WO2001085107A1 - Method for the treatment of dandruff using 1-hydroxy-2-pyridone derivatives - Google Patents
Method for the treatment of dandruff using 1-hydroxy-2-pyridone derivatives Download PDFInfo
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- WO2001085107A1 WO2001085107A1 PCT/EP2001/004823 EP0104823W WO0185107A1 WO 2001085107 A1 WO2001085107 A1 WO 2001085107A1 EP 0104823 W EP0104823 W EP 0104823W WO 0185107 A1 WO0185107 A1 WO 0185107A1
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- dandruff
- shampoo
- hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
Definitions
- the invention relates to a method for the cosmetic treatment of the hair and the scalp against dandruff, in which a shampoo with a low content of anti-dandruff active ingredient and an anti-dandruff lotion with a high content of anti-dandruff active ingredient are used in a defined regime.
- the invention relates to a process for the cosmetic treatment of the hair and the scalp against dandruff, in which the hair is washed at least twice a week with a shampoo (A) and after the 1st to 3rd shampooing, and thereafter not more often than once in 2 weeks, treated with an anti-dandruff lotion (B) which is not rinsed off, the shampoo (A) being an aqueous composition containing skin-friendly surfactants and not more than 0.1% by weight of an 1-hydroxy -2-pyridone derivative, and the anti-dandruff lotion (B) is an aqueous-alcoholic preparation containing at least 0.1% by weight of a 1-hydroxy-2-pyridone derivative.
- Octopirox ® also known as Piroctone Olamine
- other, similarly acting l-hydroxy-2-pyridone derivatives can also be present.
- the process according to the invention has the advantage that the shampoo used daily contains only a very low concentration of 1-hydroxy-2-pyridone derivative and in this way does not lead to the feared disadvantages of regreasing and yogurt. the scalp, but can delay the return of dandruff for a long time.
- the 1 to 3 times treatment with a more concentrated preparation of the l-hydroxy-2-pyridone derivative is sufficient to significantly reduce dandruff formation in a short time, but also does not yet lead to the undesirable effects of long-term treatment.
- Repeat treatment with the anti-dandruff lotion (B) is only necessary if necessary, but never more often than once in 2 weeks.
- the shampoo (A) is intended for permanent use and can be used up to once a day if necessary. It is therefore necessary for the shampoo to contain a skin-friendly surfactant or a surfactant mixture that does not excessively degrease the hair even with daily use.
- the good-foaming anionic sulfate and sulfonate surfactants should be mentioned, e.g. B. the sulfuric acid semiester salts of Cio - C ⁇ 8 fatty alcohols and C ⁇ o- C ⁇ 8 - fatty alcohol polyglycol ethers with 2-10 glycol ether groups, for. B.
- the acyl isethionate salts the acyl taurides, the fatty acid monoglyceride sulfates, the alkane sulfonates, the alpha-olefin sulfonates, the sulfosuccinic acid half ester salts of fatty alcohols and fatty alcohol polyglycol ethers.
- ether and amide soaps e.g. B. the fatty alcohol polyglycol ether carboxylates, the acylamino acid salts, for. B.
- the hair washing is carried out daily over a period of at least three weeks with a shampoo (A) which contains 1-15% by weight of an alkyl ether sulfate surfactant and 0.01-0.1% by weight of one Contains l-hydroxy-2-pyridone derivative.
- A a shampoo which contains 1-15% by weight of an alkyl ether sulfate surfactant and 0.01-0.1% by weight of one Contains l-hydroxy-2-pyridone derivative.
- the alkyl ether sulfate surfactants mentioned have a particularly good tolerance to the mucous membrane in particular when they are present as magnesium salts or when a corresponding amount of magnesium in the form of a dissolved salt, eg. B. MgCl 2 or MgSO is included. Another way to improve the compatibility of these anionic surfactants with mucous membranes is to combine them with zwitterionic surfactants.
- the shampoo (A) contains 0.1-2% by weight of magnesium in the form of a dissolved salt and 0.5-5% by weight of a zwitterionic surfactant.
- Suitable zwitterionic surfactants are e.g. B. the alkyl betaines, e.g. B. lauryl-dimethyl-carboxymethyl-acetobetaine or the acylamidopropyl betaines, e.g. B. cocoacylamido propyl dimethyl acetobetaine.
- Other suitable zwitterionic surfactants are the inidazoline betaines or the sulfobetaines with a Cio-Cj 8 alkyl or acyl group.
- the shampoo (A) may also contain other components which are customary in hair shampoos and are useful for the care of the hair and the scalp.
- Such further optional components of the shampoo are e.g. B.
- Non-ionic surface-active substances which, for. B. for thickening or emulsification of fragrances are required.
- the anti-dandruff lotion (B) is an aqueous-alcoholic preparation that is used like a hair tonic, i.e. remains on the hair after use.
- the carrier liquid consists of water and lower, mono- or polyhydric alcohols with 2-6 C atoms in a weight ratio of water to alcohol of 1:10 to 10: 1. Monohydric alcohols with 2-4 C atoms, in particular ethanol and or isopropanol, are preferably used as alcohols.
- the anti-dandruff lotion (B) contains 10-50% by weight of ethanol and 0.1-1.0% by weight of piroctone olamine.
- the anti-dandruff lotion (B) can contain other components that are useful for the care of the hair and scalp. Such components are e.g. B.
- UV absorbers UV absorbers
- Plant extracts e.g. B. hop extracts, birch water, avocado extract, camomile extract
- - antistatic agents e.g. B. cetyl-trimethylammonium chloride and other quaternary ammonium salts
- Structurants such as B. sugar or gluconic acid
- plant extracts which have an anti-inflammatory, healing and anti-allergic effect and which are derived from the formation tissue (meristem) of deciduous trees or shrubs, e.g. B. extracted from the crown of the shoot or the cambium.
- tissue extracts e.g. B. from young shoots of beech or birch or from Meristem cell cultures, both the anti-dandruff lotion (B) and the shampoo (A) can be added.
- the shampoo (A) or the anti-dandruff lotion (B) or both contains an extract from the meristem of deciduous plants in an amount of 0.001-0.01% by weight (dry matter). This component eliminates problems such as scalp itching, scalp irritation and allergic intolerance. ten even with long-term dandruff control avoided by the inventive method.
