WO2001085176A1 - The solid oral pharmaceutical composition comprising a bisphosphonic acid derivative - Google Patents

The solid oral pharmaceutical composition comprising a bisphosphonic acid derivative Download PDF

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Publication number
WO2001085176A1
WO2001085176A1 PCT/PL2001/000039 PL0100039W WO0185176A1 WO 2001085176 A1 WO2001085176 A1 WO 2001085176A1 PL 0100039 W PL0100039 W PL 0100039W WO 0185176 A1 WO0185176 A1 WO 0185176A1
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Prior art keywords
acid derivative
bisphosphonic acid
composition
cores
solid oral
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PCT/PL2001/000039
Other languages
French (fr)
Inventor
Stanisław ADAMSKI
Andrzej Zaremba
Wiesław SZELEJEWSKI
Zofia Marchlewska-Cela
Katarzyna Berkan
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Instytut Farmaceutyczny
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Application filed by Instytut Farmaceutyczny filed Critical Instytut Farmaceutyczny
Priority to SK1584-2002A priority Critical patent/SK287298B6/en
Priority to UA2002118915A priority patent/UA75072C2/en
Publication of WO2001085176A1 publication Critical patent/WO2001085176A1/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Definitions

  • the solid oral pharmaceutical composition comprising a bisphosphonic acid derivative
  • the present invention provides the solid oral pharmaceutical composition comprising a bisphosphonic acid derivative and the process for preparing thereof.
  • Bisphosphonic acid derivatives such as clodronic, pamidronic, alendronic, risedronic acids and the salts thereof, are known to be active in calcium and phosphate metabolism mediated disorders.
  • Alendronic acid i.e. (4- amino-1-hydroxybutylidene) bisphosphonic acid
  • a German Patent specification No DE 3.016.289 Henkel AG
  • Alendronic acid as monosodium salt trihydrate is an active ingredient of the pharmaceutical oral dosage form known as Fosamax, indicated for the treatment and prevention of osteoporosis.
  • this formulation comprises the following inactive excipients: microcrystalline cellulose, anhydrous lactose, croscarmellose sodium and magnesium stearate.
  • European Patent publication No EP 0 336 851 discloses pharmaceutical compositions containing a bisphosphonic acid derivative for oral administration, such as, but not limited to tablets, capsules, pellets, powders and dispersions.
  • Said compositions comprise the following excipients: microcrystalline lactose and sodium lauryl sulphate, crosslinked carboxyethylcellulose and magnesium stearate, along with the active ingredient.
  • Solid oral dosage forms of bisphosphonic acids are also disclosed in a French Patent specification No FR 2.703.590 and in an International Patent Publication No WO 96/39410. Said forms also contain lactose. Lactose is generally used as a filler for solid dosage forms due to its excellent compressibility, high purity and stability.
  • this substance may generate formulation incompatibilities with primary or secondary amine group containing com- pounds.
  • the incompatibilities are caused by the reaction between reducing aldehyde moiety of lactose and amine group present in the active ingredient, known as the Maillard reaction.
  • the resulting degradation products decrease the therapeutic value of the drug.
  • the forma- tion of said products is evidenced by a brown colouring of the final drug forms.
  • the presence of water enhance the degradation process. See e.g. Handbook of Pharmaceutical Excipients, 2 nd Ed., 1994, p. 257 (ISBN 091730 60 8) .
  • Lately, D.D. Wirth et al . have shown on the example of fluoxetine that the Maillard reaction proceeds also between lactose and secondary amines (J. Pharm. Sci. 87, 1, p. 31-39) .
  • the molecule of alendronic acid contains a primary amine group.
  • WO 94/12200 proposes the method of avoiding the interaction of bisphosphonic acid derivatives comprising an amine group in the molecule with lactose by providing the dry composition of the active ingredient and excipients and the process of rpre- paration thereof comprising the direct blending of said dry mix without granulation or addition of water before compression.
  • the method cannot solve the instability problem of the pharmaceutical preparations during a long storage, especially in warm and dump conditions.
  • the object of the present invention is to provide a solid oral pharmaceutical composition of bisphosphonic acid, particularly alendronic acid or the salt thereof, characterized by the desired physicochemical properties, the adequate release rate of the active ingredient and storage stability, without any degradation of bisphos- phonate and without forming of degradation products.
  • the object was achieved by employing as a filler a carbohydrate alcohol, preferably D-mannitol, and also by developing an internal formulation structure, which as- sures the uniformity of the dose, the required release rate of the active ingredient from the unit dosage form and the high stability of the final product.
  • a carbohydrate alcohol preferably D-mannitol
  • One aspect of the invention is the solid oral pharmaceutical composition comprising bisphosphonic acid de- rivative, characterised in that it comprises the cores based on the carbohydrate alcohol, preferably the cores based on mannitol, uniformly dispersed in the blend of a bisphosphonic acid derivative and excipients.
