 Spiro-lactam and di-spiro-lactam NMDA receptor modulators and uses thereof
WO2018026798A1 (en) 2016-08-01 2018-02-08 Aptinyx Inc. Spiro-lactam nmda modulators and methods of using same
MX2020008107A (en) 2018-01-31 2020-09-25 Aptinyx Inc Spiro-lactam nmda receptor modulators and uses thereof.
US12012413B2 (en) 2019-11-11 2024-06-18 Tenacia Biotechnology (Hong Kong) Co., Limited Methods of treating painful diabetic peripheral neuropathy

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997043306A1 (en) * 1996-05-17 1997-11-20 Neurotherapeutics, L.P. Neuroactive peptides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997043306A1 (en) * 1996-05-17 1997-11-20 Neurotherapeutics, L.P. Neuroactive peptides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PRIESTLEY T ET AL.: "The effect of NMDA receptor glycine site antagonists on hypoxia-induced neurodegeneration of rat cortical cell cultures", BRAIN RESEARCH, vol. 531, 1990, pages 183 - 188, XP002196464 *
RAZDAN B ET AL.: "Modification of the glycine (co-activator) binding site of the N-methyl-D-aspartate receptor in the guinea pig fetus brain during development following hypoxia", BRAIN RESEARCH, vol. 733, 1996, pages 15 - 20, XP002196465 *

Also Published As

Publication number Publication date
WO2001098367A2 (en) 2001-12-27
JP2004500874A (en) 2004-01-15
EP1296999A2 (en) 2003-04-02
CA2413974A1 (en) 2001-12-27
AU2001271366A1 (en) 2002-01-02

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