WO2001074792A3 - Procede de preparation d'inhibiteurs de metalloproteinases matricielles - Google Patents

Procede de preparation d'inhibiteurs de metalloproteinases matricielles Download PDF

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Publication number
WO2001074792A3
WO2001074792A3 PCT/US2001/010276 US0110276W WO0174792A3 WO 2001074792 A3 WO2001074792 A3 WO 2001074792A3 US 0110276 W US0110276 W US 0110276W WO 0174792 A3 WO0174792 A3 WO 0174792A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
matrix metalloproteinase
metalloproteinase inhibitors
inhibitors
matrix
Prior art date
Application number
PCT/US2001/010276
Other languages
English (en)
Other versions
WO2001074792A2 (fr
Inventor
Anne E Bailey
David R Hill
Chi-Nung Hsiao
Ravi Kurukulasuriya
Steve Wittenberger
Todd Mcdermott
Maureen Mclaughlin
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of WO2001074792A2 publication Critical patent/WO2001074792A2/fr
Publication of WO2001074792A3 publication Critical patent/WO2001074792A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention porte sur un procédé de synthèse d'inhibiteurs de métalloprotéinases matricielles.
PCT/US2001/010276 2000-03-31 2001-03-30 Procede de preparation d'inhibiteurs de metalloproteinases matricielles WO2001074792A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53995000A 2000-03-31 2000-03-31
US09/539,950 2000-03-31

Publications (2)

Publication Number Publication Date
WO2001074792A2 WO2001074792A2 (fr) 2001-10-11
WO2001074792A3 true WO2001074792A3 (fr) 2002-02-07

Family

ID=24153329

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/010276 WO2001074792A2 (fr) 2000-03-31 2001-03-30 Procede de preparation d'inhibiteurs de metalloproteinases matricielles

Country Status (1)

Country Link
WO (1) WO2001074792A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2847473B1 (fr) * 2002-11-25 2007-06-29 Expanscience Lab Composition comprenant au moins une oxazolidinone, son utilisation cosmetique et comme medicament

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4139538A (en) * 1975-08-29 1979-02-13 Nordmark-Werke Gmbh Oxazolidinones as therapeutic agents
FR2545488A1 (fr) * 1983-05-02 1984-11-09 Delalande Sa Nouveaux carbamates cycliques a chaine laterale du type arylmethyle ou aryloxymethyle, leurs procedes de preparation et leur application en therapeutique
WO1999006361A2 (fr) * 1997-07-31 1999-02-11 Abbott Laboratories Inhibiteurs d'hydroxamates inverses de metalloproteinases matricielles

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4139538A (en) * 1975-08-29 1979-02-13 Nordmark-Werke Gmbh Oxazolidinones as therapeutic agents
FR2545488A1 (fr) * 1983-05-02 1984-11-09 Delalande Sa Nouveaux carbamates cycliques a chaine laterale du type arylmethyle ou aryloxymethyle, leurs procedes de preparation et leur application en therapeutique
WO1999006361A2 (fr) * 1997-07-31 1999-02-11 Abbott Laboratories Inhibiteurs d'hydroxamates inverses de metalloproteinases matricielles

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ALLIN S M ET AL: "The preparation and first application of a polymer-supported "Evans" oxazolidinone", TETRAHEDRON LETTERS, vol. 37, no. 44, 28 October 1996 (1996-10-28), pages 8023 - 8026, XP004031033 *
SAIJO S ET AL: "Heterocyclic prostaglandins. VI. Synthesis of 11-deoxy-8,10-diazaprostaglandin E1 and its 10-methyl derivative", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 28, no. 5, May 1980 (1980-05-01), pages 1459 - 1467, XP002173910 *
SIBI M P ET AL: "A new electrophilic alanilol synthon. A general route to oxazolidinones of D or (R)-2-amino alcohols from L-serine", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, no. 13, 7 July 1994 (1994-07-07), pages 1675 - 1678, XP002173911 *
SIBI M P ET AL: "Investigation of a nucleophilic alanilol synthon derived from serine", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 121, no. 33, 25 August 1999 (1999-08-25), pages 7509 - 7516, XP002173912 *

Also Published As

Publication number Publication date
WO2001074792A2 (fr) 2001-10-11

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