  • the second aspect of the present invention is the process of preparation of the solid oral composition, comprising the steps of forming the cores containing a carbohydrate alcohol with the addition of a disintegrant and a binder, and admixing the cores with a bisphosphonic acid derivative, lubricants and optionally with fillers, binders and/or disintegrants .
  • the cores containing mannitol as a carbohydrate alcohol are formed by a wet granulation process.
  • Mannitol is employed to prepare many different pharmaceutical dosage forms, including also solid oral dosage forms, where it serves primarily as a filler.
  • Mannitol, or 1, 2, 3, 4, 5, 6-hexahexanol is a hexahydroxide carbohydrate alcohol, a mannose derivative without a reducing aldehyde group in a molecule, and therefore it does not react with amine group containing compounds.
  • Physicochemical properties of the substance, and mainly its dry and aqueous stability as well as its non- hygroscopicity, enable its use to prepare dry pharmaceutical formulations by both dry and wet granulation proc- esses.
  • the solid oral composition of the invention may comprise some other non-reducing sugar, e.g. sorbitol.
  • the solid oral composition of the invention may also comprise other inactive ingredients to enhance the preparation process and to render the dosage form required physical and mechanical properties, such as other diluents, among others cellulose and its derivatives, disintegrants, such as starch and its derivatives, cro- scarmellose, crosslinked polyvinylpyrrolidone, sodium starch glycolate or other product based on crosslinked polymer, binders, such as polyvinylpyrrolidone, gelatin, gums of natural and synthetic origin, cellulose derivatives, e.g. hydroxypropyl methylcellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, lubricants, e.g. sodium lauryl sulphate, magnesium stearate, as well as water soluble or insoluble colourants.
  • other inactive ingredients such as other diluents, among others cellulose and its derivatives, disintegrants, such as starch and its derivatives, cro- scarmellose, crosslinked polyvinylpyrrolidone
  • the tablets may be protected by coating, as illustrated in Pharmaceutical Dosage Forms (vol. 3), Ed. H.A. Liebermann, L.Lach ann, J.B. Schwartz (1990), Marcel Dekker Inc. New York and Basel, p. 93- 125.
  • the preparation process of the pharmaceutical composition of the invention comprise preparing the cores containing a carbohydrate alcohol and optionally disintegrants and binders, admixing the cores with a bisphosphonic acid derivative and remaining excipients, such as binders, disintegrants, lubricants and preparing the final dosage forms.
  • the cores are formed by wet granulation of mannitol supplemented by a disintegrant, such as crosslinked polyvinylpyrrolidone, and binder, such as polyvinylpyrrolidone, the resulting granulate is rubbed through a selected screen size sieve, preferably 1 mm, dried, and, with stirring, a bisphosphonic acid derivative, such as alen- dronate, a lubricant (lubricants), such as sodium lauryl sulphate, magnesium stearate and other excipients are added.
  • a disintegrant such as crosslinked polyvinylpyrrolidone
  • binder such as polyvinylpyrrolidone
  • the solid oral dosage forms obtained from the above blend are characterised with the internal structure, wherein a homogenous mass of the active ingredient and the fillers, binders and optionally other excipients, comprise uniformly distributed core particles preferably with the diameter equal to or lower than 1 mm.
  • the dis- integrant contained in the cores causes the disintegration of the unit dosage form in an aqueous environment (in gastric juices) .
  • the pharmaceutical composition of the invention comprises from 3 to 60% by weight of a bisphosphonic acid derivative, from 50 to 80% by weight of mannitol, from 1.5 to 5.0% by weight of the crosslinked polyvinylpyrrolidone, from 1.5 to 3.0% by weight of polyvinylpyrrolidone, from 1.0 to 4.0% by weight of sodium lauryl sulphate and from 3.0 to 20.0% by weight of the potato starch.
  • Tablets containing 13.05 mg of alendronic acid monosodium salt trihydrate were stored in conditions of the accelerated ageing, in chambers at the temperature of 25°C and 60% relative humidity and in chambers at the temperature of 40°C and 70% relative humidity in the pe- riod of 12 months. Each 3 months the samples were characterised in terms of physicochemical properties and stability.
  • Measured parameters the appearance of tablets, purity, alendronic acid contents and active substance re- lease.
  • Purity of the solid dosage form was estimated by determining the contents of a main impurity, i.e. 4- aminobutyric acid.
  • TLC thin layer chroma- tography
  • the determination of active ingredient contents in terms of alendronic acid was carried by high pressure liquid chromatography (HPLC) on a liquid chromatograph with 250 nm length and internal diameter 4.1 mm column, packed with PRP-1 10 ⁇ m HAMILTON granulation.
  • HPLC high pressure liquid chromatography
  • mannitol, crosslinked polyvinylpyrrolidone and polyvinylpyrrolidone were mois- tened with water and rubbed through a selected mesh size of 1 mm sieve.
  • the granulate was dried at 28°C to the loss on drying of about 1.5-2.0%.
  • the granulate was subsequently supplemented with: an active ingredient, sodium lauryl sulphate, starch, and magnesium stearate. After thorough mixing the mass was tabletted with concave punches of the diameter of 6 mm.

