WO2001090093A1 - Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 - Google Patents

Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 Download PDF

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WO2001090093A1
WO2001090093A1 PCT/SE2001/001154 SE0101154W WO0190093A1 WO 2001090093 A1 WO2001090093 A1 WO 2001090093A1 SE 0101154 W SE0101154 W SE 0101154W WO 0190093 A1 WO0190093 A1 WO 0190093A1
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thiazol
benzenesulfonamide
methyl
chloro
compound
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PCT/SE2001/001154
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French (fr)
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Marianne Nilsson
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Biovitrum Ab
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Priority to AU2001262830A priority Critical patent/AU2001262830A1/en
Publication of WO2001090093A1 publication Critical patent/WO2001090093A1/en

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    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D513/04—Ortho-condensed systems

Definitions

  • the present invention relates to novel compounds, to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11- ⁇ -hydroxysteroid dehydrogenase type 1 enzyme (1 l ⁇ HSDl).
  • glucocorticoids have a central role in diabetes, e.g. the removal of the pituitary or the adrenal gland from a diabetic ariimal alleviates the most severe symptoms of diabetes and lowers the concentration of glucose in the blood (Long, CD. and F.D.W. Leukins (1936) J. Exp. Med. 63: 465- 490; Houssay, B.A. (1942) Endocrinology 30: 884-892). It is also well established that glucocorticoids enable the effect of glucagon on the liver.
  • Obesity is an important factor in syndrome X as well as in the majority (> 80%) of type 2 diabetic, and omental fat appears to be of central importance.
  • Abdominal obesity is closely associated with glucose intolerance, hyperinsulinemia, hypertriglyceridemia, and other factors of the so-called syndrome X (e.g. raised blood pressure, decreased levels of HDL and increased levels of VLDL) (Montague & O'Rahilly, Diabetes 49: 883-888, 2000).
  • Inhibition of the enzyme in pre-adipocytes (stromal cells) has been shown to decrease the rate of differentiation into adipocytes. This is predicted to result in diminished expansion (possibly reduction) of the omental fat depot, i.e. reduced central obesity (Bujalska, I.J., S. Kumar, and P.M. Stewart (1997) Lancet 349: 1210-1213).
  • Adrenalectomy attenuates the effect of fasting to increase both food intake and hypothalamic neuropeptide Y expression. This supports the role of glucocorticoids in promoting food intake and suggests that inhibition of 1 l ⁇ HSDl in the brain might increase satiety and therefore reduce food intake (Woods, S.C. et al. (1998) Science, 280: 1378-1383).
  • glucocorticoids suppress the immune system. But in fact there is a dynamic interaction between the immune system and the HPA (hypothalamo-pituitary-adrenal) axis (Rook, G.A.W. (1999) Baillier's Gin.
  • ll ⁇ HSDl is suggested to have a role in aqueous production, rather than drainage, but it is presently unknown if this is by interfering with activation of the glucocorticoid or the mineralocorticoid receptor, or both.
  • Glucocorticoids have an essential role in skeletal development and function but are detrimental in excess.
  • Glucocorticoid-induced bone loss is derived, at least in part, via inhibition of bone formation, which includes suppression of osteoblast proliferation and collagen synthesis (Kim, C.H., S.L. Cheng, and G.S. Kim (1999) J. Endocrinol. 162: 371-379).
  • the negative effect on bone nodule formation could be blocked by the non-specific inhibitor carbenoxolone suggesting an important role of 1 l ⁇ HSDl in the glucocorticoid effect (Bellows, C.G., A. Ciaccia, and J.N.M. Heersche, (1998) Bone 23 : 119-125).
  • WO 99/65884 discloses carbon subtituted aminothiazole inhibitors of cyclin dependent kinases. These compounds may e.g. be used against cancer, inflammation and arthritis.
  • US 5,856,347 discloses an antibacterial preparation or bactericide comprising 2- aminothiazole derivative and/or salt thereof.
  • US 5,403,857 discloses benzenesulfonamide derivatives having 5-lipoxygenase inhibitory activity.
  • tefrahydrotlriazolo[5,4-c]pyridines are disclosed in: Analgesic tetiahydrothiazolo[5,4-c]pyridines. Fr. Addn. (1969), 18 pp, Addn. to Fr. 1498465.
  • FR 2384498 discloses thiazolo-benzenesulfonamides which show antibacterial, antifungal and hypoglycaemic properties.
  • WO99/28306 and EP 0 819 681 A2 relate to thiazolobenzenesulfonamides which can be used for treating neurodegenerative pathologies, such as Alzheimer's disease.
  • JP 7149745 A2 and JP 7149746 A2 both describe 2-aminothiazole derivatives as esterase inhibitors. None is disclosed about inhibiting 1 l ⁇ HSDl.
  • JP 7309757 A2 relates to treating Alzheimer's disease using N- (5-nitro-2-thiazolyl)benzenesulfonamides.
  • JP 3173876 A2 presents preparation of diphenylthiazoles. These compounds are used as anti-inflammatories, analgesics, anti- allergy agents, uric acid accelerators and blood platelet aggregation inhibitors.
  • EP 0 790 057 Al discloses an antibacterial or bactericide comprising a 2-aminothiazole derivative.
  • US 2 362 087 describes the preparation of thiazolobenzenesulfonamides, such as 2-bromobenzenesulfonamido-4-methylthiazole. None is disclosed about inhibiting ll ⁇ HSDl and no therapeutic use of such substances is disclosed.
  • the compounds according to the present invention solve the above problems and embraces a novel class of compounds which has been developed and which inhibit the human 11- ⁇ -hydroxysteroid dehydrogenase type 1 enzyme (11- ⁇ -HSD ⁇ ), and may therefore be of use in the treating disorders such as diabetes, obesity, glaucoma, osteoporosis, cognitive disorders, immune disorders, and depression.
  • 11- ⁇ -HSD ⁇ human 11- ⁇ -hydroxysteroid dehydrogenase type 1 enzyme
  • One object of the present invention is a compound of the formula (I)
  • T is an aryl ring, substituted with at least one of Ci- ⁇ -alkyl, halogen, aryl or aryloxy, wherein the arylpxy residue can be further optionally substituted in one or more positions independently of each other by cyano and halogen;
  • T is not 4-methylphenyl, 4-tert-butylphenyl, 4-chlorophenyl, and 4-fluorophenyl;
  • T is phenyl substituted with one or more of chloro, 3-chloro-2- cyanophenoxy, methyl, phenyl and n-propyl; with the proviso that T is not 4- methylphenyl and 4-chl ⁇ rophenyl.
  • T is a substituted phenyl group
  • the phenyl ring is substituted with at least one of n-propyl, phenyl and 3-chloro-2-cyanophenoxy and, in o- or reposition, methyl and chloro.
  • Another object of the present invention is a compound of the formula (I) as described above for medical use.
  • Another object of the present invention is a process for the preparation of a compound as described above comprising sulfonamide coupling by reacting a 2-aminothiazole derivative with a sulfonylchloride in the presence of a base.