- the anti-dandruff lotion (B) is used in the customary manner by distributing a few ml of the product on the hair and by means of a light massage ensuring that the scalp is also wetted by the product.
- the amount of lotion required also depends on how long and how long the user has hair. In the case of short and thinning hair, 1 ml of the product may therefore be sufficient to wet the scalp adequately, however, in the case of full and long hair, a multiple of this amount is required, since a larger amount of the lotion is adsorbed on the large surface of the hair.
- the shampoo and the anti-dandruff lotion are used according to the regime according to the invention and their effects are thus complementary.
- this can best be achieved by having both products by the user in a single sales unit, e.g. B. in a common box, can be purchased, which then also contains the corresponding instructions for use.
- Another object of the invention is therefore a dandruff treatment composition consisting of two separately packaged components combined into a sales unit, of which one component (A) is a shampoo in the form of an aqueous composition containing skin-friendly surfactants and not more than 0.1 % By weight of an l-hydroxy-2-pyridone derivative and the second component (B) is an anti-dandruff lotion in the form of an aqueous-alcoholic preparation containing at least 0.2% by weight of an l-hydroxy- 2-pyridone derivative.
- one component (A) is a shampoo in the form of an aqueous composition containing skin-friendly surfactants and not more than 0.1 %
- the second component (B) is an anti-dandruff lotion in the form of an aqueous-alcoholic preparation containing at least 0.2% by weight of an l-hydroxy- 2-pyridone derivative.
- Dehyton ® GN (2-hydroxyethyl) -N-cocoalkylamidoethyl carboxymethyl glycinate, Na salt, 30% in water
- Meristem extract Extract from the meristem (growth and cell division tissue) of hardwoods, 1% by weight in water (contains quinone derivatives).
- test group consisting of 28 subjects with clearly visible head dandruff was treated as follows:
- the dandruff reduction continued until the end of the test (3 weeks) without re-treatment with anti-dandruff lotion. In 4 subjects, the dandruff reduction continued for 1 week. In 1 subject, the dandruff reduction only lasted 4 days.
Abstract
A method for the cosmetic treatment of hair against dandruff, comprises washing the hair at least twice per week with a shampoo (A) and, in conjunction with the 1?st to 3rd¿ hair washing and thereafter no more frequently than once every two weeks, treating the hair with an anti-dandruff lotion (B), which is not rinsed out. The shampoo (A) is an aqueous composition, containing some skin acceptable detergents and not more than 0.1 wt. % of a 1-hydroxy-2-pyridone derivative. The washing of the hair is preferably carried out on a daily basis over a period of at least three weeks.
Description
VERFAHREN ZUR SCHUPPENBEKÄMPFUNG l-HYDROXY-2-PYRIDON-DERIVATE EINSETZENDMETHOD FOR DANDRUFFING USING L-HYDROXY-2-PYRIDONE DERIVATIVES
Die Erfindung betrifft ein Verfahren zur kosmetischen Behandlung des Haars und der Kopfhaut gegen Schuppenbefall, bei welchem ein Haarwaschmittel mit niedrigem Gehalt an Antischuppen- Wirkstoff und eine Antischuppen-Lotion mit hohem Gehalt an An- tischuppen- Wirkstoff in einem definierten Regime zur Anwendung kommen.The invention relates to a method for the cosmetic treatment of the hair and the scalp against dandruff, in which a shampoo with a low content of anti-dandruff active ingredient and an anti-dandruff lotion with a high content of anti-dandruff active ingredient are used in a defined regime.
Obwohl viele Menschen unter einer verstärkten Schuppenbildung der Kopfhaut leiden, wird dieses Problem in der Regel nicht als Erkrankung, sondern als kosmetische Beeinträchtigung gesehen. Als eine Ursache der vermehrten Schuppenbildung wird eine veränderte Mikroflora der Kopfhaut angenommen. Insbesondere hat man bei Personen mit starker Schuppenbildung eine erhöhte Dichte der Besiedelung der Kopfhaut mit dem Hefepilz Pityrosporum ovale festgestellt. Unter den wenigen Wirkstoffen, die die Schuppenbildung auf dem Kopf verringern können, wie z. B. Zink-Pyrithion und Climbazol, sind auch die Derivate des l-Hydroxy-2-pyridons aus DE 2234009 AI bekannt.Although many people suffer from increased scaling of the scalp, this problem is usually not seen as a disease, but as a cosmetic impairment. An altered microflora of the scalp is assumed to be the cause of the increased dandruff formation. In particular, people with severe dandruff have found an increased density of scalp colonization with the yeast Pityrosporum ovale. Among the few active ingredients that can reduce dandruff on the head, such as B. zinc pyrithione and climbazole, the derivatives of l-hydroxy-2-pyridone are known from DE 2234009 AI.
Aus WO 98/23258 AI waren z. B. Shampoos bekannt, die 0,1 - 3 Gew.-% Piroctone Olamine und ein Polyethylenimin zur verbesserten Abscheidung des Wirkstoffs auf dem Haar und der Haut enthalten.From WO 98/23258 AI z. B. Shampoos known that contain 0.1 - 3 wt .-% Piroctone Olamine and a polyethylene imine for improved deposition of the active ingredient on the hair and skin.
Die bekannten Antischuppenpräparate mit l-Hydroxy-2-pyridon-Derivaten weisen erhebliche Nachteile auf:The known anti-dandruff preparations with l-hydroxy-2-pyridone derivatives have considerable disadvantages:
Zunächst ist bekannt, daß die Wirksamkeit dieser Produkte nur so lange anhält, wie sie regelmäßig angewendet werden. Daher ist es erforderlich, diese Mittel im Dauergebrauch zu verwenden. Durch die dabei verwendeten hohen Konzentrationen von Antischuppen- Wirkstoffen kommen dann aber andere Nachteile zum Tragen, insbesondere das stärkere
Nachfetten der Haare, das Auftreten von Kopfjucken und von Allergieproblemen. Bei zu geringen Konzentrationen kann hingegen keine ausreichende Verringerung der Schuppen erreicht werden.First of all, it is known that the effectiveness of these products only lasts as long as they are used regularly. It is therefore necessary to use these agents in long-term use. Due to the high concentrations of antidandruff active ingredients used, other disadvantages then come into play, in particular the stronger one Regreasing the hair, the appearance of itchy head and allergy problems. If the concentrations are too low, however, a sufficient reduction in dandruff cannot be achieved.