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  • Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Solid oral pharmaceutical composition comprising bisphosphonic acid derivative contains the cores based on a carbohydrate alcohol, preferably mannitol, uniformly dispersed in a homogenous blend of an active ingredient and excipients. The process of preparation of the above pharmaceutical formulation is also disclosed. The invention is particularly suitable to prepare solid oral dosage forms of the medicines comprising alendronic acid derivative, especially alendronic acid monosodium salt trihydrate.

Description

The solid oral pharmaceutical composition comprising a bisphosphonic acid derivative
The present invention provides the solid oral pharmaceutical composition comprising a bisphosphonic acid derivative and the process for preparing thereof.
Bisphosphonic acid derivatives, such as clodronic, pamidronic, alendronic, risedronic acids and the salts thereof, are known to be active in calcium and phosphate metabolism mediated disorders. Alendronic acid, i.e. (4- amino-1-hydroxybutylidene) bisphosphonic acid, is taught by a German Patent specification No DE 3.016.289 (Henkel AG) . Alendronic acid as monosodium salt trihydrate is an active ingredient of the pharmaceutical oral dosage form known as Fosamax, indicated for the treatment and prevention of osteoporosis. Besides the active substance this formulation comprises the following inactive excipients: microcrystalline cellulose, anhydrous lactose, croscarmellose sodium and magnesium stearate.
European Patent publication No EP 0 336 851 discloses pharmaceutical compositions containing a bisphosphonic acid derivative for oral administration, such as, but not limited to tablets, capsules, pellets, powders and dispersions. Said compositions comprise the following excipients: microcrystalline lactose and sodium lauryl sulphate, crosslinked carboxyethylcellulose and magnesium stearate, along with the active ingredient. Solid oral dosage forms of bisphosphonic acids are also disclosed in a French Patent specification No FR 2.703.590 and in an International Patent Publication No WO 96/39410. Said forms also contain lactose. Lactose is generally used as a filler for solid dosage forms due to its excellent compressibility, high purity and stability. However, it is known that this substance may generate formulation incompatibilities with primary or secondary amine group containing com- pounds. The incompatibilities are caused by the reaction between reducing aldehyde moiety of lactose and amine group present in the active ingredient, known as the Maillard reaction. The resulting degradation products decrease the therapeutic value of the drug. The forma- tion of said products is evidenced by a brown colouring of the final drug forms. The presence of water enhance the degradation process. See e.g. Handbook of Pharmaceutical Excipients, 2nd Ed., 1994, p. 257 (ISBN 091730 60 8) . Lately, D.D. Wirth et al . have shown on the example of fluoxetine that the Maillard reaction proceeds also between lactose and secondary amines (J. Pharm. Sci. 87, 1, p. 31-39) .
The molecule of alendronic acid contains a primary amine group.
The problem of browning of lactose containing solid dosage forms with alendronic acid and other bisphosphonic acid derivatives with a primary or secondary amine group was disclosed in an International Patent Publication No WO 94/12200. WO 94/12200 proposes the method of avoiding the interaction of bisphosphonic acid derivatives comprising an amine group in the molecule with lactose by providing the dry composition of the active ingredient and excipients and the process of rpre- paration thereof comprising the direct blending of said dry mix without granulation or addition of water before compression. However, the method cannot solve the instability problem of the pharmaceutical preparations during a long storage, especially in warm and dump conditions. The object of the present invention is to provide a solid oral pharmaceutical composition of bisphosphonic acid, particularly alendronic acid or the salt thereof, characterized by the desired physicochemical properties, the adequate release rate of the active ingredient and storage stability, without any degradation of bisphos- phonate and without forming of degradation products.