  • Another object of the present invention is a method for the treatment or prevention of diabetes, syndrome X, obesity, glaucoma, hyperhpidemia, hyperglycemia, hyperinsulinemia, osteoporosis, tuberculosis, depression, virus diseases and inflammatory disorders, said method comprising administering to a mammal, including man, in need of such treatment an effective amount of a compound of the formula (I)
  • T is an aryl ring, optionally independently substituted by [R] n , wherein n is an integer 0-5, and R is hydrogen, C ⁇ -alkyl, halogen, aryl or aryloxy, wherein the aryloxy residue can be further optionally substituted in one or more positions independently of each other by cyano and halogen;
  • These compounds may also be used in the manufacture of a medicament for the prevention, management or treatment of diabetes, syndrome X, obesity, glaucoma, hyperlipidemia, hyperglycemia, hyperinsulinemia, osteoporosis, tuberculosis, depression, virus diseases and inflammatory disorders.
  • T is phenyl substituted with one or more of chloro, 3-chloro-2- cyanophenoxy, methyl, phenyl and n-propyl.
  • Another object of the present invention is a pharmaceutical composition
  • a pharmaceutical composition comprising at least one compound of the formula (I) as defined above, and a pharmaceutically acceptable carrier.
  • the compounds according to the present invention may be used in several indications which involve 11- ⁇ -hydroxysteroid dehydrogenase type 1 enzyme.
  • the compounds according to the present invention may be used against dementia (see WO97/07789), osteoporosis (see Canalis E 1996, Mechanisms of glucocorticoid action in bone: implications to glucocorticoid-induced osteoporosis, Journal of Clinical Endocrinology and Metabolism, 81, 3441-3447) and may also be used disorders in the immune system (see Franchimont et al, "Inhibition of Thl immune response by glucocorticoids: dexamethasone selectively inhibits IL-12-induced Stat 4 phosphorylation in T lymphocytes", The journal of Immunology 2000, Feb 15, vol 164 (4), pages 1768-74) and also in the above listed indications.
  • the various terms used, separately and in combinations, in the above definition of the compounds having the formula (I) will be explained.
  • aryl in the present description is intended to include aromatic rings
  • phenyl (Ph) and naphthyl which optionally may be substituted by Ci- ⁇ -alkyl.
  • substituted aryl groups are benzyl and 2-methylphenyl.
  • C ⁇ _6-alkyl in the compound of formula (I) according to the present application is preferably C ⁇ _4-alkyl.
  • Exemplary alkyl groups include methyl, ethyl, n-propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, isopentyl, hexyl, and isohexyl.
  • halogen in the present description is intended to include fluorine, chlorine, bromine and iodine.
  • prodrug forms in the present description means a pharmacologically acceptable derivative, such as an ester or an amide, which derivative is biotransformed in the body to form the active drug (see Goodman and Gilman's, The Pharmacological basis of Therapeutics, 8 th ed., McGraw-Hill, Int. Ed. 1992, "Biotransformation of Drugs, p. 13-15).
  • “Pharmaceutically acceptable” means in the present description being useful in preparing a pharmaceutical composition that is generally safe, non-toxic and neither biologically nor otherwise undesirable and includes being useful for veterinary use as well as human pharmaceutical use.
  • “Pharmaceutically acceptable salts” mean in the present description salts which are pharmaceutically acceptable, as defined above, and which possess the desired pharmacological activity.
  • Such salts include acid addition salts formed with organic and inorganic acids, such as hydrogen chloride, hydrogen bromide, hydrogen iodide, sulfuric acid, phosphoric acid, acetic acid, glycolic acid, maleic acid, malonic acid, oxalic acid, methanesulfonic acid, trifluoroacetic acid, fumaric acid, succinic acid, tartaric acid, citric acid, benzoic acid, ascorbic acid and the like.
  • Base addition salts may be formed with organic and inorganic bases, such as sodium, ammonia, potassium, calcium, ethanolamine, (tiethanolamine, N-methylglucamine, choline and the like.
  • compositions according to the present invention contain a pharmaceutically acceptable carrier together with at least one of the compounds comprising the formula (I) as described herein above, dissolved or dispersed therein as an active, mtimicrobial, ingredient.
  • the therapeutic composition is not immunogenic when administered to a human patient for therapeutic purposes, unless that purpose is to induce an immune response.
  • compositions that contains active ingredients dissolved or dispersed therein are well understood in the art.
  • compositions are prepared as sterile injectables either as liquid solutions or suspensions, aqueous or non-aqueous, however, solid forms suitable for solution, or suspensions, in liquid prior to use can also be prepared.
  • the preparation can also be emulsified.
  • the active ingredient may be mixed with excipients, which are pharmaceutically acceptable and compatible with the active ingredient and in amounts suitable for use in the therapeutic methods described herein.
  • Suitable excipients are, for example, water, saline, dextrose, glycerol, ethanol or the like and combinations thereof.
  • the composition may contain minor amounts of auxiliary substances such as wetting or emulsifying agents, pH buffering agents and the like which enhance the effectiveness of the active ingredient.
  • Adjuvants may also be present in the composition.
  • Pharmaceutically acceptable carriers are well known in the art.
  • liquid carriers are sterile aqueous solutions that contain no materials in addition to the active ingredients and water, or contain a buffer such as sodium phosphate at physiological pH value, physiological saline or both, such as phosphate-buffered saline. Still further, aqueous carriers can contain more than one buffer salt, as well as salts such as sodium and potassium chlorides, dextrose, propylene glycol, polyethylene glycol and other solutes.
  • Liquid compositions can also contain liquid phases in addition to and to the exclusion of water.
  • additional liquid phases are glycerine, vegetable oils such as cottonseed oil, organic esters such as ethyl oleate, and water-oil emulsions.
  • composition according to one of the preferred embodiments of the present invention comprising compounds comprising the formula (I), may include pharmaceutically acceptable salts of mat component therein as set out above.
  • Pharmaceutically acceptable salts include the acid addition salts (formed with the free amino groups of the polypeptide) that are formed with inorganic acids such as, for example, hydrochloric or phosphoric acids, or such organic acids as acetic acid, tartaric acid, mandelic acid and the like. Salts formed with the free carboxyl groups can also be derived from inorganic bases such as, for example, sodium, potassium, ammonium, calcium or ferric hydroxides, and such organic bases as isopropylamine, trimethylamine, 2-ethylamino ethanol, histidine, procaine and the like.
  • inorganic acids such as, for example, hydrochloric or phosphoric acids, or such organic acids as acetic acid, tartaric acid, mandelic acid and the like.
  • Salts formed with the free carboxyl groups can also be derived from inorganic bases such as, for example, sodium, potassium, ammonium, calcium or ferric hydroxides, and such organic bases as isopropylamine, trimethylamine
  • the preparations according to the preferred embodiments may be administered orally, topically, intraperitoneally, intraarticularly, intracranially, intradermally, intramuscularly, intraocularly, intrathecally, intravenously, subcutaneously.
  • Other routes which are known for the skilled person in the art are thinkable.
  • compositions according to the present invention may be in the form of tablets, capsules, powders, granules, lozenges, liquid or gel preparations, such as oral, topical or sterile parenteral solutions or suspensions.