Es bestand daher die Aufgabe, ein wirksames Verfahren zur kosmetischen Behandlung des Haars gegen Schuppenbefall zu finden, das nicht zu den geschilderten nachteiligen Langzeiteffekten führt, dennoch aber die Schuppenbildung wirksam und dauerhaft vermindert.It was therefore the task of finding an effective method for the cosmetic treatment of hair against dandruff which does not lead to the disadvantageous long-term effects described, but nevertheless effectively and permanently reduces dandruff formation.
Durch das erfindungsgemäße Verfahren wird das gestellte Problem auf unerwartet elegante Weise gelöst:The posed problem is solved in an unexpectedly elegant manner by the method according to the invention:
Gegenstand der Erfindung ist ein Verfahren zur kosmetischen Behandlung des Haars und der Kopfhaut gegen Schuppenbefall, bei dem man das Haar wenigstens zweimal pro Woche mit einem Haarwaschmittel (A) wäscht und im Anschluß an die 1. bis 3. Haarwäsche, und danach nicht öfter als einmal in 2 Wochen, mit einer Antischuppen-Lotion (B) behandelt, die nicht abgespült wird, wobei das Haarwaschmittel (A) eine wässrige Zusammensetzung mit einem Gehalt an hautfreundlichen Tensiden und nicht mehr als 0,1 Gew.- % eines l-Hydroxy-2-pyridon-Derivats ist, und die Antischuppen-Lotion (B) eine wässrig- alkoholische Zubereitung mit einem Gehalt von wenigstens 0,1 Gew.-% eines 1- Hydroxy-2-pyridon-Derivats ist.The invention relates to a process for the cosmetic treatment of the hair and the scalp against dandruff, in which the hair is washed at least twice a week with a shampoo (A) and after the 1st to 3rd shampooing, and thereafter not more often than once in 2 weeks, treated with an anti-dandruff lotion (B) which is not rinsed off, the shampoo (A) being an aqueous composition containing skin-friendly surfactants and not more than 0.1% by weight of an 1-hydroxy -2-pyridone derivative, and the anti-dandruff lotion (B) is an aqueous-alcoholic preparation containing at least 0.1% by weight of a 1-hydroxy-2-pyridone derivative.
Von den antimykotisch wirksamen l-Hydroxy-2-pyridon-Derivaten ist das unter der Handelsbezeichnung Octopirox®, auch als Piroctone Olamine bekannte l-Hydroxy-4- methyl-6-(2,4,4-trimethylpentyl) 2 (lH)-pyridon, Monoethanolaminsalz besonders bevorzugt. Es können aber auch andere, ähnlich wirkende l-Hydroxy-2-pyridon-Derivate enthalten sein.Of the antifungal l-hydroxy-2-pyridone derivatives, l-hydroxy-4-methyl-6- (2,4,4-trimethylpentyl) 2 (1H) - known under the trade name Octopirox ® , also known as Piroctone Olamine - is pyridone, monoethanolamine salt particularly preferred. However, other, similarly acting l-hydroxy-2-pyridone derivatives can also be present.
Das erfindungsgemäße Verfahren hat den Vorteil, daß das täglich verwendete Haarwaschmittel nur eine sehr geringe Konzentration an l-Hydroxy-2-pyridon-Derivat enthält und auf diese Weise nicht zu den befürchteten Nachteilen des Nachfettens und des Juk-
kens der Kopfhaut führt, trotzdem aber das Wiederkehren des Schuppenbefalls für lange Zeit verzögern kann. Die 1 bis 3-malige Behandlung mit einer höherkonzentrierten Zubereitung des l-Hydroxy-2-pyridon-Derivats andererseits ist ausreichend, die Schuppenbildung in kurzer Zeit wesentlich zu verringern, führt aber ebenfalls noch nicht zu den unerwünschten Effekten einer Dauerbehandlung. Eine Wiederholung der Behandlung mit der Antischuppenlotion (B) ist nur im Bedarfsfalle, jedoch in keinem Falle häufiger als einmal in 2 Wochen, erforderlich.The process according to the invention has the advantage that the shampoo used daily contains only a very low concentration of 1-hydroxy-2-pyridone derivative and in this way does not lead to the feared disadvantages of regreasing and yogurt. the scalp, but can delay the return of dandruff for a long time. The 1 to 3 times treatment with a more concentrated preparation of the l-hydroxy-2-pyridone derivative, on the other hand, is sufficient to significantly reduce dandruff formation in a short time, but also does not yet lead to the undesirable effects of long-term treatment. Repeat treatment with the anti-dandruff lotion (B) is only necessary if necessary, but never more often than once in 2 weeks.
Das Haarwaschmittel (A) ist für die Daueranwendung bestimmt und kann bei Bedarf bis zu einmal täglich angewendet werden. Daher ist es erforderlich, daß das Haarwaschmittel ein hautfreundliches Tensid oder ein Tensidgemisch enthält, das auch bei täglicher Anwendung das Haar nicht übermäßig entfettet.The shampoo (A) is intended for permanent use and can be used up to once a day if necessary. It is therefore necessary for the shampoo to contain a skin-friendly surfactant or a surfactant mixture that does not excessively degrease the hair even with daily use.