The object was achieved by employing as a filler a carbohydrate alcohol, preferably D-mannitol, and also by developing an internal formulation structure, which as- sures the uniformity of the dose, the required release rate of the active ingredient from the unit dosage form and the high stability of the final product.
One aspect of the invention is the solid oral pharmaceutical composition comprising bisphosphonic acid de- rivative, characterised in that it comprises the cores based on the carbohydrate alcohol, preferably the cores based on mannitol, uniformly dispersed in the blend of a bisphosphonic acid derivative and excipients.
The second aspect of the present invention is the process of preparation of the solid oral composition, comprising the steps of forming the cores containing a carbohydrate alcohol with the addition of a disintegrant and a binder, and admixing the cores with a bisphosphonic acid derivative, lubricants and optionally with fillers, binders and/or disintegrants .
In a preferred embodiment of the invention the cores containing mannitol as a carbohydrate alcohol are formed by a wet granulation process.
Mannitol is employed to prepare many different pharmaceutical dosage forms, including also solid oral dosage forms, where it serves primarily as a filler. Mannitol, or 1, 2, 3, 4, 5, 6-hexahexanol, is a hexahydroxide carbohydrate alcohol, a mannose derivative without a reducing aldehyde group in a molecule, and therefore it does not react with amine group containing compounds. Physicochemical properties of the substance, and mainly its dry and aqueous stability as well as its non- hygroscopicity, enable its use to prepare dry pharmaceutical formulations by both dry and wet granulation proc- esses.
Instead of mannitol, the solid oral composition of the invention may comprise some other non-reducing sugar, e.g. sorbitol.
The solid oral composition of the invention may also comprise other inactive ingredients to enhance the preparation process and to render the dosage form required physical and mechanical properties, such as other diluents, among others cellulose and its derivatives, disintegrants, such as starch and its derivatives, cro- scarmellose, crosslinked polyvinylpyrrolidone, sodium starch glycolate or other product based on crosslinked polymer, binders, such as polyvinylpyrrolidone, gelatin, gums of natural and synthetic origin, cellulose derivatives, e.g. hydroxypropyl methylcellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, lubricants, e.g. sodium lauryl sulphate, magnesium stearate, as well as water soluble or insoluble colourants.
If desired, the tablets may be protected by coating, as illustrated in Pharmaceutical Dosage Forms (vol. 3), Ed. H.A. Liebermann, L.Lach ann, J.B. Schwartz (1990), Marcel Dekker Inc. New York and Basel, p. 93- 125.
The preparation process of the pharmaceutical composition of the invention comprise preparing the cores containing a carbohydrate alcohol and optionally disintegrants and binders, admixing the cores with a bisphosphonic acid derivative and remaining excipients, such as binders, disintegrants, lubricants and preparing the final dosage forms. In a preferred embodiment of the invention, the cores are formed by wet granulation of mannitol supplemented by a disintegrant, such as crosslinked polyvinylpyrrolidone, and binder, such as polyvinylpyrrolidone, the resulting granulate is rubbed through a selected screen size sieve, preferably 1 mm, dried, and, with stirring, a bisphosphonic acid derivative, such as alen- dronate, a lubricant (lubricants), such as sodium lauryl sulphate, magnesium stearate and other excipients are added. The blend thus prepared is compressed to provide solid forms, such as tablets, coated tablets, dragees, or filled into hard gelatine capsules.
