WO2001080721A3 - Methods and compositions for the diagnosis of schizophrenia - Google Patents

Methods and compositions for the diagnosis of schizophrenia Download PDF

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Publication number
WO2001080721A3
WO2001080721A3 PCT/US2001/013088 US0113088W WO0180721A3 WO 2001080721 A3 WO2001080721 A3 WO 2001080721A3 US 0113088 W US0113088 W US 0113088W WO 0180721 A3 WO0180721 A3 WO 0180721A3
Authority
WO
WIPO (PCT)
Prior art keywords
schizophrenia
methods
diagnosis
compositions
scz
Prior art date
Application number
PCT/US2001/013088
Other languages
French (fr)
Other versions
WO2001080721A9 (en
WO2001080721A2 (en
Inventor
Linda M Brzustowicz
Anne S Bassett
Original Assignee
Univ Rutgers
Linda M Brzustowicz
Anne S Bassett
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rutgers, Linda M Brzustowicz, Anne S Bassett filed Critical Univ Rutgers
Priority to AU2001257180A priority Critical patent/AU2001257180A1/en
Publication of WO2001080721A2 publication Critical patent/WO2001080721A2/en
Publication of WO2001080721A3 publication Critical patent/WO2001080721A3/en
Publication of WO2001080721A9 publication Critical patent/WO2001080721A9/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Abstract

The invention maps a gene (SCZ) associated with schizophrenia to the q22 region of chromosome 1. The invention exploits this discovery to provide methods of diagnosing schizophrenia and schizophrenia susceptibility, methods of screening for the SCZ gene, and libraries of cloned segments including the SCZ gene.
PCT/US2001/013088 2000-04-21 2001-04-23 Methods and compositions for the diagnosis of schizophrenia WO2001080721A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001257180A AU2001257180A1 (en) 2000-04-21 2001-04-23 Methods and compositions for the diagnosis of schizophrenia

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19908500P 2000-04-21 2000-04-21
US60/199,085 2000-04-21

Publications (3)

Publication Number Publication Date
WO2001080721A2 WO2001080721A2 (en) 2001-11-01
WO2001080721A3 true WO2001080721A3 (en) 2002-05-23
WO2001080721A9 WO2001080721A9 (en) 2003-01-16

Family

ID=22736148

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/013088 WO2001080721A2 (en) 2000-04-21 2001-04-23 Methods and compositions for the diagnosis of schizophrenia

Country Status (2)

Country Link
AU (1) AU2001257180A1 (en)
WO (1) WO2001080721A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130123433A1 (en) 2011-11-14 2013-05-16 Formosa Laboratories, Inc. Method for preparing poly(allylamine) hydrochloride and derivatives therefrom

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BRZUSTOWICZ L.M. ET AL.: "Location of a major susceptibility locus for familial chizophrenia on chromosome 1q21-q22", SCIENCE, vol. 288, no. 5466, 28 April 2000 (2000-04-28), pages 678 - 682, XP002949636 *
GOODMAN A.B.: "Medical conditions in Ashkenazi schizophrenic pedigrees", SCHIZOPHRENIA BULLETIN, vol. 20, no. 3, 1994, pages 507 - 517, XP002949639 *
PULVER A.E. ET AL.: "Genetic heterogeneity in schizophrenia: Stratification of genome scan data using C-segregating related phenotypes", MOLECULAR PSYCHIATRY, vol. 5, no. 6, November 2000 (2000-11-01), pages 650 - 653, XP002949638 *
WITTEKINDT O. ET AL.: "The human small conductance calcium-regulated potassium channel gene (hSKCa3) contains two CAG repeats in exon 1, is on chromosome 1q21.3 and shows a possible association with schizophrenia", NEUROGENETICS, vol. 1, no. 4, August 1998 (1998-08-01), pages 259 - 265, XP002949637 *

Also Published As

Publication number Publication date
WO2001080721A9 (en) 2003-01-16
WO2001080721A2 (en) 2001-11-01
AU2001257180A1 (en) 2001-11-07

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