Als hautfreundliche Tenside, die sich für das Haarwaschmittel (A) besonders eignen, sind vor allem die gutschäumenden anionischen Sulfat- und Sulfonat-Tenside zu nennen, z. B. die Schwefelsäurehalbester-Salze von Cio - Cι8-Fettalkoholen und Cιo- Cι8- Fettalkoholpolyglycolethern mit 2-10 Glycolethergruppen, z. B. Natrium Laureth Sulfate und Natrium Myreth Sulfate, die Acylisethionat-Salze, die Acyltauride, die Fettsäuremo- noglyceridsulfate, die Alkansulfonate, die Alpha-Olefinsulfonate, die Sulfobernsteinsäu- rehalbester-Salze von Fettalkoholen und Fettalkoholpolyglycolethern. Auch die sogenannten Ether- und Amidseifen, z. B. die Fettalkoholpolyglycolether-carboxylate, die Acylaminosäure-Salze, z. B. die Acylsarkoside, die Acylglutamate, die N-acyl-N-methyl- betaalanine, jeweils mit Cio - C18-Acylgruppen. Diese milden anionischen Tenside können als Alkali-, Ammonium- oder Alkanolammoniumslaze enthalten sein. In einer besonderen Ausführung der Erfindung wird die Haarwäsche täglich über einen Zeitraum von wenigstens drei Wochen mit einem Haarwaschmittel (A) durchgeführt, das 1 - 15 Gew.- % eines Alkylethersulfat-Tensids und 0,01 - 0,1 Gew.-% eines l-Hydroxy-2-pyridon- Derivats enthält.As skin-friendly surfactants, which are particularly suitable for the shampoo (A), the good-foaming anionic sulfate and sulfonate surfactants should be mentioned, e.g. B. the sulfuric acid semiester salts of Cio - Cι 8 fatty alcohols and Cιo- Cι 8 - fatty alcohol polyglycol ethers with 2-10 glycol ether groups, for. B. sodium laureth sulfate and sodium myreth sulfate, the acyl isethionate salts, the acyl taurides, the fatty acid monoglyceride sulfates, the alkane sulfonates, the alpha-olefin sulfonates, the sulfosuccinic acid half ester salts of fatty alcohols and fatty alcohol polyglycol ethers. Also the so-called ether and amide soaps, e.g. B. the fatty alcohol polyglycol ether carboxylates, the acylamino acid salts, for. B. the acyl sarcosides, the acyl glutamates, the N-acyl-N-methyl-betaalanine, each with Cio - C 18 acyl groups. These mild anionic surfactants can be contained as alkali, ammonium or alkanolammonium salts. In a special embodiment of the invention, the hair washing is carried out daily over a period of at least three weeks with a shampoo (A) which contains 1-15% by weight of an alkyl ether sulfate surfactant and 0.01-0.1% by weight of one Contains l-hydroxy-2-pyridone derivative.
Eine besonders gute Schleimhautverträglichkeit weisen die genannten Alkylethersulfat- Tenside insbesondere dann auf, wenn sie als Magnesiumsalze vorliegen oder wenn eine entsprechende Menge an Magnesium in Form eines gelösten Salzes, z. B. MgCl2 oder
MgSO enthalten ist. Eine weitere Möglichkeit, die Schleimhautverträglichkeit dieser anionischen Tenside zu verbessern, besteht darin, sie mit zwitterionischen Tensiden zu kombinieren. In einer besonders bevorzugten Ausfuhrung des erfindungsgemäßen Verfahrens enthält das Haarwaschmittel (A) 0,1 - 2 Gew.-% Magnesium in Form eines gelösten Salzes und 0,5 - 5 Gew.-% eines zwitterionischen Tensids.The alkyl ether sulfate surfactants mentioned have a particularly good tolerance to the mucous membrane in particular when they are present as magnesium salts or when a corresponding amount of magnesium in the form of a dissolved salt, eg. B. MgCl 2 or MgSO is included. Another way to improve the compatibility of these anionic surfactants with mucous membranes is to combine them with zwitterionic surfactants. In a particularly preferred embodiment of the method according to the invention, the shampoo (A) contains 0.1-2% by weight of magnesium in the form of a dissolved salt and 0.5-5% by weight of a zwitterionic surfactant.
Geeignete zwitterionische Tenside sind z. B. die Alkylbetaine, z. B. Lauryl-dimethyl- carboxymehtyl-acetobetain oder die Acylamidopropyl-Betaine, z. B. Kokosacylamido- propyl-dimethyl-acetobetain. Andere geeignete zwitterionische Tenside sind die Inidazo- linium-Betaine oder die Sulfobetaine mit einer Cio - Cj8 Alkyl- oder Acylgruppe.Suitable zwitterionic surfactants are e.g. B. the alkyl betaines, e.g. B. lauryl-dimethyl-carboxymethyl-acetobetaine or the acylamidopropyl betaines, e.g. B. cocoacylamido propyl dimethyl acetobetaine. Other suitable zwitterionic surfactants are the inidazoline betaines or the sulfobetaines with a Cio-Cj 8 alkyl or acyl group.
Neben diesen bevorzugten Komponenten kann das Haarwaschmittel (A) noch andere, in Haarshampoos übliche und für die Pflege des Haars und der Kopfhaut nützliche Komponenten enthalten. Solche weiteren fakultiven Bestandteile des Haarwaschmittels sind z. B.In addition to these preferred components, the shampoo (A) may also contain other components which are customary in hair shampoos and are useful for the care of the hair and the scalp. Such further optional components of the shampoo are e.g. B.
- nichtionische oberflächenaktive Substanzen, die z. B. zur Verdickung oder zur Emulgierung von Duftstoffen erforderlich sind.- Non-ionic surface-active substances which, for. B. for thickening or emulsification of fragrances are required.
- Hautfeuchthaltemittel- skin moisturizer
- wasserlösliche Proteine, Proteinhydrolysate oder Proteinderivate- Water-soluble proteins, protein hydrolyzates or protein derivatives
- Pflanzenextrakte mit bioaktiver Wirkung- Plant extracts with a bioactive effect
- Farbstoffe, Perlglanzmittel- dyes, pearlescent agents
- Duftstoffe und- fragrances and
- Konservierungsmittel- preservatives
Die Antischuppen-Lotion (B) ist eine wässrig-alkoholische Zubereitung, die wie ein Haarwasser angewandt wird, also nach der Anwendung auf dem Haar verbleibt. Die Trägerflüssigkeit besteht aus Wasser und niederen, ein- oder mehrwertigen Alkoholen mit 2-6 C-Atomen in einem Gewichtsverhältnis von Wasser zu Alkohol von 1:10 bis 10:1. Als Alkohole werden bevorzugt einwertige Alkohole mit 2-4 C-Atomen, insbesondere Ethanol und oder Isopropanol eingesetzt.