The solid oral dosage forms obtained from the above blend are characterised with the internal structure, wherein a homogenous mass of the active ingredient and the fillers, binders and optionally other excipients, comprise uniformly distributed core particles preferably with the diameter equal to or lower than 1 mm. The dis- integrant contained in the cores causes the disintegration of the unit dosage form in an aqueous environment (in gastric juices) .
Thanks to developing the above internal structure of the pharmaceutical composition of the invention, it was possible to reach desired disintegration properties of the final solid dosage form and a proper kinetics of bisphosphonic acid derivative release, as shown in the Table 1.
In the preferred embodiment, the pharmaceutical composition of the invention comprises from 3 to 60% by weight of a bisphosphonic acid derivative, from 50 to 80% by weight of mannitol, from 1.5 to 5.0% by weight of the crosslinked polyvinylpyrrolidone, from 1.5 to 3.0% by weight of polyvinylpyrrolidone, from 1.0 to 4.0% by weight of sodium lauryl sulphate and from 3.0 to 20.0% by weight of the potato starch.
Studies on physicochemical properties and stability
Tablets containing 13.05 mg of alendronic acid monosodium salt trihydrate (equivalent to 10 mg free al- endronic acid per tablet) were stored in conditions of the accelerated ageing, in chambers at the temperature of 25°C and 60% relative humidity and in chambers at the temperature of 40°C and 70% relative humidity in the pe- riod of 12 months. Each 3 months the samples were characterised in terms of physicochemical properties and stability.
Measured parameters: the appearance of tablets, purity, alendronic acid contents and active substance re- lease.
Analytical methods Determination of purity:
Purity of the solid dosage form was estimated by determining the contents of a main impurity, i.e. 4- aminobutyric acid.
The determination was carried by thin layer chroma- tography (TLC) , with the following mobile phase system: chloroform/methanol/17% ammonia (2:2:1, v/v/v) and with an immobile phase of Merck glass plates covered with silica gel G of a 0.25 mm thickness. As a developing agent a butanol solution of ninhydrine with acetic acid added was used. The size and intensity of a blot at Rf 0.5 was assessed.
The determination of active ingredient release from tab- lets:
The studies were carried in an apparatus for release equipped with the paddle stirrer according to the specifications of Polish Pharmacopoeia V, p. 63. The de- termination was carried at 37 °C with 50 rpm of the stir- rer .
The determination of active ingredient contents in terms of alendronic acid: The determination was carried by high pressure liquid chromatography (HPLC) on a liquid chromatograph with 250 nm length and internal diameter 4.1 mm column, packed with PRP-1 10 μm HAMILTON granulation. As a mobile phase the phosphate buffer (pH 8.0) /acetonitrile/methanol (75:20:5, v/v/v) was used with the mobile phase flow rate of 1.0 ml/ in.
The investigation results for tablets determined directly after their preparation and after 12 months of storage in accelerated ageing conditions are shown in the Table 1.
Figure imgf000010_0001
Table 1. The investigation results for tablets with sodium alendronate (containing 10 mg of the active ingredient in terms of free alendronic acid) , directly after the preparation and after 12
Figure imgf000010_0002
months of storage in the conditions of an accelerated ageing.
Figure imgf000010_0004
Figure imgf000010_0003
The invention is further illustrated by the following examples without limiting the scope of the invention. Example
Tablets with sodium alendronate at 5 mg Tablet formulation:
Figure imgf000011_0001
The method for tablet preparation
After an intimate blending, mannitol, crosslinked polyvinylpyrrolidone and polyvinylpyrrolidone were mois- tened with water and rubbed through a selected mesh size of 1 mm sieve. The granulate was dried at 28°C to the loss on drying of about 1.5-2.0%. With continuous stirring, the granulate was subsequently supplemented with: an active ingredient, sodium lauryl sulphate, starch, and magnesium stearate. After thorough mixing the mass was tabletted with concave punches of the diameter of 6 mm.

