WO2001094391A3 - Intracellular signaling proteins - Google Patents

Intracellular signaling proteins Download PDF

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Publication number
WO2001094391A3
WO2001094391A3 PCT/US2001/018595 US0118595W WO0194391A3 WO 2001094391 A3 WO2001094391 A3 WO 2001094391A3 US 0118595 W US0118595 W US 0118595W WO 0194391 A3 WO0194391 A3 WO 0194391A3
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WO
WIPO (PCT)
Prior art keywords
intracellular signaling
signaling proteins
isigp
provides
polynucleotides
Prior art date
Application number
PCT/US2001/018595
Other languages
French (fr)
Other versions
WO2001094391A2 (en
Inventor
Henry Yue
Ann He
Danniel B Nguyen
Monique G Yao
Olga Bandman
Neil Burford
Y Tom Tang
Yuming Xu
April Hafalia
Yalda Azimzai
Narinder K Walia
Original Assignee
Incyte Genomics Inc
Henry Yue
Ann He
Danniel B Nguyen
Monique G Yao
Olga Bandman
Neil Burford
Y Tom Tang
Yuming Xu
April Hafalia
Yalda Azimzai
Narinder K Walia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc, Henry Yue, Ann He, Danniel B Nguyen, Monique G Yao, Olga Bandman, Neil Burford, Y Tom Tang, Yuming Xu, April Hafalia, Yalda Azimzai, Narinder K Walia filed Critical Incyte Genomics Inc
Priority to US10/297,880 priority Critical patent/US20030211513A1/en
Priority to JP2002501939A priority patent/JP2004500862A/en
Priority to AU2001275401A priority patent/AU2001275401A1/en
Priority to EP01942108A priority patent/EP1283886A2/en
Priority to CA002409392A priority patent/CA2409392A1/en
Publication of WO2001094391A2 publication Critical patent/WO2001094391A2/en
Publication of WO2001094391A3 publication Critical patent/WO2001094391A3/en

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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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Abstract

The invention provides human intracellular signaling proteins (ISIGP) and polynucleotides which identify and encode ISIGP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of ISIGP.
PCT/US2001/018595 2000-06-08 2001-06-07 Intracellular signaling proteins WO2001094391A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US10/297,880 US20030211513A1 (en) 2000-06-08 2001-06-07 Intracellular signaling proteins
JP2002501939A JP2004500862A (en) 2000-06-08 2001-06-07 Intracellular signaling protein
AU2001275401A AU2001275401A1 (en) 2000-06-08 2001-06-07 Intracellular signaling proteins
EP01942108A EP1283886A2 (en) 2000-06-08 2001-06-07 Intracellular signaling proteins
CA002409392A CA2409392A1 (en) 2000-06-08 2001-06-07 Intracellular signaling proteins

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US21058200P 2000-06-08 2000-06-08
US60/210,582 2000-06-08
US21244300P 2000-06-16 2000-06-16
US60/212,443 2000-06-16

Publications (2)

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WO2001094391A2 WO2001094391A2 (en) 2001-12-13
WO2001094391A3 true WO2001094391A3 (en) 2002-07-18

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US (1) US20030211513A1 (en)
EP (1) EP1283886A2 (en)
JP (1) JP2004500862A (en)
AU (1) AU2001275401A1 (en)
CA (1) CA2409392A1 (en)
WO (1) WO2001094391A2 (en)

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ES2251866B1 (en) 2004-06-18 2007-06-16 Laboratorios Almirall S.A. NEW DERIVATIVES OF PIRIDAZIN-3 (2H) -ONA.
CN104306960A (en) * 2014-09-24 2015-01-28 郭和友 Method for treating viruses and cancers by using cutting enzyme
CN104306961A (en) * 2014-10-05 2015-01-28 郭和友 Method for eliminating latent dormant viruses or bacteria by utilizing excisionase
CN104306962A (en) * 2014-10-05 2015-01-28 郭和友 Method for cutting viral transcriptase by utilizing excisionase
WO2024031003A2 (en) * 2022-08-04 2024-02-08 Regents Of The University Of Michigan Grail-1 peptide products and methods

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602019A (en) * 1991-04-19 1997-02-11 The Board Of Regents Of The University Of Washington DNA encoding mammalian phosphodiesterases
WO1997044347A1 (en) * 1996-05-21 1997-11-27 Smithkline Beecham Corporation Human cis protein
WO2001062921A2 (en) * 2000-02-22 2001-08-30 Lexicon Genetics Incorporated Novel human regulatory protein and polynucleotides encoding the same
WO2001062922A2 (en) * 2000-02-24 2001-08-30 Incyte Genomics, Inc. Polypeptides and corresponding molecules for disease detection and treatment

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030165881A1 (en) * 2000-03-07 2003-09-04 Tang Y. Tom Novel nucleic acids and polypeptides
CA2405912A1 (en) * 2000-04-12 2001-10-18 Human Genome Sciences, Inc. Albumin fusion proteins

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602019A (en) * 1991-04-19 1997-02-11 The Board Of Regents Of The University Of Washington DNA encoding mammalian phosphodiesterases
WO1997044347A1 (en) * 1996-05-21 1997-11-27 Smithkline Beecham Corporation Human cis protein
WO2001062921A2 (en) * 2000-02-22 2001-08-30 Lexicon Genetics Incorporated Novel human regulatory protein and polynucleotides encoding the same
WO2001062922A2 (en) * 2000-02-24 2001-08-30 Incyte Genomics, Inc. Polypeptides and corresponding molecules for disease detection and treatment

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 29 April 1999 (1999-04-29), STRAUSBERG, R.: "tt33f03.x1 NCI_CGAP_GC6 Homo sapiens cDNA clone IMAGE:2242589 3', mRNA sequence.", XP002189503 *
DOWLER SIMON ET AL: "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities", BIOCHEMICAL JOURNAL, THE BIOCHEMICAL SOCIETY, LONDON, GB, vol. 351, no. 1, 1 October 2000 (2000-10-01), pages 19 - 31, XP002183400, ISSN: 0264-6021 *
NAGASE T ET AL: "PREDICTION OF THE CODING SEQUENCES OF UNIDENTIFIED HUMAN GENES XIX. THE COMPLETE SEQUENCES OF 100 NEW CDNA CLONES FROM BRAIN WHICHCODE FOR LARGE PROTEINS IN VITRO", DNA RESEARCH, UNIVERSAL ACADEMY PRESS, JP, vol. 7, no. 6, 31 December 2000 (2000-12-31), pages 347 - 355, XP002944073, ISSN: 1340-2838 *

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