In einer bevorzugten Aufuhrung enthält die Antischuppen-Lotion (B) 10 - 50 Gew.-% Ethanol und 0,1 - 1,0 Gew.-% Piroctone Olamine. Zusätzlich zu den obligatorischen Komponenten kann die Antischuppenlotion (B) weitere, für die Pflege des Haars und der Kopfhaut nützliche Kompoenten enthalten. Solche Bestandteile sind z. B.The anti-dandruff lotion (B) is an aqueous-alcoholic preparation that is used like a hair tonic, i.e. remains on the hair after use. The carrier liquid consists of water and lower, mono- or polyhydric alcohols with 2-6 C atoms in a weight ratio of water to alcohol of 1:10 to 10: 1. Monohydric alcohols with 2-4 C atoms, in particular ethanol and or isopropanol, are preferably used as alcohols. In a preferred embodiment, the anti-dandruff lotion (B) contains 10-50% by weight of ethanol and 0.1-1.0% by weight of piroctone olamine. In addition to the mandatory components, the anti-dandruff lotion (B) can contain other components that are useful for the care of the hair and scalp. Such components are e.g. B.
- Hautfeuchthaltemittel- skin moisturizer
- hautberuhigende und entzündungshemmende Stoffe wie z. B. D-Panthenol, Al- lantoin, Bisabolol, Biotin- Soothing and anti-inflammatory substances such as B. D-panthenol, allantoin, bisabolol, biotin
- Lichtschutzmittel (UV-Absorber)- light stabilizers (UV absorbers)
- haarwuchsfördernde Komponenten wie z. B. Pyridoxin (Vitamin B6), Pentadecan- säure, Cholesterin- Hair growth-promoting components such. B. pyridoxine (vitamin B6), pentadecanoic acid, cholesterol
- Pflanzenextrakte, z. B. Hopfen-Extrakte, Birkenwasser, Avocado-Extrakt, Kamillen-Extrakt- Plant extracts, e.g. B. hop extracts, birch water, avocado extract, camomile extract
- Ölkomponenten oder Rückfettungsmittel- Oil components or refatting agents
- Antistatika, z. B. Cetyl-trimethylammoniumchlorid und andere quartäre Ammoniumsalze- antistatic agents, e.g. B. cetyl-trimethylammonium chloride and other quaternary ammonium salts
Strukturanten wie z. B. Zucker oder GluconsäureStructurants such as B. sugar or gluconic acid
- festigende Polymere wie z. B. Polyvinylpyrrolidon- setting polymers such. B. polyvinyl pyrrolidone
- Duftstoffe und Farbstoffe- fragrances and dyes
Von besonderem Vorteil, insbesondere für das erfindungsgemäße Verfahren, sind bestimmte Pflanzenextrakte, die eine entzündungshemmende, heilungsförderne und antiallergische Wirkung haben und die aus dem Bildungsgewebe (Meristem) von Laubbäumen oder Sträuchern, z. B. aus dem Sproßscheitel oder dem Kambium, extrahiert werden. Solche Meristem-Extrakte, z. B. aus jungen Trieben von Buchen oder Birken oder aus Meristem-Zellkulturen, können sowohl der Antischuppen-Lotion (B) als auch dem Haarwaschmittel (A) zugesetzt werden.Of particular advantage, especially for the method according to the invention, are certain plant extracts which have an anti-inflammatory, healing and anti-allergic effect and which are derived from the formation tissue (meristem) of deciduous trees or shrubs, e.g. B. extracted from the crown of the shoot or the cambium. Such meristem extracts, e.g. B. from young shoots of beech or birch or from Meristem cell cultures, both the anti-dandruff lotion (B) and the shampoo (A) can be added.
In einer bevorzugten Ausführung enthält das Haarwaschmittel (A) oder die Antischuppen-Lotion (B) oder beide einen Extrakt aus dem Meristem von Laubholzgewächsen in einer Menge von 0,001 - 0,01 Gew.-% (Trockenmasse). Durch diese Komponente werden Probleme wie das Kopfhautjucken, Kopfhautreizungen und allergische Unverträglichkei-
ten auch bei langdauernder Schuppenbekämpfung nach dem erfindungsgemäßen Verfahren vermieden.In a preferred embodiment, the shampoo (A) or the anti-dandruff lotion (B) or both contains an extract from the meristem of deciduous plants in an amount of 0.001-0.01% by weight (dry matter). This component eliminates problems such as scalp itching, scalp irritation and allergic intolerance. ten even with long-term dandruff control avoided by the inventive method.
Die Anwendung der Antischuppen-Lotion (B) erfolgt in üblicher Weise dadurch, daß man einige ml des Produkts auf dem Haar verteilt und durch leichte Massage dafür sorgt, daß auch die Kopfhaut von dem Produkt benetzt wird. Die benötigte Menge der Lotion ist dabei auch davon abhängig, wie viele und wie lange Haare der Verwender hat. Bei kurzem und schütterem Haar kann daher schon 1 ml des Produkts ausreichen, um die Kopfhaut ausreichend zu benetzen, bei vollen und langen Haar ist hingegen ein mehrfaches dieser Menge erforderlich, da an der großen Oberfläche des Haars eine größere Menge der Lotion adsorbiert wird.The anti-dandruff lotion (B) is used in the customary manner by distributing a few ml of the product on the hair and by means of a light massage ensuring that the scalp is also wetted by the product. The amount of lotion required also depends on how long and how long the user has hair. In the case of short and thinning hair, 1 ml of the product may therefore be sufficient to wet the scalp adequately, however, in the case of full and long hair, a multiple of this amount is required, since a larger amount of the lotion is adsorbed on the large surface of the hair.
Um eine sichere und effektive Schuppenbekämpfung zu gewährleisten ist es wünschenswert, daß das Haarwaschmittel und die Antischuppen-Lotion nach dem erfindungsgemäßen Regime angewandt werden und sich so in ihrer Wirkung ergänzen. Dies kann in der Praxis am besten dadurch erreicht werden, daß beide Produkte vom Verwender in einer einzigen Verkaufseinheit, z. B. in einem gemeinsamen Umkarton, erworben werden können, der dann auch die entsprechende Gebrauchsanleitung enthält.In order to ensure a safe and effective dandruff control, it is desirable that the shampoo and the anti-dandruff lotion are used according to the regime according to the invention and their effects are thus complementary. In practice, this can best be achieved by having both products by the user in a single sales unit, e.g. B. in a common box, can be purchased, which then also contains the corresponding instructions for use.