Claims

What is claimed is:
1. A solid oral pharmaceutical composition comprising a bisphosphonic acid derivative, characterised in that it contains the cores based on carbohydrate alco- hoi, uniformly dispersed in a homogenous blend of an active ingredient and excipients.
2. Composition as claimed in claim 1, characterised in that it contains mannitol as a carbohydrate alcohol.
3. Composition as claimed in claim 1, characterised in that it has a form of a dry powder.
4. Composition as claimed in claim 1, characterised in that it is formulated in unit dosage forms.
5. Composition as claimed in claim 1, characterised in that it has a form of tablets.
6. Composition as claimed in claim 1, characterised in that it contains alendronic acid monosodium salt trihydrate as a bisphosphonic acid derivative.
7. Composition as claimed in claim 1, characterised in that said included cores comprise about 50-80% of mannitol, about 1.5-5.0% of crosslinked polyvinylpyrrolidone, and 1.5-3.0% of polyvinylpyrrolidone relative to a total weight of the formulation, and said cores are surrounded with the homogenous blend of 3.0-60.0% of alendronic acid monosodium salt trihydrate, 3.0-20.0% of starch, and 1.0-4.0% of sodium lauryl sulphate, relative to a total weight of the formulation.
8. A process of preparation of the solid oral pharmaceutical composition comprising bisphosphonic acid derivative, which comprises the step of forming the cores containing a carbohydrate alcohol with a disintegrant and a binder and combining said cores with a bisphosphonic acid derivative, lubricants and optionally fillers, binders and/or disintegrants.
9. The process, as claimed in claim 8, which comprises forming cores by a wet granulation technique.
10. The process as claimed in claim 8, wherein mannitol is used as a carbohydrate alcohol.
11. The process as claimed in claim 8, wherein an alendronic acid derivative is used as a bisphosphonic acid derivative.
12. The process as claimed in claim 8, wherein alendronic acid monosodium salt trihydrate is used as a bisphosphonic acid derivative.
PCT/PL2001/000039 2000-05-11 2001-05-10 The solid oral pharmaceutical composition comprising a bisphosphonic acid derivative WO2001085176A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SK1584-2002A SK287298B6 (en) 2000-05-11 2001-05-10 Solid peroral pharmaceutical composition having a form of tablets containing bisphosphonic acid derivative substituted by amino groups and method for the production thereof
UA2002118915A UA75072C2 (en) 2000-05-11 2001-10-05 Solid oral pharmaceutical composition comprising bisphosphonic acid derivative and process for preparing this composition

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL340087A PL196485B1 (en) 2000-05-11 2000-05-11 Solid oral pharmacological composition containing a derivative of bisphosphonic acid and method of obtaining same
PLP.340087 2000-05-11

