WO2001078575A3 - Ext2 as a predictive marker for osteoporosis - Google Patents

Ext2 as a predictive marker for osteoporosis Download PDF

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Publication number
WO2001078575A3
WO2001078575A3 PCT/US2001/012447 US0112447W WO0178575A3 WO 2001078575 A3 WO2001078575 A3 WO 2001078575A3 US 0112447 W US0112447 W US 0112447W WO 0178575 A3 WO0178575 A3 WO 0178575A3
Authority
WO
WIPO (PCT)
Prior art keywords
osteoporosis
ext2
predictive marker
subject
bone mineral
Prior art date
Application number
PCT/US2001/012447
Other languages
French (fr)
Other versions
WO2001078575A2 (en
Inventor
Robert F Klein
Eric S Orwoll
John K Belknap
Original Assignee
Univ Oregon Health & Science
Us Dept Veterans Affairs
Robert F Klein
Eric S Orwoll
John K Belknap
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Oregon Health & Science, Us Dept Veterans Affairs, Robert F Klein, Eric S Orwoll, John K Belknap filed Critical Univ Oregon Health & Science
Priority to AU2001257071A priority Critical patent/AU2001257071A1/en
Publication of WO2001078575A2 publication Critical patent/WO2001078575A2/en
Publication of WO2001078575A3 publication Critical patent/WO2001078575A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Abstract

This disclosure provides the identification of polymorphisms of the Ext2 gene that are linked to a predisposition to osteoporosis or an increased likelihood of having low bone mineral density in a subject. Also provided are methods for diagnosing and/or treating osteoporosis and low bone mineral density in a subject.
PCT/US2001/012447 2000-04-17 2001-04-17 Ext2 as a predictive marker for osteoporosis WO2001078575A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001257071A AU2001257071A1 (en) 2000-04-17 2001-04-17 Ext2 as a predictive marker for osteoporosis

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US19791700P 2000-04-17 2000-04-17
US60/197,917 2000-04-17
US23784800P 2000-10-04 2000-10-04
US60/237,848 2000-10-04

Publications (2)

Publication Number Publication Date
WO2001078575A2 WO2001078575A2 (en) 2001-10-25
WO2001078575A3 true WO2001078575A3 (en) 2002-03-14

Family

ID=26893281

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/012447 WO2001078575A2 (en) 2000-04-17 2001-04-17 Ext2 as a predictive marker for osteoporosis

Country Status (2)

Country Link
AU (1) AU2001257071A1 (en)
WO (1) WO2001078575A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003292404A1 (en) * 2002-12-13 2004-07-09 Oxagen Limited Genetic susceptibility
CA2574014A1 (en) * 2004-07-16 2006-01-26 Oy Jurilab Ltd Method for detecting the risk of and for treatment of type 2 diabetes
CN116287280B (en) * 2023-05-25 2023-08-15 北京大学第三医院（北京大学第三临床医学院） EXT1 or EXT2 diagnostic kit based on single cell transcriptome mRNA level

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997038135A1 (en) * 1996-04-05 1997-10-16 Medical Science Systems, Inc. Detecting genetic predisposition for osteoporosis
EP0837127A2 (en) * 1996-10-21 1998-04-22 Hunan Medical University Hereditary multiple exostose gene, Ext2
WO1998044150A1 (en) * 1997-03-27 1998-10-08 Gemini Research Ltd. Polymorphisms of an il-1 receptor antagonist gene

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997038135A1 (en) * 1996-04-05 1997-10-16 Medical Science Systems, Inc. Detecting genetic predisposition for osteoporosis
EP0837127A2 (en) * 1996-10-21 1998-04-22 Hunan Medical University Hereditary multiple exostose gene, Ext2
WO1998044150A1 (en) * 1997-03-27 1998-10-08 Gemini Research Ltd. Polymorphisms of an il-1 receptor antagonist gene

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KOBAYASHI ET AL.: "Association of EXT1 and EXT2, hereditary multiple exostoses gene products, in Golgi apparatus", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 268, 24 February 2000 (2000-02-24), pages 860 - 867, XP002947042 *
NOVEE ET AL.: "Ext-mutation analysis and loss of heterozygosity in sporadic and hereditary osteochondromas and secondary chondrosarcomas", vol. 65, December 1999 (1999-12-01), pages 689 - 698, XP002947043 *

Also Published As

Publication number Publication date
AU2001257071A1 (en) 2001-10-30
WO2001078575A2 (en) 2001-10-25

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