WO2001080945A1 - Administration transdermique d'acide ascorbique - Google Patents

Administration transdermique d'acide ascorbique Download PDF

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Publication number
WO2001080945A1
WO2001080945A1 PCT/KR2001/000648 KR0100648W WO0180945A1 WO 2001080945 A1 WO2001080945 A1 WO 2001080945A1 KR 0100648 W KR0100648 W KR 0100648W WO 0180945 A1 WO0180945 A1 WO 0180945A1
Authority
WO
WIPO (PCT)
Prior art keywords
ascorbic acid
skin
transdermal administration
iontophoresis
ultrasonic
Prior art date
Application number
PCT/KR2001/000648
Other languages
English (en)
Inventor
Won-Seok Kim
Jong-Wook Park
Hee-Yoon Cho
Original Assignee
Doctors Tech Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020000021350A external-priority patent/KR100354291B1/ko
Priority claimed from KR20000075649A external-priority patent/KR100303157B1/ko
Application filed by Doctors Tech Co., Ltd. filed Critical Doctors Tech Co., Ltd.
Priority to AU2001252733A priority Critical patent/AU2001252733A1/en
Publication of WO2001080945A1 publication Critical patent/WO2001080945A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/83—Electrophoresis; Electrodes; Electrolytic phenomena
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/0436—Material of the electrode

