WO2001092215A2 - Diazeniumdiolates generateurs de superoxyde, compositions renfermant lesdits diazeniumdiolates et procedes d'utilisation correspondants - Google Patents

Diazeniumdiolates generateurs de superoxyde, compositions renfermant lesdits diazeniumdiolates et procedes d'utilisation correspondants Download PDF

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Publication number
WO2001092215A2
WO2001092215A2 PCT/US2001/017868 US0117868W WO0192215A2 WO 2001092215 A2 WO2001092215 A2 WO 2001092215A2 US 0117868 W US0117868 W US 0117868W WO 0192215 A2 WO0192215 A2 WO 0192215A2
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WO
WIPO (PCT)
Prior art keywords
compound
superoxide
group
substituted
sep
Prior art date
Application number
PCT/US2001/017868
Other languages
English (en)
Other versions
WO2001092215A3 (fr
Inventor
Challice Bonifant
Joseph Saavedra
Larry Keefer
Michael Citro
Gregory Buzard
Anthony Fitzhugh
Paul Donovan
Xinhua Ji
Paul Shami
Shivendra Singh
Aloka Srinivasan
Original Assignee
Us Health
Challice Bonifant
Joseph Saavedra
Larry Keefer
Michael Citro
Gregory Buzard
Anthony Fitzhugh
Paul Donovan
Xinhua Ji
Paul Shami
Shivendra Singh
Aloka Srinivasan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health, Challice Bonifant, Joseph Saavedra, Larry Keefer, Michael Citro, Gregory Buzard, Anthony Fitzhugh, Paul Donovan, Xinhua Ji, Paul Shami, Shivendra Singh, Aloka Srinivasan filed Critical Us Health
Priority to AU2001275155A priority Critical patent/AU2001275155A1/en
Publication of WO2001092215A2 publication Critical patent/WO2001092215A2/fr
Publication of WO2001092215A3 publication Critical patent/WO2001092215A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C07C291/08—Azoxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/50—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24—Anthracenes; Hydrogenated anthracenes

Abstract

L'invention concerne un composé comprenant un groupe fonctionnel [N(O)NO] et une fraction génératrice de superoxyde, ledit composé étant caractérisé en ce qu'il peut générer de l'oxyde nitrique et du superoxyde. L'invention concerne également des compositions renfermant ledit composé, ainsi que ses procédés d'utilisation correspondants.
PCT/US2001/017868 2000-06-02 2001-06-01 Diazeniumdiolates generateurs de superoxyde, compositions renfermant lesdits diazeniumdiolates et procedes d'utilisation correspondants WO2001092215A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001275155A AU2001275155A1 (en) 2000-06-02 2001-07-01 Superoxide-generating diazeniumdiolates, compositions comprising same, and methods for using same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20906700P 2000-06-02 2000-06-02
US60/209,067 2000-06-02

Publications (2)

Publication Number Publication Date
WO2001092215A2 true WO2001092215A2 (fr) 2001-12-06
WO2001092215A3 WO2001092215A3 (fr) 2002-06-27

Family

ID=22777186

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/017868 WO2001092215A2 (fr) 2000-06-02 2001-06-01 Diazeniumdiolates generateurs de superoxyde, compositions renfermant lesdits diazeniumdiolates et procedes d'utilisation correspondants

Country Status (2)

