WO2001083737A3 - Vaccin d"adenovirus porcin - Google Patents

Vaccin d"adenovirus porcin Download PDF

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Publication number
WO2001083737A3
WO2001083737A3 PCT/CA2001/000598 CA0100598W WO0183737A3 WO 2001083737 A3 WO2001083737 A3 WO 2001083737A3 CA 0100598 W CA0100598 W CA 0100598W WO 0183737 A3 WO0183737 A3 WO 0183737A3
Authority
WO
WIPO (PCT)
Prior art keywords
vaccine
vector
adenovirus type
porcine adenovirus
vaccines
Prior art date
Application number
PCT/CA2001/000598
Other languages
English (en)
Other versions
WO2001083737A2 (fr
Inventor
Eva Nagy
Tamas Tuboly
Miklos Nagy
Original Assignee
Univ Guelph
Eva Nagy
Tamas Tuboly
Miklos Nagy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Guelph, Eva Nagy, Tamas Tuboly, Miklos Nagy filed Critical Univ Guelph
Priority to CA002413265A priority Critical patent/CA2413265A1/fr
Priority to EP01929140A priority patent/EP1311698A2/fr
Publication of WO2001083737A2 publication Critical patent/WO2001083737A2/fr
Publication of WO2001083737A3 publication Critical patent/WO2001083737A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La présente invention concerne la totalité de la séquence nucléotidique du sérotype 5 d"adénovirus porcin (PAdV-5) ainsi que des procédés d"insertion de séquences nucléotidiques hétérologues, telles que le gène TGEV S, dans la région E3 du virus. L"invention concerne également des vaccins et des procédés de préparation de vaccins au moyen de l"adénovirus de recombinaison ainsi que des applications du virus de recombinaison et des vaccins.
PCT/CA2001/000598 2000-05-03 2001-05-03 Vaccin d"adenovirus porcin WO2001083737A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002413265A CA2413265A1 (fr) 2000-05-03 2001-05-03 Vaccin d'adenovirus porcin
EP01929140A EP1311698A2 (fr) 2000-05-03 2001-05-03 Vaccin d'adenovirus porcin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20166600P 2000-05-03 2000-05-03
US60/201,666 2000-05-03

Publications (2)

Publication Number Publication Date
WO2001083737A2 WO2001083737A2 (fr) 2001-11-08
WO2001083737A3 true WO2001083737A3 (fr) 2002-08-22

Family

ID=22746770

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2001/000598 WO2001083737A2 (fr) 2000-05-03 2001-05-03 Vaccin d"adenovirus porcin

Country Status (3)

Country Link
EP (1) EP1311698A2 (fr)
CA (1) CA2413265A1 (fr)
WO (1) WO2001083737A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA82647C2 (uk) * 2001-03-27 2008-05-12 Юниверсити Оф Саскачеван Спосіб культивування цирковірусу ссавця
US7276353B2 (en) 2001-12-12 2007-10-02 Virginia Tech Intellectual Properties, Inc. Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
US7279166B2 (en) 2001-12-12 2007-10-09 Virginia Tech Intellectual Properties, Inc. Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
US7906311B2 (en) 2002-03-20 2011-03-15 Merial Limited Cotton rat lung cells for virus culture
CU23544A1 (es) 2006-02-28 2010-06-17 Ct Ingenieria Genetica Biotech Antígenos vacunales quiméricos contra el virus de la peste porcina clásica
CN108410885A (zh) * 2018-03-29 2018-08-17 中国农业科学院北京畜牧兽医研究所 一种猪细小病毒的全长感染性dna克隆及其构建方法和应用
CN110981945B (zh) * 2019-12-08 2021-10-19 中牧实业股份有限公司 一种猪圆环病毒2型重组Cap蛋白的表达制备及应用
CN111166875A (zh) * 2020-01-08 2020-05-19 广州恩宝生物医药科技有限公司 一种腺病毒二价疫苗
CN111471657A (zh) * 2020-04-22 2020-07-31 四川农业大学 一种表达ASFV P30蛋白的PRV gE/gI双基因缺失株的构建方法
CN112226408B (zh) * 2020-09-30 2024-04-02 西北农林科技大学 一种猪病原或外源性蛋白特异性抗原肽筛选和鉴定的方法
CN112625095B (zh) * 2021-01-13 2023-01-03 武汉科前生物股份有限公司 一种猪轮状病毒重组蛋白以及表达该蛋白的重组腺病毒和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999008706A1 (fr) * 1997-08-14 1999-02-25 Commonwealth Scientific And Industrial Research Organisation Vecteur d'adenovirus de recombinaison porcin
WO1999053047A2 (fr) * 1998-04-15 1999-10-21 University Of Saskatchewan Genome d'adenovirus porcin de type 3
WO2000047756A1 (fr) * 1999-02-11 2000-08-17 Merial Vecteurs et vaccins viraux a base d'adenovirus porcins recombines