  • Tablets and capsules for oral administration may be in unit dose presentation form and may contain conventional excipients such as bmding agents, for example syrup, acacia, gelatin, sorbitol, traganath or polyvinyl-pyrrolidone; fillers e.g. lactose, sugar, maize-starch, calcium phosphate, sorbitol or glycine; tabletting lubricant e.g.
  • Oral liquid preparations may be in the form of e.g. aqueous or oily suspensions ⁇ solutions, emulsions, syrups or elixirs or may be presented as a dry product for reconstitution with water or other suitable vehicle before use.
  • Such liquid preparations may contain conventional additives such as suspending agents, e.g. sorbitol, syrup, methyl cellulose, glucose syrup, gelatin hydrogenated edible fats; emulsifying agents e.g.
  • non-aqueous vehicles which may include edible oils, e.g. almond oil, fractionated coconut oil, oily esters such as glycerine, propylene glycol, or ethyl alcohol; preservatives e.g. methyl or n-propyl p-hydroxybenzoate or sorbic acid, and if desired conventional flavouring or colouring agents.
  • edible oils e.g. almond oil, fractionated coconut oil, oily esters such as glycerine, propylene glycol, or ethyl alcohol
  • preservatives e.g. methyl or n-propyl p-hydroxybenzoate or sorbic acid, and if desired conventional flavouring or colouring agents.
  • a pharmaceutical composition according to the present invention may comprise typically an amount of at least 0.1 weight percent of compound comprising the formula (I) per weight of total therapeutic composition.
  • a weight percent is a ratio by weight of total composition.
  • 0.1 weight percent is 0.1 grams of compound comprising the formula (I) per 100 grams of total composition.
  • a suitable daily oral dose for a mammal, preferably a human being may vary widely depending on the condition of the patient. However a dose of compound comprising the formula (I) of about 0.1 to 300 mg/kg body weight may be appropriate.
  • compositions according to the present invention may also be used veterinarily and thus they may comprise a veterinarily acceptable excipient or carrier.
  • the compounds of the present invention in labelled form may be used as a diagnostic agent.
  • the compounds of the formula (I) above may be prepared by, or in analogy with, conventional methods, and especially according to or in analogy with the following methods. Further, the pharmacology in-vitro was studied using the following reagents and methods.
  • [1, 2(n) - 3 H]-cortisone was purchased from Amersham Pharmacia Biotech.
  • Anti- cortisol monoclonal mouse antibody, clone 6D6.7 was obtained from Immunotech and Scintillation proximity assay (SPA) beads coated with monoclonal antimouse antibodies were from Amersham Pharmacia Biotech.
  • NADPH, tetrasodium salt was from Calbiochem and glucose-6-phosphate (G-6-P) was supplied by Sigma.
  • the human 11- ⁇ -hydroxysteroid dehydrogenase type-1 enzyme (11- ⁇ -HSD was expressed in Pichiapastoris.
  • 18- ⁇ -glycyrrhetinic acid (GA) was obtained from Sigma.
  • the 11- ⁇ -HSD ⁇ enzyme assay was carried out in 96 well microtiter plates (Packard, Optiplate) in a total well volume of 220 ⁇ L and contained 30 mM Tris-HCl, pH 7.2 with 1 mM EDTA, a substrate mixture tritiated Cortisone/NADPH (175 nM / 181 ⁇ M), G-6-P (1 mM) and inhibitors in serial dilutions (9 to 0.15 ⁇ M). Reactions were initiated by the addition of human ll- ⁇ -HSD l5 either as Pichiapastoris cell homogenate or microsomes prepared from Pichia astoris (the final amount of enzyme used was varied between 0.057 to 0.11 mg/mL).
  • the plates were covered with plastic film and incubated on a shaker for 30 minutes, at room temperature, before counting.
  • the amount of [ 3 H]-cortisol, bound to the beads was determined in a microplate liquid scintillation counter.
  • the calculation of the Kj values for the inhibitors was performed by use of Activity Base.
  • the IC 5 0 is measured experimentally in an assay wherein the decrease of the turnover of cortisone to cortisol is dependent on the inhibition potential of each substance.
  • the Ki values of the compounds of the present invention for the 11- ⁇ -HSDl enzyme lie typically between about 10 nM and about 10 ⁇ M.
  • the Ki value for the compound according to Example 6 is 545 nM.
  • Reverse phase preparative HPLC was carried out on a 100 x 21.2 mm, 5 ⁇ Hypersil Elite column eluting with a gradient of 5% ACN in 95% water to 95% ACN in 5% water (0.2% TFA buffer) over 10 rnins at a flow rate of 20 mL / min with the UV detector set at 254 nm.
  • Thin layer chromatography was carried out using pre-coated silica gel F-254 plates (thickness 0.25 mm). Electrospray MS spectra were obtained on a Micromass platform LCMS spectrometer.
  • DMAP 4-dimethylaminopyridine
  • DMF dimethylformamide
  • DMSO dimethyl sulfoxide
  • EDTA ethylenediaminetetraacetic acid

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Abstract

The present invention relates to compounds with formula (I) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.

Description

INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1
TECHNICAL FIELD
The present invention relates to novel compounds, to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme (1 lβHSDl).
BACKGROUND ART
1. Glucorticoids, diabetes and hepatic glucose production
It has been known for more than half a century that glucocorticoids have a central role in diabetes, e.g. the removal of the pituitary or the adrenal gland from a diabetic ariimal alleviates the most severe symptoms of diabetes and lowers the concentration of glucose in the blood (Long, CD. and F.D.W. Leukins (1936) J. Exp. Med. 63: 465- 490; Houssay, B.A. (1942) Endocrinology 30: 884-892). It is also well established that glucocorticoids enable the effect of glucagon on the liver.
The role of llβHSDl as an important regulator of local glucocorticoid effect and thus of hepatic glucose production is well substantiated (see e.g. Jamieson et al. (2000) J. Endocrinol. 165: p. 685-692). The hepatic insulin sensitivity was improved in healthy human volunteers treated with the non-specific llβHSDl inhibitor carbenoxolone (Walker, B.R. et al. (1995) J. Ctin. Endocrinol. Metab. 80: 3155-3159). Furthermore, the expected mechanism has been established by different experiments with mice and rats. These studies showed that the mRNA levels and activities of two key enzymes in hepatic glucose production were reduced, namely: the rate-limiting enzyme in gluconeogenesis, phosphoenolpyruvate carboxykinase (PEPCK), and glucose-6- phosphatase (G6Pase) catalyzing the last common step of gluconeogenesis and glycogenolysis. Finally, the blood glucose level and hepatic glucose production is reduced in mice having the llβHSDl gene knocked-out. Data from this model also confirm that inhibition of llβHSDl will not cause hypoglycemia, as predicted since the basal levels of PEPCK and G6Pase are regulated independently of glucocorticoids (Kotelevtsev, Y. et al., (1997) Proc. Natl. Acad. Sci. USA 94: 14924-14929).
