WO2001092297A3 - Regulation of human lgr4-like g protein-coupled receptor - Google Patents

Regulation of human lgr4-like g protein-coupled receptor Download PDF

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Publication number
WO2001092297A3
WO2001092297A3 PCT/EP2001/006089 EP0106089W WO0192297A3 WO 2001092297 A3 WO2001092297 A3 WO 2001092297A3 EP 0106089 W EP0106089 W EP 0106089W WO 0192297 A3 WO0192297 A3 WO 0192297A3
Authority
WO
WIPO (PCT)
Prior art keywords
protein
lgr4
coupled receptor
regulation
human lgr4
Prior art date
Application number
PCT/EP2001/006089
Other languages
French (fr)
Other versions
WO2001092297A2 (en
Inventor
Shyam Ramakrishnan
Original Assignee
Bayer Ag
Shyam Ramakrishnan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Shyam Ramakrishnan filed Critical Bayer Ag
Priority to EP01960250A priority Critical patent/EP1290030A2/en
Priority to US10/276,340 priority patent/US20030139341A1/en
Priority to AU2001281791A priority patent/AU2001281791A1/en
Publication of WO2001092297A2 publication Critical patent/WO2001092297A2/en
Publication of WO2001092297A3 publication Critical patent/WO2001092297A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Reagents which regulate human LGR4-like G protein-coupled receptor (LGR4-like GPCR) and reagents which bind to human LGR4-like GPCR gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases in which G protein-coupled receptors are implicated including, but not limited to, obesity and diseases related to obesity, cancer, diabetes, osteoporosis, anxiety, depression, hypertension, migraine, compulsive disorders, schizophrenia, autism, neurodegenerative disorders, such as Alzheimer's disease, Parkinsonism, and Huntington's chorea, and cancer chemotherapy-induced vomiting.
PCT/EP2001/006089 2000-05-30 2001-05-29 Regulation of human lgr4-like g protein-coupled receptor WO2001092297A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP01960250A EP1290030A2 (en) 2000-05-30 2001-05-29 Regulation of human lgr4-like g protein-coupled receptor
US10/276,340 US20030139341A1 (en) 2000-05-30 2001-05-29 Regulation of human lgr4-like g protein -coupled receptor
AU2001281791A AU2001281791A1 (en) 2000-05-30 2001-05-29 Regulation of human lgr4-like g protein-coupled receptor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20734900P 2000-05-30 2000-05-30
US60/207,349 2000-05-30

Publications (2)

Publication Number Publication Date
WO2001092297A2 WO2001092297A2 (en) 2001-12-06
WO2001092297A3 true WO2001092297A3 (en) 2002-12-19

Family

ID=22770166

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/006089 WO2001092297A2 (en) 2000-05-30 2001-05-29 Regulation of human lgr4-like g protein-coupled receptor

Country Status (4)

Country Link
US (1) US20030139341A1 (en)
EP (1) EP1290030A2 (en)
AU (1) AU2001281791A1 (en)
WO (1) WO2001092297A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4967137B2 (en) * 2005-04-18 2012-07-04 国立大学法人浜松医科大学 Cancer treatment composition
WO2006112400A1 (en) * 2005-04-18 2006-10-26 National University Corporation Hamamatsu University School Of Medicine Method of examining metastatic property and infiltration ability of cancer
PL3009148T3 (en) 2007-07-02 2019-03-29 Oncomed Pharmaceuticals, Inc. Compositions and methods for treating and diagnosing cancer
CA2841745A1 (en) 2011-07-15 2013-01-24 Oncomed Pharmaceuticals, Inc. Rspo binding agents and uses thereof
US10039777B2 (en) 2012-03-20 2018-08-07 Neuro-Lm Sas Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders
WO2014012007A2 (en) 2012-07-13 2014-01-16 Oncomed Pharmaceuticals, Inc. Rspo3 binding agents and uses thereof
EP3193935A4 (en) 2014-09-16 2018-03-21 Oncomed Pharmaceuticals, Inc. Treatment of fibrotic diseases

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999015660A1 (en) * 1997-09-24 1999-04-01 Merck & Co., Inc. G-protein coupled glycoprotein hormone receptor hg38
WO1999015545A1 (en) * 1997-09-24 1999-04-01 Merck & Co., Inc. G-protein coupled glycoprotein hormone receptor aomf05
WO1999048921A1 (en) * 1998-03-26 1999-09-30 The Board Of Trustees Of The Leland Stanford Junior University Novel mammalian g-protein coupled receptors having extracellular leucine rich repeat regions
WO2001085768A2 (en) * 2000-05-08 2001-11-15 Millennium Pharmaceuticals, Inc. G-protein coupled receptors and uses therefor
WO2001085791A1 (en) * 2000-05-11 2001-11-15 Lifespan Biosciences, Inc. Nucleic acid sequences for novel gpcrs

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999015660A1 (en) * 1997-09-24 1999-04-01 Merck & Co., Inc. G-protein coupled glycoprotein hormone receptor hg38
WO1999015545A1 (en) * 1997-09-24 1999-04-01 Merck & Co., Inc. G-protein coupled glycoprotein hormone receptor aomf05
WO1999048921A1 (en) * 1998-03-26 1999-09-30 The Board Of Trustees Of The Leland Stanford Junior University Novel mammalian g-protein coupled receptors having extracellular leucine rich repeat regions
WO2001085768A2 (en) * 2000-05-08 2001-11-15 Millennium Pharmaceuticals, Inc. G-protein coupled receptors and uses therefor
WO2001085791A1 (en) * 2000-05-11 2001-11-15 Lifespan Biosciences, Inc. Nucleic acid sequences for novel gpcrs

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 19 November 1998 (1998-11-19), "Rattus norvegicus G protein-coupled receptor LGR4 (LGR4) mRNA, complete cds.", XP002215547, Database accession no. AF061443 *
HSU S Y ET AL: "CHARACTERIZATION OF TWO LGR GENES HOMOLOGOUS TO GONADOTROPIN AND THYROTROPIN RECEPTORS WITH EXTRACELLULAR LEUCINE-RICH REPEATS AND A G PROTEIN-COUPLED, SEVEN-TRANSMEMBRANE REGION", MOLECULAR ENDOCRINOLOGY, BALTIMORE, MD, US, vol. 12, no. 12, AF061443, 1998, pages 1830 - 1845, XP000857281, ISSN: 0888-8809 *
HSU SHEAU YU ET AL: "Discovering new hormones, receptors, and signaling mediators in the genomic era.", MOLECULAR ENDOCRINOLOGY, vol. 14, no. 5, May 2000 (2000-05-01), pages 594 - 604, XP002215546, ISSN: 0888-8809 *
KUDO MASATAKA ET AL: "The nematode leucine-rich repeat-containing, G protein-coupled receptor (LGR) protein homologous to vertebrate gonadotropin and thyrotropin receptors is constitutively activated in mammalian cells.", MOLECULAR ENDOCRINOLOGY, vol. 14, no. 2, February 2000 (2000-02-01), pages 272 - 284, XP002215545, ISSN: 0888-8809 *
STADEL J M ET AL: "Orphan G protein-coupled receptors: a neglected opportunity for pioneer drug discovery", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER TRENDS JOURNAL, CAMBRIDGE, GB, vol. 18, no. 11, 1 November 1997 (1997-11-01), pages 430 - 437, XP004099345, ISSN: 0165-6147 *

Also Published As

Publication number Publication date
WO2001092297A2 (en) 2001-12-06
EP1290030A2 (en) 2003-03-12
AU2001281791A1 (en) 2001-12-11
US20030139341A1 (en) 2003-07-24

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