Ein weiterer Gegenstand der Erfindung ist daher ein Kopfschuppenbehandlungsmittel, bestehend aus zwei getrennt verpackten, zu einer Verkaufseinheit zusammengefassten Komponenten, von denen die eine Komponente (A) ein Haarwaschmittel in Form einer wässrigen Zusammensetzung mit einem Gehalt an hautfreundlichen Tensiden und nicht mehr als 0,1 Gew.-% eines l-Hydroxy-2-pyridon-Derivats ist und die zweite Komponente (B) eine Antischuppen-Lotion in Form einer wässrig-alkoholischen Zubereitung mit einem Gehalt von wenigstens 0,2 Gew.-% eines l-Hydroxy-2-pyridon-Derivats ist.Another object of the invention is therefore a dandruff treatment composition consisting of two separately packaged components combined into a sales unit, of which one component (A) is a shampoo in the form of an aqueous composition containing skin-friendly surfactants and not more than 0.1 % By weight of an l-hydroxy-2-pyridone derivative and the second component (B) is an anti-dandruff lotion in the form of an aqueous-alcoholic preparation containing at least 0.2% by weight of an l-hydroxy- 2-pyridone derivative.
Es ist dabei gleichgültig, aufweiche Weise die beiden Komponenten (A) und (B) zu einer Verkaufseinheit vereinigt sind. Es kann sich dabei, wie oben aufgeführt z. B. um einen gemeinsamen Karton handeln, in dem sowohl eine Flasche des Shampoos als auch ein Fläschchen des erfindungsgemäßen Haarwassers verpackt sind. Es ist aber auch denkbar,
daß beide Produkte mit einer Schleife zusammengebunden oder von einer transparenten Folie eingehüllt zum Verkauf kommen.It does not matter how the two components (A) and (B) are combined to form a sales unit. It can be, as listed above z. B. is a common box in which both a bottle of the shampoo and a bottle of the hair tonic according to the invention are packaged. But it is also conceivable that both products are tied with a bow or wrapped in a transparent film for sale.
Die folgenden Beispiele sollen den Gegenstand der Erfindung näher erläutern:
The following examples are intended to explain the subject matter of the invention in more detail:
Beispiele:Examples:
1. Antischuppenshampoo (A)1. Antidandruff shampoo (A)
Antischuppen-Lotion (Haarwasser) (B)Anti-dandruff lotion (hair tonic) (B)
Test-Lotion weiteres BeispielTest lotion another example
Ethanol 43,0 43,0Ethanol 43.0 43.0
Octopirox® 0,5 0,5Octopirox ® 0.5 0.5
D-Panthenol 0,02 0,05D-panthenol 0.02 0.05
Meristem-Extrakt - 0,5Meristem extract - 0.5
Avocado-Extrakt - 0,5Avocado extract - 0.5
Wasser ad 100 ad 100 pH-Wert 5,1 5,3
Es wurden folgende Handelsprodukte verwendet:Water ad 100 ad 100 pH 5.1 5.3 The following commercial products were used:
Texapon® ASV 50 Gemisch aus Lauryl- und Oleylethersulfaten (Na- und Mg-Salz), 50 Gew.-%ig in WasserTexapon ® ASV 50 mixture of lauryl and oleyl ether sulfates (Na and Mg salt), 50% by weight in water
Dehyton® G N(2-Hydroxyethyl)-N-kokosalkylamidoethyl- carboxymethylglycinat, Na-Salz, 30%ig in WasserDehyton ® GN (2-hydroxyethyl) -N-cocoalkylamidoethyl carboxymethyl glycinate, Na salt, 30% in water
Lamesoft® PO 65 Gemisch aus Alkyl(oligo)glucosid und Glycerin- monooleat (65 Gew.-% in Wasser)Lamesoft ® PO 65 mixture of alkyl (oligo) glucoside and glycerol monooleate (65% by weight in water)
Arlypon® F Fettalkohol(Cι2/ι4) polyglycolether (2,5 EO) Rheodol TW/ S399 PEG 160 Sorbitan-triisosterat Octopirox® l-Hydroxy-4-methyl-6-(2,2,4-trimethylpentyl)-2- pyridon, Monoethanolamin-Salz (Piroctone Olami- ne)Arlypon ® F fatty alcohol (Cι 2 / ι 4 ) polyglycol ether (2.5 EO) Rheodol TW / S399 PEG 160 sorbitan triisosterate Octopirox ® l-hydroxy-4-methyl-6- (2,2,4-trimethylpentyl) -2 - pyridone, monoethanolamine salt (piroctone olamine)
Meristem-Extrakt Extrakt aus dem Meristem (Wachstum- und Zellteilungsgewebe) von Laubhölzern, 1 Gew.-% in Wasser (enthält Chinon-Derivate).Meristem extract Extract from the meristem (growth and cell division tissue) of hardwoods, 1% by weight in water (contains quinone derivatives).
Probandentesttest subjects
Eine Prüfgruppe aus 28 Probanden mit deutlich sichtbarem Kopfschuppenbefall wurde wie folgt behandelt:A test group consisting of 28 subjects with clearly visible head dandruff was treated as follows:
■=> 2 Wochen tägliches Haarewaschen mit dem Basis-Shampoo. ■ => 2 weeks of daily hair washing with the basic shampoo.
^ 2 Haarwäschen (an aufeinanderfolgenden Tagen) mit dem Test-Shampoo und nachfolgende Behandlung mit der Antischuppen Test-Lotion (Haarwasser) mit^ 2 washes (on consecutive days) with the test shampoo and subsequent treatment with the anti-dandruff test lotion (hair tonic) with
0,5 Gew.-% Oxtopirox. "= Weitere 4 Wochen tägliche Haarwäsche mit dem Antischuppenshampoo mit 0,050.5% by weight oxtopirox. "= Another 4 weeks of daily hair washing with the anti-dandruff shampoo at 0.05
Gew.-% Oxtopirox®.% By weight Oxtopirox ® .