2. Possible reduction of obesity and obesity related cardiovascular risk factors
Obesity is an important factor in syndrome X as well as in the majority (> 80%) of type 2 diabetic, and omental fat appears to be of central importance. Abdominal obesity is closely associated with glucose intolerance, hyperinsulinemia, hypertriglyceridemia, and other factors of the so-called syndrome X (e.g. raised blood pressure, decreased levels of HDL and increased levels of VLDL) (Montague & O'Rahilly, Diabetes 49: 883-888, 2000). Inhibition of the enzyme in pre-adipocytes (stromal cells) has been shown to decrease the rate of differentiation into adipocytes. This is predicted to result in diminished expansion (possibly reduction) of the omental fat depot, i.e. reduced central obesity (Bujalska, I.J., S. Kumar, and P.M. Stewart (1997) Lancet 349: 1210-1213).
Inhibition of 1 lβHSDl in mature adipocytes is expected to attenuate secretion of the plasminogen activator inhibitor 1 (PAI-1) - an independent cardiovascular risk factor (Halleux, CM. et al. (1999) J. Clin. Endocrinol. Metab. 84: 4097-4105). Furthermore, there is a clear correlation between glucocorticoid "activity" and cardiovascular risk factore suggesting that a reduction of the glucocorticoid effects would be beneficial (Walker, B.R. et al. (1998) Hypertension 31: 891-895; Fraser, R. et al. (1999) Hypertension 33: 1364-1368).
Adrenalectomy attenuates the effect of fasting to increase both food intake and hypothalamic neuropeptide Y expression. This supports the role of glucocorticoids in promoting food intake and suggests that inhibition of 1 lβHSDl in the brain might increase satiety and therefore reduce food intake (Woods, S.C. et al. (1998) Science, 280: 1378-1383).
3. Possible beneficial effect on the pancreas
Inhibition of 1 lβHSDl in isolated murine pancreatic β-cells improves the glucose- stimulated msulin secretion (Davani B. et al. (2000) J. Biol. Chem. 2000 Nov 10; 275(45): 34841-4). Glucocorticoids were previously known to reduce pancreatic insulin release in vivo (Billaudel, B. and B.C.J. Sutter (1979) Horm. Metab. Res. 11: 555-560). Thus, inhibition of 1 lβHSDl is predicted to yield other beneficial effects for diabetes treatment, besides effects on liver and fat.
4. Possible beneficial effects on cognition and dementia
Stress and glucocorticoids influence cognitive function (de Quervain, D.J.-F., B.
Roozendaal, and J.L. McGaugh (1998) Nature 394: 787-790). The enzyme llβHSDl controls the level of glucocorticoid action in the brain and thus contributes to neurotoxicity (Rajan, V., C.R.W. Edwards, and J.R. Seckl, J. (1996) Neuroscience 16: 65-70; Seckl, J.R., Front. (2000) Neuroendocrinol. 18: 49-99). Unpublished results indicate significant memory improvement in rats treated with a non-specific 11 βHSD 1 inhibitor (J. Seckl, personal communication). Based the above and on the known effects of glucocorticoids in the brain, it may also be suggested that inhibiting 1 lβHSDl in the brain may result in reduced anxiety (Tronche, F. et al. (1999) Nature Genetics 23: 99-103). Thus, taken together, the hypothesis is that inhibition of 1 lβHSD 1 in the human brain would prevent reactivation of cortisone into cortisol and protect against deleterious glucocorticoid-mediated effects on neuronal survival and other aspects of neuronal function, including cognitive impairment, depression, and increased appetite (previous section). 5. Possible use of immuno-modulation using llβHSDl inhibitors
The general perception is that glucocorticoids suppress the immune system. But in fact there is a dynamic interaction between the immune system and the HPA (hypothalamo-pituitary-adrenal) axis (Rook, G.A.W. (1999) Baillier's Gin.
Endocrinol. Metab. 13: 576-581). The balance between the cell-mediated response and humoral responses is modulated by glucocorticoids. A high glucocorticoid activity, such as at a state of stress, is associated with a humoral response. Thus, inhibition of the enzyme 1 lβHSDl has been suggested as a means of shifting the response towards a cell-based reaction.
In certain disease states, including tuberculosis, lepra and psoriasis the immune reaction is normaly biased towards a humoral response when in fact the appropriate response would be cell based. Temporal inhibition of llβHSDl, local or systemic, might be used to push the immune system into the appropriate response (Mason, D. (1991) Immunology Today 12: 57-60; Rook et al., supra).
An analogous use of 1 lβHSDl inhibition, in this case temporal, would be to booster the immune response in association with immunization to ensure that a cell based response would be obtained, when desired.
6. Reduction of intraocular pressure
Recent data suggest that the levels of the glucocorticoid target receptors and the 1 lβHSD enzymes determines the susceptibility to glaucoma (Stokes, J. et al. (2000) Invest. Ophthalmol. 41: 1629-1638). Further, inhibition of llβHSDl was recently presented as a novel approach to lower the intraocular pressure (Walker E. A. et al, poster P3-698 at the Endocrine society meeting June 12-15, 1999, San Diego). Ingestion of carbenoxolone, a non-specific inhibitor of llβHSDl, was shown to reduce the intraocular pressure by 20% in normal subjects. In the eye, expression of 1 lβHSDl is confined to basal cells of the cornea! epithelium and the non-pigmented epithelialium of the cornea (the site of aqueous production), to ciliary muscle and to the sphincter and dilator muscles of the iris. In contrast, the distant isoenzyme 1 lβHSD2 is highly expressed in the non-pigmented ciliary epithelium and corneal endothelium. None of the enzymes is found at the trabecular meshwork, the site of drainage. Thus, llβHSDl is suggested to have a role in aqueous production, rather than drainage, but it is presently unknown if this is by interfering with activation of the glucocorticoid or the mineralocorticoid receptor, or both.
7. Reduced osteoporosis
Glucocorticoids have an essential role in skeletal development and function but are detrimental in excess. Glucocorticoid-induced bone loss is derived, at least in part, via inhibition of bone formation, which includes suppression of osteoblast proliferation and collagen synthesis (Kim, C.H., S.L. Cheng, and G.S. Kim (1999) J. Endocrinol. 162: 371-379). The negative effect on bone nodule formation could be blocked by the non-specific inhibitor carbenoxolone suggesting an important role of 1 lβHSDl in the glucocorticoid effect (Bellows, C.G., A. Ciaccia, and J.N.M. Heersche, (1998) Bone 23 : 119-125). Other data suggest a role of 1 lβHSDl in providing sufficiently high levels of active glucocorticoid in osteoclasts, and thus in augmenting bone resorption (Cooper, M.S. et al. (2000) Bone 27: 375-381). Taken together, these different data suggest that inhibition of llβHSDl may have beneficial effects against osteoporosis by more than one mechanism working in parallel.
WO 99/65884 discloses carbon subtituted aminothiazole inhibitors of cyclin dependent kinases. These compounds may e.g. be used against cancer, inflammation and arthritis. US 5,856,347 discloses an antibacterial preparation or bactericide comprising 2- aminothiazole derivative and/or salt thereof. Further, US 5,403,857 discloses benzenesulfonamide derivatives having 5-lipoxygenase inhibitory activity. Additionally, tefrahydrotlriazolo[5,4-c]pyridines are disclosed in: Analgesic tetiahydrothiazolo[5,4-c]pyridines. Fr. Addn. (1969), 18 pp, Addn. to Fr. 1498465.