Definitions

  • the present invention relates to a method for transdermal
  • the present invention relates to a method for
  • ascorbic acid also known as Vitamin C
  • Vitamin C has an efficacy
  • ascorbic acid is known to have an effect of inhibiting the
  • histamine which is believed to be a cause of the formation of melanin, which induces pigmentations, and various allergies, particularly skin
  • ascorbic acid can be stored and
  • administrated into skin is preferable in order to increase the actual efficiency.
  • ascorbic acid has very low solubility in a non-aqueous medium, and if
  • Korean Patent Application No. 97-23005 discloses
  • composition that can be transdermally administrated by iontophoresis.
  • transdermal administration which can penetrate ascorbic acid into skin in a
  • the present invention provides an
  • ascorbic acid composition for iontophoresis comprising: (a) 1 to 10wt% of a mixture comprising:
  • aloe vera gel and alantoin in a weight ratio of 1 -25 : 1 -50 :
  • the present invention provides a method for transdermal
  • the iontophoresis is preferably
  • the present invention provides a skin-care apparatus
  • a resonance part that is connected to the electric source part by AC and causes pulses to resonate to ultrasonic waves
  • vibrations are generated by surface-attached piezoelectric elements.
  • Fig. 1 is a block diagram showing the skin-care apparatus of the
  • Fig. 2 is a planar view of a vibration part of the skin-care apparatus
  • Fig. 3 is a side view of a vibration part of the skin-care apparatus of
  • Fig. 4 shows the iontophoresis apparatus used in the present
  • Fig. 5 is a photo of a patient having melasma before medical
  • Fig. 6 is a photo of the same person of Fig. 5 after administrating an
  • Fig. 7 is a photo of a patient having melasma before medical
  • Fig. 8 is a photo of the same person of Fig. 7 after ultrasonic
  • Fig. 9 is a photo of a patient having acne before medical treatment
  • Fig. 10 is a photo of the same person of Fig. 9 after administrating
  • Fig. 1 1 is a photo of a patient having acne before medical treatment
  • Fig. 12 is a photo of the same person after ultrasonic cleansing and
  • Fig. 13 is a photo showing the appearance around wrinkles before
  • Fig. 14 is a photo showing the same part of Fig. 13 after ultrasonic
  • the present inventors have discovered that if ascorbic acid is converted to its metal phosphate salt form and transdermally administrated
  • the metal phosphate salts of ascorbic acid can be rapidly
  • salts are decomposed by enzymes and changed to ascorbic acid, which
  • a metal phosphate salt of ascorbic acid can be prepared by reacting
  • the metal phosphate salts of ascorbic acid is preferably selected
  • magnesium phosphate salt is most preferable.
  • An L-ascorbic acid is mixed with acetone and strength oleum at 0 ° C ,
  • the mixture is stirred for 6 hours, its temperature is lowered to -15 ° C , and the
  • magnesium chloride (MgCI 2 - 6H 2 0) is added to the mixture, and the mixture is stirred for 1 to 2 hours and the produced crystals are removed.
  • Methanol magnesium chloride
  • magnesium-L-ascorbyl-2-phosphate is penetrated into bodies, phosphate
  • the ascorbic acid composition for transdermal administration of the ascorbic acid composition for transdermal administration of the ascorbic acid composition
  • present invention is prepared by mixing ⁇ -G-rutin, alantoin, aloe vera gel,
  • metal phosphate salt of ascorbic acid and 1 to 80wt% of additives, and 90 to
  • the additives preferably comprise ⁇ -G-rutin, alantoin, aloe vera gel,
  • phosphate salt of ascorbic acid is stable even in an aqueous solution and
  • the ascorbic acid composition for transdermal administration is a mixture of the ascorbic acid composition for transdermal administration.
  • the present invention includes
  • iontophoresis which passes currents through electrolyte comprising ionic
  • iontophoresis is a method for transdermal
  • present invention is preferably conducted by periodically generating a
  • the formed electric energy may have hypersensitive responses due to chlorine or medicine, and if the voltage is less than 3v, the formed electric energy will be insufficient for the
  • the produced ascorbic acid reduces dopaquinone at a
  • melanocyte which is an important intermediate of tyrosinase reaction
  • transdermal administration rate of metal phosphate salt of ascorbic acid can be any transdermal administration rate.
  • openings of sebaceous glands as well as skin-contaminations can be
  • ultrasonic vibrations are generated through 3 steps of
  • the lifting step can be conducted after iontophoresis.
  • the most preferable ultrasonic massage method comprises cleansing,
  • the ultrasonic massage according to the above method penetrates
  • the present invention provides a skin-care apparatus for
  • present invention comprises an electric source part to which an alternating
  • AC current
  • DC direct current
  • Fig. 1 is a block diagram showing the skin-care apparatus of the
  • An alternating current (AC) electric source is applied to an electric
  • the processor part (20) is operated by DC that is input through the
  • the resonance part (30) comprises a coil and a condenser, and it
  • resonance part is amplified to a degree of 20 to 40kHz, and more preferably
  • An iontophoresis-vibration part is divided into an iontophoresis part
  • the contact plate (72) is made of stainless steel that is harmless to
  • TiN titanium nitride
  • zirconium nitride is formed so as to protect skin that is sensitive to
  • the coating film can be deposited using a Chemical Vapor
  • a circuit for iontophoresis is connected to the stainless steel contact
  • ultrasonic cleansing can be individually conducted, or the
  • ultrasonic massage and the iontophoresis can be simultaneously conducted.
  • a ground part (78) can be connected to the contact plate (72).
  • the electrodes of the electric source (10) and the ground part (78) can be positive voltage/negative voltage or negative voltage/positive voltage.
  • a sponge cover (80) can be inserted into the front end of
  • agents such as medicines, cosmetics or an ascorbic acid composition, etc.
  • the sponge cover (80) is inserted into the front end of
  • composition of the present invention so that the aqueous solution can be
  • the 4 skin-care modes include a cleansing mode, a scaling mode, a
  • the processor part (20) controls the
  • amplitude are applied to the skin for 5 minutes.
  • the epidermal layer of the skin may have
  • ascorbic acid to penetrate cell membranes of the epidermal layer.
  • Example is to illustrate the present
  • the mixed solution was slowly added to 1.2 liters of methanol, and the
  • Fig. 4 shows the iontophoresis device used in the present invention
  • the electric source part is transferred via the stainless steel plate to the
  • the iontophoresis device of Fig. 4 can tansdermally
  • composition by iontophoresis was conducted as follows: 3 to 10 i of the ascorbic acid composition were coated on the face,
  • Vitamin Ultrasonic vibrations of 25kHz were applied to the skin
  • the ascorbic acid was transdermally administrated to persons
  • Figs. 5 to 14 are photos showing the results of Table 1. Fig. 5
  • Fig. 6 shows the same person after treating
  • Fig. 7 shows the
  • Fig. 8 shows the same person after treating with the
  • Fig. 10 shows the same person after treating
  • Fig. 11 shows the
  • Fig. 12 shows the same person after treating with
  • Fig. 14 shows the appearance of the same part after
  • composition is transdermally administrated by iontophoresis using a

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Electrotherapy Devices (AREA)

Abstract

Cette invention concerne une méthode d'administration transdermique d'acide ascorbique et un dispositif pour soins de la peau. Ladite méthode se caractérise en ce que l'on fait pénétrer le sel de phosphate métallique de l'acide ascorbique dans la peau par ionophorèse. A cette fin, on applique par intervalles une tension positive de 3 à 20V, une tension négative de 3 à 20V sou une intensité de 0,01 à 1,0 mA pour l'administration transdermique d'une composition comprenant un sel de phosphate de métal d'acide ascorbique. L'invention concerne également un dispositif pour soins de la peau qui fait intervenir l'ionophorèse et des ondes ultrasoniques. La méthode selon la présente invention convient pour l'élimination des taches de rousseur, du mélasma, de l'acné, des matières sébacées, des rides ainsi que pour la prévention du vieillissement de la peau et pour le blanchissement.
PCT/KR2001/000648 2000-04-21 2001-04-18 Administration transdermique d'acide ascorbique WO2001080945A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001252733A AU2001252733A1 (en) 2000-04-21 2001-04-18 Method for transdermal administration of ascorbic acid