Die Probanden wurden vor dem Test, nach 2 Wochen Haarewaschen mit dem Basis- Shampoo, nach der 2. Anwendung der Antischuppen-Lotion sowie nach der 1, 2. und 3. Woche nach der Behandlung mit Antischuppen-Lotion im Haarstudio untersucht. Dabei wurden die Schuppen ausgekämmt, aufgefangen und ausgewogen.
Es wurden folgende Ergebnisse erzielt:The subjects were examined before the test, after 2 weeks of washing the hair with the basic shampoo, after the 2nd application of the anti-dandruff lotion and after the 1st, 2nd and 3rd week after the treatment with anti-dandruff lotion in the hair studio. The scales were combed out, caught and weighed out. The following results were achieved:
Bei 5 Probanden Schuppenverringerung nach der 2. Anwendung der Antischuppen-Lotion Bei 3 Probanden Schuppenverringerung 1 Woche nach Anwendung der Antischuppen-Lotion Bei 13 Probanden Schuppenverringerung 2 Wochen nach Anwendung der Antischuppen-Lotion Bei 4 Probanden Schuppenverringerung 3 Wochen nach Anwendung der Antischuppen-Lotion Bei 3 Probanden keine SchuppenreduzierungWith 5 subjects, dandruff reduction after the 2nd application of the anti-dandruff lotion With 3 subjects, dandruff reduction 1 week after using the anti-dandruff lotion With 13 subjects, dandruff reduction 2 weeks after application of the anti-dandruff lotion With 4 subjects, dandruff reduction 3 weeks after application of the anti-dandruff lotion 3 subjects did not reduce dandruff
Bei 20 Probanden hielt die Schuppenverringerung bis Testende (3 Wochen) ohne erneute Behandlung mit Antischuppen-Lotion an. Bei 4 Probanden hielt die Schuppenverringerung 1 Woche lang an. Bei 1 Probanden hielt die Schuppenverringerung nur 4 Tage an.
In 20 test subjects, the dandruff reduction continued until the end of the test (3 weeks) without re-treatment with anti-dandruff lotion. In 4 subjects, the dandruff reduction continued for 1 week. In 1 subject, the dandruff reduction only lasted 4 days.
Claims
1. Verfahren zur kosmetischen Behandlung des Haars gegen Schuppenbefall, dadurch gekennzeichnet, daß man das Haar wenigstens zweimal pro Woche mit einem Haarwaschmittel (A) wäscht und im Anschluß an die 1. bis 3. Haarwäsche und danach nicht öfter als einmal in 2 Wochen mit einer Antischuppen-Lotion (B) behandelt, die nicht abgespült wird, wobei das Haarwaschmittel (A) eine wässrige Zusammensetzung mit einem Gehalt an hautfreundlichen Tensiden und nicht mehr als 0,1 Gew.-% eines l-Hydoxy-2-pyridon-Derivats ist und die Antischuppen- Lotion (B) eine wässrig-alkoholische Zubereitung mit einem Gehalt von wenigstens 0,1 Gew.-% eines l-Hydroxy-2-pyridon-Derivats ist.1. A method for the cosmetic treatment of hair against dandruff, characterized in that the hair is washed at least twice a week with a shampoo (A) and after the 1st to 3rd hair wash and then no more than once in 2 weeks with treated with an anti-dandruff lotion (B) which is not rinsed off, the shampoo (A) being an aqueous composition containing skin-friendly surfactants and not more than 0.1% by weight of an 1-hydoxy-2-pyridone derivative and the anti-dandruff lotion (B) is an aqueous-alcoholic preparation containing at least 0.1% by weight of an l-hydroxy-2-pyridone derivative.
2. Verfahren nach Anspruch 1, dadurch gekennzeichnet, daß man die Haarwäsche täglich über einen Zeitraum von wenigstens drei Wochen mit einem Haarwaschmittel (A) durchfuhrt, das 1 - 15 Gew.-% eines Alkylethersulfat-Tensids und 0,01 - 0,1 Gew.-% eines l-Hydroxy-2-pyridon-Derivats enthält.2. The method according to claim 1, characterized in that the hair washing is carried out daily for a period of at least three weeks with a shampoo (A) containing 1 - 15 wt .-% of an alkyl ether sulfate surfactant and 0.01 - 0.1 % By weight of an l-hydroxy-2-pyridone derivative.
3. Verfahren nach Anspruch 1 oder 2, dadurch gekennzeichnet, daß das Haarwaschmittel (A) 0,1 - 2 Gew.-% Magnesium in Form eines gelösten Salzes und 1 - 5 Gew.-% eines zwitterionischen Tensids enthält.3. The method according to claim 1 or 2, characterized in that the shampoo (A) contains 0.1 - 2 wt .-% magnesium in the form of a dissolved salt and 1 - 5 wt .-% of a zwitterionic surfactant.
4. Verfahren nach einem der Ansprüche 1 - 3, dadurch gekennzeichnet, daß die Antischuppen-Lotion (B) 10 - 50 Gew.-% Ethanol und 0,1 - 1,0 Gew.-% Piroctone Olamine enthält.4. The method according to any one of claims 1-3, characterized in that the anti-dandruff lotion (B) contains 10-50% by weight of ethanol and 0.1-1.0% by weight of piroctone olamine.
5. Verfahren nach einem der Ansprüche 1 - 4, dadurch gekennzeichnet, daß das Haarwaschmittel (A) oder die Antischuppenlotion (B) oder beide einen Extrakt aus dem Meristem von Laubholzgewächsen in einer Menge von 0,001 - 0,01 Gew.-% Trockenmasse) enthält.5. The method according to any one of claims 1-4, characterized in that the shampoo (A) or the anti-dandruff lotion (B) or both an extract from the meristem of hardwood plants in an amount of 0.001 - 0.01 wt .-% dry matter) contains.