CODEN: FAXXA3; FR 94123 19690704 CAN 72:100685 AN 1970:100685 CAPLUS and 4,5,6,7-Tetiahydrothiazolo[5,4-c]ρyridines. Neth. Appl. (1967), 39 pp. CODEN: NAXXAN NL 6610324 19670124 CAN 68:49593, AN 1968: 49593 CAPLUS.
FR 2384498 discloses thiazolo-benzenesulfonamides which show antibacterial, antifungal and hypoglycaemic properties. WO99/28306 and EP 0 819 681 A2 relate to thiazolobenzenesulfonamides which can be used for treating neurodegenerative pathologies, such as Alzheimer's disease. JP 7149745 A2 and JP 7149746 A2 both describe 2-aminothiazole derivatives as esterase inhibitors. Nothing is disclosed about inhibiting 1 lβHSDl. JP 7309757 A2 relates to treating Alzheimer's disease using N- (5-nitro-2-thiazolyl)benzenesulfonamides. JP 3173876 A2 presents preparation of diphenylthiazoles. These compounds are used as anti-inflammatories, analgesics, anti- allergy agents, uric acid accelerators and blood platelet aggregation inhibitors. EP 0 790 057 Al discloses an antibacterial or bactericide comprising a 2-aminothiazole derivative. US 2 362 087 describes the preparation of thiazolobenzenesulfonamides, such as 2-bromobenzenesulfonamido-4-methylthiazole. Nothing is disclosed about inhibiting llβHSDl and no therapeutic use of such substances is disclosed.
However, none of the above disclosures discloses the compounds according to the present invention, or their use for the treatment of diabetes, obesity, glaucoma, osteoporosis, cognitive disorders, immune disorders, and depression.
Consequently, there is a need of new compounds that are useful in the treatment of diabetes, obesity, glaucoma, osteoporosis, cognitive disorders, immune disorders, and depression.
DISCLOSURE OF THE INVENTION
The compounds according to the present invention solve the above problems and embraces a novel class of compounds which has been developed and which inhibit the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme (11-β-HSDι), and may therefore be of use in the treating disorders such as diabetes, obesity, glaucoma, osteoporosis, cognitive disorders, immune disorders, and depression.
One object of the present invention is a compound of the formula (I)
Figure imgf000008_0001
wherein T is an aryl ring, substituted with at least one of Ci-β-alkyl, halogen, aryl or aryloxy, wherein the arylpxy residue can be further optionally substituted in one or more positions independently of each other by cyano and halogen;
with the proviso that T is not 4-methylphenyl, 4-tert-butylphenyl, 4-chlorophenyl, and 4-fluorophenyl;
as well as pharmaceutically acceptable salts, hydrates and solvates thereof.
It is preferred that T is phenyl substituted with one or more of chloro, 3-chloro-2- cyanophenoxy, methyl, phenyl and n-propyl; with the proviso that T is not 4- methylphenyl and 4-chlόrophenyl.
When T is a substituted phenyl group, it is preferred that the phenyl ring is substituted with at least one of n-propyl, phenyl and 3-chloro-2-cyanophenoxy and, in o- or reposition, methyl and chloro.
Specific examples of compounds according to the invention are:
4-(3-c oro-2-cyanophenoxy)-N-(5-nitro-l,3-thiazol-2-yl)benzenesulfonamide; 3-chloro-2-methyl-N-(5-m^o-l,3-tlήazol-2-yl)benzenesulfonanιide; N-(5-nitro-l,3-thiazol-2-yl)[l,r-biphenyl]-4-sulfonamide; N-(5-nitro-l,3-tMazol-2-yl)-4-n-propylberιzenesulfonamide; N-(5-m^o-l,3-t azol-2-yl)-2,4,6-trichlorobenzenesulfonamide; 2,4-dicWoro-6-methyl-N-(5-nitio-l,3-thiazol-2-yl)benzenesulfonarnide.
Another object of the present invention is a compound of the formula (I) as described above for medical use.
Another object of the present invention is a process for the preparation of a compound as described above comprising sulfonamide coupling by reacting a 2-aminothiazole derivative with a sulfonylchloride in the presence of a base.
Another object of the present invention is a method for the treatment or prevention of diabetes, syndrome X, obesity, glaucoma, hyperhpidemia, hyperglycemia, hyperinsulinemia, osteoporosis, tuberculosis, depression, virus diseases and inflammatory disorders, said method comprising administering to a mammal, including man, in need of such treatment an effective amount of a compound of the formula (I)
Figure imgf000009_0001
wherein T is an aryl ring, optionally independently substituted by [R]n, wherein n is an integer 0-5, and R is hydrogen, C δ-alkyl, halogen, aryl or aryloxy, wherein the aryloxy residue can be further optionally substituted in one or more positions independently of each other by cyano and halogen;
as well as pharmaceutically acceptable salts, hydrates and solvates thereof. These compounds may also be used in the manufacture of a medicament for the prevention, management or treatment of diabetes, syndrome X, obesity, glaucoma, hyperlipidemia, hyperglycemia, hyperinsulinemia, osteoporosis, tuberculosis, depression, virus diseases and inflammatory disorders.
It is preferred that T is phenyl substituted with one or more of chloro, 3-chloro-2- cyanophenoxy, methyl, phenyl and n-propyl.
Specific examples of compounds according to the invention are: 4-(3-chloro-2-cyanophenoxy)-N-(5-mtio-l,3-thiazol-2-yl)benzenesulfonamide,
3-chloro-2-methyl-N-(5-nitro- l,3-tMazol-2-yl)benzenesulfonamide,
N-(5-nitio-l,3-thiazol-2-yl)[l, -biphenyl]-4-sulfonamide,
4-c oro-N-(5-mtio-l,3-tMazol-2-yl)benzenesulfonamide,
N-(5-nitio- l,3-thiazol-2-yl)-4-n-propylbenzenesulfonamide, N-(5-nitio-l,3-tMazol-2-yl)-2,4,6-trichlorobenzenesulfonamide,
2,4-diclύoro-6-memyl-N-(5-mtio-l,3-tMazol-2-yl)benzenesulfonamide.
Another object of the present invention is a pharmaceutical composition comprising at least one compound of the formula (I) as defined above, and a pharmaceutically acceptable carrier.
The compounds according to the present invention may be used in several indications which involve 11-β-hydroxysteroid dehydrogenase type 1 enzyme. Thus the compounds according to the present invention may be used against dementia (see WO97/07789), osteoporosis (see Canalis E 1996, Mechanisms of glucocorticoid action in bone: implications to glucocorticoid-induced osteoporosis, Journal of Clinical Endocrinology and Metabolism, 81, 3441-3447) and may also be used disorders in the immune system (see Franchimont et al, "Inhibition of Thl immune response by glucocorticoids: dexamethasone selectively inhibits IL-12-induced Stat 4 phosphorylation in T lymphocytes", The journal of Immunology 2000, Feb 15, vol 164 (4), pages 1768-74) and also in the above listed indications. The various terms used, separately and in combinations, in the above definition of the compounds having the formula (I) will be explained.