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR1020000021350A KR100354291B1 (ko) 2000-04-21 2000-04-21 경피투여용 아스코르빈산 조성물
KR2000/21350 2000-04-21
KR20000075649A KR100303157B1 (ko) 2000-12-12 2000-12-12 피부 관리장치
KR2000/75649 2000-12-12

Publications (1)

Publication Number Publication Date
WO2001080945A1 true WO2001080945A1 (fr) 2001-11-01

Family

ID=26637900

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2001/000648 WO2001080945A1 (fr) 2000-04-21 2001-04-18 Administration transdermique d'acide ascorbique

Country Status (2)

Country Link
AU (1) AU2001252733A1 (fr)
WO (1) WO2001080945A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2844719A1 (fr) * 2002-09-24 2004-03-26 Francois Duret Dispositif electro-chimique pour le blanchiment d'un corps
EP1429670A2 (fr) * 2001-09-20 2004-06-23 David L. Kellogg Procede de nettoyage de la peau
WO2005004984A1 (fr) * 2003-07-14 2005-01-20 Power Paper Ltd. Dispositif et procede permettant de traiter des troubles pilosebaces
WO2009009818A1 (fr) * 2007-07-17 2009-01-22 Tanti Diana Tanujaya Thérapie cellulaire bio-vivante
US8239017B2 (en) 2003-06-30 2012-08-07 Johnson & Johnson Consumer Companies, Inc. Device for treatment of barrier membranes
US8734421B2 (en) 2003-06-30 2014-05-27 Johnson & Johnson Consumer Companies, Inc. Methods of treating pores on the skin with electricity
US9044397B2 (en) 2009-03-27 2015-06-02 Ethicon, Inc. Medical devices with galvanic particulates
CN112198553A (zh) * 2020-10-12 2021-01-08 吉林大学 集成反射振幅补偿的人机交互式深海水体三维速度分析法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999049878A1 (fr) * 1998-03-31 1999-10-07 Mary Kay Inc. Composition eclaircissant la peau, contenant du phosphate d'ascorbyle de magnesium et l'extrait uninontan-u34tm (formulation d'extrait de concombre et d'extrait de citron)
US6030374A (en) * 1998-05-29 2000-02-29 Mcdaniel; David H. Ultrasound enhancement of percutaneous drug absorption

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999049878A1 (fr) * 1998-03-31 1999-10-07 Mary Kay Inc. Composition eclaircissant la peau, contenant du phosphate d'ascorbyle de magnesium et l'extrait uninontan-u34tm (formulation d'extrait de concombre et d'extrait de citron)
US6030374A (en) * 1998-05-29 2000-02-29 Mcdaniel; David H. Ultrasound enhancement of percutaneous drug absorption

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1429670A2 (fr) * 2001-09-20 2004-06-23 David L. Kellogg Procede de nettoyage de la peau
EP1429670A4 (fr) * 2001-09-20 2005-02-02 David L Kellogg Procede de nettoyage de la peau
FR2844719A1 (fr) * 2002-09-24 2004-03-26 Francois Duret Dispositif electro-chimique pour le blanchiment d'un corps
WO2004028626A1 (fr) * 2002-09-24 2004-04-08 Duret Francois Dispositif pour le blanchiment utilisant des moyens électro­optiques et chimiques, notamment dans le domaine médical et dentaire
US8239017B2 (en) 2003-06-30 2012-08-07 Johnson & Johnson Consumer Companies, Inc. Device for treatment of barrier membranes
US8734421B2 (en) 2003-06-30 2014-05-27 Johnson & Johnson Consumer Companies, Inc. Methods of treating pores on the skin with electricity
WO2005004984A1 (fr) * 2003-07-14 2005-01-20 Power Paper Ltd. Dispositif et procede permettant de traiter des troubles pilosebaces
WO2009009818A1 (fr) * 2007-07-17 2009-01-22 Tanti Diana Tanujaya Thérapie cellulaire bio-vivante
US9044397B2 (en) 2009-03-27 2015-06-02 Ethicon, Inc. Medical devices with galvanic particulates
CN112198553A (zh) * 2020-10-12 2021-01-08 吉林大学 集成反射振幅补偿的人机交互式深海水体三维速度分析法
CN112198553B (zh) * 2020-10-12 2021-10-22 吉林大学 集成反射振幅补偿的人机交互式深海水体三维速度分析法

Also Published As

Publication number Publication date
AU2001252733A1 (en) 2001-11-07

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