6. Kopfschuppen-Behandlungsmittel, bestehend aus zwei getrennt verpackten, zu einer Verkaufseinheit zusammengefassten Komponenten, von denen die eine Komponente (A) ein Haarwaschmittel in Form einer wässrigen Zusammensetzung mit einem Gehalt an hautfreundlichen Tensiden und nicht mehr als 0,1 Gew.-% eines l-Hydroxy-2-pyridon-Derivats ist, und die zweite Komponente (B) eine Antischuppen-Lotion in Form einer wässrig-alkoholischen Zubereitung mit einem Gehalt von wenigstens6. Head dandruff treatment agent, consisting of two separately packaged components combined into a sales unit, one of which Component (A) is a shampoo in the form of an aqueous composition containing skin-friendly surfactants and not more than 0.1% by weight of an 1-hydroxy-2-pyridone derivative, and the second component (B) is an anti-dandruff Lotion in the form of an aqueous alcoholic preparation containing at least
0,1 Gew.-% eines l-Hydroxy-2-pyridon-Derivats ist. 0.1% by weight of an 1-hydroxy-2-pyridone derivative.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01951464A EP1282390A1 (en) | 2000-05-09 | 2001-04-28 | Method for the treatment of dandruff using 1-hydroxy-2-pyridone derivatives |
| AU2001272381A AU2001272381A1 (en) | 2000-05-09 | 2001-04-28 | Method for the treatment of dandruff using 1-hydroxy-2-pyridone derivatives |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10022418.0 | 2000-05-09 | ||
| DE2000122418 DE10022418A1 (en) | 2000-05-09 | 2000-05-09 | Anti-dandruff treatment involves washing with shampoo containing a small amount of 1-hydroxy-2-pyridone derivative and then treating the hair with lotion containing this derivative in higher concentration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2001085107A1 true WO2001085107A1 (en) | 2001-11-15 |
Family
ID=7641218
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2001/004823 WO2001085107A1 (en) | 2000-05-09 | 2001-04-28 | Method for the treatment of dandruff using 1-hydroxy-2-pyridone derivatives |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1282390A1 (en) |
| AU (1) | AU2001272381A1 (en) |
| DE (1) | DE10022418A1 (en) |
| WO (1) | WO2001085107A1 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003028695A1 (en) * | 2001-09-25 | 2003-04-10 | Beiersdorf Ag | Use of surfactants with a ratio of hemolysis value to denaturation index of greater than or equal to 1 for obtaining or increasing the selectivity of cleansing preparations |
| WO2004032895A1 (en) * | 2002-09-26 | 2004-04-22 | Beiersdorf Ag | Use of detergents with a quotient from the haemolysis value and denaturing index of greater than or equal to 1 for achieving or increasing the selectivity of cleaning preparations |
| WO2009100999A1 (en) * | 2008-02-12 | 2009-08-20 | Henkel Ag & Co. Kgaa | Hair and body cleansers having a prolonged odoriferous effect |
| US20140147402A1 (en) * | 2010-07-27 | 2014-05-29 | Clariant Finance (Bvi) Limited | Compositions Comprising Hydrogen Peroxide or Hydrogen Peroxide Donor Substances |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0217635A2 (en) * | 1985-09-27 | 1987-04-08 | The Procter & Gamble Company | Hair treatment |
| EP0315912A1 (en) * | 1987-11-12 | 1989-05-17 | Henkel Kommanditgesellschaft auf Aktien | Sebosuppressive preparations |
| US5132107A (en) * | 1986-07-07 | 1992-07-21 | Lange Bouke J | Two-phase cleansing, conditioning and medicinal treatment shampoo |
| DE29507578U1 (en) * | 1995-05-06 | 1996-09-05 | Kao Corp Gmbh | Liquid detergent |
| US5650145A (en) * | 1994-05-05 | 1997-07-22 | L'oreal | Dermatological/cosmetic compositions comprising antifungal and antibacterial compounds and reduction of hair loss therewith |
| JPH09291016A (en) * | 1996-04-25 | 1997-11-11 | Sunstar Inc | Hair cosmetic material |
-
2000
- 2000-05-09 DE DE2000122418 patent/DE10022418A1/en not_active Ceased
-
2001
- 2001-04-28 AU AU2001272381A patent/AU2001272381A1/en not_active Abandoned
- 2001-04-28 EP EP01951464A patent/EP1282390A1/en not_active Ceased
- 2001-04-28 WO PCT/EP2001/004823 patent/WO2001085107A1/en active Application Filing
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0217635A2 (en) * | 1985-09-27 | 1987-04-08 | The Procter & Gamble Company | Hair treatment |
| US5132107A (en) * | 1986-07-07 | 1992-07-21 | Lange Bouke J | Two-phase cleansing, conditioning and medicinal treatment shampoo |
| EP0315912A1 (en) * | 1987-11-12 | 1989-05-17 | Henkel Kommanditgesellschaft auf Aktien | Sebosuppressive preparations |
| US5650145A (en) * | 1994-05-05 | 1997-07-22 | L'oreal | Dermatological/cosmetic compositions comprising antifungal and antibacterial compounds and reduction of hair loss therewith |
| DE29507578U1 (en) * | 1995-05-06 | 1996-09-05 | Kao Corp Gmbh | Liquid detergent |
| JPH09291016A (en) * | 1996-04-25 | 1997-11-11 | Sunstar Inc | Hair cosmetic material |
Non-Patent Citations (1)
| Title |
|---|
| PATENT ABSTRACTS OF JAPAN vol. 1998, no. 03 27 February 1998 (1998-02-27) * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003028695A1 (en) * | 2001-09-25 | 2003-04-10 | Beiersdorf Ag | Use of surfactants with a ratio of hemolysis value to denaturation index of greater than or equal to 1 for obtaining or increasing the selectivity of cleansing preparations |
| WO2004032895A1 (en) * | 2002-09-26 | 2004-04-22 | Beiersdorf Ag | Use of detergents with a quotient from the haemolysis value and denaturing index of greater than or equal to 1 for achieving or increasing the selectivity of cleaning preparations |
| WO2009100999A1 (en) * | 2008-02-12 | 2009-08-20 | Henkel Ag & Co. Kgaa | Hair and body cleansers having a prolonged odoriferous effect |
| US20140147402A1 (en) * | 2010-07-27 | 2014-05-29 | Clariant Finance (Bvi) Limited | Compositions Comprising Hydrogen Peroxide or Hydrogen Peroxide Donor Substances |
| US11110121B2 (en) * | 2010-07-27 | 2021-09-07 | Clariant International Ltd. | Compositions comprising hydrogen peroxide or hydrogen peroxide donor substances |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1282390A1 (en) | 2003-02-12 |
| AU2001272381A1 (en) | 2001-11-20 |
| DE10022418A1 (en) | 2001-11-15 |
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