The term "aryl" in the present description is intended to include aromatic rings
(monocyclic or bicyclic) having from 6 to 10 ring carbon atoms, such as phenyl (Ph) and naphthyl, which optionally may be substituted by Ci-β-alkyl. Examples of substituted aryl groups are benzyl and 2-methylphenyl.
Cι_6-alkyl in the compound of formula (I) according to the present application, which may be straight or branched, is preferably Cι_4-alkyl. Exemplary alkyl groups include methyl, ethyl, n-propyl, isopropyl, butyl, sec-butyl, tert-butyl, pentyl, isopentyl, hexyl, and isohexyl.
The term "halogen" in the present description is intended to include fluorine, chlorine, bromine and iodine.
The term "prodrug forms" in the present description means a pharmacologically acceptable derivative, such as an ester or an amide, which derivative is biotransformed in the body to form the active drug (see Goodman and Gilman's, The Pharmacological basis of Therapeutics, 8th ed., McGraw-Hill, Int. Ed. 1992, "Biotransformation of Drugs, p. 13-15).
"Pharmaceutically acceptable" means in the present description being useful in preparing a pharmaceutical composition that is generally safe, non-toxic and neither biologically nor otherwise undesirable and includes being useful for veterinary use as well as human pharmaceutical use.
"Pharmaceutically acceptable salts" mean in the present description salts which are pharmaceutically acceptable, as defined above, and which possess the desired pharmacological activity. Such salts include acid addition salts formed with organic and inorganic acids, such as hydrogen chloride, hydrogen bromide, hydrogen iodide, sulfuric acid, phosphoric acid, acetic acid, glycolic acid, maleic acid, malonic acid, oxalic acid, methanesulfonic acid, trifluoroacetic acid, fumaric acid, succinic acid, tartaric acid, citric acid, benzoic acid, ascorbic acid and the like. Base addition salts may be formed with organic and inorganic bases, such as sodium, ammonia, potassium, calcium, ethanolamine, (tiethanolamine, N-methylglucamine, choline and the like.
Pharmaceutical compositions according to the present invention contain a pharmaceutically acceptable carrier together with at least one of the compounds comprising the formula (I) as described herein above, dissolved or dispersed therein as an active, mtimicrobial, ingredient. In a preferred embodiment, the therapeutic composition is not immunogenic when administered to a human patient for therapeutic purposes, unless that purpose is to induce an immune response.
The preparation of a pharmacological composition that contains active ingredients dissolved or dispersed therein is well understood in the art. Typically such compositions are prepared as sterile injectables either as liquid solutions or suspensions, aqueous or non-aqueous, however, solid forms suitable for solution, or suspensions, in liquid prior to use can also be prepared. The preparation can also be emulsified.
The active ingredient may be mixed with excipients, which are pharmaceutically acceptable and compatible with the active ingredient and in amounts suitable for use in the therapeutic methods described herein. Suitable excipients are, for example, water, saline, dextrose, glycerol, ethanol or the like and combinations thereof. In addition, if desired, the composition may contain minor amounts of auxiliary substances such as wetting or emulsifying agents, pH buffering agents and the like which enhance the effectiveness of the active ingredient. Adjuvants may also be present in the composition. Pharmaceutically acceptable carriers are well known in the art. Exemplary of liquid carriers are sterile aqueous solutions that contain no materials in addition to the active ingredients and water, or contain a buffer such as sodium phosphate at physiological pH value, physiological saline or both, such as phosphate-buffered saline. Still further, aqueous carriers can contain more than one buffer salt, as well as salts such as sodium and potassium chlorides, dextrose, propylene glycol, polyethylene glycol and other solutes.
Liquid compositions can also contain liquid phases in addition to and to the exclusion of water. Exemplary of such additional liquid phases are glycerine, vegetable oils such as cottonseed oil, organic esters such as ethyl oleate, and water-oil emulsions.
The pharmaceutical composition according to one of the preferred embodiments of the present invention comprising compounds comprising the formula (I), may include pharmaceutically acceptable salts of mat component therein as set out above.
Pharmaceutically acceptable salts include the acid addition salts (formed with the free amino groups of the polypeptide) that are formed with inorganic acids such as, for example, hydrochloric or phosphoric acids, or such organic acids as acetic acid, tartaric acid, mandelic acid and the like. Salts formed with the free carboxyl groups can also be derived from inorganic bases such as, for example, sodium, potassium, ammonium, calcium or ferric hydroxides, and such organic bases as isopropylamine, trimethylamine, 2-ethylamino ethanol, histidine, procaine and the like.
The preparations according to the preferred embodiments may be administered orally, topically, intraperitoneally, intraarticularly, intracranially, intradermally, intramuscularly, intraocularly, intrathecally, intravenously, subcutaneously. Other routes which are known for the skilled person in the art are thinkable.
The orally aclministrable compositions according to the present invention may be in the form of tablets, capsules, powders, granules, lozenges, liquid or gel preparations, such as oral, topical or sterile parenteral solutions or suspensions. Tablets and capsules for oral administration may be in unit dose presentation form and may contain conventional excipients such as bmding agents, for example syrup, acacia, gelatin, sorbitol, traganath or polyvinyl-pyrrolidone; fillers e.g. lactose, sugar, maize-starch, calcium phosphate, sorbitol or glycine; tabletting lubricant e.g. magnesium stearate, talc, polyethylene glycol or silica; disintegrants e.g. potato starch, or acceptable wetting agents such as sodium lauryl sulfate. The tablets may be coated according to methods well known in normal pharmaceutical practice. Oral liquid preparations may be in the form of e.g. aqueous or oily suspensions^ solutions, emulsions, syrups or elixirs or may be presented as a dry product for reconstitution with water or other suitable vehicle before use. Such liquid preparations may contain conventional additives such as suspending agents, e.g. sorbitol, syrup, methyl cellulose, glucose syrup, gelatin hydrogenated edible fats; emulsifying agents e.g. lecithin, sorbitan monooleate or acacia, non-aqueous vehicles (which may include edible oils), e.g. almond oil, fractionated coconut oil, oily esters such as glycerine, propylene glycol, or ethyl alcohol; preservatives e.g. methyl or n-propyl p-hydroxybenzoate or sorbic acid, and if desired conventional flavouring or colouring agents.
A pharmaceutical composition according to the present invention, may comprise typically an amount of at least 0.1 weight percent of compound comprising the formula (I) per weight of total therapeutic composition. A weight percent is a ratio by weight of total composition. Thus, for example, 0.1 weight percent is 0.1 grams of compound comprising the formula (I) per 100 grams of total composition. A suitable daily oral dose for a mammal, preferably a human being, may vary widely depending on the condition of the patient. However a dose of compound comprising the formula (I) of about 0.1 to 300 mg/kg body weight may be appropriate.
The compositions according to the present invention may also be used veterinarily and thus they may comprise a veterinarily acceptable excipient or carrier.
The compounds of the present invention in labelled form, e.g. isotopically labelled, may be used as a diagnostic agent. The compounds of the formula (I) above may be prepared by, or in analogy with, conventional methods, and especially according to or in analogy with the following methods. Further, the pharmacology in-vitro was studied using the following reagents and methods.
