WO2001076507A3 - Use of oxygen carriers to improve grafted cell survival in neural transplantation - Google Patents

Use of oxygen carriers to improve grafted cell survival in neural transplantation Download PDF

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Publication number
WO2001076507A3
WO2001076507A3 PCT/US2001/011564 US0111564W WO0176507A3 WO 2001076507 A3 WO2001076507 A3 WO 2001076507A3 US 0111564 W US0111564 W US 0111564W WO 0176507 A3 WO0176507 A3 WO 0176507A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell survival
oxygen carriers
neural transplantation
grafted cell
improve
Prior art date
Application number
PCT/US2001/011564
Other languages
French (fr)
Other versions
WO2001076507A2 (en
Inventor
Jacqueline Sagen
Elizabeth Potter
Original Assignee
Univ Miami
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Miami filed Critical Univ Miami
Publication of WO2001076507A2 publication Critical patent/WO2001076507A2/en
Publication of WO2001076507A3 publication Critical patent/WO2001076507A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

A stem cell transplantation medium containing a serum-free physiologically suitable aqueous carrier; about 1 % to about 20 % of an oxygen carrier; and optionally one or more growth factors or differentiation factors is disclosed. Also disclosed is the use of an oxygen carrier in a stem cell transplantation medium.
PCT/US2001/011564 2000-04-11 2001-04-11 Use of oxygen carriers to improve grafted cell survival in neural transplantation WO2001076507A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19609400P 2000-04-11 2000-04-11
US60/196,094 2000-04-11

Publications (2)

Publication Number Publication Date
WO2001076507A2 WO2001076507A2 (en) 2001-10-18
WO2001076507A3 true WO2001076507A3 (en) 2002-07-04

Family

ID=22724083

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/011564 WO2001076507A2 (en) 2000-04-11 2001-04-11 Use of oxygen carriers to improve grafted cell survival in neural transplantation

Country Status (1)

Country Link
WO (1) WO2001076507A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL147412A0 (en) * 2001-12-31 2002-08-14 Yeda Res & Dev The use of il6r/il6 chimera in nerve cell regeneration
CA2593668A1 (en) * 2005-01-11 2006-07-20 Cognate Therapeutics, Inc. Bone marrow stromal cells for immunoprotection of transplanted neural stem cells
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
WO2007053596A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
CA2651813A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
US20090197823A1 (en) 2006-05-09 2009-08-06 Braincells, Inc. Aliskiren modulation of neurogenesis
US9381273B2 (en) 2008-01-31 2016-07-05 Yissum Research Development Company Of The Hebrew University Of Jerusalem Scaffolds with oxygen carriers, and their use in tissue regeneration
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US9790468B2 (en) 2013-03-15 2017-10-17 Avita Iinternational Ltd. Multifunctional immature dental pulp stem cells and therapeutic applications

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1146759A (en) * 1997-08-06 1999-02-23 Terumo Corp Cell culture fluid
WO2000005343A2 (en) * 1998-07-24 2000-02-03 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Cell expansion system for use in neural transplantation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5895810A (en) 1995-03-23 1999-04-20 Biopure Corporation Stable polymerized hemoglobin and use thereof
US6150507A (en) 1995-03-23 2000-11-21 Biopure Corporation Method for producing a purified hemoglobin product
US5952470A (en) 1995-06-07 1999-09-14 Biopure Corporation Method for separating unmodified hemoglobin from cross-linked hemoglobin

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1146759A (en) * 1997-08-06 1999-02-23 Terumo Corp Cell culture fluid
WO2000005343A2 (en) * 1998-07-24 2000-02-03 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Cell expansion system for use in neural transplantation

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2001, POTTER E D ET AL: "Cytokine-treated mesencephalic progenitor nigral grafts in a Parkinson's Disease model.", XP002182960, Database accession no. PREV200100498298 *
DATABASE WPI Section Ch Week 199918, Derwent World Patents Index; Class B04, AN 1999-208102, XP002182961 *
POTTER E D ET AL: "Effects of ultrapurified hemoglobin on survival of mesencephalic progenitor cells in striatal grafts.", EXPERIMENTAL NEUROLOGY, vol. 164, no. 2, August 2000 (2000-08-01), Seventh Annual Conference of the American Society for Neural Transplantation and Repair;Clearwater, Florida, USA; April 27-30, 2000, pages 445, XP001031488, ISSN: 0014-4886 *
POTTER ELIZABETH D ET AL: "Cytokine-induced conversion of mesencephalic-derived progenitor cells into dopamine neurons.", CELL & TISSUE RESEARCH, vol. 296, no. 2, May 1999 (1999-05-01), pages 235 - 246, XP002182959, ISSN: 0302-766X *
SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 27, no. 1, 2001, 31st Annual Meeting of the Society for Neuroscience;San Diego, California, USA; November 10-15, 2001, pages 936, ISSN: 0190-5295 *
WASCHKE K F ET AL: "Biomedical applications of artificial oxygen carriers.", INFUSIONSTHERAPIE UND TRANSFUSIONMEDIZIN., vol. 26, no. Suppl. 2, November 1999 (1999-11-01), pages 31 - 36, XP001031476, ISSN: 1019-8466 *

Also Published As

Publication number Publication date
WO2001076507A2 (en) 2001-10-18

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