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WO (1) WO2001085176A1 (en)

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Publication number Priority date Publication date Assignee Title
GR1004331B (en) * 2002-10-07 2003-09-05 Verisfield (Uk) Ltd New pharmaceutical compositions that contain a salt of alendronic acid.
WO2006046100A1 (en) * 2004-10-25 2006-05-04 Ranbaxy Laboratories Limited Pharmaceutical composition of alendronic acid
EP1680092A2 (en) * 2003-09-29 2006-07-19 Cipla Ltd. Pharmaceutical formulation with improved stability
WO2008023184A3 (en) * 2006-08-24 2008-04-24 Arrow Int Ltd Solid dosage form
WO2009018834A1 (en) * 2007-08-06 2009-02-12 Pharmathen S.A. Pharmaceutical composition containing bisphosphonate and method for the preparation thereof

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Publication number Priority date Publication date Assignee Title
EP0421921A1 (en) * 1989-09-07 1991-04-10 Ciba-Geigy Ag Double coated granules
WO1995029679A1 (en) * 1994-04-29 1995-11-09 Merck & Co., Inc. Wet granulation formulation for bisphosphonic acids

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FI89364C (en) * 1990-12-20 1993-09-27 Leiras Oy FRUIT PROCESSING FOR METHYLENBISPHOSPHONE PHARMACEUTICALS, PHARMACOLOGICAL PROPERTIES
US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate
US5358941A (en) * 1992-12-02 1994-10-25 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids with lactose
BR9916850A (en) * 1998-12-23 2001-10-16 Jomaa Pharmaka Gmbh Use of bisphosphonates for the prophylaxis and treatment of infectious processes
CZ20004762A3 (en) * 1999-06-24 2001-04-11 Hassan Jomaa Bisphosphonic acids and their derivatives containing medicaments for prophylaxis and treatment of auto-immune diseases and allergies

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0421921A1 (en) * 1989-09-07 1991-04-10 Ciba-Geigy Ag Double coated granules
WO1995029679A1 (en) * 1994-04-29 1995-11-09 Merck & Co., Inc. Wet granulation formulation for bisphosphonic acids

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR1004331B (en) * 2002-10-07 2003-09-05 Verisfield (Uk) Ltd New pharmaceutical compositions that contain a salt of alendronic acid.
EP1407766A2 (en) * 2002-10-07 2004-04-14 Verisfield (UK) Ltd. Pharmaceutical compositions that contain a salt of alendronic acid
EP1407766A3 (en) * 2002-10-07 2004-04-28 Verisfield (UK) Ltd. Pharmaceutical compositions that contain a salt of alendronic acid
EP1680092A2 (en) * 2003-09-29 2006-07-19 Cipla Ltd. Pharmaceutical formulation with improved stability
WO2006046100A1 (en) * 2004-10-25 2006-05-04 Ranbaxy Laboratories Limited Pharmaceutical composition of alendronic acid
WO2008023184A3 (en) * 2006-08-24 2008-04-24 Arrow Int Ltd Solid dosage form
US8697124B2 (en) 2006-08-24 2014-04-15 Arrow International Limited Solid dosage form of coated bisphosphonate particles
US10420725B2 (en) 2006-08-24 2019-09-24 Allergan Pharmaceuticals International Limited Solid dosage form of coated bisphosphonate particles
WO2009018834A1 (en) * 2007-08-06 2009-02-12 Pharmathen S.A. Pharmaceutical composition containing bisphosphonate and method for the preparation thereof

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RU2288705C2 (en) 2006-12-10
SK15842002A3 (en) 2003-03-04
SK287298B6 (en) 2010-06-07
CZ20023700A3 (en) 2003-04-16
PL196485B1 (en) 2008-01-31
CZ301047B6 (en) 2009-10-21
UA75072C2 (en) 2006-03-15
PL340087A1 (en) 2001-11-19

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