All publications mentioned herein are hereby incorporated by reference. By the expression "comprising" we understand including but not limited to. Thus, other non- mentioned substances, additives or carriers may be present.
The invention will now be described in reference to the following Figures and Examples. These Figures and Examples are not to be regarded as limiting the scope of the present invention, but shall only serve in an illustrative manner.
EXPERIMENTAL METHODS
Scintillation Proximity Assay
[1, 2(n) - 3H]-cortisone was purchased from Amersham Pharmacia Biotech. Anti- cortisol monoclonal mouse antibody, clone 6D6.7 was obtained from Immunotech and Scintillation proximity assay (SPA) beads coated with monoclonal antimouse antibodies were from Amersham Pharmacia Biotech. NADPH, tetrasodium salt was from Calbiochem and glucose-6-phosphate (G-6-P) was supplied by Sigma. The human 11-β-hydroxysteroid dehydrogenase type-1 enzyme (11-β-HSD was expressed in Pichiapastoris. 18-β-glycyrrhetinic acid (GA) was obtained from Sigma. The serial dilutions of the compounds were performed on a Tecan Genesis RSP 150. Compounds to be tested were dissolved in DMSO (1 mM) and diluted in 50 mM Tris- HC1, pH 7.2 containing 1 mM EDTA. The multiplication of plates was done on a WallacQuadra. The amount of the product [3H]-cortisol, bound to the beads was determined in a Packard, Top Count microplate liquid scintillation counter.
The 11-β-HSDι enzyme assay was carried out in 96 well microtiter plates (Packard, Optiplate) in a total well volume of 220 μL and contained 30 mM Tris-HCl, pH 7.2 with 1 mM EDTA, a substrate mixture tritiated Cortisone/NADPH (175 nM / 181 μM), G-6-P (1 mM) and inhibitors in serial dilutions (9 to 0.15 μM). Reactions were initiated by the addition of human ll-β-HSDl5 either as Pichiapastoris cell homogenate or microsomes prepared from Pichia astoris (the final amount of enzyme used was varied between 0.057 to 0.11 mg/mL). Following mixing, the plates were shaken for 30 to 45 minutes at room temperature. The reactions were terminated with 10 μL 1 mM GA stop solution. Monoclonal mouse antibody was then added (10 μL of 4 μM) followed by 100 μL of SPA beads (suspended according to the manufacturers instructions). Appropriate controls were set up by omitting the 11-β- HSDi to obtain the non-specific binding (NSB) value.
The plates were covered with plastic film and incubated on a shaker for 30 minutes, at room temperature, before counting. The amount of [3H]-cortisol, bound to the beads was determined in a microplate liquid scintillation counter.
The calculation of the Kj values for the inhibitors was performed by use of Activity Base. The Kj value is calculated from IC50 and the Km value is calculated using the Cheng Prushoff equation (with reversible inhibition that follows the Michaelis-Menten equation): K; = IC50(l+[S]/Km) [Cheng, Y.C; Prushoff, W.H. Biochem. Pharmacol. 1973, 22, 3099-3108]. The IC50 is measured experimentally in an assay wherein the decrease of the turnover of cortisone to cortisol is dependent on the inhibition potential of each substance. The Ki values of the compounds of the present invention for the 11- β-HSDl enzyme lie typically between about 10 nM and about 10 μM. The Ki value for the compound according to Example 6 is 545 nM. METHODS FOR PREPARATION
General:
For preparative straight phase HPLC purification a Phenomenex column (250 x 21.1 mm, 10 μm) was used on a Gilson system eluting with ethanol in chloroform (gradient from 0 - 10% in 10 m n) with a flow of 20 mL/min. Column chromatography was performed on silica using Silica gel 60 (230-400 mesh), Merck. Melting points were determined on a Gallenkamp apparatus. Elemental analyses were recorded using a Vario EL instrument. HPLC analyses were performed using a Hypersil Elite column (150 x 4.6 mm, 3μ) with a flow of 3 mL / min on a Waters 600E system with monitoring at 254 nm. Reverse phase preparative HPLC was carried out on a 100 x 21.2 mm, 5μ Hypersil Elite column eluting with a gradient of 5% ACN in 95% water to 95% ACN in 5% water (0.2% TFA buffer) over 10 rnins at a flow rate of 20 mL / min with the UV detector set at 254 nm. Thin layer chromatography was carried out using pre-coated silica gel F-254 plates (thickness 0.25 mm). Electrospray MS spectra were obtained on a Micromass platform LCMS spectrometer. Crude, worked up compounds were purified by flash column chromatography using pre packed silica SPE columns (10 g silica) on an Isco Foxy 200 Combiflash system, and a gradient of 16.67% ethyl acetate in hexane increasing incrementally to 100% ethyl acetate.
List of Abbreviations DMAP = 4-dimethylaminopyridine DMF = dimethylformamide DMSO = dimethyl sulfoxide EDTA = ethylenediaminetetraacetic acid
SULFONAMIDE COUPLINGS:
A solution of the 2-aminothiazole derivative (0.27 mmol), triethylamine (0.54 mmol) and DMAP (0.27 mmol) in DMF (250 μL) and dichloromethane (1.2 mL) was dispensed into a reaction vial. The sulfonyl chloride was dissolved in dichloromethane (1 mL) and added. The reaction mixtures were kept at room temperature over night. The mixture was then added to petroleum ether (35 mL). After some hours in refrigerator the supernatants were decanted and the residual materials were dissolved in DMSO-methanol-acetic acid (300 μL + 500 μL + 50 μL) and purified by preparative LCMS (acetonitrile-water gradients). The purest fractions were collected and lyophilized. Alternatively, the crude was isolated using extractive work-up and purified using standard procedures.
EXAMPLES
The following specific compounds were synthesized.
EXAMPLE 1 [321A] 4-(3-Chloro-2-cyanophenoxy)-N-(5-nitro-l,3-thiazol-2-yl)benzenesulfonamide The title compound was prepared from 2-amino-5-nitrothiazole and 4-(3-chloro-2- cyanophenoxy)benzenesulfonyl chloride as described in the sulfonamide couplings to give a yellow solid (8.7 mg) with purity >90%. LCMS (pos) m/z 437.2.B
EXAMPLE 2 [335A] 3-Chloro-2-methyl-N-(5-nitro-l,3-thiazol-2-yl)benzenesuIfonamide
The title compound was prepared from 2-amino-5-nitrothiazole and 3-chloro-2- methylbenzenesulfonyl chloride as described in the sulfonamide couplings to give a yellow solid (15.2 mg) with purity >90%. LCMS (pos) m/z 332.0.
EXAMPLE 3 [336A]
N-(5-nitro-l,3-thiazol-2-yI)[l,l'-biphenyl]-4-sulfonamide
The title compound was prepared from 2-anιino-5-nitrothiazole and 4- biphenylsulfonyl chloride as described in the sulfonamide couplings to give a yellow solid (5.5 mg) with purity >90%. LCMS (pos) m/z 362.0. EXAMPLE 4 [337A] 4-Chloro-N-(5-nitro-l,3-thiazol-2-yl)benzenesulfonamide
The title compound was prepared from 2-amino-5-nitrothiazole and 4- chlorobenzenesulfonyl chloride as described in the sulfonamide couplings to give a yellow solid (19.5 mg) with purity >90%. LCMS (pos) m/z 320.0.
