WO2001012664A3 - Notch receptor ligands and uses thereof - Google Patents

Notch receptor ligands and uses thereof Download PDF

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Publication number
WO2001012664A3
WO2001012664A3 PCT/US2000/022609 US0022609W WO0112664A3 WO 2001012664 A3 WO2001012664 A3 WO 2001012664A3 US 0022609 W US0022609 W US 0022609W WO 0112664 A3 WO0112664 A3 WO 0112664A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor ligands
notch receptor
polypeptides
enhancing
compositions
Prior art date
Application number
PCT/US2000/022609
Other languages
French (fr)
Other versions
WO2001012664A2 (en
Inventor
Chan Vivien
Michael Rohan
Lewis T Williams
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Priority to EP00957528A priority Critical patent/EP1206487A2/en
Priority to JP2001517562A priority patent/JP2003507029A/en
Priority to AU69131/00A priority patent/AU6913100A/en
Publication of WO2001012664A2 publication Critical patent/WO2001012664A2/en
Publication of WO2001012664A3 publication Critical patent/WO2001012664A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention provides polynucleotides encoding two human Notch receptor ligands, encoded polypeptides, and antibodies specific to the polypeptides. Also provided are methods and compositions for enhancing or inhibiting angiogenesis as well as modulating immune responses.
PCT/US2000/022609 1999-08-19 2000-08-17 Notch receptor ligands and uses thereof WO2001012664A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP00957528A EP1206487A2 (en) 1999-08-19 2000-08-17 Notch receptor ligands and uses thereof
JP2001517562A JP2003507029A (en) 1999-08-19 2000-08-17 Notch receptor ligands and uses thereof
AU69131/00A AU6913100A (en) 1999-08-19 2000-08-17 Notch receptor ligands and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14993499P 1999-08-19 1999-08-19
US60/149,934 1999-08-19

Publications (2)

Publication Number Publication Date
WO2001012664A2 WO2001012664A2 (en) 2001-02-22
WO2001012664A3 true WO2001012664A3 (en) 2002-01-10

Family

ID=22532424

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/022609 WO2001012664A2 (en) 1999-08-19 2000-08-17 Notch receptor ligands and uses thereof

Country Status (4)

Country Link
EP (1) EP1206487A2 (en)
JP (1) JP2003507029A (en)
AU (1) AU6913100A (en)
WO (1) WO2001012664A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1446424A2 (en) * 2001-11-14 2004-08-18 Lorantis Limited Composition comprising inhibitors of the notch signalling pathway for the modulation of the immune system
EP1654383A1 (en) 2003-08-08 2006-05-10 Licentia, Ltd. Materials and methods for colorectal cancer screening, diagnosis, and therapy
SI2530091T1 (en) 2010-01-29 2018-06-29 Chugai Seiyaku Kabushiki Kaisha Anti-dll3 antibody
PE20190658A1 (en) 2012-02-24 2019-05-08 Abbvie Stemcentrx Llc NEW MODULATORS AND EMPLOYMENT METHODS
JP6462591B2 (en) 2013-02-22 2019-01-30 アッヴィ・ステムセントルクス・エル・エル・シー Novel antibody conjugates and uses thereof
BR112016004242A8 (en) 2013-08-28 2018-06-12 Stemcentrx Inc METHODS FOR SITE-SPECIFIC CONJUGATION OF ANTIBODIES AND COMPOSITIONS
US10308721B2 (en) 2014-02-21 2019-06-04 Abbvie Stemcentrx Llc Anti-DLL3 antibodies and drug conjugates for use in melanoma
TWI817974B (en) 2017-12-28 2023-10-11 日商中外製藥股份有限公司 Cytotoxicity-inducing therapeutic agent
CN115397866A (en) 2020-03-31 2022-11-25 中外制药株式会社 DLL 3-targeted multispecific antigen-binding molecules and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998045434A1 (en) * 1997-04-04 1998-10-15 Millennium Biotherapeutics, Inc. Novel human delta3 compositions and therapeutic and diagnostic uses therefor
WO1998051799A1 (en) * 1997-05-14 1998-11-19 Asahi Kasei Kogyo Kabushiki Kaisha Novel differentiation inhibitor
JPH11299493A (en) * 1998-02-19 1999-11-02 Asahi Chem Ind Co Ltd Human delta-3

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5786158A (en) * 1992-04-30 1998-07-28 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998045434A1 (en) * 1997-04-04 1998-10-15 Millennium Biotherapeutics, Inc. Novel human delta3 compositions and therapeutic and diagnostic uses therefor
WO1998051799A1 (en) * 1997-05-14 1998-11-19 Asahi Kasei Kogyo Kabushiki Kaisha Novel differentiation inhibitor
JPH11299493A (en) * 1998-02-19 1999-11-02 Asahi Chem Ind Co Ltd Human delta-3

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL "Human delta-1 probe", XP002167529 *
DATABASE EMBL 19 October 1997 (1997-10-19) *
DATABASE EMBL 24 March 2000 (2000-03-24) *
DATABASE EMBL 3 June 1999 (1999-06-03), ALMEIDA J., XP002157678 *
DATABASE EMBL 9 October 1998 (1998-10-09), NAKAYAMA K. ET AL., XP002157677 *
DATABASE WPI Section Ch Week 199850, Derwent World Patents Index; Class B04, AN 1998-594482, XP002157679 *
DATABASE WPI Section Ch Week 200007, Derwent World Patents Index; Class B04, AN 2000-075282, XP002157719 *
DUNWOODIE S L ET AL: "Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo.", DEVELOPMENT, (1997 AUG) 124 (16) 3065-76., XP002126914 *
GRAY G.E. ET AL: "Human ligands of the Notch receptor.", AMERICAN JOURNAL OF PATHOLOGY, (1999) 154/3 (785-794)., XP000960906 *

Also Published As

Publication number Publication date
EP1206487A2 (en) 2002-05-22
WO2001012664A2 (en) 2001-02-22
JP2003507029A (en) 2003-02-25
AU6913100A (en) 2001-03-13

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