Country Link
AU (1) AU2001275155A1 (fr)
WO (1) WO2001092215A2 (fr)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002041902A1 (fr) * 2000-11-27 2002-05-30 The University Of Akron Traitement de troubles au moyen de polyethylenimine diazeniumdiolate
WO2003080039A1 (fr) 2002-03-21 2003-10-02 The University Of Utah Research Foundation Utilisation in vivo de donneurs d'oxyde nitrique actives par la glutathion s-transferase
WO2006031719A2 (fr) * 2004-09-14 2006-03-23 Novacea, Inc. Composes de 1,4-bis-n-oxyde-5,8-dihydroxyanthracenedione et leur utilisation
EP1718316A2 (fr) * 2004-02-09 2006-11-08 Amulet Pharmaceuticals, Inc. Polymeres liberant du monoxyde d'azote
US7432305B2 (en) 2005-09-15 2008-10-07 Edison Pharmaceuticals, Inc. Tail variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
US7468435B2 (en) 2002-05-07 2008-12-23 The United States Of America As Represented By The Department Of Health And Human Services Polydiazeniumdiolated cyclic polyamines with polyphasic nitric oxide release and related compounds, compositions comprising same and methods of using same
DE102007035323A1 (de) 2007-07-25 2009-01-29 Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e.V. -Hans-Knöll-Institut- Neue Ketoconazol-Derivate sowie deren Herstellung und Verwendung als antimikrobielle und antiinflammatorische Wirkstoffe
KR101351130B1 (ko) 2012-11-05 2014-01-15 포항공과대학교 산학협력단 카테콜아민을 이용하여 재료의 표면에 일산화질소 함유 코팅막을 형성하는 방법
US9005656B2 (en) 2008-03-07 2015-04-14 University Of Utah Research Foundation Activated nitric oxide donors and methods of making and using thereof
US9278085B2 (en) 2006-02-22 2016-03-08 Edison Pharmaceuticals, Inc. Side-chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
US9447006B2 (en) 2005-06-01 2016-09-20 Edison Pharmaceuticals, Inc. Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
US10105325B2 (en) 2008-09-10 2018-10-23 Bioelectron Technology Corporation Treatment of pervasive developmental disorders with redox-active therapeutics
CN109053618A (zh) * 2018-02-22 2018-12-21 青岛科技大学 一种噁唑衍生物的制备方法
US10703701B2 (en) 2015-12-17 2020-07-07 Ptc Therapeutics, Inc. Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
CN112939886A (zh) * 2021-02-04 2021-06-11 山西大学 一种可检测GSTs含量的近红外荧光探针及其合成方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5405919A (en) * 1992-08-24 1995-04-11 The United States Of America As Represented By The Secretary Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
CA2266908C (fr) * 1996-09-27 2010-07-20 Joseph E. Saavedra Diazen-1-ium-1,2-diolates 1-substitutes o2-aryles ou o2-glycosyles et 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates o2-subtitutes

Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002041902A1 (fr) * 2000-11-27 2002-05-30 The University Of Akron Traitement de troubles au moyen de polyethylenimine diazeniumdiolate
EP1490045A4 (fr) * 2002-03-21 2007-12-19 Univ Utah Res Found Utilisation in vivo de donneurs d oxyde nitrique actives par la glutathion s-transferase
WO2003080039A1 (fr) 2002-03-21 2003-10-02 The University Of Utah Research Foundation Utilisation in vivo de donneurs d'oxyde nitrique actives par la glutathion s-transferase
EP1490045A1 (fr) * 2002-03-21 2004-12-29 University of Utah Research Foundation Utilisation in vivo de donneurs d oxyde nitrique actives par la glutathion s-transferase
US8404665B2 (en) 2002-03-21 2013-03-26 University Of Utah Research Foundation In vivo use of glutathione S-transferase activated nitric oxide donors
US7468435B2 (en) 2002-05-07 2008-12-23 The United States Of America As Represented By The Department Of Health And Human Services Polydiazeniumdiolated cyclic polyamines with polyphasic nitric oxide release and related compounds, compositions comprising same and methods of using same
US7928096B2 (en) 2002-05-07 2011-04-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Polydiazeniumdiolated cyclic polyamines with polyphasic nitric oxide release and related compounds, compositions comprising same and methods of using same
EP1718316A2 (fr) * 2004-02-09 2006-11-08 Amulet Pharmaceuticals, Inc. Polymeres liberant du monoxyde d'azote
EP1718316A4 (fr) * 2004-02-09 2009-05-13 Amulet Pharmaceuticals Inc Polymeres liberant du monoxyde d'azote
WO2006031719A3 (fr) * 2004-09-14 2006-09-14 Novacea Inc Composes de 1,4-bis-n-oxyde-5,8-dihydroxyanthracenedione et leur utilisation
WO2006031719A2 (fr) * 2004-09-14 2006-03-23 Novacea, Inc. Composes de 1,4-bis-n-oxyde-5,8-dihydroxyanthracenedione et leur utilisation
US11021424B2 (en) 2005-06-01 2021-06-01 Ptc Therapeutics, Inc. Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
US9447006B2 (en) 2005-06-01 2016-09-20 Edison Pharmaceuticals, Inc. Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
US7432305B2 (en) 2005-09-15 2008-10-07 Edison Pharmaceuticals, Inc. Tail variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
US9278085B2 (en) 2006-02-22 2016-03-08 Edison Pharmaceuticals, Inc. Side-chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
US9932286B2 (en) 2006-02-22 2018-04-03 Bioelectron Technology Corporation Side-chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers
DE102007035323A1 (de) 2007-07-25 2009-01-29 Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e.V. -Hans-Knöll-Institut- Neue Ketoconazol-Derivate sowie deren Herstellung und Verwendung als antimikrobielle und antiinflammatorische Wirkstoffe
US9005656B2 (en) 2008-03-07 2015-04-14 University Of Utah Research Foundation Activated nitric oxide donors and methods of making and using thereof
US9439915B2 (en) 2008-03-07 2016-09-13 University Of Utah Research Foundation Activated nitric oxide donors and methods of making and using thereof
US10105325B2 (en) 2008-09-10 2018-10-23 Bioelectron Technology Corporation Treatment of pervasive developmental disorders with redox-active therapeutics
US10736857B2 (en) 2008-09-10 2020-08-11 Ptc Therapeutics, Inc. Treatment of pervasive developmental disorders with redox-active therapeutics
KR101351130B1 (ko) 2012-11-05 2014-01-15 포항공과대학교 산학협력단 카테콜아민을 이용하여 재료의 표면에 일산화질소 함유 코팅막을 형성하는 방법
WO2014069728A1 (fr) * 2012-11-05 2014-05-08 포항공과대학교 산학협력단 Procédé pour former un film de revêtement comprenant du monoxyde d'azote sur la surface d'un matériau en utilisant des catécholamines
US9623156B2 (en) 2012-11-05 2017-04-18 Postech Academy-Industry Foundation Method of preparing coating film containing nitrogen monoxide on surface of material using catecholamine
US20140127277A1 (en) * 2012-11-05 2014-05-08 Postech Academy-Industry Foundation Method of preparing coating film containing nitrogen monoxide on surface of material using catecholamine
US10703701B2 (en) 2015-12-17 2020-07-07 Ptc Therapeutics, Inc. Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
US10981855B2 (en) 2015-12-17 2021-04-20 Ptc Therapeutics, Inc. Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
US11680034B2 (en) 2015-12-17 2023-06-20 Ptc Therapeutics, Inc. Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders
CN109053618A (zh) * 2018-02-22 2018-12-21 青岛科技大学 一种噁唑衍生物的制备方法
CN109053618B (zh) * 2018-02-22 2022-05-13 青岛科技大学 一种噁唑衍生物的制备方法
CN112939886A (zh) * 2021-02-04 2021-06-11 山西大学 一种可检测GSTs含量的近红外荧光探针及其合成方法和应用
CN112939886B (zh) * 2021-02-04 2022-05-31 山西大学 一种可检测GSTs含量的近红外荧光探针及其合成方法和应用

Also Published As

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WO2001092215A3 (fr) 2002-06-27
AU2001275155A1 (en) 2001-12-11

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