EXAMPLE 5 [338A] N-(5-nitro-l,3-thiazol-2-yl)-4-n-propylbenzenesulfonamide
The title compound was prepared from 2-amino-5-nitrothiazole and 4-n- propylbenzenesulfonyl chloride as described in the sulfonamide couplings to give a yellow solid (28.5 mg) with purity >90%. LCMS (pos) m/z 328.2.
EXAMPLE 6 [339A] N-(5-nitro-l,3-thiazoI-2-yI)-2,4,6-trichlorobenzenesulfonamide The title compound was prepared from 2-amino-5-nitrothiazole and 2,4,6- trichlorobenzenesulfonyl chloride as described in the sulfonamide couplings to give a yellow solid (26.7 mg) with purity >90%. LCMS (pos) m/z 389.8; HRMS m/z 386.8718 (calc. of monoisotopic mass for C9 H4 Cl3 N304 S2 gives 386.8709).
EXAMPLE 7 [340A]
2,4-Dichloro-6-methyl-N-(5-nitro-l,3-thiazol-2-yl)benzenesulfonamide
The title compound was prepared from 2-amino-5-mtrothiazole and 2,4-dichloro-6- methylbenzenesulfonyl chloride as described in the sulfonamide couplings to give a yellow solid (28.4 mg) with purity >80%. LCMS (pos) m/z 368.
Various embodiments of the present invention have been described above but a person skilled in the art realizes further minor alterations which would fall into the scope of the present invention. The breadth and scope of the present invention should not be limited by any of the above-described exemplary embodiments, but should be defined only in accordance with the following claims and their equivalents.

Claims

Claims
1. A compound of the formula (I)
Figure imgf000020_0001
wherein T is an aryl ring, substituted with at least one of Cι.6-alkyl5 halogen, aryl or aryloxy, wherein the aryloxy residue can be further optionally substituted in one or more positions independently of each other by cyano and halogen;
with the proviso that T is not 4-methylphenyl, 4-tert-butylphenyl, 4-chlorophenyl, and 4-fluorophenyl;
as well as pharmaceutically acceptable salts, hydrates and solvates thereof.
2. A compound according to claim 1, wherein T is phenyl substituted with one or more of chloro, 3-chloro-2-cyanophenoxy, methyl, phenyl and n-propyl; with the proviso that T is not 4-methylphenyl and 4-chlorophenyl.
3. A compound according to claim 1-2 selected from the group consisting of: 4-(3 -chloro-2-cyanophenoxy)-N-(5-nitro- l,3-thiazol-2-yl)benzenesulfonamide,
3-cWoro-2-methyl-N-(5-mtio-l,3-t azol-2-yl)benzenesulfonarnide, N-(5-nitro-l,3-thiazol-2-yl)[l, l'-biphenyl]-4-sulfonamide, N-(5-nitro- l,3-thiazol-2-yl)-4-n-propylbenzenesulfonamide, N-(5-nifro-l,3-t azol-2-yl)-2,4,6-tricUorobenzenesulfonamide, 2,4-(hchloro-6-methyl-N-(5-nifro-l,3-tMazol-2-yl)benzenesulfonamide.
4. A compound according to anyone of claims 1-3, for medical use.
5. A process for the preparation of a compound according to claim 1-3, comprising sulfonamide coupling by reacting a 2-arninothiazole derivative with a sulfonylchlori.de in the presence of a base.
6. A method for the treatment or prevention of diabetes, syndrome X, obesity, glaucoma, hyperlipidemia, hyperglycemia, hyperinsulinemia, osteoporosis, tuberculosis, depression, virus diseases and inflammatory disorders, said method comprising administering to a mammal, including man, in need of such treatment an effective amount of a compound of the formula (I)
Figure imgf000021_0001
wherein T is an aryl ring, optionally independently substituted by [R]n, wherein n is an integer 0-5, and R is hydrogen, Ci-β-alkyl, halogen, aryl or aryloxy, wherein the aryloxy residue can be further optionally substituted in one or more positions independently of each other by cyano and halogen;
as well as pharmaceutically acceptable salts, hydrates and solvates thereof.
7. A method according to claim 6, wherein T is phenyl substituted with one or more of chloro, 3-chloro-2-cyanophenoxy, methyl, phenyl and n-propyl.
8. A method according to claim 6-7, wherein the compound is selected from: 4-(3-cWoro-2-cyanophenoxy)-N-(5-nitio-l,3-t azol-2-yl)benzenesulfonamide, 3-c oro-2-methyl-N-(5-mtio-l,3-t azol-2-yl)benzenesulfonamide,
N-(5-nitio-l,3-thiazol-2-yl)[l,r-biphenyl]-4-sulfonamide, 4-cMoro-N-(5-mtio-l,3-thiazol-2-yl)benzenesulfonamide, N-(5-nitro-l,3-tihiazol-2-yl)-4-n-propylbenzenesulfonamide, N-(5-mtro-l,3-tMazol-2-yi)-2,4,6-tricldorobenzenesulfonamide, 2,4-dicUoro-6-methyl-N-(5-mtio-l,3-t azol-2-yl)benzenesulfonamide.
9. The use of a compound of the formula (I)
Figure imgf000022_0001
wherein T is an aryl ring, optionally independently substituted by [R]n, wherein n is an integer 0-5, and R is hydrogen, Cμδ-alkyl, halogen, aryl or aryloxy, wherein the aryloxy residue can be further optionally substituted in one or more positions independently of each other by cyano and halogen;
as well as pharmaceutically acceptable salts, hydrates and solvates thereof,
in the manufacture of a medicament for the prevention, management or treatment of diabetes, syndrome X, obesity, glaucoma, hyperlipidemia, hyperglycemia, hyperinsulinemia, osteoporosis, tuberculosis, depression, virus diseases and inflammatory disorders.
10. The use according to claim 9, wherein T is phenyl substituted with one or more of chloro, 3-chloro-2-cyanophenoxy, methyl, phenyl and n-propyl.
11. The use according to claim 9-10, wherein the compound is selected from: 4-(3-cHoro-2-cyanophenoxy)-N-(5-nitio-l,3-thiazol-2-yl)benzenesulfonamide,
3 -chloro-2-methyl-N-(5-mtro- l,3-thiazol-2-yl)benzenesulfonamide, N-(5-nitro-l,3-thiazol-2-yl)[l,r-biphenyl]-4-sulfonamide, 4-c oro-N-(5-mtio-l,3-tMazol-2-yl)benzenesulfonamide, N-(5-nitro- 1 ,3 -thiazol-2-yl)-4-n-propylbenzenesulfonamide, N-(5-nitio-l,3-thiazol-2-yl)-2,4,6-tricHoroberιzenesulfonarnide, 2,4-mcMoro-6-methyl-N-(5-m^o-l,3-thiazol-2-yl)berιzenesulfonamide.
12. A pharmaceutical composition comprising at least one compound of the formula (I) as defined in any of the claims 1-3, and a pharmaceutically acceptable carrier.
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