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999008706A1 (fr) * 1997-08-14 1999-02-25 Commonwealth Scientific And Industrial Research Organisation Vecteur d'adenovirus de recombinaison porcin
WO1999053047A2 (fr) * 1998-04-15 1999-10-21 University Of Saskatchewan Genome d'adenovirus porcin de type 3
WO2000047756A1 (fr) * 1999-02-11 2000-08-17 Merial Vecteurs et vaccins viraux a base d'adenovirus porcins recombines

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
NAGY M ET AL: "Porcine adenoviruses: An update on genome analysis and vector development.", ACTA VETERINARIA HUNGARICA, vol. 48, no. 4, 2000, pages 491 - 499, XP001040324, ISSN: 0236-6290 *
NAGY MIKLOS ET AL: "The complete nucleotide sequence of porcine adenovirus serotype 5.", JOURNAL OF GENERAL VIROLOGY, vol. 82, no. 3, March 2001 (2001-03-01), pages 525 - 529, XP002190138, ISSN: 0022-1317 *
REDDY P S ET AL: "Comparison of the inverted terminal repetition sequences from five porcine adenovirus serotypes", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 212, no. 1, 1995, pages 237 - 239, XP002120931, ISSN: 0042-6822 *
TUBOLY T ET AL: "Potential viral vectors for the stimulation of mucosal antibody responses against enteric viral antigens in pigs", RESEARCH IN VETERINARY SCIENCE, BRITISH VETERINARY ASSOCIATION, LONDON, GB, vol. 54, no. 3, May 1993 (1993-05-01), pages 345 - 350, XP002120927, ISSN: 0034-5288 *
TUBOLY T ET AL: "RESTRICTION ENDONUCLEASE ANALYSIS AND PHYSICAL MAPPING OF THE GENOME OF PORCINE ADENOVIRUS TYPE 5", VIRUS RESEARCH, AMSTERDAM, NL, vol. 37, no. 1, 1995, pages 49 - 54, XP000866400, ISSN: 0168-1702 *
TUBOLY T ET AL: "Sequence analysis and deletion of porcine adenovirus serotype 5 E3 region.", VIRUS RESEARCH, vol. 68, no. 2, July 2000 (2000-07-01), pages 109 - 117, XP001040323, ISSN: 0168-1702 *
TUBOLY TAMAS ET AL: "Characterization of early region 4 of porcine adenovirus serotype 5.", VIRUS GENES, vol. 20, no. 3, 2000, pages 217 - 219, XP001040322, ISSN: 0920-8569 *
TUBOLY TAMAS ET AL: "Construction and characterization of recombinant porcine adenovirus serotype 5 expressing the transmissible gastroenteritis virus spike gene.", JOURNAL OF GENERAL VIROLOGY, vol. 82, no. 1, January 2001 (2001-01-01), pages 183 - 190, XP002190137, ISSN: 0022-1317 *

Also Published As

Publication number Publication date
EP1311698A2 (fr) 2003-05-21
WO2001083737A2 (fr) 2001-11-08
CA2413265A1 (fr) 2001-11-08

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