EP1047942A4 - Methods and compositions for the identification of growth factor mimetics, growth factors and inhibitors - Google Patents
Methods and compositions for the identification of growth factor mimetics, growth factors and inhibitorsInfo
- Publication number
- EP1047942A4 EP1047942A4 EP99903279A EP99903279A EP1047942A4 EP 1047942 A4 EP1047942 A4 EP 1047942A4 EP 99903279 A EP99903279 A EP 99903279A EP 99903279 A EP99903279 A EP 99903279A EP 1047942 A4 EP1047942 A4 EP 1047942A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- inhibitors
- compositions
- identification
- methods
- growth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Virology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Crystallography & Structural Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7225398P | 1998-01-23 | 1998-01-23 | |
US72253P | 1998-01-23 | ||
PCT/US1999/001331 WO1999038008A1 (en) | 1998-01-23 | 1999-01-22 | Methods and compositions for the identification of growth factor mimetics, growth factors and inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1047942A1 EP1047942A1 (en) | 2000-11-02 |
EP1047942A4 true EP1047942A4 (en) | 2002-10-30 |
Family
ID=22106479
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99903279A Withdrawn EP1047942A4 (en) | 1998-01-23 | 1999-01-22 | Methods and compositions for the identification of growth factor mimetics, growth factors and inhibitors |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1047942A4 (en) |
JP (2) | JP3515072B2 (en) |
AU (1) | AU2333999A (en) |
CA (1) | CA2316755C (en) |
WO (1) | WO1999038008A1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0001401D0 (en) * | 2000-01-22 | 2000-03-08 | Univ Edinburgh | Methods for amplifying genetic material and use thereof |
AU2001286173B2 (en) | 2000-08-01 | 2007-10-25 | Yissum Research Development Company | Directed differentiation of embryonic cells |
AU1091802A (en) * | 2000-10-20 | 2002-04-29 | Chugai Pharmaceutical Co Ltd | Degraded agonist antibody |
WO2003091424A1 (en) | 2002-04-26 | 2003-11-06 | Chugai Seiyaku Kabushiki Kaisha | Method of screening agonistic antibody |
JP2004016021A (en) | 2002-06-12 | 2004-01-22 | Japan Science & Technology Corp | Antibody and inhibitor, and method and kit for transformation using the same |
US7833979B2 (en) | 2005-04-22 | 2010-11-16 | Amgen Inc. | Toxin peptide therapeutic agents |
US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
PE20081140A1 (en) | 2006-10-25 | 2008-09-22 | Amgen Inc | THERAPEUTIC AGENTS BASED ON PEPTIDES DERIVED FROM TOXINS |
AU2008262490B2 (en) | 2007-05-22 | 2011-11-17 | Amgen Inc. | Compositions and methods for producing bioactive fusion proteins |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995027062A1 (en) * | 1994-04-04 | 1995-10-12 | Genentech, Inc. | Agonist antibodies against the flk2/flt3 receptor and uses thereof |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3434393A (en) * | 1992-01-17 | 1993-08-03 | Regents Of The University Of Michigan, The | Targeted virus |
WO1993018136A1 (en) * | 1992-03-05 | 1993-09-16 | Cytomed, Inc. | Process for supporting hematopoietic progenitor cells |
IL106255A0 (en) * | 1993-04-23 | 1993-11-15 | Baxter Int | Method for isolating human blood cells |
US5554512A (en) * | 1993-05-24 | 1996-09-10 | Immunex Corporation | Ligands for flt3 receptors |
US5753516A (en) * | 1995-02-03 | 1998-05-19 | Heagy; Wyrta E. | Screening method for ligands of the EBI-1 receptor |
US5686292A (en) * | 1995-06-02 | 1997-11-11 | Genentech, Inc. | Hepatocyte growth factor receptor antagonist antibodies and uses thereof |
-
1999
- 1999-01-22 WO PCT/US1999/001331 patent/WO1999038008A1/en not_active Application Discontinuation
- 1999-01-22 EP EP99903279A patent/EP1047942A4/en not_active Withdrawn
- 1999-01-22 CA CA002316755A patent/CA2316755C/en not_active Expired - Fee Related
- 1999-01-22 JP JP2000528865A patent/JP3515072B2/en not_active Expired - Fee Related
- 1999-01-22 AU AU23339/99A patent/AU2333999A/en not_active Abandoned
-
2003
- 2003-03-26 JP JP2003086460A patent/JP2004123695A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995027062A1 (en) * | 1994-04-04 | 1995-10-12 | Genentech, Inc. | Agonist antibodies against the flk2/flt3 receptor and uses thereof |
Non-Patent Citations (4)
Title |
---|
HUANG Y-W ET AL: "A MONOCLONAL ANTI-HUMAN IL-6 RECEPTOR ANTIBODY INHIBITS THE PROLIFERATION OF HUMAN MYELOMA CELLS", HYBRIDOMA, LIEBERT, NEW YORK, NY, US, vol. 5, no. 12, October 1993 (1993-10-01), pages 621 - 630, XP001069958, ISSN: 0272-457X * |
KRUIF DE J ET AL: "SELECTION AND APPLICATION OF HUMAN SINGLE CHAIN FV ANTIBODY FRAGMENTS FROM A SEMI-SYNTHETIC PHAGE ANTOBODY DISPLEY LIBRARY WITHDESIGNED CDR3 REGIONS", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 248, no. 1, 21 April 1995 (1995-04-21), pages 97 - 105, XP000646544, ISSN: 0022-2836 * |
NISHIDA Y ET AL: "CLONING AND EXPRESSION OF A SINGLE-CHAIN FV FRAGMENT SPECIFIC FOR THE HUMAN INTERLEUKIN 18 RECEPTOR", HYBRIDOMA, LIEBERT, NEW YORK, NY, US, vol. 17, no. 6, December 1998 (1998-12-01), pages 577 - 580, XP000973543, ISSN: 0272-457X * |
See also references of WO9938008A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP1047942A1 (en) | 2000-11-02 |
AU2333999A (en) | 1999-08-09 |
JP2003517566A (en) | 2003-05-27 |
JP2004123695A (en) | 2004-04-22 |
CA2316755A1 (en) | 1999-07-29 |
CA2316755C (en) | 2006-04-04 |
WO1999038008A1 (en) | 1999-07-29 |
JP3515072B2 (en) | 2004-04-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20000706 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
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AX | Request for extension of the european patent |
Free format text: AL PAYMENT 20000706;LT PAYMENT 20000706;LV PAYMENT 20000706;MK PAYMENT 20000706;RO PAYMENT 20000706;SI PAYMENT 20000706 |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: ALEXION ANTIBODY TECHNOLOGIES INC. |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20020918 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
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17Q | First examination report despatched |
Effective date: 20040420 |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20060831 |