WO2001092295A3 - Ligands for cd21 and compositions thereof for modulating immune responses - Google Patents

Ligands for cd21 and compositions thereof for modulating immune responses Download PDF

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Publication number
WO2001092295A3
WO2001092295A3 PCT/CA2001/000785 CA0100785W WO0192295A3 WO 2001092295 A3 WO2001092295 A3 WO 2001092295A3 CA 0100785 W CA0100785 W CA 0100785W WO 0192295 A3 WO0192295 A3 WO 0192295A3
Authority
WO
WIPO (PCT)
Prior art keywords
ligands
compositions
immune responses
modulating immune
molecule
Prior art date
Application number
PCT/CA2001/000785
Other languages
French (fr)
Other versions
WO2001092295A2 (en
Inventor
David E Isenman
Liliana Clemenza
Original Assignee
Univ Toronto
David E Isenman
Liliana Clemenza
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Toronto, David E Isenman, Liliana Clemenza filed Critical Univ Toronto
Publication of WO2001092295A2 publication Critical patent/WO2001092295A2/en
Publication of WO2001092295A3 publication Critical patent/WO2001092295A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Ligands for the CD21 molecule corresponding to the CD21 contacting amino acid residies 36-39 and 160-167 of the C3d molecule are provided. These ligands have the ability to bind CD21 and stimulate the CD21/CD19 complex and may be polypeptides, peptides or mimetics. The ligands coupled to antigens modulate the immune response of hosts immunized therewith. Site-specific mutated analogs of C3d are provided that have enhanced binding to CD21.
PCT/CA2001/000785 2000-05-30 2001-05-30 Ligands for cd21 and compositions thereof for modulating immune responses WO2001092295A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20743400P 2000-05-30 2000-05-30
US60/207,434 2000-05-30

Publications (2)

Publication Number Publication Date
WO2001092295A2 WO2001092295A2 (en) 2001-12-06
WO2001092295A3 true WO2001092295A3 (en) 2002-08-08

Family

ID=22770521

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2001/000785 WO2001092295A2 (en) 2000-05-30 2001-05-30 Ligands for cd21 and compositions thereof for modulating immune responses

Country Status (1)

Country Link
WO (1) WO2001092295A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996017625A1 (en) * 1994-12-06 1996-06-13 Cambridge University Technical Services Limited Modulating the immune response
US5777093A (en) * 1995-05-16 1998-07-07 Ramot-University Authority For Applied Research & Industrial Development Ltd. cDNAs associated with ataxia-telangiectasia
US5849297A (en) * 1994-09-08 1998-12-15 Imutran Limited Modified human C3 proteins
WO1999035260A1 (en) * 1997-12-31 1999-07-15 Adprotech Limited Non-identical genes and their application in improved molec ular adjuvants
WO2001077324A1 (en) * 2000-04-08 2001-10-18 Adprotech Limited Dna immunization vectors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849297A (en) * 1994-09-08 1998-12-15 Imutran Limited Modified human C3 proteins
WO1996017625A1 (en) * 1994-12-06 1996-06-13 Cambridge University Technical Services Limited Modulating the immune response
US5777093A (en) * 1995-05-16 1998-07-07 Ramot-University Authority For Applied Research & Industrial Development Ltd. cDNAs associated with ataxia-telangiectasia
WO1999035260A1 (en) * 1997-12-31 1999-07-15 Adprotech Limited Non-identical genes and their application in improved molec ular adjuvants
WO2001077324A1 (en) * 2000-04-08 2001-10-18 Adprotech Limited Dna immunization vectors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HAMMERMANN R ET AL.: "Anisoosmotic regulation of the Mi-2 autoantigen mRNA in H4IIE rat hepatoma cells and primary hepatocytes", FEBS LETTERS, vol. 435, 1998, pages 21 - 24, XP002197165 *
HELLMANN U ET AL.: "Amino acid sequence of the trypsin-generated C3d fragment from human complement factor C3", BIOCHEMICAL JOURNAL, vol. 230, 1 September 1985 (1985-09-01), pages 353 - 361, XP008002499 *

Also Published As

Publication number Publication date
WO2001092295A2 (en) 2001-12-06

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