WO2001097794A8 - Inhibitors of matriptase for the treatment of cancer - Google Patents
Inhibitors of matriptase for the treatment of cancerInfo
- Publication number
- WO2001097794A8 WO2001097794A8 PCT/US2001/018773 US0118773W WO0197794A8 WO 2001097794 A8 WO2001097794 A8 WO 2001097794A8 US 0118773 W US0118773 W US 0118773W WO 0197794 A8 WO0197794 A8 WO 0197794A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- matriptase
- subject
- inhibitors
- cancer
- treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96486—Metalloendopeptidases (3.4.24)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Hospice & Palliative Care (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2001266838A AU2001266838A1 (en) | 2000-06-21 | 2001-06-12 | Inhibitors of matriptase for the treatment of cancer |
EP01944426A EP1355637A2 (en) | 2000-06-21 | 2001-06-12 | Inhibitors of matriptase for the treatment of cancer |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21307300P | 2000-06-21 | 2000-06-21 | |
US60/213,073 | 2000-06-21 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2001097794A2 WO2001097794A2 (en) | 2001-12-27 |
WO2001097794A3 WO2001097794A3 (en) | 2003-08-21 |
WO2001097794A8 true WO2001097794A8 (en) | 2003-10-30 |
Family
ID=22793641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/018773 WO2001097794A2 (en) | 2000-06-21 | 2001-06-12 | Inhibitors of matriptase for the treatment of cancer |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1355637A2 (en) |
AU (1) | AU2001266838A1 (en) |
WO (1) | WO2001097794A2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9290757B2 (en) | 2006-07-05 | 2016-03-22 | Catalyst Biosciences, Inc. | Protease screening methods and proteases identified thereby |
US9359598B2 (en) | 2004-04-12 | 2016-06-07 | Catalyst Biosciences, Inc. | Mutant MT-SP1 proteases with altered substrate specificity or activity |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6797504B1 (en) | 2000-09-08 | 2004-09-28 | Dendreon San Diego Llc | Inhibitors of serine protease activity of matriptase or MTSP1 |
US7157596B2 (en) | 2000-09-08 | 2007-01-02 | Dendreon Corporation | Inhibitors of serine protease activity of matriptase or MTSP1 |
WO2003076391A2 (en) | 2002-03-11 | 2003-09-18 | Curacyte Ag | Urokinase inhibitors, production and use thereof |
US7939304B2 (en) | 2002-10-02 | 2011-05-10 | Catalyst Biosciences, Inc. | Mutant MT-SP1 proteases with altered substrate specificity or activity |
US7019019B2 (en) | 2002-12-23 | 2006-03-28 | Dendreon Corporation | Matriptase inhibitors and methods of use |
DE10301300B4 (en) | 2003-01-15 | 2009-07-16 | Curacyte Chemistry Gmbh | Use of acylated 4-amidino- and 4-guanidinobenzylamines for the inhibition of plasma kallikrein |
DE10322191B4 (en) | 2003-05-16 | 2014-02-27 | The Medicines Company (Leipzig) Gmbh | N-sulfonylated amino acid derivatives, process for their preparation and their use |
DE10342108A1 (en) | 2003-09-11 | 2005-04-14 | Curacyte Chemistry Gmbh | Basic substituted benzylamine analogs as coagulation factor Xa inhibitors, their preparation and use |
US7439226B2 (en) | 2003-09-30 | 2008-10-21 | The United States Of America As Represented By The Department Of Health And Human Services | Serine protease inhibitors |
DE102006050672A1 (en) | 2006-10-24 | 2008-04-30 | Curacyte Discovery Gmbh | New glycylglycine derivatives with a benzylsulfonylamido group and an amidino-organylamido group at the opposite chain ends, used in drugs for reducing loss of blood, e.g. in operations |
DE102008007440A1 (en) * | 2008-02-01 | 2009-08-13 | Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co.Kg | Amino acid derivatives as drugs |
SG175711A1 (en) | 2009-05-18 | 2011-12-29 | Orion Corp | Protease inhibitors |
US10175238B2 (en) * | 2014-05-13 | 2019-01-08 | Georgetown University | Markers for abnormal cells |
MX2019007522A (en) * | 2016-12-22 | 2019-11-08 | Verlyx Pharma Inc | Amidine substituted analogues and uses thereof. |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH525897A (en) * | 1961-09-11 | 1972-07-31 | Wander Ag Dr A | Cyclic bis-amidine cpds - esp useful as tuberculostats |
AU4432597A (en) * | 1996-09-25 | 1998-04-17 | Regents Of The University Of California, The | Methods of using agmatine to reduce intracellular polyamine levels and to inhibit inducible nitric oxide synthase |
MXPA01011000A (en) * | 1999-04-30 | 2003-06-30 | Slil Biomedical Corp | Conformationally restricted polyamine analogs as disease therapies. |
AU780538B2 (en) * | 1999-11-16 | 2005-03-24 | Oncozyme Pharma Inc. | Inhibitors of endo-exonuclease activity for treating cancer |
DE19955476A1 (en) * | 1999-11-18 | 2001-05-23 | Boehringer Ingelheim Pharma | Bis-basic compounds as tryptase inhibitors, process for their preparation and their use as medicaments |
-
2001
- 2001-06-12 AU AU2001266838A patent/AU2001266838A1/en not_active Abandoned
- 2001-06-12 EP EP01944426A patent/EP1355637A2/en not_active Withdrawn
- 2001-06-12 WO PCT/US2001/018773 patent/WO2001097794A2/en not_active Application Discontinuation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9359598B2 (en) | 2004-04-12 | 2016-06-07 | Catalyst Biosciences, Inc. | Mutant MT-SP1 proteases with altered substrate specificity or activity |
US9290757B2 (en) | 2006-07-05 | 2016-03-22 | Catalyst Biosciences, Inc. | Protease screening methods and proteases identified thereby |
Also Published As
Publication number | Publication date |
---|---|
WO2001097794A2 (en) | 2001-12-27 |
WO2001097794A3 (en) | 2003-08-21 |
EP1355637A2 (en) | 2003-10-29 |
AU2001266838A1 (en) | 2002-01-02 |
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Free format text: IN PCT GAZETTE 52/2001 UNDER (51) REPLACE THE EXISTING TEXT BY "A61K 31/155, A61K 31/655, A61K 31/341, A61K 31/4178, A61K 31/506, A61P 33/00" Free format text: IN PCT GAZETTE 52/2001 UNDER (51) REPLACE THE EXISTING TEXT BY "A61K 31/155, A61K 31/655, A61K 31/341, A61K 31/4178, A61K 31/506, A61P 33/00" |
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